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WO/2006/073365A1 |
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) &agr (NR1H3) and/or β (NR1H2) ...
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WO/2006/068092A1 |
The invention provides a process for producing (4,5-dihydro- isoxazol-3-yl)thiocarboxamidine salts easily and safely in a high yield which is freed from the disadvantages of the prior art. Specifically, a process for producing (4,5-dihyd...
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WO/2006/062249A1 |
A compound represented by the formula (1): (1) wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are defined in the present specification, a tautomer of said compound, a prodrug or pharmaceutically acceptable salt thereof or a solvated p...
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WO/2006/061135A1 |
The present invention relates to compounds of the general formula (I) wherein R1 is the group (A) or (B) or (C) or (D); R2 is a non aromatic heterocycle, or is OR' or N(R')2; R' is lower alkyl, lower alkyl substituted by halogen or -(CH2...
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WO/2006/054102A1 |
The present invention pertains to synthetic analogues of microcin B17 component units, methods of making and using these analogues, including, for example, as inhibitors of DNA gyrase. More particularly, the present invention pertains to...
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WO/2006/051704A1 |
An imine compound represented by the formula (X) (wherein A represents a heterocyclic group; R1, R2, and R3 each represents hydrogen, halogeno, C1-10 alkyl optionally substituted by haloaryl, C3-10 cycloalkyl, C1-6 haloalkyl, C1-10 alkox...
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WO/2006/040351A1 |
The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
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WO/2006/037274A1 |
An alkoxypropyl isothiazolinone of Formula : C6H6C12N02SR, in which R is CH3, CH2CH3, CH (CH3) 2, CH2CH2CH2CH3, CH2CH2OCH3 or CH2CH2OC6H5Cl. A method for preparing the isothiazolinone by reacting sodium polysulphide with methyl acrylate ...
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WO/2006/037480A1 |
The invention is concerned with hexafluoroisopropanol substituted ether derivatives of formula (I), wherein Rl to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. The...
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WO/2006/015829A1 |
Compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof are disclosed: wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1 4alkylamino; R2 and R3, which may be the same ...
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WO/2006/009134A1 |
A novel fungicide that exhibits a wide disease control spectrum against pathogenic fungi acting on various crops and helps resolve worsening resistant strain problems. There are provided diamine derivatives of the formula (1), a process ...
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WO/2005/113534A2 |
The present invention is directed to a compound having the general structure of formula (1) useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease.
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WO/2005/113525A1 |
The present invention relates to novel ketone compounds having Asp2 (β-secretase, BACE1 or Memapsin 2) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases c...
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WO/2005/110406A2 |
The invention relates to compounds of the formula (1) wherein X1, X2 and X3 independently is a halogen; p is an integer from 1 to 3; and R is -COOH, OR1 wherein R1 is a substituted isothiazole ring, or SR2 wherein R2 is (CH2)qC(COOH)(NHC...
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WO/2005/100329A1 |
New protecting reagents are provided that allow for the selective placement of a new protecting group onto a reactive site of a multifunctional compound. The reagents are 2, 3, and 4-trialkylsilylxylyl, triarylsilylxylyl or a combination...
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WO/2005/100334A1 |
The invention provides compounds of Formula (I) or prodrugs thereof, or pharmaceutically acceptable salts of said compounds or prodrugs, or solvates of said compounds, prodrugs or salts, wherein A, N, X and R1 are as defined herein; phar...
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WO/2005/090297A1 |
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC is -NR1R2, RA is a group having the formula (A), (B) or (C) RB is h...
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WO/2005/090298A1 |
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzo...
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WO/2005/086735A2 |
The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as ag...
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WO/2005/086904A2 |
Modulators of PPAR&gammad activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.
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WO/2005/081997A2 |
Hydroxy containing isothiazole base derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
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WO/2005/082001A2 |
Hydroxy containing isothiazole base derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
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WO/2005/080344A1 |
The present invention relates to agricultural insecticide and germicide and discloses substituted azole compounds, its preparation and application. The substituted azole compounds of the present invention is represented as formula (I). T...
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WO/2005/079576A1 |
A plant disease control agent for agricultural or horticultural use which contains as an active ingredient a 1,2-benzisothiazolin-3-one 1,1-dioxide derivative represented by the general formula [I]: (wherein R1 represents C2-6 alkenyl, C...
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WO/2005/075973A2 |
Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical ...
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WO/2005/072376A2 |
One aspect of the present invention relates to ionic liquids comprising an anionic sweetener. Another aspect of the present invention relates to the use of an ionic liquid of the present invention comprising a pendant Bronsted-acidic gro...
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WO/2005/073165A1 |
The invention aims at providing highly effective insecticides. Compounds represented by the general formula (1); insecticides containing the same as the active ingredient; and a process for the production thereof: (1) wherein A1, A2, A3 ...
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WO/2005/070889A1 |
Compounds of Formula (I), and their N oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation. In Formula (I), J is (J-1), (J-2), (J-3) or (J-4); Y is O, S(O)n or NR8; and R, R1, R2, ...
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WO/2005/068460A1 |
Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include h...
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WO/2005/068432A1 |
The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represen...
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WO/2005/065370A2 |
Soluble polymers and methods for the preparation thereof, wherein the polymers of the present invention have pendant acylsulfonamide amine-reactive groups that can be used for the capture of amine containing materials.
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WO/2005/066121A2 |
Multifunctional compounds having acylsulfonamide amine-reactive groups are described that can be used for the capture of amine containing materials.
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WO/2005/064349A2 |
Detection cartridges and associated components, as well as methods of using the same that provide sample materials to a sensor for detection are disclosed. Among the components that may be used in connection with the detection cartridges...
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WO/2005/063690A1 |
&agr -Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a i...
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WO/2005/060750A1 |
A plant disease control agent or pest control agent for agricultural or horticultural use which each contains a 1,2-benzisothiazole derivative or a salt thereof as an active ingredient. The control agents have the following remarkable ef...
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WO/2005/056540A1 |
This invention relates to compounds of the formula (I) wherein J, M, G, m, X, R', R2, R4, R5, R6, R7, R8, R9, Y, n, z, and R' are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment...
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WO/2005/054204A2 |
The invention relates to a class of polycyclic compounds that reacts with and neutralizes a reactive oxygen species, such as a free oxygen radical, in a patient and which can then be regenerated back to their original reactive chemical f...
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WO/2005/049590A2 |
Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a ...
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WO/2005/041959A1 |
The invention features phenoxyacetic acids and analogs of formula (I), compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
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WO/2005/042513A1 |
There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected...
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WO/2005/040143A1 |
The present invention relates to novel 5-(2-arylacetamido)isothiazole compounds and to their agriculturally acceptable salts, and to the use of these compounds for controlling plant-damaging microorganisms and animal plant pests.
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WO/2005/035551A2 |
The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or d...
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WO2004110364A9 |
The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using novel thiotungstate derivatives to treat ...
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WO/2005/030736A1 |
A description follows of 1,3-diones having general formula (I): together with their use as herbicides for the control of weeds in agricultural crops.
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WO/2005/028445A2 |
Compounds of formula (I): wherein A, B and D are each C, N, O or S; E is C or N; the dotted circle within the five-membered ring indicates that the ring may be unsaturated or partially saturated;. R 1 is halogen, hydroxy, C 1-6 álkyl, h...
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WO/2005/018327A1 |
A plant disease control agent for agricultural or horticultural use and a pest control agent for agricultural or horticultural use which contain a benzisothiazoline derivative or a salt thereof as an active ingredient and have the follow...
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WO/2005/016862A1 |
A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting car...
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WO/2005/009982A2 |
Aryl-substituted benzo[d]isothiazol-3-ylamine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate capsaicin in vivo or in vitro, and are particula...
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WO/2005/005374A1 |
The present invention provides compounds having the formula: (I) wherein R1, R', R2, R3, R3’, R4, X1, X2 and X3 are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting p...
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WO/2004/111022A1 |
The present invention relates to hydroxyethylene compounds of formula (I); having A sp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treat...
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