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Matches 351 - 400 out of 2,231

Document Document Title
WO/2004/103366A1
The present invention relates to substituted diphenyl heterocycle compounds according to structural formula (I) where the B ring is an aromatic ring that includes from one to four heteroatomes, and pharmaceutical compositions thereof tha...  
WO/2004/099165A2
The present invention relates to substituted diphenyl heterocycle compounds according to formula (I), (II), (III) and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the us...  
WO/2004/099175A2
The present invention relates to the use of compounds of the general Formula (XIII), wherein A7 is C=O, C=S, S02, CH-OR13, C=NR12 or CH2-CHOR13; A8 is C(R14 )2, 0, S, or NR 12; A9 is C=O, C=S, S02, CH-OR13, C=NR12 or CH2-CHOR13 m is 0, o...  
WO/2004/094394A1
A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or...  
WO/2004/089921A1
A method for producing a compound represented by the formula (I): (wherein R1, R2 and R3 independently represent a lower alkyl) is characterized by conducting a dehydration reaction of a compound represented by the formula (II): (wherein...  
WO/2004/080376A2
The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of d...  
WO/2004/080423A2
The invention encompasses 7-amido-isoindolyl compounds of formula (I) and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples include, but are n...  
WO/2004/076420A1
A compound represented by the following formula (I): (I) [wherein X1 represents oxygen, etc.; X2 represents oxygen, etc.; R1 represents an alkylsulfonyl or another group on the ring A; R2 represents, e.g., C3-7 cyclic alkyl optionally su...  
WO/2004/067522A1
Novel azaphenylalanine derivatives of the formula I and pharmaceutically acceptable salts thereof are described wherein the substituents have the meanings as specified in the description. The compounds are useful as anticoagulants.  
WO/2004/055026A1
The present invention relates to novel substituted tetracyclic 3-substituted indoles, represented by general formula (I), its stereoisomers, its radioisotopes, its N-oxides, its polymorphs, its pharmaceutically acceptable salts, its phar...  
WO/2004/050619A1
The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in ...  
WO/2004/046140A1
Novel isothiazolyl-benzoxazine derivatives of the formula (I) wherein R and n have the meanings given in the specification, a process for the preparation of the new compounds and their use as microbicides Novel intermediates of the formu...  
WO/2004/043908A1
A process for interconverting a mixture of cis-trans erythro-threo isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are usefull intermediates in the synthesis of cis isomers of benzamide...  
WO/2004/043931A1
There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from ...  
WO/2004/043903A1
There is provided a compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl o...  
WO/2004/041264A1
Compounds of formula (I): Formula (I) wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.  
WO/2004/041793A1
This invention relates to compounds of the formula (1) wherein R?1¿, R?3¿, R?4¿, X?1¿, and X?2¿ are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous syste...  
WO/2004/035553A1
The present invention relates to an isothiazole derivative of the following formula 1 or nontoxic salt thereof: wherein, R1 is hydrogen, alkoxy group or halogen group; R2 is methyl or amino group. According to the present invention, isot...  
WO/2004/031139A1
Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.  
WO/2004/031138A1
The invention provides compounds of formula (I) : which are inhibitors of &gammad -secretase and hence useful in the treatment or prevention of Alzheimer's disease.  
WO2003051276B1
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...  
WO/2004/024687A1
A novel benzoyl compound having imino group represented by the following general formula [I]: [I] Q1 Q2 Q3 Q4 Q5 wherein Q is a group represented by any of Q1 to Q5; R1 to R12 represent each hydrogen, alkyl, etc.; A represents an optiona...  
WO/2004/024735A2
The present invention provides a synthesis for the preparation of epothilone derivatives of formula (9) wherein R1 is methyl, and R2 has the meaning of an unsubstituted or substituted aryl, an unsubstituted or substituted heteroaryl or a...  
WO/2004/024692A1
Disclosed are novel heterocyclylcarbonyl aminocyclopropane carboxylic acid derivatives of formula (I), in which G represents five-membered or six-membered heterocyclyl that is substituted by halogen and/or alkyl having 1 to 4 hydrocarbon...  
WO/2004/020393A1
A dibenzylamine compound represented by the general formula (1): (1) (wherein R1 and R2 each is optionally halogenated C1-6 alkyl, etc.; R3, R4, and R5 each is hydrogen, halogeno, etc., provided that R3 and R4 may form an optionally subs...  
WO/2004/010761A2
Cyanine dye derivatives provide unexpected pesticidal activity. These compounds are represented by formula (I): where Ar, Ar1, p, q, r, and R through R4, inclusively, are described. Preferred compounds of formula I include those where Ar...  
WO/2004/011444A2
The invention concerns a method for synthesizing styryl isoxazole, styryl pyrazole and styryl isothazole derivatives in a synthesis step followed by a recrystallization in a basic alcohol medium.  
WO/2004/002969A1
The invention relates to a novel one-pot method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) isatoic acid anhydride is reacted with ammonia gas in the presence of dimethylformamide...  
WO/2004/002965A1
The invention relates to novel arylcarboxamides and heteroarylcarboxamides of general formula (I), to the production thereof, and to the use of the same as pharmaceuticals, especially for treating tumours.  
WO/2004/002968A1
The invention relates to a novel method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) 3,4-dichloro-isothiazole-5-carboxylic acid chloride is reacted with anthranilic acid amide in t...  
WO/2003/106405A1
The present invention provides compounds having formula (I): wherein R’, R0, R1, X1, R2, R3, R3’, X2, X3, and R4 are as defined herein, and pharmaceuticals compositions thereof. The present invention also provides methods of inhibiti...  
WO/2003/099799A1
The present invention relates to an isothiazolone composition and a method for stabilizing the same, and particularly to an isothiazolone composition that does not comprise alkali earth metal salt of a divalent metal such as magnesium ch...  
WO/2003/099221A2
The present invention relates to methods useful for the treatment or prevention of disease-related wasting. The methods of the invention comprise the administration of an effective amount of a JNK Inhibitor. In one embodiment, the diseas...  
WO/2003/091202A1
Diketohydrazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of having a cysteine protease inhibitory activ...  
WO/2003/087071A1
Sulfonamide derivatives of formula (1) are described wherein X is an O or S atom; Y is an 0 or S atom; A is a group -S02NR1R2; m is zero or the integer 1; n is zero or the integer 1; provided that at least one but not both of m and n are...  
WO/2003/087072A1
A preventive and/or therapeutic agent for sicknesses associated with endothelial disorder, sepsis, severe sepsis or septic shock and sicknesses associated with signals through TLR, which comprises as an active ingredient a 3-amino-1,2-be...  
WO/2003/084927A1
Haloalkenes represented by the general formula (I) which are useful as pest controllers: (I) wherein X1 and X2 are each halogeno; Y is hydrogen or halogeno; n is 0 to 5; and Q is (1) a heterocyclic group selected from among thienyl, fury...  
WO/2003/077828A2
The present invention relates to novel florfenicol compounds having the chemical structure (I) wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without lim...  
WO/2003/076374A1
A process for producing a compound (I) which comprises the step of reacting a compound (II) with a base in an aprotic solvent as shown by the scheme: (II) (I) wherein R1 and R2 each independently represents lower alkyl.  
WO/2003/074503A1
The present invention relates to a method of preparing of N-n-alkyl benzoyl-2-sulfonylendoimine, in which sodium ortho-benzosulfimide and n-alkyl halide react in organic solvent in the presence of efficient amount of phase transfer catal...  
WO/2003/074495A1
Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseas...  
WO/2003/070712A1
The present invention relates to novel compounds of formula Ia or Ib&semi wherein the variable groups are as defined in the claims or a pharmaceutically acceptable addition salt thereof.The compounds of the invention are agonists at the ...  
WO/2003/064406A1
Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.  
WO/2003/061651A1
The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of...  
WO/2003/057173A2
The invention features a method of designing broad spectrum inhibitors using structural data, compositions having broad spectrum activity, and methods for treating disease using those compositions.  
WO/2003/053358A2
Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor−associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.  
WO/2003/051123A1
Compounds of the formula (I) wherein R represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, phenyl, phenoxy, cyano, nitro or alkoxycarbony...  
WO/2003/042198A1
Novel isothiazole derivatives of the formula (I) wherein R has the meanings given in the specification, a process for the preparation of the new-compounds and their use as microbicides.  
WO/2003/039543A1
Novel compounds of formula (I), wherein D, W, X, Y, T and R?1¿ have the meanings cited in Claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatmen...  
WO/2003/040096A2
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...  

Matches 351 - 400 out of 2,231