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Matches 1 - 50 out of 20,386

Document Document Title
WO/2020/186006A1
This application is directed to inhibitors of RAD51 represented by the following structural formula, (I), and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.  
WO/2020/176863A1
Provided herein are secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same, wherein the compound has a structure of Formula (I), (II), or (III).  
WO/2020/176424A1
The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenera...  
WO/2020/171221A1
The purpose of the present invention is to provide an organic EL element in which a capping layer is combined with various materials of the element so that properties of each of the materials of the element can be effectively demonstrate...  
WO/2020/168152A2
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selec...  
WO/2020/165403A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2020/164403A1
A 1,1-dicyano-oxime-ether compound, having a structure as represented by general formula I. The compound of general formula I has excellent bactericidal activity, and has good prevention and control effects on plant bacterial diseases an...  
WO/2020/051207A3
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/160332A1
Provided herein are crystalline forms of 2-(2-(2-(2-(4-(benzo[d]thiazol-2-yl)phenoxy)ethoxy)ethoxy)et hoxy)ethan-l-ol (Compound I): Also provided are processes of manufacture and methods of using the crystalline forms.  
WO/2020/157069A1
The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inh...  
WO/2020/160295A1
The present invention relates to bi-functional compounds which function to recruit endogenous proteins to an E3 ubiquitin ligase for degradation, and methods for using same. More specifically, the present disclosure provides specific pro...  
WO/2020/156512A1
Disclosed in the present invention is an aromatic (hetero)cyclic ether compound having insecticidal activity, or an optical isomer, cis-trans isomer, or agrichemically acceptable salt thereof. Also disclosed in the present invention is a...  
WO/2020/156298A1
Disclosed by the present invention is an application of a malononitrile compound as represented by general formula I as a bactericide. See the description for the definition of each substituent in the formula. The compound represented by...  
WO/2020/158870A1
The purpose in one embodiment of the present invention is to provide a therapeutic for Parkinson's disease, etc. A compound represented by formulas (1), (2), or (8) or a pharmacologically acceptable salt thereof can be used in the treatm...  
WO/2020/154499A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/151687A1
Provided is an N-benzyl-N-arylsulfonamide derivative, which is an N-benzyl-N-arylsulfonamide compound represented by a general formula (I), or a pharmaceutically acceptable salt or solvate thereof. The N-benzyl-N-arylsulfonamide derivati...  
WO/2020/151686A1
Provided in the present invention are an N-heteroaryl sulfonamide derivative, the preparation and use thereof. The N-heteroaryl sulfonamide derivative is an N-heteroaryl sulfonamide compound shown in general formula (I) or general formul...  
WO/2020/132378A3
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use thereof for treatment of a neurological disorder.  
WO/2020/147739A1
The present invention belongs to the technical field of pharmaceutical chemistry, and specifically relates to lysophosphatidic acid receptor antagonists and a preparation method therefor. The compounds of the present invention have high ...  
WO/2020/148617A1
The present invention disclosed 3-substituted phenylamidine compounds of general formula (I), wherein R1, R2, R3, R4, R4a, R4b, A and E have the same meanings as defined in description. The present invention further discloses methods for...  
WO/2020/148619A1
The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates...  
WO/2020/146822A1
Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseas...  
WO/2020/146657A1
Methods of treating a subject for cancer using a PI4-kinase inhibitor are provided. Also provided are methods of inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation. The PI4-kinase inhibitor can be a compound that is ...  
WO/2020/146810A1
Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders.  
WO/2020/142865A1
Disclosed in the present invention are a Benzamide compound, intermediates, a preparation method, and an application. The present invention provides a Benzamide compound as represented by formula I, and pharmaceutically acceptable salts,...  
WO/2020/102901A8
Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium...  
WO/2020/141514A1
The present invention provides a process for preparing a compound of formula [I] from a compound of formula [II] using an oxidizing agent and a catalyst, the process is carried out at a low temperature.  
WO/2020/141195A1
The present invention relates to a compound of general formulae (I) and their use as reagents  
WO/2020/130214A1
The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at the terminal amine group thereof and a use thereof.  
WO/2020/132496A1
In some aspects, the present disclosure provides compounds of the formulae: (A), (B), (III), and/or (IV), wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, the c...  
WO/2020/132378A2
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use thereof for treatment of a neurological disorder.  
WO/2020/119616A1
Disclosed are a class of sulfonamide substituted compounds and the use thereof. Specifically, provided are compounds as shown in general formula (I) below. The compounds of the present invention have a selective inhibitory effect on Nav1...  
WO/2020/121823A1
The present invention addresses the problem of providing: a liquid crystal composition which is to be used in an active drive display element and improves chromatic dispersion properties; a display element which uses said liquid crystal ...  
WO/2020/109509A1
Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.  
WO/2020/108500A1
Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the field of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceut...  
WO/2020/109511A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.  
WO/2020/103930A1
Disclosed in the present invention are a thiazolo ring compound, a preparation method therefor, an intermediate thereof and an application thereof. The structure of the thiazolo ring compound of the present invention is represented by fo...  
WO/2020/102901A1
Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium...  
WO/2020/104657A1
The present application relates to compounds with NLRP3inhibitory activity and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present application further relates to the use of such compounds in the treatment...  
WO/2020/102576A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: Formula AA or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/102575A1
The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates and salts of the solvates thereof, pharmaceutical compositions containing compounds of formula (I), as well as the use of compounds ...  
WO/2020/102574A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: Formula AA or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/097398A1
The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided ...  
WO/2020/095161A1
The present invention relates to novel nitrone compounds of formula (I), wherein, A, A1, R1, R2, R3, R4 and n are as defined in the description. The present invention further relates to their preparation and use to protect crops against ...  
WO/2020/091204A1
The present invention provides a novel benzo-heterocyclic compound or a pharmaceutically acceptable salt thereof. The compound or the salt exhibited a high antiproliferative effect on a cancer cell line. By using same, the present invent...  
WO/2020/089844A1
The present invention relates to novel pharmaceutical agents and the process of preparation thereof. The present invention discloses compounds of general formula I, and the process of their preparation. The compounds of the invention are...  
WO/2020/092650A1
This invention is in the field of medicinal chemistry. In particular, provided herein are compositions and methods for preventing or reversing T cell exhaustion. In certain embodiments, the present invention relates to methods of prevent...  
WO/2020/087565A1
The present invention relates to a kinase inhibitor, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention further relates to ph...  
WO/2020/086728A1
In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/085504A1
A method for producing a compound represented by general formula (I) or a salt thereof by reacting a compound represented by general formula (II) or a salt thereof, with a diazotizing agent and hydrochloric acid, characterized by irradia...  

Matches 1 - 50 out of 20,386