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Matches 1 - 50 out of 19,779

Document Document Title
WO/2018/187414A1
The present disclosure provides compounds and methods for inhibiting mTORC2, as well as methods for treating cancers such as glioblastoma.  
WO/2018/186365A1
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt th...  
WO/2018/177970A1
The present invention relates to pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof, their mixtures and to compositions comprising such compounds or mixtures. The invention also relates to ...  
WO/2018/177865A1
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L1- Ar1- L - Ar]2- X, wherein X is selected from the group consisting of SO2, C1 -C4 a lkylene, linear or branched, and wherein Ζ...  
WO/2018/176343A1
Compounds of Formula (A), where the definition of the variables are as described in the description, as well as their preparation and uses, and pharmaceutical compositions comprising these compounds and their uses as modulators of dysfun...  
WO/2018/183411A1
Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxida...  
WO/2018/180716A1
The present invention provides a polymerizable compound production method that enables production of, in high yield, a polymerizable compound used for producing an optical film or the like. The polymerizable compound production method ac...  
WO/2018/178345A1
The present invention is directed to a salt of a compound of formula (I), R1 is halogen or methyl; X is methyl, OR2, or SR2; Y1, Y2 is CR3 or N, and one of Y1, Y2 is N and one of Y1, Y2 is CR3; R2 is methyl or ethyl; R3 is hydrogen or me...  
WO/2018/172423A1
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compound...  
WO/2018/170165A1
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...  
WO/2018/168778A1
Provided is a polymerizable compound useful for preparing a polymer that enables the production of a film, such as an optical film, having a good balance of lightness and saturation, and can improve inverse wavelength dispersibility on t...  
WO/2018/162505A1
The present invention relates to the tromethamine salt of (1R,3S)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcarbamoyl)cyclop entane carboxylic acid, a process for obtaining said salt, combination products and pharmaceutical compositions compri...  
WO/2018/162364A1
The present invention refers to a process for a catalytic aryl transfer to rearrange the backbone of aromatic C-X bonds.  
WO/2018/163077A1
The invention relates to indanyl compounds, their pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising the same for the treatment, management and /or lessening severity of ...  
WO/2018/159515A1
Provided is a method for producing a pentafluorosulfanyl aromatic compound represented by general formula (3), Ar-(SF5)k, (in the formula, Ar is a substituted or unsubstituted aryl group or heteroaryl group, and k is an integer between 1...  
WO/2018/158137A1
The present invention provides a process to enhance the productivity such as yield of radioactive fluorine labeled flutemetamol. Provided is a process for producing a radioactive fluorine labeledflutemetamol, which comprises: (a) a step ...  
WO/2018/157813A1
The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine 1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acc...  
WO/2018/155942A1
The present disclosure relates to a plurality of host materials and an organic electroluminescent device comprising the same. The organic electroluminescent device of the present disclosure can exhibit excellent lifespan characteristics ...  
WO/2018/155661A1
The present invention addresses the problem of providing thiazole compounds and herbicides containing said thiazole compounds. The present invention pertains to thiazole compounds represented by general formula (1): [in the formula, R1 a...  
WO/2018/153297A1
The present invention provides a novel ligand for the dopamine D3 receptor and a preparation method therefor. The compound, and a pharmaceutically acceptable salt and a pharmaceutical combination or a pharmaceutical preparation thereof a...  
WO/2018/151861A1
Provided herein are methods for determining if a compound has potential efficacy for the treatment for a specific symptom domain of schizophrenia, such as for example, the treatment of a negative symptom of schizophrenia. In addition, pr...  
WO/2018/151470A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present disclosure is contained in an electro...  
WO/2018/149309A1
The present invention provides a crystal form of a 4-phenylthiazole derivative, a pharmaceutical composition comprising the same, a preparation method, and a use of the crystal form in preparing a drug for treating thrombocytopenia assoc...  
WO/2018/145217A1
This invention provides compound having a structure of Formula (I): (I) Uses of such compounds for treatment of ERG, FLI1, ETV4, or ETV1 -mediated indications, including cancer. Also provided are pharmaceutical composition and methods of...  
WO/2018/145118A1
Provided herein, inter alia, are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihyd roxybenzamide)).  
WO/2018/141854A1
The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity ...  
WO/2018/143638A1
The present invention relates to a 4'-phosphopantetheinyl transferase enzyme inhibitor derived from Mycobacterium tuberculosis, and a pharmaceutical composition for preventing or treating tuberculosis, containing the same as an active in...  
WO/2018/139174A1
A fluoroether compound represented by formula (1). R1-R2-CH2-R3-CH2-R4-R5 (1) (In formula (1), R1 and R5 may be the same or different and are each a group having a heteroring, R2 and R4 may be the same or different and are each a divalen...  
WO/2018/137854A1
The invention relates to active ingredient combinations consisting of one or more alkylamidothiazoles and trans-4-t-butylcyclohexanol.  
WO/2018/138692A1
An object of the present invention is to provide a carbamate compound or a salt thereof that controls diseases. The present invention provides a carbamate compound represented by Formula (1), or a salt thereof, wherein R1, R3 and R6 are ...  
WO/2018/133870A1
A compound represented by formula (I), a pharmaceutically acceptable salt or tautomer thereof, and an application of the compound as a caspase inhibitor.  
WO/2018/131690A1
[Problem] To provide a novel agrochemical, especially a novel herbicide. [Solution] A ketone or oxime compound represented by formula (1), and a herbicide which contains this compound. (In the formula, B represents B-1 or B-2; Q represen...  
WO/2018/127207A1
Disclosed in the present invention are a new thiazole compound, particularly a compound represented by formula (I), a pharmaceutical composition thereof and applications thereof in the preparation of drugs for the treatment of diseases r...  
WO/2018/123586A1
Provided is a polymerizable compound having a use in the production of a polymer that allows the manufacture of an optical film or similar with good reverse wavelength dispersion on a long wavelength side. A polymerizable compound indica...  
WO/2018/122510A1
The invention relates to a method for synthetising functionalised cyclic dithiocarbamates of formula (I), in which the various substituents are as defined in the description, by reacting a compound of formula (II): G-(CH2)n-C*H(NHR1)-X-R...  
WO/2018/121610A1
Provided are a compound as shown in general formula I, a pharmaceutically acceptable salt, an isomer and a solvate thereof, or a compound obtained through the substitution of any atom in the compound of formula I with an isotope thereof,...  
WO/2018/123625A1
A purpose of the present invention is to provide a polymerizable compound that can be used in the production of an optical film or similar with good reverse wavelength dispersion. This polymerizable compound is indicated by formula (I). ...  
WO/2018/115421A1
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).  
WO/2018/114786A1
The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds...  
WO/2018/114657A1
The present invention relates to compounds of the formula (I), in which the substituents are as defined in claim 1, which are suitable for use as nematicides.  
WO/2018/117166A1
The present invention addresses the problem of providing: a novel thiazole derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition which contains the thiazole derivative or a pharmacologically acceptable s...  
WO/2018/112136A1
The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other -threonine kinase mediated diseases, having the Formula: (I) wherein A, L, R1, R2, R3, and n are described herein.  
WO/2018/108671A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description. The com...  
WO/2018/107332A1
The invention belongs to the technical field of compound synthesis, and specifically discloses a class of chiral aromatic heteroamine derivative and a synthesis method and application thereof. The chiral aromatic heteroamine derivative h...  
WO/2018/104856A1
A process of obtaining a purified geometric isomer of an unsaturated macrocyclic compound is disclosed herein. The process is effected by contacting an ion exchange medium comprising silver ions with a mixture comprising at least one geo...  
WO/2018/106284A1
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or condit...  
WO/2018/106643A1
The invention relates to heterocyclic compounds of formula (I) and (IV) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases. The invention also provides pharmaceutically acceptable compositions co...  
WO/2018/102399A1
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.  
WO/2018/102358A1
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.  
WO/2018/101207A1
The present invention addresses the problem of providing: a polymerizable liquid crystal composition that makes it possible to manufacture an optical film that has excellent light resistance; and an optically anisotropic membrane, an opt...  

Matches 1 - 50 out of 19,779