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WO/1995/014687A1 |
The present invention relates to novel substituted thiosemicarbazonic acid esters of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is hydrogen, lower alkyl, aryl, aryl-lower alky...
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WO/1995/014686A1 |
The present invention relates to novel substituted thiosemicarbazonethiones containing 6-ring members of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is hydrogen, lower alkyl, l...
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WO/1995/013269A1 |
A compound represented by general formula (I) or a salt thereof and an intermediate for synthesizing the same wherein R1 represents optionally protected hydroxy; R2 represents lower alkyl; R3 represents hydrogen, lower alkyl, optionally ...
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WO/1995/011231A1 |
The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors.
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WO/1995/009000A1 |
The present invention comprises analogs of the CAAX motif of the protein Ras that is modified by farnesylation in vivo. These CAAX analogs inhibit the farnesylation of Ras. Furthermore, these CAAX analogs differ from those previously des...
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WO/1995/004048A1 |
Compounds of general formula (I) wherein X is an oxygen or sulfur atom; Y is alkylene or cycloalkylene; A is hydroxy, alkoxy, acyloxy, mercapto, alkyl-sulfonyloxy, phenyl-sulfonyloxy, (a) or (b) wherein R3 is an alkyl or alkylene group o...
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WO/1995/003279A1 |
Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents...
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WO/1995/003289A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1994/026700A1 |
Compounds of formula (I) in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group (a) or (b) and R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubs...
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WO/1994/024152A1 |
Novel heterocyclic acyldipeptides of formula (I) wherein Z represents an oxygen or sulphur atom or a -CH2- group; R1 represents hydrogen, a straight or branched chain 1-4C alkyl, cycloalkyl, cycloalkylalkyl, trifluoromethyl or benzyl gro...
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WO/1994/022843A1 |
Disclosed are compounds of Formula (I) wherein: Y represents -CO2H, -CO2R6, -C(O)NHR7, -SO2H, -SO3H, -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8, or a group of formula (a), (b), (c), (d) or (e); or a pharmaceutically acceptable addition salt or sol...
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WO/1994/019329A1 |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as Human Immnunodeficiency Virus (HIV) protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these com...
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WO/1994/019340A1 |
Compounds of formula (I), wherein the substituent A is in the alpha-, beta-, gamma- or delta-position, and wherein: X is oxygen or sulfur; Y is a group -CH(R15)-, oxygen, sulfur or a group -N(R16)-; n is 1 or 2; and wherein R1 to R16 are...
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WO/1994/014783A1 |
A compound represented by general formula (I) and a pest control agent, whrein Z represents oxygen or sulfur; Y represents halogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkoxy, S(O)p...
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WO/1994/014793A1 |
The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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WO/1994/014785A1 |
Novel substituted 5-aryl-1,3,-thiazine derivatives of general formula (I) for use as pesticides, preferably as athropodicides, nematicides and herbicides, and as ectoparasiticides and endoparasiticides.
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WO/1994/013652A1 |
A compound of formula (I), where E is oxygen or sulphur; A is CR3 or N where R3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxyge...
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WO/1994/012461A1 |
This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDEIV and in the treatment of AIDS, ast...
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WO/1994/010178A1 |
Compounds of formula (I) in which: R1 is hydrogen or an organic substituent group; R2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R4 and R5 are independently hydrogen or one or more substituents replacing ...
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WO/1994/008943A1 |
A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substitut...
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WO/1994/005634A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1994/005646A1 |
An optically active carboxamide derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen or halogen; R2 represents halogen; R3 represents pyrrolidino or piperidino; Y re...
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WO/1994/005647A1 |
A compound represented by general formula (I), which is useful as a cataract remedy, wherein R1 represents optionally protected hydroxy; R2 represents lower alkyl; R3 represents hydrogen, lower alkyl, optionally protected hydroxy or lowe...
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WO/1994/003425A2 |
Compounds of formula (I), wherein m is 0, 1 or 2; n is 0, 1 or 2; R1 is hydrogen, lower alkyl, or phenyl lower alkyl; R2 is hydrogen, lower alkyl, trifluoromethyl, lower alkoxy, or phenyl lower alkoxy; R3 is hydrogen, lower alkyl, triflu...
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WO/1994/001408A1 |
Compounds are described of general formula (I) and salts and solvates thereof, including physiologically acceptable salts and solvates thereof, in which: Z represents either Het, (a), or (b); Het represents an optionally substituted bicy...
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WO/1994/000440A1 |
Substituted heterocycles of general structural formula (I) are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma and calcium channel blockers useful in the treatment of cardiov...
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WO/1993/025542A1 |
Benzoxazinone and benzothiazinone derivatives having cardiovascular activity and the salts thereof with pharmaceutically acceptable acids and bases are of formula (I), wherein Y is methylene, optionally branched (C3-C6) alkylene or cyclo...
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WO/1993/024471A1 |
The present invention comprises the compounds selected from the group of stereoisomers or mixtures thereof of compounds represented by formula (a), wherein R1 and R2 are selected from the group consisting of H and OA, wherein A is H or i...
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WO/1993/019757A1 |
Novel therapeutical use of phenothiazine derivatives of general formula (I), wherein R is a straight or branched chain C1-5 alkyl radical, and R1 and R2, which are the same or different, are C1-2 alkyl radicals or form, together with the...
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WO/1993/015052A1 |
Compounds of formula (I) in which W is -CH2-, a bond, O or S; k is 0, or when W represents -CH2- k may also be 2, in which case the dotted lines represent single bonds; R is C1-8alkyl(phenyl)p, C2-8alkenyl(phenyl)p, C2-8alkynyl(phenyl)p,...
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WO/1993/012754A2 |
The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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WO/1993/011761A1 |
Aryltriflates and related compounds having general formula (1) wherein Ar is an aromatic or heteroaromatic system of a compound which has a therapeutic, biological activity when it, in the same position, carries a hydroxy, alkyloxy, halo...
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WO/1993/010108A1 |
Processes are provided for preparing crystalline moricizine hydrochloride from moricizine using hydrochloric acid, wherein the crystalline moricizine hydrochloride so obtained is substantially free of occluded water.
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WO/1993/008847A1 |
A biological stain composition contains toluidine blue O and a pharmaceutically acceptable oxidizing agent to convert any leuco toluidine blue O to the chromo form. A dry composition for preparing the stain includes the toluidine blue O,...
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WO/1993/007534A1 |
A photographic element comprising a support, at least one photosensitive silver halide layer and associated therewith a colour coupler of general formula (1) or (2), wherein A and B represent the same or different electron-withdrawing gr...
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WO/1993/004032A1 |
A compound having a high insecticidal activity, represented by general formula (I), or a salt thereof wherein R¿1? represents optionally substituted alkyl; R¿2? represents hydrogen, optionally substituted alkyl or COR¿3? wherein R¿3?...
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WO/1993/003714A2 |
A method for treating or preventing non-insulin (Type II) diabetes mellitus by administering to an animal, including humans, a compound selected from Table 1 or a pharmaceutically acceptable salt thereof; and a method for treating or pre...
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WO/1993/003037A1 |
Organic nitrates, methods for preparing same and the use thereof for treating vascular diseases, particularly angina, are disclosed. Said nitrates have formula (I): R-CO-(A)n-Y-B, wherein R is, in particular, a sulphur residue and a sulp...
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WO/1992/020658A1 |
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are ...
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WO/1992/020749A1 |
A water-based recording ink comprising water, pigment, a water-soluble homopolymer, and a copolymer having both hydrophobic and hydrophilic parts. This ink can give printed characters excellent in density, lightfasteness and water resist...
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WO/1992/019584A1 |
Arylalkyle esters of 4,5-dihydro-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, a process for the preparation thereof and the use thereof as therapeutical agents.
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WO/1992/019595A1 |
Fibrinogen receptor antagonists of formula (I) are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
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WO/1992/016524A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1992/008722A1 |
Labelling agents comprising non-proteinaceous boronic acid conjugates having absorption maxima at not less than 600 nm, said label being provided by e.g. an azine, triphenylmethane, cyanine or phthalocyanine dye, are useful in the estima...
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WO/1992/005164A1 |
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.
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WO/1992/004324A1 |
The present invention relates to phenolic thioetheramides of formula (I) wherein R1 and R2 are tert-alkyl or phenyl, Alk1 and Alk2 are alkylene; X is sulfer or oxygen, m is 0, 1, or 2; and R is a) wherein R3 and R4 are hydrogen or alkyl ...
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WO/1992/000286A1 |
A derivative of N-alkyl 1-oxo and 1,1-dioxo 3-thiamorpholinones having formula (I), wherein n is 1 or 2, and R is a straight- or branched-chain alkyl radical having 10 to 18 carbon atoms. Said derivative can be used as a permeating agent...
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WO/1991/019719A1 |
The present invention comprises the compounds selected from the group of compounds represented by formula (1), wherein R1 and R2 are selected from the group consisting of H and OA, wherein A is H or is selected from the group consisting ...
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WO/1991/018893A1 |
A novel 1,4-thiazine derivative of general formula (I) and a pharmaceutically acceptable acid addition salt thereof, useful as a cardiotonic, formula (I), wherein R1 and R2 represent each hydrogen or lower alkyl; and R3 represents -E-(CR...
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WO/1991/017151A1 |
Compounds of formula (I), wherein R�1? is an electronegative substituent such as nitro, halogeno or cyano group and R�2? is a group selected from (Ia) and (Ib), wherein R is hydrogen, or an alkyl, cycloalkyl, aralkyl or aryl group, w...
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