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JPH0327357A |
NEW MATERIAL:A compound expressed by formula I or salt of said compound [R1 to R3 are H, halogen, 1-3C alkyl, 1-3C alkoxy or amino, etc.; R4 and R5 are H, 1-3C alkyl or cyano, etc.; R6 is H, 1-3C alkyl or benzyl; X is single bond, -CHR7-...
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JPH037284A |
NEW MATERIAL:A compound expressed by formula I {Q represents formulae II-IV [R1 to R5 represent H, 1-6C alkyl, 2-6C alkenyl, halogen, nitro, (substituted) phenoxy, etc.], etc.; X represents O or S; M represents H, 1-6C alkyl, 2-6C alkeny...
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JPH02290856A |
NEW MATERIAL: A compound of formula I [X is -CH2- or -S-; R1 is -O-Y3 (Y3 is H, an alkyl, an alkanoyl or the like) or the like; R2 is heterocyclo or heteroaryl; R3 and R4 are each H, a halogen, an alkyl or the like; n is 0, 1, 2 or 3; an...
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JPH02290855A |
NEW MATERIAL: A compound of formula I [Y is CH2 or S; X is O, S(O)q or the like; R is H, an alkyl or the like; R1 is formula II or O-Y12; R2 and R3 are each H, a halogen, an alkyl or the like; n and m are each 0-3; p is 1-5; q is 0-2; Y1...
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JPH02289555A |
NEW MATERIAL: Compd. of formula I [R' is a halogen, hydroxy, a 1-8C alkyl, a 1-6C alkoxy, phenoxy, cyano, CO2R3 (wherein R3 is H or a 1-4C alkyl), etc.; R2 is H, a halogen, hydroxy, a 1-6C alkyl, etc.] or their salts. EXAMPLE: Dihydro-1-...
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JPH02250875A |
NEW MATERIAL:A 1,5-benzothiazepine derivative expressed by formula I (R1 is lower alkyl, lower alkenyl, phenyl-substituted lower alkyl, hydroxymethyl, lower alkanoyloxy-substituted lower alkyl or formyl; R2 is H, lower alkanoyl, phenyl-s...
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JPH02502726A |
Novel compounds of the formula wherein A is a group useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation of such compounds as well as interm...
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JPH0233715B2 |
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JPH02191266A |
NEW MATERIAL:The compound of formula I (R1 is aryl; R2 and R3 are H, alkyl, alkoxy, halogen or together form alkylene containing 1-2 O atoms; R4 is H, acyl or alkoxycarbonyl; R5 and R6 are alkyl; X is O or S) and its salt. EXAMPLE: (±)-...
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JPH02188574A |
NEW MATERIAL:A compound shown by formula I (R1 is lower alkyl or lower alkoxy; R2 is H or halogen; R3 and R4 are lower alkyl; n is 2 or 3; R5 is acyl derived from thioctic acid, linoleic acid, α-linolenic acid, 5,8,11,14,17- eicosapenta...
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JPH0228594B2 |
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JPH02104572A |
NEW MATERIAL:A compound shown by formula I [R1 is lower alkyl or (substituted) aryl lower alkyl; R2 is OH, alkoxy, alkenyloxy, etc.; R3 is amino, di-substituted amino or acylamino; R4 is halogen or R3 and R4 are bonded to form group show...
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JPH0214350B2 |
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JPH024592B2 |
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JPH0217168A |
NEW MATERIAL: Optically active 2-hydroxy-3-(4-alkyloxyphenyl)-3-(2- aminophenylthio)propionate. EXAMPLE: Methyl (+)578-(2S,3S)-threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2- aminophenylthio)propionate. USE: An intermediate producing benzothia...
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JPH0217170A |
PURPOSE: To obtain an acid by reacting (1R,2S)-2-phenylcyclohexyl (2S-3S)-3-[(2- amino-1-naphthalenyl)thio]-2-hydroxy-3-(4-methoxyphenyl) propanate with a base and hydrolyzing the reaction product. CONSTITUTION: A compd. represented by f...
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JPH0215056A |
PURPOSE: To obtain a compd. useful as a synthetic intermediate for medicines by resolving race-β-[(2-amino-1-naphthalenyl)thio]-2hydroxy-4- methoxybenzenepropanoic acid by using a specific resolving agent. CONSTITUTION: Race-β-[(2-amin...
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JPH01311073A |
NEW MATERIAL: Benzothiazepin-4-one derivative of formula I [R1 is H, 2-4C alkanoyl; R2, R3 are H, linear, branched chain 1-4C alkyl, 3-5C cycloalkyl, phenyl, benzyl, phenethyl, or R2, R3 are combined with bonded N to form a heterocycle s...
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JPH01272575A |
NEW MATERIAL: A (+)-cis compound, (-)-cis-enantiomer or (±)cis racemic modification of formula I [wherein R is a lower alkyl; R1 is pyridyl, phenyl which may have 1-3 substituents (NO2, OH, halogens, lower alkoxyls or lower alkanoyloxys...
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JPH01197475A |
NEW MATERIAL: The compound of formula I [R1 is lower alkoxy or phenyl substituted with halogen; R2 is OH, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy; R3 and R4 are each lower alkyl, phenyl lower alkyl or together form a...
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JPH01190674A |
NEW MATERIAL: Pure diastereomers or their mixed compounds and acid-added salts of formula I (R1 is H or 2-4C alkanoyl; R2 is phenyl having optionally 1-3 substituent selected from halogen, methylenedioxy, ethylenedioxy or 1-4C alkoxy). E...
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JPH01190632A |
PURPOSE: To obtain a medicine composition useful for treating diseases caused by a blood platelet activating factor, containing a specific benzothiazepine derivative. CONSTITUTION: This composition comprises a compound of the formula [R<...
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JPH01186875A |
PURPOSE:To produce the title compound useful as a medicine or intermediate therefor, etc., having hypotensive action, etc., by condensing a propionic acid derivative with an N,N-dilower alkylethylenediamine and intramolecularly cyclizing...
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JPH01128975A |
PURPOSE: To obtain the title compound readily by reaction of d-cis-2,3-dihydro-3 hydroxy-2-(4-methoxyphenyl)-1,5-henzothiazepin-4-(5H)-one with 2-chloro-N,N- dimethylethylamine in the presence of a specific compound. CONSTITUTION: The re...
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JPH01128974A |
PURPOSE: To obtain the title compound which is used as a medicine, because of its hypotensive and cerebral and coronary vasodilative actions, readily in high yield, by intramolecular cyclization of a propionic acid derivative as a starti...
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JPH01117860A |
NEW MATERIAL:The compound of formula I (R1 is lower alkyl, etc.; R2 is hydroxy, alkoxy, alkenyloxy, etc.; R3 is amino, disubstituted amino, etc.; R4 is halogen, etc., R5 is H or lower alkyl; X is single bond or lower alkylene; Y is singl...
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JPS6450872A |
PURPOSE: To readily obtain the titled compound useful as a drug, having hypotensive action, vasodilating action on cerebral blood vessel and crown blood vessel, by condensing an N-nonsubstituted 1,5-benzothiqazepine derivative as a raw m...
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JPS6445376A |
PURPOSE: To readily obtain the titled compound useful as a medicinal compound having excellent hypotensive, cerebral coronary vasodilator and/or blood platelet agglutination inhibitory action, by reacting a specific compound with amines ...
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JPS649981A |
NEW MATERIAL:A compound shown by formula I [R1 is lower alkyl or lower alkoxy; R2 is di- lower alkylamino; Alk is lower alkylene; R3 is H, halogen, OH or (halogen-substituted) lower alkyl or lower alkoxy; n is 1 or 2; X is H or halogen; ...
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JPS649982A |
NEW MATERIAL:A compound shown by formula I [R1 is lower alkyl or lower alkoxy; R2 is lower alkyl, aryl or aralkyl; R3 is di- lower alkylamino; Alk is lower alkylene; R4 is H, halogen, OH or lower alkyl or lower alkoxy; n is 1 or 2; with ...
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JPS64389B2 |
A naphthalene derivative of the formula: wherein R1 is hydrogen and R2 is lower alkyl or phenyl-lower alkyl; or R1 and R2 are combined together to form lower alkylene; X is halogen; and the absolute configuration at the asymmetric carbon...
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JPS63307866A |
PURPOSE: To introduce dimethylaminoethyl group into d-cis-3-OH-2,3-dihydro-2-(4- methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, by reacting the compound with 2-Cl-N,N-dimethylethylamine. CONSTITUTION: The objective compound of formula II c...
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JPS6358809B2 |
A formulation for the prophylaxis and treatment of arteriosclerosis comprises, as an active ingredient, diltiazem or a pharmaceutically or veterinarily acceptable acid addition salt thereof. Also described are a therapeutic kit or a pack...
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JPS63275572A |
NEW MATERIAL:A compound expressed by formula I (R1 is lower alkyl or lower alkoxy; R2 is cycloalkyl, carboxyl, heterocyclic ring, phenyl, etc.; Y is single bond, lower alkylene, etc.; R3 is H or substituted amino; Alk is alkylene which m...
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JPS63222117A |
The use of benzothiazepine derivatives for the protection of lymphocytes in humans and higher mammals, especially in the treatment of acquired immune deficiency syndrome.
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JPS6345675B2 |
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JPS6343393B2 |
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JPS6343366B2 |
An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition comprising the diltiazem or an acid additio...
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JPS6343395B2 |
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JPS6343394B2 |
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JPS6342623B2 |
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JPS63174980A |
Disclosed are the compound of the formula (I) wherein n represents zero, 1 or 2; Ar represents a carbocyclic or heterocyclic aryl radical; R and R1 independently represent hydrogen, lower alkyl or Ar-lower alkyl; R2 and R3 independently ...
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JPS63162681A |
NEW MATERIAL:The 2,3,4,5-tetrahydro-1,5-benzotiazepine derivative of formula I (R1WR3 are OH, lower, alkyl, alkoxy, nitro, amino or halogen; X is O or S) or its acid addition salt. EXAMPLE: 5-[3-(2-(2,6-Dimethoxyphenoxy)ethylamino)propio...
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JPS63149644A |
PURPOSE: To improve stability of an org. coloring material to light by allowing specific compds. to co-exist with said coloring material. CONSTITUTION: ≥1 Kinds of the compds. expressed by the formula are made to co-exist with the org....
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JPS6324511B2 |
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JPS6317831B2 |
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JPS6317810B2 |
Hypolipidemic composition comprising as an active ingredient d -3-acetoxy-cis-2,3-dihydro-5-[2- (dimethylamino)-ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepi
n -4(5H)-one diltiazem) or a pharmaceutically acceptable acid addition salt ther...
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JPS6317832B2 |
A benzothiazepine derivative of the formula: (I) wherein R is hydrogen or acetyl, is prepared by condensing a compound of the formula: (II) wherein R is the same as defined above, with 2-(diamethylamino)ethyl halide (i) in the presence o...
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JPS6317044B2 |
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JPS6317045B2 |
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