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JPS6316388B2 |
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JPS6313994B2 |
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JPS6313966B2 |
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JPS6351381A |
Calcium channel blocking activity is exhibited by compounds having the formula or a pharmaceutically accpetable salt thereof, wherein the stereochemistry at the chiral centers in the 3 and 4-positions of the benzothiazepine nucleus is ci...
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JPS6335522A |
The present invention provides combination of materials for strengthening the antithrombotic action of acetylsalicylic acid. It covers a composition which contains diltiazem or a pharmaceutically acceptable acid-addition salt thereof in ...
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JPS6322556A |
NEW MATERIAL:L-Lysine salt of d-threo-2-hydroxyl-3-(2-aminophenylthio)-3-(4- methoxyphenyl-)-propionic acid of formula I (*C means the carbon of the molecule which has been optically resolved). USE: A synthetic intermediate of medicines....
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JPS63435B2 |
Aminoalcohol derivatives corresponding to the formula (I) in which Q is a group and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group or , with a...
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JPS6254102B2 |
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JPS62242674A |
Compounds which are 1,5-benzothiazepine derivatives of general formula (I) (I) in which R denotes hydrogen or C1-C4 alkyl and R1 and R2 either separately denote C1-C4 alkyl groups or together denote a tetramethylene or pentamethylene gro...
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JPS62230777A |
Naphtho(1,8-bc)-1,5- thiazocinones of general formula (I) and their acid addn. salts are new; where R1 = phenyl substd. with 1-3 1-4C alkoxy gps. or 1-3 halogens; R2 = OH or 2-5C alkanoyloxy; R3,R4 = 1-4C alkyl; or NR3R4 = pyrrolidino or...
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JPS62212379A |
NEW MATERIAL:A tetrahydrothiazepine derivative expressed by formula I (R1 is alkyl, cycloalkylalkyl or aralkyl; R2 and R4 are carboxy-pretecting group R3 is aryl or heterocyclic group; A is lower alkylene). EXAMPLE: tert-Butyl α-{6(R)-[...
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JPS62205067A |
It has been found that the novel compounds of the formula wherein R1 is phenyl substituted with 1 to 3 lower alkoxy groups or 1 to 3 halogens, R2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy, -O- @-O-(C1-C...
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JPS6241511B2 |
NEW MATERIAL:Benzthiazepine derivatives of formula I (R<1> is H, halogen, lower alkyl; R<2> and R<3> are the same or different H, lower alkyl; T8 is formula II). EXAMPLE:2-(p-Toluenesulfonyl)-3,4,5-tetrahydro-1,2-benzothia
zepin-5-one. U...
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JPS62187427A |
NEW MATERIAL:Threo-2,3-dihydroxy-3-(4-methoxyphenyl)-propionic acid of formula I. USE: It is used as a synthetic intermediate of d-3-acetoxy-cis-2,3- dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1, 5-benzazepin-4(5H)-one hydroc...
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JPS62187446A |
NEW MATERIAL:A compound expressed by formula I (W is nitro or amino). EXAMPLE: l-threo-2-Acetoxy-3-( 2-nitrophenylthio )-3-(4-methoxyphenyl)-propionic acid. USE: A synthetic intermediate for α-form diltiazem hydrochoride which is a reme...
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JPS62187448A |
PURPOSE: To readily obtain a compound useful as a synthetic intermediate for diltiazem hydrochloride which is a remedy for angina pectoris and essential hypertension in high purity and yield, by reacting a 4-methoxyphenyl-propionic acid ...
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JPS62187447A |
PURPOSE: To obtain a compound useful as a synthetic intermediate for diltiazem hydrochloride which is a remedy for angina pectoris and essential hypertension in high purity and yield, by reacting a 4-methoxyphenyl-propionic acid ester de...
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JPS62167725A |
The present invention is a new method of use for diltiazem, verapamil or nifedipine having activity for the treatment of stroke.
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JPS62158267A |
NEW MATERIAL:4-Alkyl-2,3,4,5-tetrahydro-1,5-benzothiazepin derivative of formula I (A is piperidino, substituted piperidino, N-substituted piperazinyl, phenethylamino, substituted phenethylamino; R is lower alkyl) and its acid adduct. EX...
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JPS6231719B2 |
4,1-Benzoxazepines and thia analogs thereof of the formula: (wherein -A-B- is the following group: +TR (wherein R1 is hydrogen, C1 to C3 alkyl, or C7 to C9 aralkyl; R2 is C1 to C3 alkyl or C1 to C3 alpha -aminoalkyl; R3 is C2 to C6 dialk...
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JPS6225664B2 |
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JPS6281316A |
PURPOSE: To provide a platelet coagulation inhibitor containing a specific 1,5- benzothiazepine derivative or its acid addition salt as an active component, having excellent platelet coagulation inhibiting activity, keeping the effect fo...
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JPS6251675A |
NEW MATERIAL:2-( 4-Methoxyphenyl )-5-( 2-dimethylaminoethyl )-1,5-benzothiaze pine-3,4(5H)-dioxo-2-carboxylic acid of formula I (R is H or alkyl) and its alkyl ester. USE: An intermediate for diltiazem hydrochloride useful as a coronary ...
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JPS6219576A |
Compounds of formulawherein X is S or SO2, R4 is aryl or hetero, and R1 is hydrogen orare disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.
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JPS61293976A |
Vasodilating activity is exhibited by new compounds having the formulaor a pharmaceutically acceptable salt thereof whereinn is 2 or 3; X is oxygen or sulfur;R, and R2 are each independently hydrogen, alkyl, cycloalkyl, or allyl, or R, a...
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JPS6156236B2 |
NEW MATERIAL:The compound of formula I (Y is O or S; R1, R2 and R3 are H, lower alkoxy, halogen or OH; R4 is H, lower alkoxycarbonyl, lower alkyl, etc.). EXAMPLE:1-Ethoxycarbonyl-8-oxo-1-aza-11a-oxa-C-homoerythrina
n. USE:An analgesic ha...
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JPS61268663A |
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for pharmaceuticals such as anticalcemic coronary circulation improver, etc., easily and economically, by reacting a mixture of trans-epoxides with 2- aminothiophe...
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JPS61254585A |
The invention provides a compound of formula (1):- and pharmaceutically acceptable salts thereof, where X<1> is oxygen; sulphur; -NR<2>- (where R<2> is hydrogen, C1-6alkyl or C1-6alkanoyl); -CHR<3>-; -CH2CHR<3>-; -O-CHR<3>-; or -S-CHR<3>...
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JPS6152150B2 |
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JPS6151568B2 |
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JPS6145609B2 |
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JPS61225175A |
PURPOSE: To obtain the titled compound useful as a coronary vasodilator under a mild condition in high purity in high yield, by alkylating hydrogen bonded to the 5-position of a 1,5-benzothiazepine derivative corresponding to the aimed c...
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JPS61165363A |
NEW MATERIAL:N-(2-Dimethylaminoethyl)-N-(o-mercaptophenyl)-p-met
hoxy-α- acetoxycinnamic acid amide shown by the formula I and its acid addition salt. USE: Useful as an intermediate for synthesizing a benzothiazepine derivative. The com...
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JPS61165378A |
PURPOSE: To produce the titled compound useful as an antidepressant, tranquillizer, coronary vasodilator, etc., with simple reaction operation in high yield, by using a novel cinnamic acid amide derivative as a raw material and cyclizing...
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JPS6129959B2 |
The present invention relates to hitherto unknown esters of the below formula I, to salts of the esters of formula I with pharmaceutically acceptable acids, to methods for producing said new compounds, to pharmaceutical compositions cont...
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JPS61148171A |
NEW MATERIAL:A benzothiazepine derivative shown by the formula I (X is O, or S; R1 is halogen; R2 and R3 are OH, or lower alkoxy; R4 is lower alkyl, lower alkoxy, OH, halogen, NH2, lower alkylamino, or NO2), its various isomers, and vari...
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JPS61145159A |
NEW MATERIAL:(+)-(2R*,3R*)-3-(2-aminophenylthio)-2-hydrox-y-3-(4
-met-hoxy- phenyl)propionic acid ester of formula I (R is 1W4C lower alkyl). USE: An intermediate of diltiazem hydrochloride useful as a coronary vasodilator. PREPARATION: ...
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JPS61130277A |
NEW MATERIAL:The compound of formula I (R1 is H, halogen, nitro, lower alkyl, or lower alkoxy; R2 is lower alkyl, aralkyl, phenyl, halogenophenyl, nitrophenyl, lower alkylphenyl, etc.; R3 is lower alkylaminoalkyl or morpholinoalkyl), its...
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JPS61130278A |
NEW MATERIAL:The 1,5-benzothiazepin-4(5H)-one derivative of formula I (R1 is H, halogen, lower alkyl or lower alkoxy; R2 is benzoyl, substituted benzoyl, or halogen- or lower alkoxy-substituted phenylsulfonyl; R3 is lower alkylaminoalkyl...
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JPS61103877A |
NEW MATERIAL:The 8-chloro-1,5-benzothiazepine derivative of formula I (R1 and R2 are lower alkyl) or its salt. EXAMPLE: (+)-cis-2-(4-Methoxyphenyl)-3-hydroxy-5-[2-(dimethylamin-o)-
ethyl]-8- chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-on...
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JPS6183176A |
NEW MATERIAL:1,4-Thiazepin derivative of formula I (R1,, R2 are H, 1W5C alkyl, aryl which may be substituted, aralkyl which mat be substituted where the substituents are selected from 1W3C alkyl, 1W3C alkoxy, nitro and halogen). EXAMPLE:...
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JPS6172772A |
NEW MATERIAL:Atrans-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-
phenyl-1, 5-benzothiazepine-4(5H)-one shown by the formula and its salt. USE: An antiulcer having the same or more improved medicinal effect than well- known drugs, and wea...
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JPS6172718A |
1. Pharmaceutical composition containing a combination of diltiazem and alfuzosin.
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JPS60239475A |
NEW MATERIAL:A compound of formula I (X and Y are H, lower alkyl, lower alkoxyl, OH, halogen or CF3 except when X and Y are H; R1 and R2 are OH or lower alkoxyl), isomer and salt thereof. EXAMPLE: 3-(L)-( 1-Ethoxycarbonyl-3-phenylproylam...
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JPS6052149B2 |
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JPS60204776A |
NEW MATERIAL:The compound of formula 1 (Ar is phenyl wherein at least one H is substituted with lower alkoxy; R1 is H or acetyl; R2 is lower alkylene; X is halogen) and its salt. EXAMPLE: 2-( 4-Methoxyphenyl )-3-acetoxy-5-( 2-chloroethyl...
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JPS6046111B2 |
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JPS60202818A |
PURPOSE: To use 1,5-benzothiazepine compounds, 1,6-benzothiazocine compounds, or their acid addition salts, as an antiulcer agent taking advantage of its strong effect to suppress the secretion of gastric juice. CONSTITUTION: The compoun...
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JPS6045636B2 |
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JPS60190773A |
NEW MATERIAL:A compound of formula I (R1 is H, 1W5C alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl; R2 is H, 1W3C alkyl; R3 is H, halogen, 1W3C alkyl; the above substituent is 1W3C alkyl, alkoxy, nitro, ha...
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