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JPS60174775A |
NEW MATERIAL:A benzothiazepine derivative shown by the formula (R1 is 5W 20C straight-chain or branched long-chain higher alkyl; one or both of R2 and R3 are hydroxyl group or lower alkoxy), its various isomers and its various salts. EXA...
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JPS60146884A |
PURPOSE: To obtain the titled compound useful as pharmaceuticals, by condensing a specific thiophenol derivative with a propionic acid derivative, reacting with acetic anhydride after hydrolysis, and cyclizing the resultant threo-type pr...
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JPS60139682A |
NEW MATERIAL:A compound expressed by formula I (R1 is H, 1W15C straight chain, branched or cyclic alkyl or phenyl substituted lower alkyl; either one or both of R2 and R3 are hydroxyl group, lower alkoxyl, amino-substituted lower alkoxyl...
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JPS60132972A |
NEW MATERIAL:The condensed heterocyclic compound of formula I (R1WR3 are H or lower alkyl; R4 and R5 are H, lower alkyl or together with adjacent N- atom form an aliphatic cyclic amino group; n is 1 or 2; m is 0 or 1). EXAMPLE: 1, 3, 4, ...
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JPS60130575A |
PURPOSE: To produce the titled compound having excellent antiulcer activity and gastric juice secretion suppressing activity, in high yield, by reacting a benzothiazepine derivative with N-methylpiperazine under heating in the presence o...
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JPS60126276A |
NEW MATERIAL:A compound expressed by formula I (R1 is H or lower alkoxyl; R2 is lower alkyl, phenyl or phenyl substituted by a lower alkyl or nitro; R3 is lower alkylaminoalkyl or morpholino lower alkyl). EXAMPLE: 2-( 4-Methoxyphenyl )-3...
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JPS60109580A |
PURPOSE: To obtain the titled substance useful as a drug for cardiopathy, in high yield, by cyclizing a cis-d-2-acetoxy-3-(4'-methoxyphenyl)-3-[(2'-dimethylaminoeth
ylamino)phenylthio]propionic acid compound. CONSTITUTION: The compound o...
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JPS60100564A |
PURPOSE: To obtain the titled substance, by acetylating 2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propio
nic acid, subjecting the resultant compound to ring closure, reacting the reaction product with N,N-dimethylaminoethyl c...
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JPS6089435A |
Pharmaceutical compositions for administration by inhalation, wherein calcium-antagonists are employed as the active substances, e.g., metered-sprays of calcium-antagonists, in particular of diltiazem and a process for their manufacture ...
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JPS6089478A |
PURPOSE: To obtain advantageously the titled substance which is an agent having coronary vasodilator action, etc., by reacting a benzothiazepine derivative with N-dimethylaminoethyl chloride in methyl ethyl ketone in the presence of pott...
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JPS6017778B2 |
Aminoalcohol derivatives corresponding to the formula (I) in which Q is a group and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group or , with a...
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JPS6078973A |
PURPOSE: To obtain the titled compound useful as a coronary vasodilator, etc. in high yield in one stage, by condensing a partially novel specific propionic acid ester derivative with a halide of a tertiary amine in the presence of a met...
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JPS6072875A |
NEW MATERIAL:The compound of formula I (R1WR3 are H, halogen, lower alkyl, lower alkoxy or OH; R4 is lower alkyl, lower alkylaminoalkyl or morpholinoalkyl) or its acid addition salt. EXAMPLE: 2-(4-Hydroxyphenyl)-5-( 2-morpholinoethyl )-2...
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JPS6072876A |
NEW MATERIAL:The compound of formula I (R1WR3 are H, halogen, lower alkyl, lower alkoxy or OH; R4 is lower alkyl, lower alkylaminoalkyl or morpholino-lower alkyl; X is halogen) or its acid addition salt. EXAMPLE: 2-( 4-Methoxyphenyl )-2,...
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JPS6067473A |
N-substituted heterocyclic compounds having insecticidal activity of the following general formula: wherein n = 2, 3 or 4 and R is an optionally-substituted acyl group selected from the following: aroyl carbamoyl aryloxycarbonyl arylthio...
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JPS6064974A |
PURPOSE: To obtain a benzothiazepine derivative, by reacting d-2-hydroxy-3-(2'- aminophenylthio)-2-(4"-methoxyphenyl)-propionic acid with acetyl chloride so that OH is acetylated and ring closure is done. CONSTITUTION: 1mol compound show...
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JPS6061574A |
NEW MATERIAL:1,2-Thiazacycloalkene derivative of formula I (n is 3W6; Ts is tosyl). EXAMPLE: 2-Tosyl-3H,6H,7H,8H-1,2-thiazocine. USE: It is used as a fungicide for agricultural and horticultural purposes, or as a synthetic intermediate o...
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JPS6061575A |
A process for preparing an N-substituted nitromethylene heterocyclic compound of the following general formula:- wherein n is 2, 3 or 4 and R is an optionally-substituted acyl group derived from an organic acid, characterised in that an ...
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JPS6056972A |
PURPOSE: To obtain easily the titled substance which is an intermediate for preparing compounds having coronary vasodilator action, etc., by reacting d-2- hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propioni
c acid as a starting ...
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JPS6011698B2 |
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JPS6048979A |
NEW MATERIAL:A compound shown by the formula I (X is H, or halogen; R is H, or lower alkyl; Y is group shown by the formula II or group shown by the formula III). EXAMPLE: 1,3,4,5,6,7-Hexahydro-2,5-benzothiazonin. USE: A drug for circula...
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JPS6042374A |
New 1,5-benzothiazepines of the following general formula I wherein: R1 represents (C1-4)alkyl, (C1-4)alkoxy or a halogen atom; R2 is selected from: benzoyl independently substituted with 1 to 3 (C1-4)alkyl or (C1-4)alkoxy groups, or wit...
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JPS6034959A |
NEW MATERIAL:The benzothiazepine derivative of formula I (R1 and R2 are H or lower alkyl; R3 is H or 1W10C alkyl). EXAMPLE: 5-Carboxymethyl-3-(1-ethoxycarbonylethylamino)-2,3-dihydro-1
,5-benzothiazepin-4(5H)-one hydrochloride. USE: Reme...
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JPS6032779A |
PURPOSE: To obtain the titled compound useful as an intermediate for drugs, by reducing a novel 2-phenyl-5-substituted-2,3-dihydro-1,5-benzothiazepine-3,4(5
H)- dione, etc. with a boron hydride compound. CONSTITUTION: A cis-2-phenyl(or 2...
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JPS6032778A |
NEW MATERIAL:A 1,5-benzothiazepine derivative shown by the formula I (R1 is H, 1W5C alkyl, aryl, aralkyl, or carboxyl; R2 is H, or 1W3C alkyl; R3 is H, halogen, or 1W3C alkyl; n is 0W2). EXAMPLE: 2-Propyl-2,3-dihydro-1,5-benzothiazepin-4...
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JPS6032777A |
PURPOSE: To obtain the titled compound useful as coronary vasodilator, etc. by one stage, by reacting a 1,5-benzothiazepine derivative with an N,N-dialkylaminoalkyl halide by the use of KF-Al2O2 as an alkylation promotor. CONSTITUTION: A...
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JPS60500176A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6016989A |
NEW MATERIAL:A compound shown by the formula I (R is H, or methoxy; R1 is H, or substituent group; R2 is H, light metal atom, or carboxy-protecting group; X is O, S, SO, or SO2; Y is alkylene containing hetero atom in chain; Z is H, or s...
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JPS608284A |
NEW MATERIAL:The compound of formula I (R is H, alkanoyl, benzyloxycarbonyl or other protecting group of amino group). EXAMPLE: 3-Acetylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one. USE: Intermediate of pharmaceuticals, agricultural ch...
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JPS608283A |
NEW MATERIAL:The compound of formula 1 (R1 and R2 are H or lower alkyl; n is 0W2). EXAMPLE: 3-Amino-5-ethoxycarbonylmethyl-2,3-dihydro-1,5-benzothiazepi
n-4( 5H )- one. USE: Remedy for hypertension and circulatory diseases. It has angiot...
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JPS604176A |
NEW MATERIAL:The heterocyclic compound of formula I (R is lower alkyl; R2 is H or CH3; Y is single bond, CH2 or CH2CH2; the substitution site of 2-hydroxy-3-alkylaminopropoxy group is a- or b-position) and its salt. EXAMPLE: 3-Methyl-7-[...
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JPS59225173A |
NEW MATERIAL:The 2-(4-lower alkoxyphenyl)-3-substituted-sulfonyloxy-5-dialkyaminoalkyl-2
,3-dihydro-1,5-benzothiazepin-4(5H)-one of formula I [R1 is lower alkyl; R2 is lower alkyl or phenyl which may have substituent group (lower alkyl o...
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JPS59196863A |
NEW MATERIAL:A compound of formula I (R1 is acyl; R2 is H, lower alkyl) and its salt. EXAMPLE: 2(S)-Hydroxy-3(S)-( 4-formyloxyphenyl )-3-( 2-nitrophenylthio ) propionic acid. USE: A synthetic intermediate of diltiazem hydrochloride, whic...
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JPS59196878A |
PURPOSE: To obtain the titled substance, by epoxidizing stereospecifically a cinnamyl alcohol, reacting the reaction product with o-nitrothiophenol, reducing it, subjecting the prepared compound to ring closure, reacting the resultant co...
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JPS59196881A |
NEW MATERIAL:An epoxide derivative having an absolute configuration shown by the formula I (R1 is acyl; R2 is CH2OH, COOH, or alkoxycarbonyl) and its salt. EXAMPLE: (2S, 3S)-2,3-Epoxy-3-(4-acetoxyphenyl)propanol. USE: An intermediate for...
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JPS59167577A |
This invention is directed to compounds of the formula wherein X is a thiazine or thiazepine selected from +TR These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
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JPS59144776A |
PURPOSE: To obtain easily and economically the titled compound useful as a coronary vasodilator, antidepressant, tranquilizer, etc., by reacting a racemic modification of a benzothiazepine derivative with a chiral large-ring polyether, a...
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JPS59144777A |
PURPOSE: To obtain easily and economically the titled compound, by developing and eluting a racemic modification of a benzothiazepine derivative adsorbed in a column packed with an adsorbent containing a chiral large-ring polyether unifo...
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JPS59110685A |
PURPOSE: To prepare an optically active benzothiazepine derivative useful as an antidepressant, tranquilizer, and a coronary vasodilator, by subjecting a recemic modification, an intermediate, to optical resolution with an optically acti...
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JPS5993047A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5993066A |
A method of counteracting the effects of histamine with aromatic azepinones and diazepinones and thiones thereof having the formula wherein: A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur: E is oxygen, sulfur or ...
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JPS5980669A |
NEW MATERIAL:A cis- or trans-1,5-benzothiazepine derivative expressed by formula I (R is CH3 or Cl). EXAMPLE: trans-2, 3-Dihydro-3-hydroxymethyl-2-( 3-methylphenyl )-1, 5-benzothaze- pin-4(5H)-one. USE: A medicine having inhibitory actio...
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JPS5919102B2 |
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JPS5912678B2 |
Compounds of the formula:
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JPS5920221A |
PURPOSE: The titled improving and treating agent, containing diltiazem or an acid addition salt thereof as an active constituent, usable continuously for a long term with almost no side effect, and administrable until there is no fear fo...
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JPS59508B2 |
Compounds of the formulae:
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JPS5857432B2 |
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JPS5857431B2 |
Compounds of the formulae:
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JPS58206577A |
NEW MATERIAL:A 2-phenyl[or 2-(4-substituted phenyl)]-2-hydro-5-substituted-1,5- benzothiazepine-3,4(5H)-dione of formula I (R1 is H, halogen or lower alkoxy; R2 is lower alkyl, lower alkoxyalkyl, lower alkyl substituted by OH or a haloge...
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JPS58201773A |
PURPOSE: To obtain advantageously the titled compound useful as an antidepressive, etc., by reacting 2-N-substituted-aminothiophenol with a novel 2-acetoxy-3- halo-3-substituted-propionic acid, subjecting the prepared novel intermediate ...
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