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JPS58180476A |
NEW MATERIAL:A 2-phenyl [or 2-(4-substituted phenyl)]-2-hydro-5-substituted-1,5- benzothiazepine-3,4(5H)-dione shown by the formula I (R1 is H, halogen, or lower alkoxy; R2 is lower alkyl, lower alkoxyalkyl, lower alkyl which may be repl...
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JPS5840955B2 |
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JPS5840954B2 |
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JPS58148871A |
Novel thiazaspirane derivatives of the general formula (I) including salts thereof with physiologically acceptable acids and bases, processes for their preparation and medicaments containing them.
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JPS58116476A |
PURPOSE: To obtain the titled compound useful as a vasodilator for coronary blood vassel through a novel substance, by acetylating a 2-(4-hydroxyphenyl)-3- hydroxy-benzothiazepine derivative corresponding to the desired compound, followe...
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JPS58116477A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS58113184A |
NEW MATERIAL:2-( 4-Benzyloxyphenyl )-3-acetoxy-5-(2-dimethylaminoethyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one of formulaI, its optically active isomer, or its acid addition salt. USE: Useful as a drug having coronary vessel dilating ...
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JPS58113186A |
PURPOSE: To prepare the titled compound useful as a remedy for stenocardia such as angia of effort, inveterate myocardial infarction, etc., in high yield, by reacting a 3-hydroxy derivative with dimethylaminoethyl halide, and successivel...
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JPS58113185A |
NEW MATERIAL:2-( 4-Hydroxyphenyl )-3-acetoxy-5-( 2-dimethylaminoethyl )-2,3- dihydro-1,3-benzothiazepin-4(5H)-one of formulaI, its optically active isomer, and their acid addition salts. USE: It has coronary vessel dilating activity and ...
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JPS5817754B2 |
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JPS5839682A |
There are presented benzazepines of the formula I wherein either R1 is hydrogen, lower alkyl, 4-pyridyl or the group -(CH2)n-NR6R7 and R2 and R3 together are an additional bond or R1 and R2 together are the oxo group and R3 is hydrogen o...
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JPS5812265B2 |
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JPS5812264B2 |
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JPS5832872A |
PURPOSE: To obtain a (+) form of a benzotiazepine derivative having improved vasodilating action on a coronal blood vessel easily efficiently in high purity and in high yield, by using inexpensively obtainable optical active mandelic aci...
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JPS5829779A |
PURPOSE: To obtain the titled compound for coronary vasodilators, etc. safely, by cyclizing an α-2-acyloxy-3-(substituted phenyl)-3-(2-aminophenylthio)-propionic acid derivative, and dialkylaminoalkylating the nitrogen atom at the 5-pos...
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JPS58424B2 |
The present invention is concerned with tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.
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JPS57175183A |
NEW MATERIAL:The compound of formulaI, its optically active isomers, or their acid addition salts. USE: A coronary vessel dilating agent, and a drug acting to the central nervous system. PROCESS: The compound of formulaIcan be prepared b...
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JPS57175182A |
PURPOSE: To prepare the titled compound useful as pharmaceuticals having coronary vessel dilating action and psychotropic action, with simple procedure, in high yield, by acetylating a 3-hydroxy-benzothiazepin derivative, and then alkyla...
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JPS57169476A |
PURPOSE: To obtain the titled compound useful for improving the stenocardiac pain advantageously in four steps, by passing through two novel substances from 2-(4-benzyloxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazep
in-4(5H)-one. CONST...
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JPS57169474A |
NEW MATERIAL:2-( 4-Benzyloxyphenyl )-3-acetoxy-5-(2-dimethylaminoethyl)-2, 3- dihydro-1,5-benzothiazepin-4-(5H)-one of formulaI, an optically active substance or acid addition salt thereof. USE: Useful as a medicine having the coronary v...
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JPS57169475A |
NEW MATERIAL:2-( 4-Hydroxyphenyl )-3-acetoxy-5-( 2-dimethylaminoethyl )-2, 3- dihydro-1,5-benzothiazepin-4(5H)-one of formulaIand an acid addition salt thereof. USE: Useful as a medicine having the coronary vasodilator action or action o...
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JPS5724356B1 |
1388582 Quinobenzoxazepine- and quinobenzothiazepine-derived amines E R SQUIBB & SONS Inc 5 June 1972 [24 June 1971] 26100/72 Heading C2C The invention comprises compounds of formulµ and their salts, wherein X, Y are each C 1-8 alkyl, a...
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JPS56167676A |
Antihypertensive compounds of the structure wherein n is the integer 1 or 2, R1, R2, R3, R4, R5, when taken separately are independently hydrogen, unsubstituted alkyl containing from 1 to 20 carbon atoms, unsubstituted alkenyl containing...
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JPS56135487A |
1388582 Quinobenzoxazepine- and quinobenzothiazepine-derived amines E R SQUIBB & SONS Inc 5 June 1972 [24 June 1971] 26100/72 Heading C2C The invention comprises compounds of formulµ and their salts, wherein X, Y are each C 1-8 alkyl, a...
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JPS565488A |
NEW MATERIAL:The titled compound of formula I (R1 and R2 are H or lower alkyl groups; X1 and X2 are H, lower alkyl, lower alkoxy groups, etc.; Y is acid residue). EXAMPLE: 2, 3-Dihydro-7-methyl-1H, 5H-isothiazolo[ 2, 1-a ][ 2, 1 ]benzois...
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JPS55162765A |
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JPS55162788A |
The invention is concerned with a novel process for the manufacture of novel thiophene derivatives and of biotin, respectively. The process starts from L or DL-cystine esters and proceeds via various novel intermediates, particularly...
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JPS55102568A |
1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives are provided having the structure wherein (CH2)n represents a straight chain alkylene group containing 2 to 5 carbons, and R1 and R2 are the same or different and may be hydr...
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JPS5519249A |
NEW MATERIAL:A cis-form optically active 1,5-benzothiazepine dervative of the formula and its salts. EXAMPLE: cis-(-)-2,3-Dihydro-3-[(4-methylpiperadinyl) methyl]-2-phenyl-1,5- benzothiazepin-4(5H)-one. USE: Anti-acetylcholine and antitu...
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JPS5442993B2 |
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JPS54132584A |
Polyfluorohydroxyisopropyl tricyclic carbostyrils, such as 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluo
romethyl)e thyl]-5H-[1,4]thiazino[2,3,4-ij]-quinolin-5-one, useful as antihypertensive agents.
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JPS5422978B2 |
The present invention relates to cyclopropylmethyl amines substituted by a heterocyclic radical.
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JPS544955B2 |
The present invention relates to cyclopropylmethyl amines substituted by a heterocyclic radical.
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JPS5343517B1 |
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JPS5335949B2 |
The present invention relates to cyclopropylmethyl amines substituted by a heterocyclic radical.
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JPS5318038B1 |
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JPS535661B2 |
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JPS535294B1 |
1347977 N - Substituted alkanolamines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 1 Nov 1971 [4 Nov 1970] 52469/70 Heading C2C Novel N-substituted alkanolamines of the general formula wherein A is -(CH 2 ) m -, -CH=CH-, -(CH...
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JPS5285192A |
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JPS51143690A |
A process for the production of new benzo-2,4-thiazepines of formula I, **(See formula)** where each of R1 and R2, independently, means hydrogen, halogen, trifluoromethyl, a lower alkoxy group or a lower alkyl group, R3 is hydrogen, a lo...
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JPS5142118B2 |
1418363 Preparation of piperidinylmorphanthridines and related tricyclic compounds WANDER Ltd 2 April 1973 [4 April 1972 (2)] 15667/73 Heading C2C The invention comprises a process for the preparation of compounds of Formula I wherein A ...
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JPS5141639B1 |
(A) Cpds. of general formula (I):- R = lower alkyl R1,R2 = H, halogen, lower alkyl/alkoxy, NO2, CF3 X = O, S Y = OH, amino opt. mono/di-lower alkylated, lower alkoxy, piperazino, 4-lower alkylpiperazino, 4-lower-hydroxyalkylpiperazino, p...
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JPS51125210A |
A process for preparing acid chlorides, wherein a silyl ester having an aliphatic, aromatic, alkanoaromatic or heterocyclic group which may support substituents, and having a low molecular weight alkyl or phenyl group is reacted with thi...
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JPS5133117B2 |
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JPS5198287A |
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JPS50151889A |
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JPS50151888A |
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JPS50117790A |
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JPS5017990B1 |
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JPS502728B1 |
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