Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 1,308

Document Document Title
WO/2018/002827A1
Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.  
WO/2017/112988A1
The present invention describes molecules with a hybrid nucleus based on tetrahydroacridine and tianeptine nuclei separated by methyl spacer chains via a coupling reaction, a pharmaceutical composition comprising these molecules, a metho...  
WO/2017/109178A1
A subject of the present invention is the use of a compound having the general formula (I): (I) wherein V, W, X4, X5, X6, X7, X'4, X'5, X'6, X'7, Y, Y', R3, R'3, R4 and R'4 are as defined in any one of claims 1 to 11, for the detection, ...  
WO/2017/055834A1
Tricyclic dibenzothiazepine compounds for use in the treatment of CDKL5 disorder. Specifically, a compound of Formula I, or a pharmaceutically or veterinarily acceptable salt thereof, or a pharmaceutically or veterinarily acceptable solv...  
WO/2017/049158A1
The present invention provides a compound having the structure of the instant invention or a pharmaceutically acceptable salt or ester thereof, methods of preparing the same, and methods of treating a subject with compounds of the instan...  
WO/2017/048954A1
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a pat...  
WO/2017/044571A1
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus : The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP...  
WO/2016/151011A1
2-homopiperazine-1-yl-4H-l, 3 -bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of ...  
WO/2016/143650A1
Provided is a compound that exhibits an excellent controlling effect against harmful arthropods. A 3-aminooxalylaminobenzamide compound represented by formula (1) has an excellent controlling effect against harmful arthropods.  
WO/2016/139181A1
The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions com...  
WO/2016/109596A1
Disclosed are novel calcium modulators having formula I: or a pharmaceutically acceptable salt, and including deuterated forms thereof, wherein: Z1, Z2, Z3, Z4 Z5, R1, R1', R2, R3, R3' R4, and R4', are as defined throughout the specifica...  
WO/2016/062848A1
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1- dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl] oxy}acetyl)amino]-2- phenylethanolyl}glycine (elobixibat).  
WO/2016/064082A3
The present invention relates to a novel aminoalkyl benzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, containing the same as an active ingredient, for preventing or treating const...  
WO/2016/064082A2
The present invention relates to a novel aminoalkyl benzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, containing the same as an active ingredient, for preventing or treating const...  
WO/2016/055028A1
The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300....  
WO/2016/020785A1
Methods for preparing the following compound are disclosed.  
WO/2015/195950A1
The present disclosure provides compounds that are Large Multifunctional Protease 7 (LMP7) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of LMP7. Also provided are pharmaceutical compositions c...  
WO/2015/195950A8
The present disclosure provides compounds that are Large Multifunctional Protease 7 (LMP7) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of LMP7. Also provided are pharmaceutical compositions c...  
WO/2015/155230A1
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...  
WO/2015/155231A1
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...  
WO/2015/138791A1
The present invention provides a compound having the structure (I) or a pharmaceutically acceptable salt or ester thereof.  
WO/2015/138220A1
The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the tre...  
WO/2015/109130A1
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.  
WO/2015/017412A1
The disclosure includes compounds and pharmaceutically acceptable salts of Formula (I). Certain compounds and salts of Formula (I) are selective inhibitors of the Dopamine D2 receptor. The variables R1-R4, n, and L are defined herein. Th...  
WO/2014/174066A1
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phen yl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)ami no]-2- phenylethanolyl}glycine (elobixibat), more specifi...  
WO/2014/155387A1
The present invention relates to extended release dosage forms of weakly basic drugs. Particularly the present invention is related to extended release dosage forms of quetiapine or pharmaceutically acceptable salts thereof.  
WO/2014/131825A1
The present invention relates to a multilayer tablet formulation comprising a combination of quetiapine or a pharmaceutically acceptable salt thereof and escitalopram or a pharmaceutically acceptable salt thereof.  
WO/2014/125444A1
Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.  
WO/2014/119636A1
Provided are: a novel compound which has an antiviral effect, in particular, HIV replication inhibitory activity; and a pharmaceutical product, in particular, an anti-HIV agent which contains the novel compound. A compound which is repre...  
WO/2014/112898A1
The invention relates to the field of medicine, and more particularly to oncology and immunology. Proposed are novel compounds of general formula (1) or (2), which have an affinity for CD16a. Proposed are novel modified proteins, active ...  
WO/2014/057439A3
Piperazine compounds or their pharmaceutically acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof are provided. The pharmaceutical compositions comprising an effective amount of piperazine ...  
WO/2014/031600A1
The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a ...  
WO/2014/030106A3
The present invention relates to a process for producing an optically active (2S,3S)-3- hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4 (5H)-one (Cis-lactam). More particularly, this invention relates to a process for making...  
WO/2014/023708A1
There are provided compounds of the formula (1) wherein W, X, Y, Z, R1, R2, R3, R4, R5 and R6 are described herein. These compounds are useful for the treatment of proliferative diseases, including cancer.  
WO/2014/009447A1
Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of maki...  
WO/2013/156505A1
The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also ...  
WO/2013/119564A1
It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequ...  
WO/2013/112809A3
25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof is provided. Methods of treatment of bowl related disorders using isolated and/or purified 25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof are also...  
WO/2013/029136A1
The present invention provides tianeptine derivatives, especially N-alkyl and N-alkenyl derivatives, use thereof, pharmaceutical compositions comprising same, and method for producing same. The tianeptine-derived compounds can potentiall...  
WO/2013/019978A1
Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probe...  
WO/2013/002329A1
The present invention relates to: a method for producing a novel lanthionine derivative having a CaSR agonistic activity; an intermediate compound for the lanthionine derivative; and use of the intermediate compound for the production of...  
WO/2012/143703A1
A compound of formula (I): or a pharmaceutically or veterinarily acceptable salt thereof, or a pharmaceutically or veterinarily acceptable solvate of either entity, wherein: R1, R2, R3, R4, R5, R6, X and m are as defined herein.  
WO/2012/063085A3
The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one ...  
WO/2011/126071A1
Provided are an agent for inhibiting viral infection and/or treating an infectious disease whereby viral infection can be inhibited without being affected by a change in the virus such as the appearance of a subspecies or a variant, and ...  
WO/2011/121602A1
The present invention discloses a process for the preparation of dibenzothiazepinone compounds of Formula I. The process for preparation of a dibenzothiazepinone compound of Formula I comprises reaction of compound of formula II in the p...  
WO/2011/107248A1
The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present inv...  
WO/2011/081184A1
A number of variation compounds having CaSR agonist activity were searched, and a novel compound having superior action for imparting rich flavor was discovered. Provided are an agent for imparting rich flavor which comprises the aboveme...  
WO/2011/034051A1
Compounds represented by general formula (1) or salts thereof. In general formula (1), A is an aromatic hydrocarbon ring or an aromatic heterocycle (with the ring and the heterocycle being optionally substituted); R1 to R11 may be the sa...  
WO/2010/100623A1
The present invention relates to an improved process for the preparation of quetiapine and pharmaceutically acceptable salts. It also relates to improved process for the preparation of intermediates of quetiapine.  
WO/2010/085976A1
The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo [b, f ] [1, 4] thiazepin- 11 (10H) -one, intermed...  

Matches 1 - 50 out of 1,308