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Matches 501 - 550 out of 4,595

Document Document Title
WO/2008/050167A1
The present invention relates to new sulfonamide derivatives of formula (I), wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective a...  
WO/2008/049864A1
This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the trea...  
WO/2008/047138A2
The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the treatment of cancers: in which R1 is an option...  
WO/2008/045558A2
Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and use thereof to treat or prevent diseases associated with monocyte a...  
WO/2008/042928A2
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of uti...  
WO/2008/038841A1
Disclosed is a compound represented by the general formula [I], a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt. The compound is excellent in selective TACE-inhibiting activity. Therefore, a pharmaceu...  
WO/2008/039023A1
A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related ...  
WO/2008/036652A2
The present invention is directed to amidino heterocyclic compounds of formula Ia and IIa which are modulators of indoleamine 2, 3 - dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.  
WO/2008/036308A2
Provided herein are Heterocyclic Compounds having the following structure: Formula (I) wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or p...  
WO/2008/033455A2
Disclosed are compounds and pharmaceutically acceptable salts of formula (I) : wherein A, B, D, L1 L2, R2, RA, RB, X, m, n, and p are as defined herein, which are useful in the treatment of metabolic disorders related to insulin resistan...  
WO/2008/031534A1
Novel compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N- oxides thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), t...  
WO/2008/032858A2
A thiadiazole compound represented by the formula (I): wherein R is a hydrogen atom, an optionally substituted C1-C7 chain hydrocarbon group etc., Z is an oxygen atom or a sulfur atom, X is a -NR2R3 group etc., R2 and R3 each independent...  
WO/2008/030618A1
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, ℗, L2, M, X, L3, and A are provided h...  
WO/2008/023720A1
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly frequent urination, urinary incontinence and/or overactive bladder. [MEANS FOR SOLVING PROB...  
WO/2008/022771A1
The present invention, relates to compounds of formula (I), wherein A is hydrogen or (C1-4)alkyl, R1 is a group Y-R2, Y is not present or is (C1-4)alkylene, which alkylene optionally is substituted, e.g. one or morefold, by halogen, such...  
WO/2008/023157A1
A compound of formula (I): Formula (I) having M3 receptor- antagonist activity or having both muscarinic receptor antagonist and β2-agonist activity; a composition comprising such a compound; the use of such a compound in therapy (such ...  
WO/2008/021849A2
Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.  
WO/2008/020256A2
(I) The present invention is related to new 3,4-dihydroberizo[1,2,3]thiadiazine-1,1-dioxide derivatives of the Formula (I), medicaments containing said new compounds, process for the preparation thereof and the use of said derivatives in...  
WO/2008/020255A1
(I) The present invention relates to new benzo[1,2,3]thiadiazine-1,1 dioxide derivatives of the general Formula (I), medicament containing such compounds and the use thereof in the medicin Benzo[1,2,3]thiadiazine-1,1-dioxide derivatives ...  
WO/2008/017164A1
The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoar...  
WO/2008/019090A2
The invention provides compounds formulae I-III, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an act...  
WO/2008/016692A2
The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activate...  
WO/2008/016674A1
The invention provides compounds of formula I and formula II, their preparation, a their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated ...  
WO/2008/014199A2
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ...  
WO/2008/009734A1
The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicament...  
WO/2008/007780A1
Disclosed is a pentadienamide derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof or the like. (I) wherein R1 represents a substituted or unsubstituted aryl or a substituted or unsubstituted aromatic h...  
WO/2008/008394A1
Disclosed herein is a novel succinate salt of tizanidine with improved properties. Also described herein are novel pharmaceutical compositions comprising tizanidine succinate salt, methods of making, and related methods of treatment.  
WO/2008/000408A1
The invention relates to compounds of the formula (I) in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors...  
WO/2008/000438A1
A compound of formula (I), wherein A1, A2, A3, A4, R1 , R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of f...  
WO/2007/140233A1
Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.  
WO/2007/136051A1
This invention provides an optical recording material, which can solve a problem of recording density in an optical recording medium, and an optical recording medium using the optical recording material. The optical recording material co...  
WO/2007/123718A1
1-Heterocyclylamino-2-hydroxy-3-amino-ω-arylalkanes of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.  
WO/2007/116374A1
The invention relates to sulfonamide compounds of formula (I), where A, B, R3 and R4 are as defined in the claims, and their use as orexin receptor antagonists in the prevention and treatment of eating and drinking disorders, all types o...  
WO/2007/117180A1
The invention relates to novel azaheterocycles of interest as potential physiologically active substances (agonists, antagonists, receptor modulators, ferment inhibitors, oncolytics, antibacterial and antiparasitic agent etc.), to combin...  
WO/2007/115058A2
Compounds of the formula (I) are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as...  
WO/2007/095050A2
The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions containing the same and methods for the treatment of IDO-associated diseases.  
WO/2007/090617A2
This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis,...  
WO/2007/092190A2
The present invention relates to compounds which modulate the activity of the SlPl receptor, the use of these compounds for treating conditions associated with signaling through the SlPl receptor, and pharmaceutical compositions comprisi...  
WO/2007/087906A1
The present invention relates to N-cycloalkyl-benzyl-amide derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fun...  
WO/2007/086584A1
Disclosed is a compound which can inhibit both of FabI and FabK which are fatty acid synthases to show a wide antibacterial spectrum including Streptococcus pneumoniae, Pseudomonas aeruginosa and Enterococcus faecalis, and therefore can ...  
WO/2007/082471A1
Anti-infective compound, preparation method thereof and use thereof. The present invention disclosed a crystal of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3 ,2-a]quinoline-3-carboxylic acid (II) methanesulfonate, which ...  
WO/2007/082472A1
Anti-infective quinolone compound, preparation method thereof and use thereof. The present invention disclosed the pharmaceutically acceptable salt of 6-fluoro-1-methyl-4-oxo-7- (1- piperazinyl) - 4H -[1,3]thiazeto[3,2-a]quinoline-3-carb...  
WO/2007/079959A1
The invention relates to the substituted propiolic acid amides of general formula (I), to methods for producing them, to drugs containing said compounds and to the use thereof for producing drugs.  
WO/2007/074171A1
Methods for the synthesis of various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds (I) and their pharmaceutically acceptable salt derivatives are provided. The compounds of the invention are claimed and a...  
WO/2007/072763A1
Disclosed are a novel cyclic fluorosulfonyl imide salt and an electrolyte. Specifically disclosed are a compound (1) shown below and an electrolyte containing a compound (1m) shown below. In this connection, n represents 1, 2, 3 or 4; [M...  
WO/2007/071900A1
Compounds of formula I: wherein R1, R2, R3, R4, m, R5, R6, n and Y are as defined in claim 1; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I),...  
WO/2007/073503A2
Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having ...  
WO/2007/067615A2
Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inh...  
WO/2007/067613A1
Compounds of the formula (I) are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as...  
WO/2007/067612A1
Compounds of the formula (I) are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as...  

Matches 501 - 550 out of 4,595