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Patent Searching and Data


Matches 651 - 700 out of 5,964

Document Document Title
WO/2005/090297A1
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC is -NR1R2, RA is a group having the formula (A), (B) or (C) RB is h...  
WO/2005/090298A1
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzo...  
WO2005068445A3
The invention relates to compounds of formula (I) wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z isomers, mixtures of E/Z isomers and/or taut...  
WO/2005/087752A2
The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disord...  
WO2005054430A3
Hepatitis C virus inhibitors are disclosed having the general formula: (I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are ...  
WO/2005/085220A1
The invention relates to the use of compounds of formula (I) where Art, Ar2 and Z have the meanings given in claim 1, for the prophylaxis and/or treatment of diseases in which the inhibition, regulation and/or modulation of signal transd...  
WO/2005/082874A1
It is intended to provide a drug useful as a remedy and a preventive for hyperlipemia; a drug also useful as a remedy and a preventive for liver disorders accompanying bile stasis, in particular, primary biliary cirrhosis, primary sclero...  
WO/2005/082871A2
The invention relates to guanidine compounds of general formula (I), corresponding enantiomeric, diastereomeric, and/or tautomeric forms thereof, and pharmaceutically acceptable salts thereof. The invention further relates to the use of ...  
WO/2005/080362A1
E-cinnamic amides of piperazine derivatives according to formula (I) wherein X is chloro or Fluor and R1 is an aromatic or heteroaromatic group. Their pharmaceutically acceptable salts, pharmaceutical compositions containing them and the...  
WO/2005/080360A1
Compounds of Formula (I) wherein: R1 is methyl; R2 is selected from -C (O) NR4R5, SO2NR4R5, S (O) pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linke...  
WO/2005/077925A1
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure of formulae (I) or (II); whereinR1 is hydrogen (H), alkyl or substitute...  
WO/2005/077124A2
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).  
WO/2005/075435A1
The present invention relates to modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'), compositions thereof, and methods therewith. The prese...  
WO/2005/072731A1
Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more s...  
WO2004060306A3
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kina...  
WO/2005/068413A1
A novel amine compound utilizable as a hole-transporting or hole-injecting material in organic electroluminescent elements, electrophotographic photoreceptors, etc. The novel amine compound is represented by the following general formula...  
WO/2005/068432A1
The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represen...  
WO/2005/067933A1
The invention relates to substituted quinazolinone compunds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Y is C or S; m is 1 when Y is C and m is 2 when Y is S; n is 1 or 2; p is from 0 to 3; q is from 1 to 3; Z ...  
WO/2005/068445A2
The invention relates to compounds of formula (I) wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z isomers, mixtures of E/Z isomers and/or taut...  
WO/2005/066114A1
The present invention relates to cornpounds of the formula (I) or (II) or pharmaceutically acceptable salts thereof useful for the prophylaxis and treatment of degenerative bone disorders and for the acceleration of bone healing.  
WO2005013914A3
The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and met...  
WO/2005/065779A1
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors ('CGRP-receptor'), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment usin...  
WO/2005/066145A1
This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R1 and R2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct trea...  
WO/2005/065683A1
The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is...  
WO/2005/066147A1
Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, ami...  
WO/2005/061465A1
The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are each hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hy...  
WO/2005/061477A1
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors: Formule (I).  
WO2002058698A8
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...  
WO/2005/058298A2
The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissu...  
WO/2005/058808A1
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-...  
WO/2005/058848A1
The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activit...  
WO/2005/057171A2
The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present inv...  
WO/2005/057171A3
The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present inv...  
WO/2005/055715A2
Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, Ra, Rb, Rc, Rd, b, c, Re, Rf, Rg, Rh, R5, d, e, U...  
WO/2005/054430A2
Hepatitis C virus inhibitors are disclosed having the general formula: (I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are ...  
WO2005025293A3
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazoli...  
WO/2005/054218A1
The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing th...  
WO/2005/051932A1
Arylheterocycle derivatives which are represented by the formula (1): (1) wherein R1 represents C1-6 alkyl, etc.; R2 represents halogeno, etc.; m is an integer of 0 to 4; and T represents a group represented by the formula (2), (3), or (...  
WO2004033440A8
Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl,...  
WO/2005/049546A1
A halogenated bisdiarylaminopolycyclic aromatic compound, polymers made therefrom, and polymeric light emitting diode devices using the polymers are described. The halogenated compound is represented by formula (I), wherein Ar and Ar' ar...  
WO2005019191A3
Compounds having the formula (I), wherein B is (a), (b), (c), or (d); A is a monocyclic or bicyclic ring selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle (the other substituents are defined...  
WO2005000231A3
This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).  
WO2005021490A3
The invention relates to N-sulfonyl-alpha-amino-acetic acid derivatives of the general formula (I): including the optical isomers thereof and mixtures of such isomers, wherein Ar1 and Ar2 independently of each other stand for an optional...  
WO2004022775A8
L'invention porte sur un procédé d'identification d'agents antibactériens modificateurs de virulence comportant les étapes suivantes: épuiser en Ca2+ les bactéries d'une souche comprenant le gène hybride luxAB; incuber les bactér...  
WO/2005/041959A1
The invention features phenoxyacetic acids and analogs of formula (I), compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2005/042493A1
The invention relates to novel hexyl carboxanilides of formula (I), in which L, R1, R3 and A are defined as cited in the description, to several methods for producing said substances, to their use for controlling undesirable micro-organi...  
WO/2005/040101A1
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These c...  
WO/2005/040100A1
This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have ...  
WO2005005395A3
Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherei...  
WO2004092116A8
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical...  

Matches 651 - 700 out of 5,964