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WO/2003/053978A1 |
The invention concerns a compound of formula (I), wherein: R1 represents an aryl or heteroaryl; R2 represents hydrogen, halogen or a hydroxy; X represents oxygen or sulphur; Y represents oxygen, sulphur or NR wherein R represents hydroge...
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WO/2003/051854A1 |
An antitumor agent which contains as an active ingredient a thiadiazoline derivative represented by the following general formula (I): (I) [wherein R1 and R4 are the same or different and each represents hydrogen, (un)substituted lower a...
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WO/2003/051841A2 |
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...
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WO/2003/051842A2 |
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...
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WO/2003/051325A1 |
The present invention provides novel compound and their use of formula (I) or a cosmetically acceptable salt thereof as a skin lightening agent wherein in formula (I), A is an optionally substituted aryl or heteroaryl group, Z is C=O, C=...
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WO/2003/044000A1 |
The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on t...
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WO/2003/042211A1 |
Phenyl substituted triazoles of formula (I) wherein R1 is naphthyl or phenyl optionally substituted with one or more substituents selected from halo, -O-C1-6alkyl, -S-C1-6alkyl, C1-6alkyl, C1-6haloalkyl, -O-(CH2)n-Ph, -S-(CH2)n-Ph, cyano...
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WO/2003/042214A2 |
Disclosed are novel compounds of the Formula I or Formula II that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
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WO/2003/040096A2 |
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
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WO/2003/039539A2 |
The invention relates to the use of endothelin receptor antagonists in the production of a medicament for treating tumour diseases.
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WO/2003/040117A1 |
The present invention is directed to novel 1,2,4−thiadiazole derivatives of the formula (II) wherein R1, R2 and R4, are ring containing radicals, useful as agonists or antagonists of the melanocortin receptor. More particularly, the co...
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WO/2003/040118A1 |
The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives of the formula (I); wherein R?1¿, R?2¿ and R?4¿ are ring containing radicals, R?3¿ is H, alkyl, alkenyl or alkynyl, useful as agonists or antagonists of th...
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WO/2003/037847A1 |
This invention relates to certain benzamide derivatives and their use as pharmaceuticals.
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WO/2003/035602A1 |
Compounds represented by the following general formula (I) and which have a PPAR&gammad modulator activity: (I) wherein A represents optionally substituted aryl&semi B represents optionally substituted aryl, optionally substituted cycloa...
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WO/2003/032916A2 |
Organosulfur modulators of tyrosine phosphatases and their use in the treatment of disease are disclosed.
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WO/2003/032993A1 |
The invention relates to the use of Phosphodiesterase IV inhibitors and/or the physiologically acceptable salts thereof in the production of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheum...
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WO/2003/032999A1 |
A compound of Formula (I) or a pharmaceutical acceptable salt thereof, or a tautomer thereof, wherein G¿1?, G¿2?, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseas...
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WO/2003/032972A1 |
Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1−6alkyl, C3−7cycloalkyl, C2−6alkenyl, −SO2NR4R5, −CONR4R5 and −COOR4&semi and when m is 2 to 4 R1 is additionally selected from C1−6alkoxy, hydroxy, N...
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WO/2003/029211A1 |
A difluoroalkene derivative which is sufficiently effective in controlling various pests even when used in a small dose and is highly safe for crops, natural enemies to the pests, and animals&semi and an intermediate for the derivative. ...
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WO/2003/029477A1 |
The compounds of formula (I) are useful for the preparation of 1,5-benzothiazepines which are useful as enzyme inhibitors, such as protease, interleukin-1$g(b)-converting enzyme, elastase or angiotensin enzyme, GPCR antagonists (cholecys...
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WO/2003/024955A2 |
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...
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WO/2003/022286A1 |
The present invention relates to compounds of formula (I) wherein R?v¿, R?1¿, R?2¿, R?x¿, R?y¿, M, R?z¿, v, R?3¿, R?4¿, R?5¿ and R?6¿ are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts an...
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WO/2003/020711A1 |
Dithiazole compounds of the general formula (I) or salts thereof: (I) [wherein R1 is hydrogen, alkyl, or the like&semi R2 is hydrogen, hydroxyl, alky, aryl, arylalkoxy, arylalkyl, or the like&semi and R3 is a group represented by the gen...
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WO/2003/018008A1 |
A medicinal composition having apo AI expression accelerating action, which comprises a compound represented by the formula (I): (I) wherein Y1 represents O, S or NR1, Y2, Y3, Y4 and Y5 represent CR2 or N, CR3 or N, CR4 or N, and CR5 or ...
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WO/2003/018029A1 |
Compounds of the structure I are useful for treating bacterial growth. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such com...
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WO/2003/015774A1 |
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R?1¿, R?2¿, R?3¿, n and m are as described in the specification, in the preparation of a medicament for the treatment or prev...
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WO/2003/013518A1 |
Biaryl ketoamide derivatives (I), which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such biaryl ketoamide derivatives as well as methods of using the same in the trea...
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WO/2003/014064A1 |
Naphthylurea and naphthylacetamide derivatives of formula (I) which have vanilloid receptor 1 (VR1) antagonistic activity are disclosed, formula (I) wherein Y represents formula (II) and formula (III) and the variables Q, X, R6, R7, R8, ...
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WO2002068399B1 |
The invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, the invention relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in th...
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WO/2003/010143A1 |
The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases ari...
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WO/2003/006443A2 |
The invention relates to the use of carboxylic acid derivatives of general formula (I) R¿1? - A - B - R¿2?, in which R¿1?, R¿2?, A and B are defined as per Claim No. 1, and to their isomers and salts, particularly their physiological...
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WO/2003/002519A1 |
The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.
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WO/2002/100437A2 |
Ophthalmic compositions comprising an ophthalmic drug, e.g. ketotifen, and a linear polysaccharide compound, e.g. a hyaluronic acid compound, are useful for topical once-a-day administration to the eye.
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WO/2002/098420A1 |
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae (I) and (II), wherein A¿1,?...
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WO/2002/096864A1 |
The invention relates to carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments, physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), in w...
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WO/2002/096884A2 |
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R?1¿ - R?5¿ and Z have the meaning given in the description and several methods for production thereof and use thereof as...
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WO/2002/096882A1 |
Substituted anilide derivatives represented by the general formula (&Verbar ), intermediates thereof, agricultural and horticultural chemicals, and their usage: (&Verbar ) wherein R1 is hydrogen, C1−6 alkyl, C1−6 haloalkyl, or the li...
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WO/2002/094791A1 |
This invention provides compounds of Formula I, their N-oxides and agriculturally suitable salts wherein A and B are independently O or S; J is an optionally substituted 5- or 6-memebered nonaromatic heterocyclic ring; K is taken togethe...
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WO/2002/092584A1 |
Thiadiazole derivatives represented by the general formula (I); pesticides for agricultural and horticultural use, containing the compounds as the active ingredient; and usage thereof: (II) wherein R is hydrogen, cyano, nitro, C¿1-6? al...
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WO/2002/092581A1 |
The invention relates to novel heterocyclyl phenyl benzyl ethers of formula (I), wherein R represents methoxy carbonyl, methylaminocarbonyl or 5,6-dihydro-1,4,2-dioxazine-3yl, R?1¿ represents alkyl, R?2¿ represents hydrogen or alkyl an...
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WO/2002/092574A1 |
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...
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WO/2002/089783A1 |
The invention relates to the use of substituted cyclohexan-1,4-diamine derivatives in the production of drugs for treating diarrhoea or irritable bowel diseases or as immunotherapeutic agents or peripheral analgesics, especially for trea...
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WO/2002/090314A1 |
Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, ...
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WO/2002/090330A1 |
The invention relates to substituted 2-pyridine-cyclohexane-1,4-diamine derivatives, to a method for the production of said derivatives, to medicaments containing these compounds and to the use of substituted 2-pyridine-cyclohexane-1,4-d...
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WO/2002/090317A1 |
The invention relates to substituted cyclohexane-1,4-diamine derivatives, methods for production thereof, medicaments comprising said compounds and the use of substituted cyclohexane-1,4-diamine derivatives for the production of medicame...
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WO/2002/085291A2 |
A compound of the having the general formula (I) or general formula (II): formula (I), formula (II) wherein Z, A, B, C, R¿1?, R¿2?, Q, W, and n are as described herein.
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WO/2002/083624A1 |
There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
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WO/2002/081426A1 |
PDF inhibitors and novel methods for their use are provided.
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WO/2002/081438A2 |
A process is provided for producing a thiosemicarbazide which includes the steps of reacting an alkylamine with carbon disulphide in the presence of a base selected from N,N-diisopropylethylamine and N,N,-diisopropyl-methylamine to produ...
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WO/2002/081435A1 |
Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of g-secretase and are therefore useful in the treatment or prevention of ...
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