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WO/1999/047507A2 |
The present invention presents novel 1,3,4-thiadiazole derivatives of formula (I) which have useful antiviral activity against herpes virus, cytomegalovirus (CMV).
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WO/1999/045027A1 |
Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase...
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WO/1999/042456A2 |
The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen...
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WO/1999/040867A1 |
A method for treating victims of cerebral edema is presented that includes the intravenous injection of a carbonic anhydrase enzyme inhibitor that passes through the blood-brain barrier, such as acetazolamide (A.K.A., DIAMOX$m(3)), which...
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WO/1999/041246A1 |
The present application describes novel lactams and derivatives thereof of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic sulfonamide containing from 0-3 additional heteroatoms sele...
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WO/1999/041245A1 |
Insecticidal dihydro-oxadiazine compounds having formula (I): wherein X is O, N or S; R is a substituted or unsubstituted phenyl or C¿4?-C¿5? heterocyclic group; R?2¿, R?3¿, R?4¿, and R?5¿ are one of the following: a) R?2¿, R?3¿,...
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WO/1999/040089A1 |
The invention provides a compound of formula (I) wherein X, R¿1?, R¿2? and Het are as defined in the description, and a process for preparing them. The compounds of formula (I) are useful as pharmaceuticals.
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WO/1999/037608A1 |
The invention relates to novel naphthyl substituted and heterocyclic substituted sulfonamides of general formula (I) in which A, D, E, R?1¿ and R?2¿ have the meanings given in the description. The invention also relates to a method for...
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WO/1999/037643A1 |
Benzene-fused heterocyclic derivatives represented by general formula (I) or salts thereof, wherein each symbol has the following meaning: R?1¿: (a) or (b); A: -CH=CR?4¿-CH¿2?-, -CH¿2?-CH¿2?-CH¿2?-, -NR?5¿-CO-CH¿2?- or -O-CH¿2?-...
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WO/1999/036384A1 |
Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.
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WO/1999/034795A1 |
Cyclic disulfide derivatives represented by general formula (I), wherein R?1¿, R?2¿ and R?3¿ represent each H or alkyl; m is 0 or 1, and n is 1 or 2. Because of having effects of inhibiting neovascularization, regulating vascular perm...
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WO/1999/034798A1 |
A method for treating COPD comprising administering compounds of Formula (I) where X¿4? is a 1-substituted cyclohexyl group.
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WO/1999/034797A1 |
A method for treating multiple sclerosis comprising administering compounds of Formula (I) where X¿4? is a 1-substituted cyclohexyl group and the other groups are ethers or thioethers or a compound of Formula (II) where W is an aliphati...
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WO/1999/033789A1 |
The invention is directed to physiologically active compounds of general formula (I), wherein R?1¿ is hydrogen, halogen, lower alkyl or lower alkoxy; X?1¿, X?2¿ and X?6¿ independently represent N or CR?2¿; and one of X?3¿, X?4¿ an...
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WO/1999/033795A1 |
Prodrugs of HIV aspartyl protease inhibitors of formula (I) wherein each Z is (a) or (b) or (c); each R?Z¿ is independently selected from (d) or (e); characterized by favorable aqueous solubility, high oral bioavailability and facile $i...
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WO1999025686B1 |
A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the...
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WO/1999/032111A1 |
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
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WO/1999/032467A1 |
1,2,4-benzothiadiazine derivatives of general formula (I) wherein R?3¿, R?5¿, R?6¿, R?7¿, R?8¿ and Z are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are usefu...
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WO/1999/032106A1 |
Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
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WO/1999/032464A1 |
Compounds of formula (I) and process for protecting and immunizing plants against attack by phytopathogenic microorganisms by applying compounds of formula (I) wherein a) X is CR¿4? and Y is N; or b) X is N and Y is CR¿5?; or c) X and ...
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WO/1999/031074A2 |
Novel amines of formulas (1A) and (1B) or a pharmaceutically acceptable salt thereof wherein: n is an integer of from 0 to 2; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; A is hydrogen or meth...
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WO/1999/031075A1 |
Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic a...
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WO/1999/031072A1 |
Compounds of Formula (I), and their agriculturally suitable salts, are disclosed which are useful as arthropodicides and fungicides wherein G is selected from the group consisting of (G-1) and (G-2); Y is a direct bond or C¿1?-C¿4? alk...
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WO1999009977A9 |
Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them, are disclosed.
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WO/1999/031096A1 |
Piperazine derivatives useful as antihyperglycemic agents, pharmaceutical compositions comprising the piperazine derivatives and methods for their use are described. The piperazine derivatives are useful for the treatment of insulin-depe...
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WO/1999/031092A1 |
The invention relates to novel compounds of formula (1) wherein X, Y, W, R?1¿, R?2¿, R?3¿ and R?4¿ have the meaning cited in Claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in prophylaxis and/...
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WO/1999/031057A1 |
Novel amines of formulas (1D) and (1E), or a pharmaceutically acceptable salt thereof, wherein: n is an integer of from 0 to 2; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; and X is -O-, -S-, ...
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WO/1999/029689A1 |
Novel oxime derivatives represented by general formulae (1) and (2) and having sufficient pesticidal effects without giving any chemical injury to plants, and agricultural chemicals, in particular, plant pesticides containing these oxime...
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WO/1999/029670A2 |
The present invention relates to bicyclene of general formula (I) substituted by an aminocarbonyl radical, wherein R¿1?-R¿6?, X¿1?-X¿3?, Y¿1?-Y¿2? are defined as in claim 1 and the tautomers, stereoisomers, mixtures and salts there...
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WO/1999/028309A1 |
Compounds of formula (I) wherein m is zero or 1; Q represents a C¿6?-C¿14? aromatic ring system or an optionally substituted, saturated or unsaturated, heteromonocyclic or heterobicyclic ring containing one or two heteroatoms chosen fr...
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WO/1999/026909A2 |
The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R¿1? is C¿4-12? alkyl, C¿4-12? alkenyl, C¿4-12? alkynyl, -(CH¿2?)¿h?-C¿3-8? cycloalkyl, substituted and unsubstituted -(C...
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WO/1999/025702A1 |
The novel compounds of formula (I) wherein Het represents an optionally substituted, optionally benzofused nitrogen containing 5- or 6-membered heteroaromatic group; R?1¿ represents an alkyl, alkoxyalkyl or cycloalkyl group; R?2¿ repre...
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WO/1999/025701A1 |
The invention relates to carboxylic acid derivatives of formula (I) wherein A represents NR?8¿R?9¿, azido, OR?10¿, SR?10¿ or C¿1?-C¿4? alkyl, R?1¿ represents tetrazole or a group (1), wherein R has the following meaning: a) a radi...
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WO/1999/022713A1 |
An ophthalmic composition that provides sustained release of a water soluble medicament is formed comprising a cross-linked carboxy-containing polymer, a medicament, a sugar and water. The composition has a pH of at least 6.7 but a visco...
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WO/1999/023084A1 |
N-(3-Chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-car
boxamide; a plant disease controlling agent characterized by containing the compound as the active ingredient; and a method of using the same. The agent is excellent in the act...
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WO/1999/021422A1 |
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the inventi...
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WO/1999/020617A1 |
The present invention provides a compound of formula (I) wherein R¿1?, R¿2? and R¿3? are as defined herein. The compounds of the present invention are therapeutically useful in the treatment of a broad range of inflammatory disease su...
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WO/1999/020618A1 |
The present invention provides a compound of formula (I) wherein R¿1?, R¿2? and R¿3? are as defined herein. The compounds of the present invention are therapeutically useful in the treatment of a broad range of inflammatory disease su...
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WO/1999/019300A1 |
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonist...
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WO1998038182A9 |
The invention concerns compounds of formula (I) wherein: I is an integer of from 1 to 4; m is an integer of from 0 to 2; R is independently selected from hydrogen, halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R'', ...
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WO1998054198A9 |
In our research, two commercially available compounds, 3-amino-1,2,4-dithiazole-5-thione (1) and xanthane hydride (2), and their derivatives 3-6 are found to be potential sulfur-transfer reagents. The efficiency and optimization of these...
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WO1998043678B1 |
The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto...
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WO/1999/011638A1 |
Compounds are provided which are represented by Formulas (I) or (II) wherein R is (III), (IV), (V), (VI), (VII), (VIII), (IX) or (X); wherein R¿9?, R¿10?, R¿11?, R¿12?, R¿13?, and R¿14? are each, independently, hydrogen or a lower ...
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WO/1999/010346A1 |
Compounds having formula (I), in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3, R?1¿ and R?2¿ are each hydrogen or C¿1-4? alkyl, R?3¿, R?4¿ and R?5¿ are each hydrogen, C¿1-4? alkyl, optionally substituted phenyl or...
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WO/1999/009019A1 |
The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sul...
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WO/1999/007688A1 |
The invention relates to substituted 2-benzoyl-cyclohexane-1,3-diones of formula (I), wherein the substituents have the following meaning: R?1¿, R?2¿ stand for hydrogen, mercapto, nitro, halogen, cyano, rhodanine, C¿1?-C¿6?-alkyl, CÂ...
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WO/1999/005132A1 |
The invention relates to novel compounds of formula (I), wherein R represents group (1), X stands for O or S, and R¿1?, R¿2?, R¿3?, R¿4?, R¿5? and R¿6? have the meaning cited in Claim 1, or a tauomeric cyclized form. The invention ...
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WO/1999/005131A1 |
Compounds of formula (I) are useful as nitric oxide synthase inhibitors.
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WO/1999/003823A2 |
Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is d...
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WO/1999/003873A2 |
In our research, 3-phenyl-1,2,4-dithiazoline-5-one is found to be a potential sulfur-transfer reagent. The efficiency and optimization of this new sulfur-transfer reagent was investigated by solid-phase syntheses of dinucleotide phosphor...
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