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Matches 151 - 200 out of 6,037

Document Document Title
WO/2015/125085A1
The present invention relates to a compound of formula (I), or a tautomer, stereoisomer, geometrical isomer, prodrug, carboxylic acid isostere, solvate, polymorph, N-oxide, S-oxide or pharmaceutically acceptable salt thereof, which are G...  
WO/2015/108136A1
The present invention provides: a novel α-substituted glycinamide derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition containing the compound or the pharmacologically acceptable salt; and a use of the...  
WO/2015/107541A1
The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use ...  
WO/2014/147021A3
The present invention relates to substituted N-(phenyl-heteroaryl) -3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing sai...  
WO/2015/104433A1
The invention relates to benzo[c][1,2,5]oxadiazole derivatives, and the use thereof as antibiotics and in particular for the treatment and/or prevention of diseases caused by bacteria, in particular of diseases caused by Helicobacter.  
WO/2015/101958A2
The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or d...  
WO/2015/100441A1
Disclosed are conjugated polymers having desirable properties as semiconducting materials. Such polymers are cheap and easy to synthesize, and can exhibit good solubility and great solution processibility, and that enable highly efficien...  
WO/2015/094930A1
In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said ta...  
WO/2015/074180A1
Disclosed is a method for preparing thiadiazolylamide compounds. 2-sulfinyl-5-(trifluoromethyl)-1,3,4-thiadiazole (II) and 2-sulfuryl--5- (trifluoromethyl)-1,3,4-thiadiazole (II') are mixed in mass ratio of 99:1-1:99 as mixed raw materia...  
WO/2015/031109A8
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R1-R5 is individually selected from H, halogen, optionally substituted alkyl, optionally substituted alkoxy, nitro, sulfonamide, hy...  
WO/2015/033303A1
The present invention relates to cyclic peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivatives of the therapeutic agents. The i...  
WO/2015/033301A1
The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeut...  
WO/2015/033299A1
The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeuti...  
WO/2015/031109A1
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R1-R5 is individually selected from H, halogen, optionally substituted alkyl, optionally substituted alkoxy, nitro, sulfonamide, hy...  
WO/2015/016442A1
The present invention relates to a novel phenylthiazole-based hydroxamic acid compound and an anti-cancer composition containing same as an active ingredient. A hydroxamic acid compound according to the present invention exhibits anti-ca...  
WO/2015/006100A1
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.  
WO/2014/153100A3
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods ...  
WO/2014/181137A1
The present invention is a compound of the formula or a pharmaceutically acceptable salt thereof. The compounds are useful as HDAC inhibitors.  
WO/2014/173904A1
The present invention relates to compounds of formula (I) and their uses. In particular, though not exclusively, it concerns heterocyclic compounds that inhibit the biogenesis of adhesive pili in Gram- negative bacteria, and their use in...  
WO/2014/170793A1
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new s...  
WO/2014/161516A1
A substituted diazole of genera l formula (1) wherein X is 0 or S; R is selected from the group consisting of: H, NH2-, C1-C11n alkyl, cyclohexyl-, benzyl-, phenyl-, pyridyl- or phenyl- substituted, in positions 2, 3, 4 or 5, by one or m...  
WO/2014/157653A1
The present invention addresses the problem of providing an efficient process for preparing important intermediate compounds (1) and (1a) for the production of FXa inhibitors (X) and (X-a). The present invention pertains to: a process wh...  
WO/2014/156553A1
A purpose of the present invention is to provide a new disulfide compound with excellent compatibility toward polymers containing fluorine and solutions containing fluorine. The compound of the present invention is a compound expressed b...  
WO/2014/157497A1
An organic photoelectric conversion element which is provided with a first electrode, a photoelectric conversion layer that contains a compound represented by formula (I), and a second electrode; an organic thin film solar cell; a compos...  
WO/2014/150340A1
In its many embodiments, the present invention provides provides certain S-imino-S-oxo iminothiadiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of sai...  
WO/2014/146275A1
The present invention relates to a method for synthesizing a thiadiazole sulfoxide compound. Steps thereof comprise: thiadiazole thioether reacting in an organic solvent or mixed liquor of an organic solvent and water, by using a specifi...  
WO/2014/152588A1
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.  
WO/2014/140059A1
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, X1, X2, X3, X4, X5, X6, Y, Z, G, R1a, R2a, R1b, R2b, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the co...  
WO/2014/138833A1
The present invention describes new compounds for binding and/or inhibiting enzymes in microorganisms. In one embodiment, the compounds of the present invention are used to inhibit the 2-trans-enoyl-ACP (CoA) reductase enzyme in microorg...  
WO/2014/136099A1
The present invention relates to a novel process of making ixabepilone, ixabepilone derivatives and analogues, and intermediates thereof.  
WO/2014/087298A4
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched...  
WO/2014/123203A1
Provided is a compound having PTP-1B inhibitory activity that is excellent as a drug, or a pharmaceutically acceptable salt thereof. A compound represented by general formula (I) (in the formula, each symbol means the same as in the spec...  
WO/2014/026039A4
The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, s...  
WO/2014/121439A1
A synthesis method of 2-[(5-(trifluoromethyl)-1,3,4-thiadiazolyl-2-yl)-oxy]amide derivative (I). The method comprises the following step: in a solvent insoluble with water, 2-sulphinyl-5-trifluoromethyl-thiadiazole (II) and amide (III) r...  
WO/2014/108791A1
The present invention relates to stable ready to use injectable liquid composition of chlorothiazide or its pharmaceutically acceptable salts.  
WO/2014/099768A1
In its many embodiments, the present invention provides certain C2-ring-substituted thiadiazine compounds, including compounds Formula (I): (structure represented) or tautomers thereof, and pharmaceutically acceptable salts of said compo...  
WO/2014/026039A3
The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, s...  
WO/2014/093190A1
In its many embodiments, the present invention provides certain C2-ring-substituted iminothiadiazine compounds, or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers. The novel compounds of th...  
WO/2014/092082A1
The purpose of the present invention is to provide a novel mercapto compound which has superior affinity to fluorine-containing polymers and fluorine-containing solvents. This compound is represented by formula (1) (in formula (1), R1 an...  
WO/2014/087298A1
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched...  
WO/2014/084410A1
The present invention provides a compound having an excellent efficacy for controlling weeds. A cyclohexanone compound of formula (I): wherein n is an integer of any one of 1 to 5; R1 represents a hydrogen atom or a methyl group; R2 and ...  
WO/2014/084405A1
A method for reacting a compound represented by formula (A) and a compound represented by formula (B) in a solvent and producing a halogen compound represented by formula (C). (In formula (A), Y1 represents a sulfur atom or the like, X1 ...  
WO/2014/078971A1
This technology comprises compounds derived from 1,3,4-thiadiazole alkylamides and chalcone, which inhibit the activation of the TRPV-1 receptor by means of capsaicin and temperature. Said compounds have a strong antagonist activity in t...  
WO/2014/081925A1
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.  
WO/2014/063199A1
Novel benzofuran derivatives are disclosed. The derivatives have S1P1 receptor activity and/or disease modifying activity and find use in the treatment of conditions or diseases associated with the immune, vascular and nervous systems in...  
WO/2014/051939A1
The present invention provides novel phenicol derivatives of formula (I), their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.  
WO/2014/049107A1
The present invention concerns compounds of general formula (I): (I) in which Y and Z are chosen from CH and N; T is chosen from CO or SO2; n is 1 to 3; R1 represents a group chosen, for example, from C1-C3 alkyl chains unsubstituted or ...  
WO/2014/008204A3
Disclosed herein are novel structures of proteasome inhibitors and methods for synthesizing and use thereof, including novel structures of proteasome inhibitors, such as syrbactins and its analogs, and methods for synthesizing them and u...  
WO/2014/031732A2
Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one co...  
WO/2014/006402A1
The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disor...  

Matches 151 - 200 out of 6,037