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JP2003511351A |
A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state, wherein the two different salts have different water...
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JP2003508430A |
A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state, wherein the two different salts have different water...
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JP2003508429A |
Disclosed are a compound of tramadol and a sugar substitute, pharmaceutical compositions and sustained-release formulations comprising the compound, and methods of treatment using the compound. The tramadol compound according to the pres...
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JP2003026649A |
To produce acylacetamido-N-sulfohalides and oxathiazine by using a novel acetoacetylation agent having excellent stability and handleability.The acylacetamido-N-sulfohalide represented by following formula (3) is produced from an acylket...
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JP2003026678A |
To provide caffeine in a form which enables a simple use thereof and a handling or a metering supply in the production of, foods, drinks or pharmaceuticals and in which a bitter taste of caffeine is masked or suppressed.This compound com...
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JP2003026665A |
To obtain a xanthine derivative and a fenazone derivative capable of being simply used in preparing an agent or other formulations and of masking or suppressing bitterness of the active ingredient.The compound consists of a heterocyclic ...
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JP2003026671A |
To effectively obtain oxadiazines from acylacetamide-N-sulfonic acids.This method produces oxadiazines expressed by formula (2) by subjecting the sulfonic acids expressed by formula (1) to cyclizing dehydration in the presence of a stabi...
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JP2003012657A |
To provide a 'form' of an antimicrobially active, especially antibacterially active compound having maximally pleasant taste and capable of markedly raising both the acceptability and possibility of the aimed applications of the active c...
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JP2003002879A |
To obtain oxathiazine derivatives of high purity.Method of the present invention consists of a separation step wherein an organic layer containing the oxathiazine derivative reparesented by formula (2), which is obtained by cyclization o...
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JP2002371071A |
To provide a method by which oxathiazines are produced industrially advantageously. This method produces the oxathiazines expressed by formula (2) by subjecting sulfonic acids expressed by formula (1) to the cyclizing dehydration reactio...
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JP2002363173A |
To provide an acesulfam salt having a pharmologically and toxicologically safe cation other than potassium. The acesulfam salt is produced by reacting acesulfam-H soluble in a solvent with a basic precursor of a nonmetallic cation.
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JP3354150B2 |
Decomposition-sensitive complex ligands can be stabilised by derivatisation with the aid of bulky secondary or tertiary carboxylic or sulphonic acids. These stabilised derivatives can be added to alignment layers and liquid-crystal mixtu...
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JP2002534515A |
1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
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JP3330972B2 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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JP2002275157A |
To provide an antithrombotic agent and a thrombolytic agent, having fibrinogenolysis-promoting activities and capable of being orally administered.This new naphthalene derivative is represented by formula (I). The derivative has excellen...
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JP2002265458A |
To obtain a salt of an L-amino acid having an improved taste and to provide a process for preparing the salt of the L-amino acid.This salt of the L-amino acid is a salt of a basic-reacting amino acid with at least one kind of acid-reacti...
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JP2002220381A |
To provide a method by which 3,4-dihydro-1,2,3-oxathiazines or salts thereof are manufactured industrially advantageously.A sulfonic acid represented by formula (1) (wherein R1 and R2 are each independently hydrogen atom or an organic gr...
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JP2002523455A |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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JP3290657B2 |
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. (* CHEMICAL STRUCTURE *) (I)
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JP2002155062A |
To provide an active compound and a pharmaceutical composition comprising the compound, designed to increase the time of sustaining the active ingredient in the plasma when administered to humans or other animals in pain therapies in par...
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JP2002513792A |
The invention relates to novel methoximinomethyloxathiazines, to two processes for their preparation and to their use as pesticides.
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JP2002509528A |
A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a ...
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JP2002508361A |
Novel amines of formulas (1A) and (1B) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathologic...
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JP2002508362A |
Novel amines of formulas 1, 1C, 1F, 1G and 1H or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, heterocycle, sulfonic acid, or hydroxamic acid; A'...
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JP3263241B2 |
PURPOSE: To obtain a benzene derivative having calcium overload inhibiting action in addition to vasohypotonic action and lipid peroxide inhibiting action and useful as an agent for preventing and treating ischemic diseases and as a hypo...
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JP2001524949A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP2001523671A |
The present invention relates to carboxylic acid derivatives of the formula Ithe substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.
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JP2001322989A |
To provide a new acesulfame-metal complex exhibiting pleasantly sweet taste and therefore suitable as sweeteners, food supplements and for enrichment of food, medicaments and feeds with trace elements.This acesulfame-metal complex is for...
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JP3229013B2 |
PURPOSE: To obtain optically active cis-nucleoside and a compd. analogous to the nucleoside by glycosylating purine or pyrimidine bases with a specified intermediate in the presence of a specified Lewis acid. CONSTITUTION: Desired purine...
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JP2001302513A |
To obtain a nicotine salt having improved palatability by reacting nicotine with an anionic substance. This nicotine salt is produced by reacting nicotine with an anionic sweetener in the molar ratio of (1:1) or (1:2). The sweetener is a...
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JP2001518446A |
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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JP2001512445A |
The invention relates to certain 8-ureido and 8-thioureido 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
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JP2001511188A |
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel discovery that Troglitazone inhibits steroid...
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JP2001502677A |
The invention relates to novel oxime derivatives of formula (I), in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (in...
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JP2001502298A |
(57) [Summary] The present invention provides intermediates and methods useful for the production of cryptophycin compounds.
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JP2000355550A |
To obtain a ketosis improver having excellent actions and a low toxicity and useful for prophylaxis and treatment of hepatic type glycogenosis, endocrine diseases, congenital glucide or organic acid dysbolism, etc., by including an insul...
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JP2000273043A |
To obtain a therapeutic agent for impaired glucose tolerance effective in preventing and delaying the onset of non-insulin-dependent type diabetes mellitus(NIDDM) by including pioglitazone. This therapeutic agent is obtained by including...
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JP3091006B2 |
Compounds of the formula: wherein: A is oxo or dioxo; R<1>, R<2> and R<3> are independently hydrogen or lower alkyl of one to six carbon atoms; R<4>, R<5>, R<6> and R<7> are independently hydrogen, lower alkyl of one to six carbon atoms,...
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JP2000239167A |
To obtain the subject therapeutic agent for restraining or delaying the onset of insulin nondependent diabetes or complications thereof found in a population which has experienced glucose tolerance insufficiency by including a methylpyri...
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JP3081245B2 |
A novel method of using thiazolidinedione derivatives and related antihyperglycemic agents to treat populations experiencing impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus (NID...
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JP2000509718A |
(57) [Summary] Compounds represented by formula (I), as well as their N-oxides and agriculturally suitable salts, are disclosed which are useful in controlling unwanted vegetation. In equation (I) above, Q is (Q-1), (Q-2) or (Q-3); and A...
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JP2000204077A |
To obtain a new compound useful in treating attack deuteropathy, cardiac insufficiency deuteropathy, arthrosis deformans, chronic arthrorheumatism, cancers including ovartan cancer and lung cancer, etc. This new compound is a compound of...
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JP2000509092A |
Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are sulfanimines. Substrates such as fabrics may be bleached in an aqueous solution containing ...
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JP2000502050A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP2855398B2 |
Compounds of the formula in which A denotes oxygen, sulphur or -NR1-; B denotes C2-C6-alkylene; D-E denotes -O-E, -S-E, -O-CH2-E, -O-C(=O)-E, -O-C(=O)-O-E, -O-C(=O)-N(H)-E or -O-C(=S)-N(H)-E; E denotes phenyl; phenyl substituted by 1 to ...
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JPH11500717A |
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.
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JP2833647B2 |
PURPOSE: To obtain the subject compound represented by a specific formula, having suppressing actions on collagenases and useful for treating or preventing degenerative joint diseases such as chronic rheumatoid arthritis and osteoarthrit...
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JP2768505B2 |
The preparation is described of compounds of the structure in which the substituents have the meanings indicated in the description. The compounds, which are in part new, are used as intermediate products for dyestuffs.
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JP2761441B2 |
The present invention provides certain 3-aryl-5,6-dihydro-1,4,2-ocathiazines and their oxides, useful for the long-term preservation of wood and composite wood materials against wood damaging and wood destroying materials. The present in...
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JP2728357B2 |
PURPOSE: To obtain a new benzylidene derivative capable of extremely strongly suppressing production of PGE2 and simultaneously suppressing production of cytokinins such as LTβ4 and IL-1 and expecting antiinflammatory action. CONSTITUTI...
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