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Matches 1 - 50 out of 20,013

Document Document Title
WO/2018/130625A1
The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable ...  
WO/2018/130942A1
The present invention provides a process for the preparation of N-phenoxyisopropyl ethanolamine of Formula (II) and its conversion to Phenoxybenzamine of Formula (I) or pharmaceutically acceptable salts thereof.  
WO/2018/129609A1
Compounds of formula (II) are useful in modulating voltage-gated sodium channel activity. Their preparation and use for reducing the severity of convulsant activity in a subject, for example in the treatment of epilepsy, is presented.  
WO/2018/129552A1
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-sta...  
WO/2018/122359A1
The present invention relates to a compound of the following formula (I). The invention also relates to uses thereof as a chromophore as such or for building pigments displaying special optical effects, including metal-like reflection.  
WO/2018/122867A1
This invention comprises a stable oral dispersible thin film and a process of making the same, the film comprising a 4-Diphenylmethyl-1-piperazinyl derivative or its pharmaceutically acceptable salts; characterized by, during storage of ...  
WO/2018/115421A1
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).  
WO/2018/116285A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, X1, X2, m and n are as defined herein, which are active as modulators of retinoid-related orphan re...  
WO/2018/119263A1
Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing o...  
WO/2018/115443A1
The invention relates to a method for producing an amine oxide by oxidation of a tertiary amine in a reactor under continuous introduction of tertiary amine in a reaction fluid and export of amine oxide, wherein a suitable surface-to-vol...  
WO/2018/110669A1
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and meth...  
WO/2018/108698A1
The invention relates to a method for producing ethanolamines and/or ethyleneamines in the gas phase by reacting ethylene glycol with ammonia in the presence of an amination catalyst. The method is characterized in that the amination cat...  
WO/2018/107112A1
Embodiments are directed to compounds of the formulae (I), (Ia), (Ib), (II), (IIa) (III), (IV), (V), and (VI); methods for treating cancer with one or more compounds of the formulae (I), (Ia), (Ib), (II), (IIa); (III), (IV), (V), and (VI...  
WO/2018/104305A1
Substituted aromatic sulfonamides of formula (I) which are antagonists or negative allosteric modulators of P2X4, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a ph...  
WO/2018/099966A1
The present invention relates to a process for the conversion of 2-aminoethanol to ethane-1,2- diamine and/or linear polyethylenimines of the formula H2N-[CH2CH2NH] n -CH2CH2NH2 wherein n≥ 1 comprising (i) providing a catalyst comprisi...  
WO/2018/099964A1
The present invention relates to a process for the conversion of 2-aminoethanol to ethane-1,2-diamine and/or linear polyethylenimines of the formula H2N-[CH2CH2NH]n-CH2CH2NH2 wherein n ≥1 comprising : (i) providing a catalyst comprisin...  
WO/2018/097126A1
Compounds represented by formula (I) or salts thereof. A fungicide or plant disease control agent containing as an active ingredient at least one selected from the group consisting of said compounds and salts thereof. In formula (I), Ar ...  
WO/2018/093949A1
Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and comp...  
WO/2018/093946A1
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful ...  
WO/2018/093947A1
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful ...  
WO/2018/093950A1
Provided herein are pharmaceutical formulations comprising a monoacylglycerol lipase (MAGL) inhibitor, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/087753A1
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their int...  
WO/2018/087019A1
The invention relates to a method for producing amide bonds, particularly peptide bonds, with the aid of new amide coupling reagents containing an anion of formula (I); the invention also relates to these new reagents and to the producti...  
WO/2018/086531A1
Disclosed are a series of sulfonamides compounds, represented by general formulas (I) and (II), serving as cccDNA inhibitors, and tautomers or pharmacologically acceptable salts thereof.  
WO/2018/081558A1
Described herein are retinoic acid related-related orphan nuclear receptor (ROR) modulators and methods of utilizing RORγ modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are pharmaceutical ...  
WO/2018/075767A1
The invention relates to crystalline forms of the bis-HCI salt of a compound represented by Structural Formula 1, and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural Fo...  
WO/2018/071741A1
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2018/068296A1
Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a c...  
WO/2018/066646A1
The present invention addresses the problem of finding a novel medicine which has an excellent tryptophanase inhibitory effect, suppresses indoxyl sulfate production in blood to thereby prevent deterioration of renal function, and thus c...  
WO/2018/053221A1
Disclosed are novel ketamine prodrugs, pharmaceutical preparations containing such prodrugs of ketamine and methods of treating, bipolar depression, neuropathic and chronic pain, including complex regional pain synthetic pain syndrome (C...  
WO/2018/053447A1
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and composition...  
WO/2018/050555A1
The present invention relates to a method for the preparation, in one step, of polyamines by reacting compounds that contain at least two nitrile groups (dinitrile) or at least one nitrile and one amino group (amino nitrile) with hydroge...  
WO/2018/044822A1
Methods for treating HIV in a human using combinations of: tenofovir alafenamide and a maturation inhibitor, as well as compositions containing such compounds.  
WO/2018/044822A8
Methods for treating HIV in a human using combinations of: tenofovir alafenamide and a maturation inhibitor, as well as compositions containing such compounds.  
WO/2018/039563A1
Mannich base compositions include the reaction products of (1) an amine component including at least one multifunctional amine of structure (I), wherein each R is independently H or CH2CH2CH2NH2; R1 is H, CH2CH2CH2NH2, C1-C21 alkyl, or C...  
WO/2018/033200A1
The present invention relates to ionic compounds containing an anion, and a cation having the following structural formula (1): R1R2R3N+-(|inker1)-O-(iinker2)-(FC) wherein: - R1 and R2 either linear or branched alkyl groups or together f...  
WO/2018/027999A1
An isocyanate polymerization catalyst, manufacturing method thereof, and a method using the catalyst to manufacture a polyisocyanate comprising an isocyanurate group. The catalyst is a di-quaternary ammonium ion of a carboxylic acid salt...  
WO/2018/027892A1
Provided are compounds of the Formula (A) below where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.  
WO/2018/026371A1
Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, ...  
WO/2018/014880A1
Provided are a vortioxetine analogue as shown in formula I or a polymorph or a solvate thereof, a composition and a kit comprising the analogue, polymorph or solvate, the use of the analogue, polymorph or solvate in the preparation of a ...  
WO/2018/015240A1
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R3, R8, R9, R10 and R11 are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2018/007986A1
I n the process of the present invention, cariprazine is prepared by converting (trans-4-amino- cyclohexyl)-acetic acid ethyl ester hydrochloride to trans-4-aminocyclohexyl) acetic acid or its hydrochloride by hydrolysis, from the obtain...  
WO/2018/005781A1
Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent- 1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3- hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)ace tamido]propanamido]propanamide (compound ...  
WO/2017/216576A1
The invention relates to difluoro heterocyclic compounds and their medical uses. Compounds of the invention have the general formula (I): wherein each X is identical and forms part of an ethoxyamine basic side chain which includes a 5- o...  
WO/2017/217553A1
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] An oxime compound represented by formula (1) and an herbicide containing the same. (In formula (1): B represents B-1 or the like; Q represents ...  
WO/2017/215636A1
Provided are a diaryl sulphide piperazine compound and a preparation method and a use thereof. In particular, the compound is a compound shown by formula (I), wherein HX is a C10-20 fatty acid or pamoic acid.  
WO/2017/216579A1
The invention relates to a heterocyclic compound 1,1'-(((propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis(etha ne-2,1-diyl))dipyrrolidine and its medical uses, for example as an autophagy inducer.  
WO/2017/212289A1
The present invention relates to a method of reducing, cleaving and/or coupling at least one C=O, C-O, C=C or C=N bond of a compound, using a reagent comprising a stannyl cation.  
WO/2017/210527A8
The present disclosure provides novel ATX inhibitors, and pharmaceutical compositions comprising said inhibitors, as well as methods of treatment comprising administration of said inhibitors.  

Matches 1 - 50 out of 20,013