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Matches 1 - 50 out of 20,330

Document Document Title
WO/2019/159596A1
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...  
WO/2019/161308A1
The invention relates to the surprising discovery that TMZ and pharmaceutical salts thereof are an effective pharmacological agent in the treatment of certain decompensating patients with an underlying chronic liver condition. In particu...  
WO/2019/155352A1
The present invention relates to a novel crystalline polymorphic form of 1-[2-(2,4-dimethyl- phenylsulfanyl)-phenyl]-piperazine hydrochloride; commonly known as vortioxetine hydrochloride (hereafter referred to as the compound (Ia) and p...  
WO/2019/154284A1
The present invention relates to the pesticide field, and discloses a piperazinone derivative, a preparation method therefor, use thereof, an accelerator and a method for controlling root parasitic weeds. The piperazinone derivative has ...  
WO/2019/154795A1
The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)eth yl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxyt...  
WO/2019/152536A1
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.  
WO/2019/150895A1
Provided is an electrolyte capable of improving the high-temperature storage characteristics and cycle characteristics of an electrochemical device. The electrolyte includes at least one type of compound indicated by general formula (1ÔÇ...  
WO/2019/149091A1
The present invention relates to the field of compounds, and in particular to a probucol derivative, a preparation method therefor and use thereof, the probucol derivative having a structure represented by general formula I. The probucol...  
WO/2019/144805A1
Provided are a substituted phenylethylamine compound as a ╬╝ opioid receptor agonist, a pharmaceutical composition comprising same, a preparation method therefor and the use of same for preventing and/or treating diseases associated with...  
WO/2019/143782A1
A plasticized PVC composition free of phthalate is disclosed. The composition comprises a tertiary diamide plasticizer prepared from biorenewable feedstock such as fatty acid selected from tall oil fatty acids, tall oil fatty acid monome...  
WO/2019/141740A1
The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, X, Z, R2 and R3 are as described herein. The inventions further relates to compositions comprising said compounds, to meth...  
WO/2019/142192A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin ╬│-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...  
WO/2019/139899A1
Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular...  
WO/2019/139902A1
Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular...  
WO/2019/139900A1
Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular...  
WO/2019/136112A1
The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmu...  
WO/2019/125655A1
The disclosure is related to EMM-31 materials, processes, and uses of the same as reagents used in the preparation of the EMM-31 materials, process and intermediates for preparing these reagents.  
WO/2019/115498A1
The present invention relates to novel benzamides derivatives of formula (I) as modulators of PPAR-gamma receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use ...  
WO/2019/116260A1
A perfluorinated 1-alkoxypropene represented by general Formula (I), compositions that include such compounds, and methods and systems that include such compositions are provided, wherein Formula (I) is represented by: RfO-CF=CFCF3 where...  
WO/2019/111225A1
Compounds and compositions are provided having the structure of Formula (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein T, T', U, U', V, W, R1, R2, R3', n, o, o', o'', and o''' are as defined herein....  
WO/2019/109934A1
The present invention provides a salt of a phenylpropionamide derivative and a preparation method therefor. The present invention specifically provides an acetate, hydrochloride, phosphate, citrate, benzoate, or fumarate of 4-amino-1-((2...  
WO/2019/106490A1
The present invention is directed towards a process for the preparation of Cariprazine (Ia) or a pharmaceutically acceptable salt thereof, wherein, N,N- dimethyl-1H-imidazole-1-carboxamide alkyl halide (VII) is reacted with trans-4- (2-(...  
WO/2019/104030A1
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.  
WO/2018/071741A8
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2019/103990A1
An electrically debondable adhesive composition is described. The adhesive is comprised of a basic ionic liquid and an optionally crosslinked polymer, wherein the basic ionic liquid is comprised of a cyclic amino-ammonium cation and a bi...  
WO/2019/101142A1
The present invention provides a dibutylfluorene derivative, an application thereof as a photoinitiator, and a preparation method of the same. The present invention also provides a photocurable composition comprising the compound and a m...  
WO/2019/099873A1
The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a signi...  
WO/2019/094732A1
The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating diseases associated with the binding of CREB to CREB-binding protein (CBP) and...  
WO/2019/087626A1
Provided are: a compound which can be used suitably as a photodegradable base in a resist composition that has good sensitivity to an active energy, has excellent resolution in lithography and enables the reduction in line width roughnes...  
WO/2019/090088A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/082900A1
The purpose of the present invention is to provide a rubber composition having excellent processability, a heteroring-modified glycerin fatty acid ester, and a production method for the heteroring-modified glycerin fatty acid ester. The ...  
WO/2019/077106A1
The present invention relates to new compounds of general formula (I) showing great affinity and activity towards the subunit ╬▒2╬┤ of voltage-gated calcium channels (VGCC), especially the ╬▒2╬┤-1 subunit of voltage-gated calcium channel...  
WO/2019/075976A1
Disclosed is a method for preparing roxatidineacetatehydrochloride and an intermediate thereof, comprising the following steps: dissolving m-hydroxybenzaldehyde in a solvent, dropping piperidine into the solution, adding sodium borohydri...  
WO/2019/070709A1
The present invention provides compounds, compositions and methods for treating and/or preventing a flavivirus infection by administering such compounds and compositions.  
WO/2019/063696A1
The invention relates to primary para-phenylenediamine compounds substituted with an aliphatic chain comprising a cationic heterocyclic group according to formula (I), as well as the organic or mineral acid or base addition salts thereof...  
WO/2019/063015A1
Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a ROR╬│ inhibitor, which compound has a good ROR╬│ inhibitory activity. It is hoped that same is used for treating diseases, which are mediated by a ROR╬│ receptor, i...  
WO/2019/056211A1
Disclosed is N-formyl vortioxetine, and also disclosed is a method for preparing the N-formyl vortioxetine and a stable solid preparation of vortioxetine.  
WO/2019/060809A1
Disclosed are piperazine derivative compounds, particularly piperazine derivative compounds having a structure of Formula (I) and methods for preparing these compounds. Also disclosed are use of a therapeutically effective amount of the ...  
WO/2019/056251A1
The present invention relates to a group of isotope labeling reagents for amino/phenolic hydroxyl labeling, and a synthesis method therefor. In a synthesis process, a reagent (such as a homologue of 6-aminocaproic acid) carrying both ami...  
WO/2019/046931A1
Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions invol...  
WO/2019/046330A1
Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.  
WO/2019/045035A1
The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage ...  
WO/2019/043372A1
There are described compounds of formula (I) in which X, R1, R2 and n are each as herein defined; and their use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the hedgehog pathway, such...  
WO/2019/046318A1
Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.  
WO/2019/042301A1
The present invention provides a new class of (E)-╬▒,╬▓-unsaturated amide compounds represented by formula I, and also relates to methods for preparing such compounds and the pharmaceutical uses thereof. The compounds have the effect of ...  
WO/2019/029211A1
Disclosed by the present invention are an SIRT6 small-molecule allosteric activator and the application thereof, and provided is an SIRT6 small-molecule allosteric activator that contains a derivative as shown in formula (1) or a pharmac...  
WO/2019/030197A1
The present invention relates to a process to prepare propylene amines of the formula NH2-(A-NH-)pR, wherein R is a hydrogen atom or an alkyl group, p is at least 1 when R is an alkyl group, and at least 2 when R is a hydrogen atom, or d...  
WO/2019/028473A1
Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polar...  
WO/2019/019851A1
Disclosed are a sodium ion channel inhibitor and a pharmaceutically acceptable salt and a polymorph thereof. The sodium ion channel inhibitor is a compound having the structure as shown in formula (X). Disclosed are a method for preparin...  
WO/2019/019049A1
The present invention provides an anti-Candida albicans piperazine derivative, a preparation method therefor and application thereof. The structural formula of the piperazine derivative is as represented by formula I, and the derivative ...  

Matches 1 - 50 out of 20,330