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Patent Searching and Data


Matches 601 - 650 out of 2,210

Document Document Title
WO/2000/052003A1
A process for the preparation of taxane derivatives by reacting 10-deacetylbaccatin III protected at the 7- and 10- positions with tricloroacetyl groups, with a compound of formula (VII) subsequent removal of the protective groups and hy...  
WO/2000/049006A1
A baccatin III derivative contains a metal alkoxide at the C-7 position and the process of making the same.  
WO/2000/047597A1
Avermectin derivatives represented by general formula (I) or salts thereof: wherein -X---Y- is -CH=CH-, -CH¿2?-C(=O)-, -CH¿2?-CH¿2?-, or -CH¿2?-CH(R?13¿)-, for example, (1) when -X---Y- is -CH=CH-, R?1¿ is (R?11¿) (R?12¿)C [where...  
WO/2000/042989A2
A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based...  
WO/2000/043000A1
Proteasome inhibitors containing as the active ingredient carboxylic acid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof: wherein m and n are each independently an integer of 0 to 10; p is 0 ...  
WO/2000/040573A1
A method of isolating paclitaxel from paclitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueou...  
WO/2000/040538A1
Nucleophilic group, such as alcohol, terminated 2-oxetanone multimers, process of making same by reacting e.g. alcohol and dicarboxylic acid chloride in the presence of triethylamine, and their use for sizing paper.  
WO/2000/035895A1
A process for production of an oxetane, which process comprises subjecting an alcohol having two or more hydroxyl groups to reaction with a carbamide at a molar ratio employing 1-2 moles of said carbamide on 1-2 moles of said alcohol. Th...  
WO/2000/035896A1
A novel process for isolation 10-deacetyl baccatin-III (10-DAB) and also complete separation of paclitaxel present in the primary extract, on a commercial scale from plant extract of $i(Taxus species) by solvent crystallization without e...  
WO/2000/020036A1
The present invention provides novel paclitaxel formulations which may be terminally sterilized and show long term stability in water containing admixtures.  
WO/2000/018823A2
The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays. A macromonomer of polyethylene gly...  
WO/2000/014080A1
4-Methyl-4-(4-methylpent-3-en-1-yl)-2-oxetanone of formula (I) or its oligomer are new intermediate products for the preparation of a series of geranic acid derivatives. Geranic acid derivatives are important synthetic building blocks in...  
WO/2000/010989A1
A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme d...  
WO/2000/010547A2
The present invention relates a new use of taxoid derivatives. It relates more precisely to a method for treating abnormal cell proliferation of different resistant cell lines expressing multidrug resistance P-glycoprotein. This type of ...  
WO/2000/010988A1
The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R¿1? = C(O)CH¿2?CH(OH)COOX, R¿2? = H, C(O)CH¿2?CH(OH)COOX, X = H, Li, Na or any other pharmaceutically acceptable counterion, as we...  
WO/2000/009123A1
Orally administrable pharmaceutical composition containing an inhibitor of gastrointestinal lipases, one (or more) additional compound(s) of the group consisting of chitosan, its derivatives and salts thereof, and auxiliary excipients.  
WO/2000/009120A1
The present invention relates to a new use of taxoid derivatives. It relates more precisely to a method for treating abnormal cell proliferation in the brain of mammals including men by administrating a taxoid derivative.  
WO/2000/002873A1
Oxetane compounds represented by general formula (1), which are excellent in radical polymerizability and cationic polymerizability and in compatibility and copolymerizability with other copolymerizable monomers; a process for producing ...  
WO/2000/001682A1
The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid deriv...  
WO/1999/067430A2
The invention relates to novel analytic substrates of general formula (I), wherein R1; R2 and R3 are the same or differ from one another and are R4, CH¿2?-ONO¿2?, CH¿2?-OR¿5?, CH¿2?-X, COOR5, COX, CH¿2?-COOR¿5?, or CH¿2?-COX, whe...  
WO1999054322B1
This invention provides a process for the preparation of Baccatin III from a compound of formula (X) which comprises the steps of: (i) protecting the hydroxy group on a compound of Formula (X) at the 7-position or C9, or both C7 and C9 s...  
WO/1999/059966A1
A method of modifying or altering the structure of a 1$g(a)-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1$g(...  
WO/1999/057105A1
The present invention relates to a method of producing paclitaxel or a paclitaxel analog comprising the esterification of C-7, C-10 di-CBZ baccatin III with an N-carbamate protected, C-2-protected 3-phenyl isoserine side chain. The C-7, ...  
WO1999048894B1
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine wit...  
WO/1999/052887A1
An antitumor compound of formula (5). Also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed by...  
WO1999033462A9
2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutic...  
WO/1999/045001A1
Process for synthesizing paclitaxel by treating baccatin III with a strong base in a solvent, adding an electrophile to the solution to form a 7-O-protected baccatin III derivative, reacting the 7-O-protected baccatin III derivative with...  
WO/1999/040216A1
The invention relates to a method for producing baccatin and/or baccatin derivatives. According to said method, 10-desacetyl baccatin or a derivative thereof is reacted in the presence of an isolated enzyme and an acetyl donor. An acetyl...  
WO/1999/037632A1
A method of acylating 10-deacetylbaccatin III at a C-10 position over a C-7 hydroxy position whererin lithium salts are used as reaction reagents.  
WO/1999/037796A1
The present invention teaches a method of extracting TAXOL$m(3) from the leaves of $i(taxus cuspidata) plants. The process comprises a series of steps, including the concentration of the extracts obtained from the plant, the separation o...  
WO/1999/037631A1
The present invention relates to novel taxaneterpine compounds represented by formula (I), which is useful as an anti-cancer agent, in which R?1¿ represents substituted or unsubstituted, straight or branched alkyl, alkenyl or alkynyl, s...  
WO/1999/037609A1
The invention relates to novel naphthyl-substituted and anilide-substituted sulfonamides of general formula (I), wherein the substituents A, D, E, G, R?1¿, R?2¿, R?3¿, R?4¿ and X have the meanings given in the description. The invent...  
WO/1999/037608A1
The invention relates to novel naphthyl substituted and heterocyclic substituted sulfonamides of general formula (I) in which A, D, E, R?1¿ and R?2¿ have the meanings given in the description. The invention also relates to a method for...  
WO/1999/036413A1
Disclosed are novel crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol, which are useful for isolating baccatin III from plant tissue cell culture and plant extracts containing baccatin III.  
WO/1999/032473A1
Taxane derivatives represented by general formula (1) or salts thereof and drugs containing the same as the active ingredient wherein A?1¿ represents (a) (wherein R?1¿ represents H or optionally substituted alkyl) or (b) (wherein R?2¿...  
WO/1999/032109A1
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.  
WO/1999/031079A2
The invention relates to a method for preparing an ester, by admixing a compound having structure (I or IV) with a base and an alcohol to produce an ester, wherein the alcohol is a precursor to Taxol and its analogs. The present inventio...  
WO/1999/026939A1
The semisynthesis of paclitaxel and its analogs uses new intermediates which are derivatives of 10-deacetyl-baccatin III, the invention also provides methods for preparing these derivatives. These novel derivatives have alkyl carbonate o...  
WO/1999/025705A1
The present invention provides new methods isolating taxanes and other metabolites from taxane-producing plant materials.  
WO/1999/025704A1
The invention concerns a novel method for preparing dialkoxylated derivatives of the class of taxoids by direct alkylation of two positions 7 and 10 of the desacetylbaccatine or esterified derivatives in position 13 thereof.  
WO/1999/025334A1
This invention is directed to novel halogenated paclitaxel derivatives, processes for their preparation and use as effective anti-tumor agents.  
WO/1999/018798A1
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases (see the dose response curves in the Figure). Further, the arsenic compounds may be used to treat metastatic neoplastic diseases.  
WO/1999/016761A1
Oxygenic heterocyclic derivatives represented by general formula (I) or salts, solvates, or hydrates of these, which are useful as cysteine protease inhibitors excellent in oral absorbability, migration to tissues, and can easily pass th...  
WO/1999/014209A1
Taxane derivatives of general formula (1), wherein A is substituted piperazino or piperidino; X is alkyl, pyridyl, thienyl, furyl, cycloalkyloxy or the like; and Y is H or trialkylsilyl, and medicines containing the same. These compounds...  
WO/1999/009021A1
Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected o...  
WO/1999/008986A1
A process for the preparation of a composition having formula (5) in which a compound having formula (4) is treated with a base and a silylating agent.  
WO/1999/001428A1
Hydrazine derivatives of formula (I) wherein Y signifies CO or SO¿2?; R?1¿ signifies lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R?2¿ signifies lower alkyl, halo-lower alkyl, a...  
WO/1998/056500A1
The use of C�3?-C�60?, substituted or unsubstituted, straight or branch-chained, alkyl, aryl, or aralkyl carboxylate Cr?+3� salts, preferably chromium +3 octoate, as catalysts for the reaction of ring systems, such as aziridines, o...  
WO/1998/052614A2
Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane,...  
WO/1998/050378A1
A process for the preparation of taxol, analogs thereof and their intermediates is described. The process includes the steps of protecting the C-7 hydroxy group of 9-dihydro-13-acetylbaccatin III with a suitable protecting group; oxidizi...  

Matches 601 - 650 out of 2,210