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Matches 1 - 50 out of 2,741

Document Document Title
WO/2019/170092A1
The present invention provides a ketone carbonyl-containing hydrophobic antitumor drug and a conjugate thereof as well as a nano preparation containing the conjugate, a preparation method therefor, and an application thereof. The conjuga...  
WO/2019/148282A1
The present disclosure concerns methods and formulations for delivery of hydrophobic agents (such as ubiquinone or poorly soluble drugs) for therapeutic and bioanalytical use. It further concerns use of lipopeptides (e.g. caspofungin) or...  
WO/2019/143220A1
The present invention relates to a transition metal-based heterogeneous carbonylation reaction catalyst, which has excellent catalyst activity and selectivity in a carbonylation reaction by polymerizing transition metal-based heterogeneo...  
WO/2019/124345A1
The present invention addresses the problem of providing: a polymerizable liquid crystal composition that satisfies the demand for the high-speed response, low-voltage drive, high contrast, long-term reliability, and the like that have h...  
WO/2019/110427A1
Compounds of the formula (I) wherein the subsitiuents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and t...  
WO/2019/104030A1
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.  
WO/2019/099314A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...  
WO/2019/080466A1
Disclosed are a 3-arylbenzofuranone propanamide compound, a composition composed of same, and a preparation method thereof. The compound of the present invention can be used as a stabilizer in various materials, for example, in organic m...  
WO/2019/074748A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated dise...  
WO/2019/070981A1
The present invention is directed to processes for producing isocyanates and isocyanate derivatives from epoxide and carbon monoxide reagents. In preferred embodiments, the processes include a step for providing carbonylation of an epoxi...  
WO/2019/061299A1
Provided is a one-step amination reaction for producing an aminomethyl substituted heterocycloalkane, notably (tetrahydrofuran-2, 5-diyl) dimethanamine.  
WO/2019/050649A1
The present invention is directed to catalysts and processes for catalyzing two or more chemical reactions with a multifunctional catalyst in a reaction vessel. The processes include steps for introducing one or more reagents to a reacti...  
WO/2019/051184A1
Provided herein are acrylamide and acrylonitrile compounds and other compounds that may be produced from hydroxy amides and/or lactones. Provided herein are methods and systems to produce such compounds.  
WO/2019/033982A1
Disclosed is an oxetane compound used in a cation photocurable system. The oxetane compound is formed by a nucleophilic substitution reaction of a compound containing at least one hydroxyl and at least one oxetane group with a halohydroc...  
WO/2019/019924A1
Disclosed is a new oxetane monomer compound, which has a structure as shown in general formula (I) or is an ester of a compound of general formula (I). The monomer compound has a high reaction activity. After being applied to a cationic ...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2018/225093A1
The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82'...  
WO/2018/225018A1
The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates...  
WO/2018/223227A1
There are provided compositions and methods for prevention or treatment of atherosclerosis and related disorders. More specifically, there are provided desmocollin 1 inhibitor compounds and pharmaceutical compositions thereof for use in ...  
WO/2018/195439A3
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.  
WO/2018/200471A1
The present invention is directed to reactor systems and processes for producing organic acids through thermolysis of polylactones. In preferred embodiments, the reactor systems and processes are capable of introducing at least one epoxi...  
WO/2018/195439A2
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.  
WO/2018/141054A1
The present document describes a method of inhibiting cancer tumor growth in a patient in need thereof, comprising at least a first treatment comprising steps a) and b): a) administering to the patient an immune adjuvant in combination w...  
WO/2018/107450A1
This invention provides an electrochemical process for producing a propiolactone compound comprising reacting a compound having at least one ethylenically unsaturated carbon-carbon double bond with carbon dioxide in the presence of an el...  
WO/2018/107185A1
The present invention is directed to biodegradable polyester polyol polymers having high bio-based content and methods for producing biodegradable polyester polyol polymers having high bio-based content. In preferred embodiments, β-lact...  
WO/2018/101057A1
Provided are a compound useful as a mold release agent, a mold release agent containing same, a curable composition, and a nanoimprint lithography resin material. Specifically, the present invention provides: a calixarene compound with a...  
WO/2018/102419A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/079333A1
The present invention provides a spontaneous alignment assistant for liquid crystal compositions, which is capable of ensuring storage stability if added to a liquid crystal composition, while enabling vertical alignment of liquid crysta...  
WO/2018/071327A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2018/039376A1
The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or composi...  
WO/2018/010604A1
A group of polyfunctional oxetane compounds and a preparation method therefor. The compound is a compound in a structure as shown in general formula (I) or a product obtained by reacting the compound as shown in general formula (I) with ...  
WO/2017/215188A1
Provided are a taxoid compound as shown in formula (I) and a preparation method and use thereof, wherein the preparation method comprises the following steps of: firstly protecting the two hydroxyl groups of gemcitabine, then condensing ...  
WO/2017/177004A8
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation ...  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/190086A1
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathw...  
WO/2017/177004A1
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation o...  
WO/2017/170808A1
To provide a technique for producing a four-membered ring lactone more efficiently with higher yield by means of a carbonylation reaction of an epoxide using a heterogeneous catalyst that is able to be handled in air and is easily separa...  
WO/2017/160925A1
Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.  
WO/2017/156165A1
The present invention provides compounds, compositions thereof, and methods of using the same.  
WO/2017/123760A1
This document relates to non-covalently bound complexes comprising cabazitaxel and human serum albumin. This document also relates to compositions comprising non-covalently bound complexes comprising cabazitaxel and human serum albumin. ...  
WO/2017/106957A8
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.  
WO/2017/119515A1
An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve ...  
WO/2017/115301A1
The present disclosure provides methods for the treatment of breast cancer, including triple negative breast cancer. Said methods comprise the administration of (a) a cationic liposomal formulation comprising a taxane, (b) a non-liposoma...  
WO/2017/106957A1
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.  
WO/2017/107907A1
The present invention relates to a condensed ring γ-amino acid derivative and a medical use thereof, and in particular relates to the condensed ring γ-amino acid derivative as shown in formula (I), or a stereisomer, a solvate, a metabo...  
WO/2017/097732A1
The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2017/098291A1
The subject of the invention relates to a centrifugal partition chromatography (CPC) method serving for separating 10- deacetylbaccatin III, where the solution to be purified containing 10-deacetylbaccatin III is purified in at least one...  
WO/2017/088058A1
The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer and increasing cellular internalization of said peptide compounds. The peptide compounds are selected fr...  

Matches 1 - 50 out of 2,741