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Matches 701 - 750 out of 27,332

Document Document Title
WO/2012/030619A1
Continuous flow systems and methods produce succinic anhydride by a double carbonylation of ethylene oxide with carbon monoxide and at least one catalyst. In some embodiments, the double carbonylation occurs using a single catalyst. In o...  
WO/2012/031298A3
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-ne...  
WO/2012/031298A2
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-ne...  
WO/2012/029071A3
The water tolerant heterogeneous acid catalyst (ICaT-2) has been disclosed herein. The catalyst of the invention comprises of rare earth metals in the form of trifluromethansulphonate anchored with hexagonal organic-inorganic functionali...  
WO/2012/029949A1
In the disclosed novel technique for producing, by hydrogenation of furans, tetrahydrofuran derivatives, which are hydrogenated products produced by hydrogenation of the starting materials furfural or furfuryl alcohol. The method of prod...  
WO/2012/025701A1
Compounds selected from the following group and their salts are inhibitors of HDAC activity, useful in the treatment of, inter alia, cell proliferative disease and inflammation: Cyclopentyl 1 -[({5-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1...  
WO/2012/024818A1
Naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones, the preparation methods and uses thereof are disclosed. The pharmaceutical compositions comprising such compounds for the treatment of various indications including p...  
WO/2012/026886A1
The invention includes a compound represented by the following structural formula: wherein R is described herein. The compounds of the invention are useful in staining embryonic stem cells.  
WO/2012/024353A1
The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharma...  
WO/2012/022467A3
The present invention relates to novel benzoquinone derivatives. The compounds are efficient as modulators of mitochondrial function and as such are useful for the treatment of pathological conditions where mitochondrial function is impa...  
WO/2012/023584A1
Provided are a composition derived from ascorbic acid, a method for preparing the composition, and a cosmetic material having the composition mixed therein. The composition derived from ascorbic acid comprises a reaction product obtained...  
WO/2012/021981A1
The present invention describes phytochemicals present in maple syrup and maple tree extracts by butanol, ethyl acetate and methanol. Novel compounds are isolated from maple syrups, including one compound Quebecol generated in the maple ...  
WO/2012/024276A1
Ethoxylated fatty acid mono-ester(s) of sorbitan with a fatty acid chain length from 8 to 14 and an overall degree of ethoxylation from 7 to 16 are new (though related to the polysorbates). These compounds are useful as adjuvants in agro...  
WO/2012/019428A8
Benzohydrol derivatives of formula (I), a preparation method, pharmaceutical compositions and pharmaceutical use thereof are disclosed in the invention. The derivatives can be used as rennin inhibitors to prepare the drugs for the treatm...  
WO/2012/019428A1
Benzohydrol derivatives of formula (I), a preparation method, pharmaceutical compositions and pharmaceutical use thereof are disclosed in the invention. The derivatives can be used as rennin inhibitors to prepare the drugs for the treatm...  
WO/2012/017166A2
or an addition salt thereof with pharmaceutically acceptable acids, for use thereof in a method for treatment of a pathological condition linked to an excessive effect of TNF-alpha and for use thereof in a method for treatment of the hum...  
WO/2012/017052A1
Process for the synthesis of 2,5-furandicarboxylic acid through the oxidation of -hydroxymethylfurfural in a flow of oxygenor a compound containing oxygen, catalysed by a supported catalyst containing a metal of the platinum group, carri...  
WO/2012/017166A3
or an addition salt thereof with pharmaceutically acceptable acids, for use thereof in a method for treatment of a pathological condition linked to an excessive effect of TNF-alpha and for use thereof in a method for treatment of the hum...  
WO/2012/015265A1
Provided are novel organic electroluminescent compounds and an organic electroluminescent device using the same. Because the organic electroluminescent device using the organic electroluminescent compound as a hole transport material or ...  
WO/2012/014818A1
Disclosed are the following ether compound, and the use of the same. In formula (1), n represents 0 or 1, m represents an integer of 0-2, Y represents -O-, -S-, -C (=O) -O- and -O- C (=O) -, X1 and X2 represent a hydrogen atom or a fluor...  
WO/2012/014181A1
The invention relates to compounds of formula (I) for use in the prevention and/or treatment of viral infections: Wherein X, Y, Z, T, R1a and R1b are as defined in claim 1.  
WO/2012/015616A1
Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (...  
WO/2012/013016A1
The invention relates to the field of medicine. Curcumalactone derivatives with antitumor activity and the process for their preparation are disclosed. The said curcumalactone derivatives and their oxidized derivatives have a spironolact...  
WO/2012/014779A1
Disclosed is an organic electroluminescent element having the following attributes in high degree: high luminous efficiency, durability, low drive voltage, and inhibition of decreased luminous efficiency after high-temperature storage. A...  
WO/2012/010174A1
The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram.  
WO/2012/012278A2
Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treat...  
WO/2012/012278A3
Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treat...  
WO/2012/010802A1
The invention relates to a process for preparing benzofuran derivatives of general formula I, in which R represents a nitro or ester-COOR' group, where R' represents an alkyl group, R1 represents hydrogen or an alkyl group and R2 represe...  
WO/2012/010555A1
The present invention discloses novel compounds useful for the inhibition of IL-6/STAT signaling and/or PI3K/ NF-ĸΒ signaling in the treatment of associated diseases or conditions, e.g. cancer. A pharmaceutical composition comprising s...  
WO/2012/010788A1
The invention relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula (I), in which R1 represents hydrogen or an alkyl group and R2 represents hydrogen, an alkyl, alkoxy or dialkylaminoalkoxy group, by reductio...  
WO/2012/011128A1
A process for preparing the prostaglandin derivatives is provided, wherein the benzoyl and p-nitrobenzoyl groups are used as the hydroxyl protective groups. A pharmaceutical composition comprising the prostaglandin derivatives is also pr...  
WO/2012/011125A1
The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are therefore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for thei...  
WO/2012/010579A3
The present invention relates to fungicidal benzocycloalkene carboxamides or their thiocarboxamide derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, partic...  
WO/2012/010913A1
The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)- propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula (I), and pharmaceutically acceptable salts thereof characterize...  
WO/2012/009609A1
The invention provides for new flame retardant non-furan dicarboxylic acid (FDCA) based polyols; oligomers and polymers made from these new polyols with flame retardation properties; and methods of using them as a part or all of the flam...  
WO/2012/006686A1
The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilog...  
WO/2012/007959A1
Disclosed is a process for preparing dronedarone and pharmaceutically acceptable salts thereof. Also disclosed are a novel amorphous form of dronedarone hydrochloride and a preparation process thereof.  
WO/2012/008435A1
Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represente...  
WO/2012/004658A2
The present invention relates to a process for the preparation of highly pure N-[2- butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5- benzofuranyljmethanesulfonamide and pharmaceutically acceptable salts thereof having HPLC purity greater ...  
WO/2012/005200A1
An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative, wherein borane is removed from a phosphine-borane compound (1), followed by lithiation, then the reaction product is react...  
WO/2012/004658A3
The present invention relates to a process for the preparation of highly pure N- [2- butyl -3- [4- [3- (dibutylamino) propoxy] benzoyl] -5- benzofuranyljmethanesulfonamide and pharmaceutically acceptable salts thereof having HPLC purity ...  
WO/2012/004069A1
The invention relates to a process for producing compounds of the general formula (I) from compounds of the general formula (IIa) and/or (IIb) with an oxygen-containing gas in the presence of a catalyst composition, the reaction taking p...  
WO/2012/004658A8
The present invention relates to a process for the preparation of highly pure N-[2- butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5- benzofuranyljmethanesulfonamide and pharmaceutically acceptable salts thereof having HPLC purity greater ...  
WO/2012/002203A1
Disclosed is a production method for obtaining an optically active β-aminocarbonyl compound by a Mannich reaction of an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and 1-...  
WO/2012/003164A1
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity agamst hepatitis C virus (HCV) and may be useful in treating those infected wi...  
WO/2012/002512A1
A polymerisable compound having a terminal having an α-methylene-γ-butyrolactone group and a terminal having a photopolymer or a photocrosslinking group; a polymer for forming a liquid crystal aligning agent capable of aligning liquid ...  
WO/2012/002513A1
Disclosed is a polymerizable compound represented by formula (1). In formula (1), V represents a single bond or -R1O-, wherein R1 represents a linear or branched alkylene group having 1 to 10 carbon atoms, and W represents a single bond ...  
WO/2012/002511A1
The liquid crystal-aligning agent comprises polyimide precursor with side chains that vertically orient liquid crystals and photoreactive side chains that contain at least one kind selected from methacrylic, acrylic, vinyl and cinnamoyl ...  
WO/2012/002527A1
Provided are a novel heterocyclic compound and salt thereof applicable in the selective inhibition of the degradation of p27Kip1. The compound and the salt thereof are represented in formula (1). [In the formula: A represents an alkyl gr...  
WO/2012/001148A1
The present invention relates to calcium salts of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group;...  

Matches 701 - 750 out of 27,332