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Matches 1 - 50 out of 2,408

Document Document Title
WO/2020/185712A1
The present disclosure relates to methods of alleviating a symptom of, treating, or preventing a sleep disorder by administering a ligand of α2δ-1 auxiliary subunit of voltage-gated calcium channels, a ligand of α2δ-2 auxiliary subun...  
WO/2020/090700A1
The present invention addresses the problem of providing an ynone compound useful for the inducement of an endoplasmic reticulum stress response. The problem can be solved by an ynone compound represented by formula (1) [in the formula, ...  
WO/2020/084005A1
The present invention relates to compounds binding to calreticulin which selectively inhibit growth of CALR mutant cells and/or exhibit selective cytotoxicity towards CALR mutant cells, to pharmaceutical compositions comprising such comp...  
WO/2020/063999A1
Disclose herein are mono halogen or methyl-substituted 5-HT 2B antagonist compounds, which have been found with increased binding activity to 5-HT 2B receptor due to the substitution of halogen or methyl, and the method of using the comp...  
WO/2020/055113A1
The present disclosure relates to an organic electroluminescent compound represented by formula 1 and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosu...  
WO/2020/023356A1
The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of prolif...  
WO/2019/232639A1
The present invention provides a new compound of formula (II), extracted from Chaetomorpha Cannabina seaweed. (II) The methods for extraction from the seaweed, the fractionation and isolation of the compound, the determination of the ste...  
WO/2019/199667A3
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, pa...  
WO/2019/207246A1
The present invention relates to a method for olefin metathesis, which comprises placing in contact: - at least one olefin, - at least one metathesis catalyst selected from the ruthenium alkylidene complexes comprising two imidazoline-2-...  
WO/2019/200100A1
The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, ...  
WO/2019/199667A2
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, pa...  
WO/2019/171278A1
The present invention is directed to heterocycloalkenyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the GPR120 and / or GPR40 receptors. 5 More particul...  
WO/2019/158485A1
The invention provides a method for synthesizing musk macrocycles comprising contacting an easily accessible diene starting materials bearing a Z-olefin moiety and performing a ring closing metathesis reaction in the presence of a Group ...  
WO/2019/144132A1
Described herein are compounds that are estrogen receptor modulators of formula I' Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen rece...  
WO/2019/124523A1
In the present invention, an efficacious therapy for glaucoma is discovered and provided as a medicine. A combination of the present invention, in particular a combination of 2-propanyl 4-{(3S, 5aR, 6R, 7R, 8aS)-6-[(1E, 3R)-4-(2, 5-diflu...  
WO/2019/113019A2
This invention relates generally to the synthesis of E-macrocycles using stereoretentive ruthenium olefin metathesis catalysts supported by dithioiate ligands. Macrocycles were generated with excellent selectivity (>99% E) and in moderat...  
WO/2019/104850A1
Disclosed is a method for preparing a lactone compound, for which a cyclic ketone compound serves as a raw material; in an oxygen-containing atmosphere, a cyclic organic nitroxide free radical serves as a catalyst, and a certain amount o...  
WO/2019/092030A1
The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.  
WO/2019/087208A1
The present invention provides a novel and improved process for the preparation of Tavaborole of Formula (I) and its pharmaceutically acceptable salts. The present invention also provides novel intermediates and process for the preparati...  
WO/2019/072669A1
The present invention relates to a method for preparing a compound of formula (I). The present invention also relates to compounds of formula (A) or a compound in the form of a stereoisomer. The present invention further relates to the u...  
WO/2018/235926A1
The purpose of the present invention is to provide an α, β-unsaturated amide compound or a pharmaceutically acceptable salt thereof or the like, which has anti-cancer activity or the like. An α, β-unsaturated amide compound represent...  
WO/2018/197963A1
The invention relates to a method for the preparation of cyclic compounds in the metathesis of olefins from acyclic dienes comprising terminal and/or non-terminal C=C double bonds; the invention also relates to the use of homogeneous rut...  
WO/2018/175418A1
16-membered macrolide compounds inhibit growth of various microbial species and have utility in the treatment of systemic or topical microbial infections, including methicillin-resistant strains (Formula I).  
WO/2018/150421A1
The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).  
WO/2018/100515A1
The invention relates to novel ruthenium complexes of formula (9). The invention also relates to the method for preparation of novel metal complexes of formula (9) and their use in olefin metathesis reactions.  
WO/2018/084120A1
A benzoic acid derivative and a dehydration-condensation agent, each of which is represented by formula (I) or (II). In formulae (I) and (II), R1 represents a haloalkyl group, a halogen atom or a cyano group; and R2, R3 and R4 independen...  
WO/2018/063049A1
Disclosed is an equipment and a process for processing of a product stream (a) comprising acetic acid, unreacted cyclohexanone, reaction water and organic heavy ends, said product stream (a) being yielded in a caprolactone production whe...  
WO/2018/049733A1
A method for preparing ε-caprolactone is provided. The method comprises the following steps: adding a cyclohexanone, an auxiliary oxidant, a certain amount of catalyst and a molecular oxygen as an oxidant into a certain amount of organi...  
WO/2018/003945A1
[Problem] Provided are a method for producing 2-propanil 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-h ydroxy-1-butene-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxe pine-3-yl}butanoate, which can solve various problems desc...  
WO/2017/184984A1
Molecular characterization of disease has become the dominant trend in modern medicine, and it has recently become increasingly important to obtain qPCR, microarray, and next-generation sequencing (NGS) data for both research and clinica...  
WO/2017/160925A1
Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.  
WO/2017/153455A1
A process for preparing a macrocyclic lactone comprising 14 to 17 ring carbon atoms, the process comprising the steps of i) subjecting a reaction mixture comprising an olefin-containing random polyester, formed by metathesis to a cyclo-d...  
WO/2017/155442A1
Disclosed is a production equipment for production of a caprolactone by reaction between peracetic acid, produced from acetic acid and hydrogen peroxide, and cyclohexanone, said equipment being split into a first section (Fig. 1) wherein...  
WO/2017/155441A1
Disclosed is a production equipment for production of a caprolactone by reaction between peracetic acid, produced from acetic acid and hydrogen peroxide, and cyclohexanone, said equipment being split into a first section (Fig. 1) wherein...  
WO/2017/152099A1
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating immune response processes, and methods of treating disease, disorders, and symptoms thereof.  
WO/2017/124184A1
The present invention provides a new compound of formula (I): extracted from a seaweed, and its use for inhibiting the growth of cancer cells, as well as methods for its extraction and isolation.  
WO/2017/118375A1
Disclosed in the present invention is a Dezocine analogue, and particularly disclosed are compounds represented by formula (I), (II) and (III), a pharmaceutically acceptable salt or tautomer thereof.  
WO/2017/116939A1
The invention relates to macrocyclic picolinamides of Formula (I) and their use as fungicides. (Formula (I))  
WO/2017/116954A1
The invention relates to macrocyclic picolinamides of Formula (I) and their use as fungicides.  
WO/2017/116956A1
This disclosure relates to macrocyclic picolinamides of Formula (I) and their use as fungicides.  
WO/2016/196256A3
This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aroma...  
WO/2017/080292A1
A trifluoromethyl-modified (+)-Patulolide C. By adding a trifluoromethyl group to (+)-Patulolide C, it is expected that favorable antibacterial and anti-inflammatory activity can be obtained.  
WO/2017/040769A1
Compositions and methods for the production of derivatives of spinosyns are provided. The method produces spinosyn derivatives that exhibit activity towards insects, arachnids, and/or nematodes and are useful in the agricultural and anim...  
WO/2017/040763A1
Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include spinosyn derivatives functionalized on the C5-C6 double bond of th...  
WO/2017/040878A1
Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include those functionalized on the C-13,14 double bond to provide an addi...  
WO/2017/040882A1
Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include spinosyn derivatives functionalized on the C5-C6 double bond of sp...  
WO/2017/030450A1
A method of increasing the rigidity of PIM homo- or co-polymers including repeating units containing at least one biscatechol monomer having a fused spiro-bisindane (SBI) ring system of Formula (I), the SBI ring system including a bicycl...  
WO/2017/026643A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure is effective in preparing an organic...  
WO/2017/019561A1
A compound having the structure (I) and (II).  
WO/2017/019550A1
A compound having the structure (I) or (II).  

Matches 1 - 50 out of 2,408