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Matches 501 - 550 out of 6,760

Document Document Title
WO/2004/113314A1
The present invention relates to optically active dihydroxy hexanoate derivatives, boronate esters of formula (IIa) which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastat...  
WO/2004/110418A2
Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anem...  
WO/2004/108697A1
The invention relates to protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid esters and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid esters for synthesizing epothilones and derivatives thereof, and to methods for producing...  
WO/2004/108733A1
Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, each X is methylene, and Y is 0, or wherein R is H, each X is 0 and Y is methylene, and solvates thereof are disclosed. Also disclosed...  
WO/2004/103560A1
The present invention concerns a catalytic composition comprising a catalyst effective for catalysing asymmetric hydrogenation reactions, which catalyst requires acid activation, an acidic material effective for activating the catalyst, ...  
WO/2004/101483A1
A novel compound for overcoming diseases including diabetes, obesity and neuroses such as nerve damage, Alzheimer and Parkinson's disease; and a medical agent comprising the same. In particular, there are provided a compound of the follo...  
WO/2004/099173A1
Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are usef...  
WO/2004/092106A2
Process for preparing alkoxy- and aryloxy-phenols, comprising oxidizing the ketone of formula (I) with peracids to give the corresponding ester of formula (II) which is then hydrolysed to give the corresponding aryloxy- or alkoxy-phenol.  
WO/2004/089927A1
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases o...  
WO/2004/083153A1
A process for production of an allyl and/or methallyl ether of a tri or polyhydric alcohol is disclosed. Said process comprises (i) subjecting at least one cyclic formal of a tri or polyhydric alcohol to allylation, (ii) subjecting obtai...  
WO/2004/080947A1
A compound represented by the following general formula (I), its salt, its solvate or its N-oxide or prodrugs thereof: (I) wherein R1 and R2 represent each an optionally substituted cyclic group, etc.; W is a spacer having from 1 to 6 ca...  
WO/2004/080377A2
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.  
WO/2004/080379A2
The invention relates to extracts of Pangium edule, advantageously from seeds, and lignanes of formula I. The invention also relates to the use thereof as a medicament which inhibits cathepsins or which has an antinecrotic effect.  
WO/2004/078144A2
The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering...  
WO/2004/077511A2
The present invention provides novel (meth)acrylic and (meth)acrylamide monomers and polymers produced from those monomers. The monomers of the invention each include only a single vinyl functionality and at least one non-vinyl functiona...  
WO/2004/076401A1
The invention relates to arlylcycloalkyl-substituted alkanoic acid derivatives and the physiologically acceptable salts and physiologically functional derivatives thereof. Disclosed are compounds of formula (I), wherein the radicals have...  
WO/2004/073606A2
The present invention is directed to a compound of Formula (I):, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferat...  
WO/2004/072254A2
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding...  
WO/2004/072087A2
The invention relates to novel metal complexes for optical data carriers, whereby the latter is preferably a transparent substrate which is, optionally already covered with one or several reflective layers. A light-inscriptible informati...  
WO/2004/064745A2
Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential ...  
WO/2004/063147A1
The invention provides salts and solvated of glucagon antagonists.  
WO/2004/063187A1
Disclosed are benzoyl derivatives of formula (I) and the use thereof as herbicides. In said general formula (I), R1, R2, and R3 represent different radicals, X represents a bridge atom from the group comprising oxygen and sulfur, and Het...  
WO/2004/062590A2
The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tu...  
WO/2004/054997A1
Compounds represented by the general formula (I) can be produced by reacting a benzene compound represented by the general formula (IV) or (V) with an alkenylidene diacetate represented by the general formula (VI) in the presence of a ca...  
WO/2004/052876A1
Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.  
WO/2004/052830A1
ABSTRACT The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, suc...  
WO/2004/052839A1
The invention relates to isophtalic acid derivatives, a method for the preparation thereof and the use of said derivatives for producing drugs for treating and/or preventing diseases, in particular cardiovascular diseases of a human bein...  
WO/2004/052919A2
Novel PDF inhibitors and novel methods for their use are provided.  
WO/2004/050613A2
This invention provides 2-substituted-propenamide derivatives and their compositions for the treament of hepatitis B virus and/or hepatitis D virus.  
WO/2004/048329A1
The present invention provides antitumor compounds of the formula (I); and antitumor methods.  
WO/2004/048320A1
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, me...  
WO/2004/046074A1
Di(ketene acetals) are prepared by photoisomerizing the corresponding di(vinyl acetals).  
WO/2004/046105A2
Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihy...  
WO/2004/041161A2
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine...  
WO/2004/041787A1
A novel process for producing a quinolinecarbaldehyde (IV) which comprises reacting an aminobenzophenone compound (I) with a β-ketoaldehyde derivative (II) in the presence of an acid to obtain a quinolinecarbaldehyde derivative (III) an...  
WO/2004/039768A1
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...  
WO/2004/039794A1
It is intended to provide a cell activator which has a high biocompatibility and activates cells of mammals including humans without showing any species-specificity, a process for producing the cell activator and an apparatus therefor. A...  
WO/2004/037806A1
The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof...  
WO/2004/037773A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO/2004/037807A2
The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use...  
WO/2004/032630A1
An agent for controlling protist and/or a harmful substance which comprises a material prepared through firing a shell powder containing calcium carbonate as a primary component in the presence of a metal component. The agent exhibits hi...  
WO/2004/026292A1
Antitussives containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) (wherein A is alkoxycarbonylalkyl or the like and R is optionally protected hydroxyl, or A and R may be united to for...  
WO/2004/024661A1
The invention relates to a method for producing aldehydes by means of hydroformylation catalysed by metals of groups eight to ten of the periodic table in the presence of cyclic carbonic acid esters.  
WO/2004/024677A1
An N-hydroxyformamidine derivative represented by the formula (I) wherein R1 represents hydrogen, C1-4 alkyl, C1-4 alkoxy, or halogeno; A represents C1-10 alkylene or a group represented by the formula (II) (wherein m, n, and p each is a...  
WO/2004/022552A1
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRaRbRc, CH2ORd, or C...  
WO/2004/022523A2
The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ...  
WO/2004/020414A1
This invention relates to compounds of formula (I).  
WO/2004/020378A2
The present invention provides a method of producing glycol ethers, which are also commonly known as glymes. The method according to the invention includes contacting a glycol with a monohydric alcohol in the presence of a polyperfluoros...  
WO/2004/020380A1
The invention relates to a method for the production of aldehydes by catalysed hydroformylation of metals in the 8th 10th groups of the periodic table of elements of olefinically unsaturated compounds in the presence of cyclic carbonic a...  
WO/2004/020430A2
The invention relates to a compound having general formula (I), wherein R1 denotes a phenyl or naphthalenyl group which is optionally substituted by one or more halogen atoms or groups hydroxy, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, trif...  

Matches 501 - 550 out of 6,760