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Patent Searching and Data


Matches 501 - 550 out of 3,567

Document Document Title
WO/2004/052919
Novel PDF inhibitors and novel methods for their use are provided.  
WO/2004/050613
This invention provides 2-substituted-propenamide derivatives and their compositions for the treament of hepatitis B virus and/or hepatitis D virus.  
WO/2004/048329
The present invention provides antitumor compounds of the formula (I); and antitumor methods.  
WO/2004/048320
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, me...  
WO/2004/046074
Di(ketene acetals) are prepared by photoisomerizing the corresponding di(vinyl acetals).  
WO/2004/046105
Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihy...  
WO/2004/041161
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine...  
WO/2004/041787
A novel process for producing a quinolinecarbaldehyde (IV) which comprises reacting an aminobenzophenone compound (I) with a β-ketoaldehyde derivative (II) in the presence of an acid to obtain a quinolinecarbaldehyde derivative (III) an...  
WO/2004/039768
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...  
WO/2004/039794
It is intended to provide a cell activator which has a high biocompatibility and activates cells of mammals including humans without showing any species-specificity, a process for producing the cell activator and an apparatus therefor. A...  
WO/2004/037806
The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof...  
WO/2004/037773
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO/2004/037807
The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use...  
WO/2004/032630
An agent for controlling protist and/or a harmful substance which comprises a material prepared through firing a shell powder containing calcium carbonate as a primary component in the presence of a metal component. The agent exhibits hi...  
WO/2004/026292
Antitussives containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) (wherein A is alkoxycarbonylalkyl or the like and R is optionally protected hydroxyl, or A and R may be united to for...  
WO/2004/024661
The invention relates to a method for producing aldehydes by means of hydroformylation catalysed by metals of groups eight to ten of the periodic table in the presence of cyclic carbonic acid esters.  
WO/2004/024677
An N-hydroxyformamidine derivative represented by the formula (I) wherein R1 represents hydrogen, C1-4 alkyl, C1-4 alkoxy, or halogeno; A represents C1-10 alkylene or a group represented by the formula (II) (wherein m, n, and p each is a...  
WO/2004/022552
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRaRbRc, CH2ORd, or C...  
WO/2004/022523
The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ...  
WO/2004/020414
This invention relates to compounds of formula (I).  
WO/2004/020378
The present invention provides a method of producing glycol ethers, which are also commonly known as glymes. The method according to the invention includes contacting a glycol with a monohydric alcohol in the presence of a polyperfluoros...  
WO/2004/020380
The invention relates to a method for the production of aldehydes by catalysed hydroformylation of metals in the 8th 10th groups of the periodic table of elements of olefinically unsaturated compounds in the presence of cyclic carbonic a...  
WO/2004/020430
The invention relates to a compound having general formula (I), wherein R1 denotes a phenyl or naphthalenyl group which is optionally substituted by one or more halogen atoms or groups hydroxy, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, trif...  
WO/2004/018414
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...  
WO/2004/018446
A process for producing high-purity &gammad -keto acetals in high yield by a simple and easy means, as represented by the following scheme: (I) wherein Ar is aryl; X is halogeno; Ra and Rb are each alkyl or the like; and W is alkylene.  
WO/2004/016213
The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to meth...  
WO/2004/014966
The invention relates to a method for producing optionally coupled, non-blocked polymers based on conjugated dienes or optionally coupled, non-blocked copolymers based on conjugated dienes and vinyl aromatic compounds by anionic polymeri...  
WO/2004/014871
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2004/014899
The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.  
WO/2004/014890
It is intended to provide a method of purifying lactide whereby crude lactide can be purified while consuming less energy and causing no heat denaturation to thereby give D- or L-lactide having a high optical purity. In a method of purif...  
WO/2004/013121
The present invention relates to preparing lactic acid derivatives that are useful as odorants and monomers for polymer synthesis.  
WO/2004/011418
Disclosed are novel compounds of the formula (I)or a pharmaceutically acceptable salt or solvate thereof. Also disclosed is the treatment of chemokine-mediated diseases using compounds of the formula (II)  
WO/2004/011420
A process by which an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-ylacetic acid derivative useful as an intermediate for medicines can be easily produced through short steps from an inexpensive, easily available material. The proce...  
WO/2004/011451
A process for easily and safely producing from inexpensive materials an optically active 1,4-benzodioxane derivative useful as an intermediate for medicines, etc. The process comprises sulfonylating an optically active triol compound (5)...  
WO/2004/006878
The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5alkyl- or C1-C5alkoxy-substituted C6-C20aryl; orl; or ...  
WO/2004/005478
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA cons...  
WO/2004/005278
The present invention relates to the use of bisarylsulfonamide compounds of formula (I) wherein W is a CI-5 branched or unbranched alkyl group or a C2-5 alkenyl group; nis0or1; R1 is H, a C, 1-8 branched or unbranched alkyl group, a C2-8...  
WO/2004/000771
The invention relates to 3,3,4,4-tetrafluorocyclopentane compounds of formula (I), in which R1, A1, A2, Z1, Z2 and m are defined as cited in claim 1. Said compounds are suitable for use as components of liquid crystal media.  
WO/2004/000783
The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to co...  
WO/2003/106443
Compounds of formula (I) (R and R1 are a wide range of substituents, Q is CO, CHOH or CHOR2, R2 is alkyl, alkenyl, alkynyl or cycloalkyl group, each of which is optionally substituted, or is alkanoyl, alkanoyoxy, aminocarbonyl, alkylamin...  
WO/2003/106447
Process for the preparation of an ester of formula (1), wherein R1represents a leaving group, CN, OH or a COOR5 group, R3 and R4each independently represent a 1-3 C alkyl group, and R2 and R5 each independently represent an ester residue...  
WO/2003/103660
Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and fo...  
WO/2003/104203
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of t...  
WO/2003/104178
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...  
WO/2003/102536
Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group that enable degradation of the surfactant under acidic conditions. The invention a...  
WO/2003/099284
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2003/099776
The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or i...  
WO/2003/097619
A novel class of compounds of the general formula (I), which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the...  
WO/2003/095439
This invention relates to dihydro-furan-2-one derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formula (V-1), wherein R2 and p are herein defined. Th...  
WO/2003/093223
Disclosed are novel biphenyl carboxamides of formula (I), in which R1, R2, m, n, R3, Y, and A have the meanings indicated in the description, several methods for producing said substances, the use thereof for controlling undesired microo...  

Matches 501 - 550 out of 3,567