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Matches 501 - 550 out of 6,974

Document Document Title
WO/2005/097773A1
The present invention is related to carboxylic acids of Formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and...  
WO/2005/094805A1
A medicine having prostaglandin D2 (PGD2) production inhibitory activity and having as an active ingredient a substance selected from compounds represented by the general formula (I): A-Y-B &lcub wherein A and B each independently repres...  
WO/2005/095343A1
The invention relates to compounds of formula (I), Z-C(R1R2)-C(R3NH2)-C(R4R5)-X-N(R6R7), wherein Z, R1-7 and X have the meaning as cited in the description and the claims. Said compounds are useful as DPP-lV inhibitors. The invention als...  
WO/2005/095378A2
The present invention is directed to carboxylic acid and ester moieties that are attached to a carbon chain that is between 2 and 24 carbons in length wherein, the chain contains at least one dioxanone ring system, said dioxanone being f...  
WO2005072681A3
N-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndrom...  
WO/2005/087236A1
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.  
WO/2005/083102A1
It is intended to provide a novel process for producing an optically active 1,4-benzodioxin-2-carboxylic acid derivative, which is usable as an intermediate in synthesizing an optically active drug, via biological conversion. Namely, a 6...  
WO/2005/082842A1
A compound (II), compound (IV), compound (VI), and compound (VII); and processes for producing these. Also provided is a process for producing the compound (X) which comprises the steps of (II)→(IV)→(VI)→(VII)→(X).  
WO/2005/080322A1
A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly...  
WO/2005/079378A2
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.  
WO/2005/077943A1
The present invention discloses novel compounds of formula (I) and their pharmaceutically useful compositions as modulators of PPAR ligands  
WO/2005/077882A1
A chain or cyclic oligolactate having an aminoethyl, hydroxyethyl, or carboxymethyl group in a side chain. A chain oligolactate having an aminoethyl, hydroxyethyl, or carboxymethyl group in a side chain is synthesized first. This chain o...  
WO/2005/077943A2
The present invention discloses novel compounds of formula (I) and their pharmaceutically useful compositions as modulators of PPAR ligands  
WO/2005/077868A2
The invention relates to congeneric, halogenated, fluorinated, aromatic compounds (I), (II), (IIIa) or (IIIb), (IV), (V), (VI) or (VII), in which A and B represent phenyl groups, L represents an oxygen atom, sulphur atom or an alkene gro...  
WO/2005/075451A1
Disclosed is a highly reliable material for organic electroluminescent devices which has high luminance and high luminous efficiency, hardly deteriorates in emission, and is excellent in use and storage at high temperatures. Also disclos...  
WO/2005/075401A1
The invention relates to a method for producing 2,5-dimethylphenyl acetic acid by reacting p-xylol with chloroacetyl chloride to form 2-chloro-1-(2,5-dimethylphenyl) ethanone, which reacts with the compound of formula (II) to form the co...  
WO2005000233A3
The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases ...  
WO/2005/072681A2
N-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndrom...  
WO2005040355A3
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity ...  
WO/2005/070885A1
bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndr...  
WO/2005/060456A2
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2005/060456A9
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2005/061459A1
The present invention relates to biaryl sulfonamides of the formula 1: wherein: R1 is H or Cl-.C6 a]kyl; R2 is H, C I -C6 alkyl, (CH2)nR2' , phenyl, or benzyl; n is 0-6; R2'is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, in...  
WO/2005/056509A1
The present case relates to a process for the purification of lactide from a crude lactide vapour product stream which process comprises a rectification/condensation step leading to a lactide-enriched condensate.  
WO/2005/051895A1
Disclosed are &dgr -amino-&gammad -hydroxy-&ohgr -aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and ...  
WO/2005/046683A1
Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals in...  
WO/2005/047249A1
The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula (I) wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaceutical compositi...  
WO2004072254A3
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding...  
WO2004064745A3
Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential ...  
WO/2005/042513A1
There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected...  
WO2005023793A3
The present invention provides for the simplified, direct synthesis of di-heteroatom containing cyclic organic compounds by forming an aqueous mixture of material of the formula (I); wherein X and Y are heteroatoms which may be the same ...  
WO2004072087A3
The invention relates to novel metal complexes for optical data carriers, whereby the latter is preferably a transparent substrate which is, optionally already covered with one or several reflective layers. A light-inscriptible informati...  
WO2005014539A3
HMGCo-A reductase inhibitor compounds of formula (I) useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compo...  
WO/2005/040138A1
This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one o...  
WO/2005/040355A2
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity ...  
WO/2005/040127A1
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPAR&gammad ) and alpha (PPAR&agr ), processes of preparing the same, and pharmaceutical compositions contain...  
WO/2005/033093A1
7,8-Bicyclic-chroman derivatives of Formula I, wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neu...  
WO/2005/032544A1
The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitoch...  
WO/2005/033092A1
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I, wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by...  
WO2005012179A3
This invention is to provide supercritical water or subcritical water with which chemical substances, in particular, harmful organic substances difficult to decompose, such as p-dichlorobenzene and PCB, can be oxidized into harmless subs...  
WO/2005/030694A1
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2005/030705A1
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2004062590A3
The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tu...  
WO/2005/030704A1
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2004014871A8
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2005/030213A1
Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions con...  
WO2004073606A3
The present invention is directed to a compound of Formula (I):, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferat...  
WO2004041161A3
The present invention is directed to compounds of the formula (I) (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<27>, R<28>, R<29>, R<30>, R<31>, X, m, n and the dashed line are defined herein) which are u...  
WO/2005/023793A2
The present invention provides for the simplified, direct synthesis of di-heteroatom containing cyclic organic compounds by forming an aqueous mixture of material of the formula (I); wherein X and Y are heteroatoms which may be the same ...  
WO2004110418A3
Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anem...  

Matches 501 - 550 out of 6,974