Heterocyclic Compounds

Matches 551 - 600 out of 3,521	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >

Document	Document Title
WO/2003/042160	ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONISTS The invention provides novel β2 adrenergic receptor agonist compounds of Formula (I). WhereinR1 is methoxy or ethoxy, and R2 is hydrogen or phenyl; or R1 is hydrogen, and R2 is phenyl; and R3 is -CH2OH or -NHCHO, and R4 is hydrogen; or ...
WO/2003/041728	NOVEL PHENYL−PROPARGYLETHER DERIVATIVES The invention relates to phenyl−propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3...
WO/2003/042164	ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONISTS The invention provides novel $g(b)¿2? adrenergic receptor agonist compounds of formula (I): wherein R?1¿-R?13¿ and w have any of the values described in the specification. The invention also provides pharmaceutical compositions compri...
WO/2003/042168	NOVEL &agr -OXYGENATED OR &agr -THIOLATED CARBOXYLIC ACID PHENETHYLAMIDE DERIVATIVES The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...
WO/2003/040074	LIQUID CRYSTALLINE COMPOUNDS CONTAINING A BIPHENYL CORE A compound of formula (I) or a dimer thereof; where R?1¿ and R?2¿ are independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, a functional group or a group of sub-formul...
WO/2003/040096	N, N'−SUBSTITUTED−1,3−DIAMINO−2−HYDROXYPROPANE DERIVATIVES Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
WO/2003/030937	REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS Preventives and&sol or remedies for diseases, which are induced, worsened or made to recrudesce by stressors, comprising mitochondrial benzodiazepine receptor (MBR) antagonists such as compounds represented by the following general formu...
WO/2003/029184	DIARYL ETHER DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT A diaryl ether derivative having excellent immunosuppressive activity and reduced in side effects. The diaryl ether derivative is represented by the general formula (1): (1) &lcub e.g., 2−amino−2−[4−(3−benzyloxyphenoxy)−2−c...
WO/2003/029195	INTERMEDIATES FOR EPOTHILONE DERIVATIVE AND PROCESS FOR PRODUCING THESE Acetonides of a ß−keto ester compound, ß−hydroxyacid compound, and 1,3−diol derivative respectively represented by the following formulae (I), (V), and (VIII): (I) (V) (VIII) (wherein the symbols are the same as defined in the de...
WO/2003/027092	METHOD FOR THE SEPARATION OF DIASTEREOMERIC 1,3−DIOL ACETALS The separation of diastereomeric 1,3−diols, or the corresponding 1,3−diol acetals, or syn− and anti 1,3−diols of general formula (I) or (II), is conventionally only achieved with high technical complexity and loss of desired prod...
WO/2003/027059	ACID AMIDE DERIVATIVES, PROCESS FOR PRODUCING THESE, AND PEST CONTROL AGENT CONTAINING THESE Acid amide derivatives represented by the formula (I) (I) [wherein A is phenyl optionally substituted by X, benzyl optionally substituted by X, naphthyl optionally substituted by X, a heterocyclic group optionally substituted by X, a fus...
WO/2003/024953	PROPANOLAMINE DERIVATIVE HAVING 1,4−BENZODIOXANE RING A medicine containing as the active ingredient either a novel propanolamine derivative having a 1,4−benzodioxane ring or a pharmacologically acceptable salt thereof. (I) The compound is represented by the above formula (wherein R1 to R...
WO/2003/024955	SMALL MOLECULE INHIBITORS OF CASPASES The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...
WO/2003/024441	NOVEL USE OF TRICYCLIC COMPOUND A medicinal composition which exasperates apo AI expression as a remedy for circulatory diseases based on the HDL function enhancement. It is an apo AI expression accelerator which contains a compound represented by the formula (I), a pr...
WO/2003/024448	INHIBITORS OF HISTONE DEACETYLASE The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...
WO/2003/022801	REVERSE HYDROXAMIC ACID DERIVATIVES Reverse hydroxamic acid derivatives having specific structures represented by the general formula (Ia): (Ia) (wherein A represents hydrogen, etc.&semi Ar1 represents arylene, etc.&semi Ar2 represents optionally substituted aryl, heteroar...
WO/2003/020688	SELECTIVE PROTEIN TYROSINE PHOSPHATASE INHIBITORS Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the c...
WO/2003/018555	PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES A process for the preparation of compounds of formula (I) wherein R¿1? is unsubstituted or substituted C¿1?-C¿8?alkyl, R¿2?, R¿3?, R¿4? and R¿5? are each independently of the others hydrogen, unsubstituted or substituted C¿1?-C¿...
WO/2003/018523	PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOPROPANEDIOL DERIVATIVE A process for easily producing from an inexpensive material an optically active halopropanediol derivative which is useful as an intermediate for medicines. An inexpensively available propargyl alcohol derivative is reacted with a hypoha...
WO/2003/014063	PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONE AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to novel protected 3.5-dihydroxy-2.2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and to a method for the production and e use of said novel compounds in the production of epothilones or ep...
WO/2003/014064	NAPHTHYLUREA AND NAPHTHYLACETAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS Naphthylurea and naphthylacetamide derivatives of formula (I) which have vanilloid receptor 1 (VR1) antagonistic activity are disclosed, formula (I) wherein Y represents formula (II) and formula (III) and the variables Q, X, R6, R7, R8, ...
WO/2003/013502	COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE Compounds which mimic the chemical and/or biological activity of discodermolide are provided.
WO/2003/014068	PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilone and epothilone derivatives and a method for producing said novel intermediate products in the synthesis and the use thereof in the product...
WO/2003/010157	DIOXANE DERIVATIVES AND A PROCESS FOR THEIR PREPARATION The present invention relates to novel antidiabetic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs and pharmaceutically acceptable compositions containing them. More particularl...
WO/2003/009850	SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, ...
WO/2003/008399	SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
WO/2003/007956	TREATMENT FOR ATTENTION-DEFICIT HYPERACTIVITY DISORDER A method for treating Attention Deficit/Hyperactivity Disorder (ADHD) in humans and the symptoms associated therewith, inattentiveness, and hyperactivity with impulsivity, using eltoprazine and related compounds is provided.
WO/2003/006423	N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and ot...
WO/2003/004459	PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS A process is provided for the preparation of a compound of Formula (1) wherein: R?1¿ is H, optionally substituted acyl, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl: R² and R³ each ind...
WO/2003/004480	SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are us...
WO/2003/002524	UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY The present invention relates to compounds of the formula I, in which R?1¿, R?2¿, R?4¿, R?5¿, D¿1?, D¿2?, X¿1?, X¿2?, X¿3?, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacol...
WO/2003/002519	PHENOL DERIVATIVES AND THEIR USE IN MEDICAMENTS The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.
WO/2003/000646	SUBSTITUTED AROMATIC ETHERS AS INHIBITORS OF GLYCINE TRANSPORT This invention relates to a series of substituted aromatic ethers of the formula (I), wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptabl...
WO/2003/000181	DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such ...
WO/2002/100822	SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medic...
WO/2002/098854	PROCESS FOR PREPARING CHIRAL DIOL SULFONES AND DIHYDROXY ACID HMG COA REDUCTASE INHIBITORS A process is provided for preparing chiral diol sulfones of the structure (I) where R¿3? is preferably (II) or (III) where R¿4a? is preferably aryl such as phenyl, and R¿1a? is preferably alkyl such as t-butyl, which are intermediates...
WO/2002/098849	HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER’S DISEASE AND SIMILAR DISEASES Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...
WO/2002/099077	METHODS AND COMPOSITIONS RELATED TO TAGGING OF MEMBRANE SURFACE PROTEINS The invention relates to methods and reagents for selectively labeling membrane surface proteins using a labeling agent. The label may be used to isolate preparations of membrane surface proteins. Preparations of membrane surface protein...
WO/2002/098832	CF¿2?O-BRIDGED, AXIALLY SUBSTITUTED CYCLOHEXANE DERIVATIVES. The invention relates to CF¿2?O-bridged cyclohexane derivatives, in particular compounds of formula (I), R1-(-A1-Z1-)k1-Q-CF2O-A2-(-Z3-A3-)K3-R2, wherein Q represents group (a); W?1¿, W?2¿ represent -CH¿2?- and/or -0- independently f...
WO/2002/098558	CATALYST FOR CARBOXYLIC ESTER PRODUCTION AND PROCESS FOR PRODUCING CARBOXYLIC ESTER A carboxylic ester production catalyst which has higher catalytic activity. The catalyst, which is used for producing a carboxylic ester by reacting oxygen, an aldehyde, and an alcohol or (b) by reacting oxygen with one or more alcohols,...
WO/2002/098851	DERIVATIVES 0F N,S-SUBSTITUTIONS N'-1 [(HETERO)ARYL] ALKYL-N'-[HETERO) ARYL] METHYL ISOTHIOUREAS, METHOD FOR PRODUCING SALTS AND BASES THEREOF, PHYSIOLOGICALLY ACTIVE N,S-SUBSTITUTIONS N'-1 [(HETERO)ARYL] ALKYL-N'-[HETERO) ARYL] METHYL ISOTHIOUREAS, A PHARMACEUTICAL COMPOSITION AND CURING METHOD The inventive derivatives of N,S-substitutions N'-1 [(hetero)aryl] alkyl-N'-[hetero) aryl] methyl isothioureas including bases and salts thereof with pharmacologically acceptable acids and individual optical isomers of said compositions ...
WO/2002/096424	HETEREOCYCLIC BETA-AMINOACIDS AND THEIR USE AS ANTI-EPILEPTOGENIC AGENTS A method for preventing or treating epileptogenesis-associated diseases comprising the administration of a $g(b)-heterocyclic-$g(b)-aminoacid to a subject is disclosed. The disease can be for example head trauma, pain, stroke, anxiety, s...
WO/2002/096858	CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS There is provided novel cinnamide derivatives of Formula I wherein R is C¿1-4? alkyl or trifluoromethyl, R?1¿ is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chrom...
WO/2002/096864	CARBOXAMIDE-SUBSTITUTED PHENYLUREA DERIVATIVES AND METHOD FOR PRODUCTION THEREOF AS MEDICAMENTS The invention relates to carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments, physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), in w...
WO/2002/089782	DIOXANES AND USES THEREOF In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, w...
WO/2002/087723	REACTOR FOR GAS/LIQUID OR GAS/LIQUID/SOLID REACTIONS The invention relates to a reactor (1) for gas/liquid or gas/liquid/solid reactions comprising a vertical longitudinal axis, a feed inlet (2) for a liquid or liquid/solid educt stream in the upper area of the reactor and for a gaseous st...
WO/2002/083661	GLYCOLIDE PRODUCTION PROCESS, AND GLYCOLIC ACID OLIGOMER FOR GLYCOLIDE PRODUCTION The invention relates to a glycolide production process wherein a depolymerization reaction system comprising a glycolic acid oligomer or a glycolic acid oligomer and a polar organic solvent is heated to depolymerize the glycolic acid ol...
WO/2002/079124	METHOD OF PRODUCING HIGH YIELD ALDITOL ACETALS WITH MINERAL ACIDS AND SURFACTANTS This invention relates to a process for preparing alditol acetals, such as dibenzylidene sorbitols, monobenzylidene sorbitols, and the like, through the reaction of unsubstituted or substituted benzaldehydes with alditols (such as sorbit...
WO/2002/079143	N-PHENPROPYLCYCLOPENTYL-SUBSTITUTED GLUTARAMIDE DERIVATIVES AS NEP INHIBITORS FOR FSAD The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R?1¿ is optionally substituted C¿1-6?alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C¿1-...
WO/2002/080161	OPTICAL DATA CARRIER THAT CONTAINS A MEROCYANINE DYE AS THE LIGHT-ABSORBING COMPOUND IN THE INFORMATION LAYER The invention relates to an optical data carrier that contains a preferably transparent substrate that is optionally already coated with one or more reflective layers, onto whose surface an information layer which can be written on with ...

Matches 551 - 600 out of 3,521	< 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 >