Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 551 - 600 out of 3,567

Document Document Title
WO/2003/091238
A catalyst and depolymerization conditions for efficiently converting a lactic acid polymer into a lactide having a high optical purity. These are used for the purpose of, e.g., subjecting a waste high-molecular lactic acid polymer to ch...  
WO/2003/089424
Methods for preparation of cyclic alkylene carbonates which include a six-membered ring as part of their chemical structure are disclosed. According to the present invention, an oxide, alkoxide, or carboxylate salt of a metal selected fr...  
WO/2003/087034
The invention relates to 3-aminophenol derivatives of formula (I) or to their physiologically compatible, water-soluble salts, wherein R1 is identical to a radical of formula (II) or to a radical of formula (III), and to dyes that contai...  
WO/2003/086288
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...  
WO/2003/086673
A method and a device for removing harmful substances capable of safely processing the harmful substances and improving a processing efficiency, the device comprising a harmful substance separating and extracting device (10) for storing ...  
WO/2003/085002
Cyclodextrins cross-linked by reaction with organic carbonates and the use thereof as agents capable or removing pollutants from fluids of various origin, in particular from contaminated waters.  
WO/2003/082205
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...  
WO/2003/082850
The present invention relates to the field of perfumery. More particularly, it concerns an aldoxane derivative of Formula (I) capable of protecting an active aldehyde R¿1?CHO, for example a perfumery or flavor aldehyde, from a chemicall...  
WO/2003/082205
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...  
WO/2003/083063
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affi...  
WO/2003/080564
This invention is directed to menthol-substituted compounds and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention...  
WO/2003/078417
A process for formation of N-aryl piperazines with chiral side-chains having the structure shown in formula below, and for making intermediate compounds therefor: (Formula I). In this process, chirality is introduced at the piperazine ri...  
WO/2003/078409
Carboxylic acid compounds represented by the following general formula (I) (wherein each symbol is as defined in the description) and drugs containing these compounds: (I) Because of binding to DP receptor and antagonizing the same, the ...  
WO/2003/078420
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula (I) wherein R, Ar, and Q are defined as set forth herein, and inter...  
WO/2003/076374
A process for producing a compound (I) which comprises the step of reacting a compound (II) with a base in an aprotic solvent as shown by the scheme: (II) (I) wherein R1 and R2 each independently represents lower alkyl.  
WO/2003/076405
The present invention relates to monocyclic aroylpyridinones, processes for their preparation, and their use in medicaments, especially for the treatment of COPD: (formula I).  
WO/2003/074467
The present invention provides HIV aspartyl protease inhibitors of the formula (I): and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N...  
WO/2003/072537
Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the ...  
WO/2003/070713
The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not ad...  
WO/2003/070676
A process for easily producing from an inexpensive material an optically active 3-halo-1,2-propanediol derivative useful as an intermediate for medicines. The process comprises reacting 2-chloroallyl alcohol, which is easily available at...  
WO/2003/070719
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and&sol or improved recognition domains are disclosed, including methods of preparing and utilizing the same.  
WO/2003/070714
The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals...  
WO/2003/064408
The present invention relates to an improved process for the preparation of ethyl 2,3-dihydrobenzo[1,4]dioxin-2-carboxylate. More particularly the present invention provides a process for the preparation of ethyl 2,3-dihydrobenzo[1,4]dio...  
WO/2003/059874
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeuticall...  
WO/2003/059901
The invention relates to a process for the conversion of group X in a 2−6(−substituted)−1,3−dioxane−4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylatin...  
WO/2003/057254
Preventives/remedies for urinary disturbance containing a compound having both of an acetylcholine esterase inhibitory effect and an &agr 1 antagonistic effect which exhibits an excellent effect of improving the urinary function of the b...  
WO/2003/055873
The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R?1-2¿, R?13-16¿ and R are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined ef...  
WO/2003/053949
The invention relates to C1-C6 fragments of epothilones and to an efficient method for producing such fragments and the derivatives thereof.  
WO/2003/053950
The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β -hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in ...  
WO/2003/053951
A method of synthesizing trimethylene carbonate is disclosed involving (a) reacting 1,3-propanediol and a compound chosen from phosgene and bis-chloroformates to form a polycarbonate intermediate having a specified structural formula; an...  
WO/2003/053952
A method of synthesizing trimethylene carbonate, which includes the steps of reacting 1,3-propanediol and phosgene in vapor form, providing a combination of temperature and pressure at which trimethylene carbonate is in its vapor phase, ...  
WO/2003/051824
&agr -Cyanoacrylates of the formula (I), where: R1 is ORa wherein Ra is hydrogen, substituted alkyl, branched alkyl, branched alkenyl, cycloloalkyl, heterocyclyl, aryl, phenylalkyl or alkyl­imino; is NRbRc wherein Rb is hydrogen, alkyl ...  
WO/2003/049702
Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.  
WO/2003/048109
Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.  
WO/2003/048117
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a -S(O)z(C1-C4)Alk wherein z is 0, 1 or 2, a -NHSO2(C1-C4)Alk, -SO2NH(C1-C4)Alk, -NHSO2-(C1-C4...  
WO/2003/046086
Azo compounds of formula (I), wherein X stands for halogen, in particular for chlorine, or C1−C4alkoxy, in particular for methoxy, Y stands for −CH2− or −O−, R1 and R2, independently from each other, stand for hydrogen, C1−C8...  
WO/2003/044065
Disclosed is a method for the production of optionally coupled, non-blocking polymers based on conjugated dienes and optionally monovinyl aromatic compounds by anionic polmerization in an inert organic solvent in the presence of a lithiu...  
WO/2003/042167
The invention relates to $g(a)-oxygenated or $g(a)-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitu...  
WO/2003/042160
The invention provides novel β2 adrenergic receptor agonist compounds of Formula (I). WhereinR1 is methoxy or ethoxy, and R2 is hydrogen or phenyl; or R1 is hydrogen, and R2 is phenyl; and R3 is -CH2OH or -NHCHO, and R4 is hydrogen; or ...  
WO/2003/041728
The invention relates to phenyl−propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3...  
WO/2003/042164
The invention provides novel $g(b)¿2? adrenergic receptor agonist compounds of formula (I): wherein R?1¿-R?13¿ and w have any of the values described in the specification. The invention also provides pharmaceutical compositions compri...  
WO/2003/042168
The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...  
WO/2003/040074
A compound of formula (I) or a dimer thereof; where R?1¿ and R?2¿ are independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, a functional group or a group of sub-formul...  
WO/2003/040096
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...  
WO/2003/030937
Preventives and&sol or remedies for diseases, which are induced, worsened or made to recrudesce by stressors, comprising mitochondrial benzodiazepine receptor (MBR) antagonists such as compounds represented by the following general formu...  
WO/2003/029184
A diaryl ether derivative having excellent immunosuppressive activity and reduced in side effects. The diaryl ether derivative is represented by the general formula (1): (1) &lcub e.g., 2−amino−2−[4−(3−benzyloxyphenoxy)−2−c...  
WO/2003/029195
Acetonides of a ß−keto ester compound, ß−hydroxyacid compound, and 1,3−diol derivative respectively represented by the following formulae (I), (V), and (VIII): (I) (V) (VIII) (wherein the symbols are the same as defined in the de...  
WO/2003/027092
The separation of diastereomeric 1,3−diols, or the corresponding 1,3−diol acetals, or syn− and anti 1,3−diols of general formula (I) or (II), is conventionally only achieved with high technical complexity and loss of desired prod...  
WO/2003/027059
Acid amide derivatives represented by the formula (I) (I) [wherein A is phenyl optionally substituted by X, benzyl optionally substituted by X, naphthyl optionally substituted by X, a heterocyclic group optionally substituted by X, a fus...  
WO/2003/024953
A medicine containing as the active ingredient either a novel propanolamine derivative having a 1,4−benzodioxane ring or a pharmacologically acceptable salt thereof. (I) The compound is represented by the above formula (wherein R1 to R...  

Matches 551 - 600 out of 3,567