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Matches 551 - 600 out of 7,044

Document Document Title
WO/2005/033093A1
7,8-Bicyclic-chroman derivatives of Formula I, wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neu...  
WO/2005/032544A1
The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitoch...  
WO/2005/033092A1
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I, wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by...  
WO2005012179A3
This invention is to provide supercritical water or subcritical water with which chemical substances, in particular, harmful organic substances difficult to decompose, such as p-dichlorobenzene and PCB, can be oxidized into harmless subs...  
WO/2005/030694A1
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2005/030705A1
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2004062590A3
The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tu...  
WO/2005/030704A1
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2004014871A8
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2005/030213A1
Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions con...  
WO2004073606A3
The present invention is directed to a compound of Formula (I):, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferat...  
WO2004041161A3
The present invention is directed to compounds of the formula (I) (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<27>, R<28>, R<29>, R<30>, R<31>, X, m, n and the dashed line are defined herein) which are u...  
WO/2005/023793A2
The present invention provides for the simplified, direct synthesis of di-heteroatom containing cyclic organic compounds by forming an aqueous mixture of material of the formula (I); wherein X and Y are heteroatoms which may be the same ...  
WO2004110418A3
Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anem...  
WO/2005/019159A1
A process for producing corresponding &agr -aminooxyketones in high yield and with high enantioselectivity, that is, a process for the production of optically active &agr -aminooxyketone derivatives represented by the general formula (1)...  
WO/2005/019192A1
The invention relates to novel urea derivatives which inhibit tyrosinkinases, especially TIE-2, and Raf kinases and which are used in the treatment of tumors.  
WO/2005/016862A1
A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting car...  
WO/2005/013928A1
The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.  
WO/2005/014539A2
HMGCo-A reductase inhibitor compounds of formula (I) useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compo...  
WO/2005/012179A2
This invention is to provide supercritical water or subcritical water with which chemical substances, in particular, harmful organic substances difficult to decompose, such as p-dichlorobenzene and PCB, can be oxidized into harmless subs...  
WO/2005/012284A1
A 4,5-dihydronaphtho[1,2-b]thiophene derivative represented by the formula (1) (wherein R1 represents C1-10 1-hydroxyalkyl or C1-10 acyl, and R2 and R3 are separately bonded in respective positions selected among the 6-, 7-, 8-, and 9-po...  
WO/2005/012228A1
The invention relates to novel o ptical recording materials that comprise specific and in some cases novel diketone enamines or metal chelates thereof and that have excellent recording and playback quality especially ata wavelength of 35...  
WO2004077511A3
The present invention provides novel (meth)acrylic and (meth)acrylamide monomers and polymers produced from those monomers. The monomers of the invention each include only a single vinyl functionality and at least one non-vinyl functiona...  
WO/2005/012280A1
The present invention is related to alkynyl aryl carboxamides of Formula (I’) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders mediated by insulin resistance or hypergl...  
WO/2005/009104A2
The present invention is directed to hepatocyte nuclear factor 4a (HNF-4a) receptor modulator compounds. This invention is also directed to pharmaceutical compositions containing such compounds as well as methods of using such compounds ...  
WO/2005/009985A1
A method for producing trimethylene carbonate poly(trimethylene carbonate which comprises (a) introducing liquid poly(trimethylene carbonate) and an optional catalyst into a wiped film evaporator reactor under a vacuum 15 kPa or less, sa...  
WO/2005/009984A1
An acetal of formula (I) is disclosed, whereby the groups R1 to R6, independently = H, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl or tert.-butyl, n = 0 or 1 and, in the location of a dotted line between two C atom...  
WO/2005/007621A2
This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides f...  
WO/2005/000233A2
The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases ...  
WO/2005/000832A1
By using a charge-transporting thin film which is made of a charge-transporting varnish containing, as an electron-acceptor material, a 1,4-benzodioxane sulfonic acid compound represented by the formula (1) below especially in an OLED de...  
WO/2004/113314A1
The present invention relates to optically active dihydroxy hexanoate derivatives, boronate esters of formula (IIa) which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastat...  
WO/2004/110418A2
Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anem...  
WO/2004/108697A1
The invention relates to protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid esters and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid esters for synthesizing epothilones and derivatives thereof, and to methods for producing...  
WO/2004/108733A1
Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, each X is methylene, and Y is 0, or wherein R is H, each X is 0 and Y is methylene, and solvates thereof are disclosed. Also disclosed...  
WO2004078144A3
The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering...  
WO2004092106A3
Process for preparing alkoxy- and aryloxy-phenols, comprising oxidizing the ketone of formula (I) with peracids to give the corresponding ester of formula (II) which is then hydrolysed to give the corresponding aryloxy- or alkoxy-phenol.  
WO/2004/103560A1
The present invention concerns a catalytic composition comprising a catalyst effective for catalysing asymmetric hydrogenation reactions, which catalyst requires acid activation, an acidic material effective for activating the catalyst, ...  
WO/2004/101483A1
A novel compound for overcoming diseases including diabetes, obesity and neuroses such as nerve damage, Alzheimer and Parkinson's disease; and a medical agent comprising the same. In particular, there are provided a compound of the follo...  
WO/2004/099173A1
Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are usef...  
WO2004052919A3
Novel PDF inhibitors and novel methods for their use are provided.  
WO2004080377A3
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.  
WO2004080379A3
The invention relates to extracts of Pangium edule, advantageously from seeds, and lignanes of formula I. The invention also relates to the use thereof as a medicament which inhibits cathepsins or which has an antinecrotic effect.  
WO/2004/092106A2
Process for preparing alkoxy- and aryloxy-phenols, comprising oxidizing the ketone of formula (I) with peracids to give the corresponding ester of formula (II) which is then hydrolysed to give the corresponding aryloxy- or alkoxy-phenol.  
WO/2004/089927A1
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases o...  
WO2004046105A3
Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihy...  
WO/2004/083153A1
A process for production of an allyl and/or methallyl ether of a tri or polyhydric alcohol is disclosed. Said process comprises (i) subjecting at least one cyclic formal of a tri or polyhydric alcohol to allylation, (ii) subjecting obtai...  
WO2004050613A3
This invention provides 2-substituted-propenamide derivatives and their compositions for the treament of hepatitis B virus and/or hepatitis D virus.  
WO/2004/080947A1
A compound represented by the following general formula (I), its salt, its solvate or its N-oxide or prodrugs thereof: (I) wherein R1 and R2 represent each an optionally substituted cyclic group, etc.; W is a spacer having from 1 to 6 ca...  
WO/2004/080377A2
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.  
WO/2004/080379A2
The invention relates to extracts of Pangium edule, advantageously from seeds, and lignanes of formula I. The invention also relates to the use thereof as a medicament which inhibits cathepsins or which has an antinecrotic effect.  

Matches 551 - 600 out of 7,044