Heterocyclic Compounds

Matches 851 - 900 out of 5,848	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >

Document	Document Title
WO/2003/042167A1	NOVEL $g(a)-OXYGENATED OR $g(a)-THIOLATED CARBOXYLIC ACID PENETHYLAMIDE DERIVATIVES The invention relates to $g(a)-oxygenated or $g(a)-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitu...
WO/2003/040096A2	N, N'−SUBSTITUTED−1,3−DIAMINO−2−HYDROXYPROPANE DERIVATIVES Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
WO/2003/040074A1	LIQUID CRYSTALLINE COMPOUNDS CONTAINING A BIPHENYL CORE A compound of formula (I) or a dimer thereof; where R?1¿ and R?2¿ are independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, a functional group or a group of sub-formul...
WO/2003/030937A1	REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS Preventives and&sol or remedies for diseases, which are induced, worsened or made to recrudesce by stressors, comprising mitochondrial benzodiazepine receptor (MBR) antagonists such as compounds represented by the following general formu...
WO/2003/029184A1	DIARYL ETHER DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT A diaryl ether derivative having excellent immunosuppressive activity and reduced in side effects. The diaryl ether derivative is represented by the general formula (1): (1) &lcub e.g., 2−amino−2−[4−(3−benzyloxyphenoxy)−2−c...
WO/2003/029195A1	INTERMEDIATES FOR EPOTHILONE DERIVATIVE AND PROCESS FOR PRODUCING THESE Acetonides of a ß−keto ester compound, ß−hydroxyacid compound, and 1,3−diol derivative respectively represented by the following formulae (I), (V), and (VIII): (I) (V) (VIII) (wherein the symbols are the same as defined in the de...
WO/2003/027092A1	METHOD FOR THE SEPARATION OF DIASTEREOMERIC 1,3−DIOL ACETALS The separation of diastereomeric 1,3−diols, or the corresponding 1,3−diol acetals, or syn− and anti 1,3−diols of general formula (I) or (II), is conventionally only achieved with high technical complexity and loss of desired prod...
WO/2003/027059A1	ACID AMIDE DERIVATIVES, PROCESS FOR PRODUCING THESE, AND PEST CONTROL AGENT CONTAINING THESE Acid amide derivatives represented by the formula (I) (I) [wherein A is phenyl optionally substituted by X, benzyl optionally substituted by X, naphthyl optionally substituted by X, a heterocyclic group optionally substituted by X, a fus...
WO/2003/024448A2	INHIBITORS OF HISTONE DEACETYLASE The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...
WO/2003/024955A2	SMALL MOLECULE INHIBITORS OF CASPASES The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...
WO/2003/024953A1	PROPANOLAMINE DERIVATIVE HAVING 1,4−BENZODIOXANE RING A medicine containing as the active ingredient either a novel propanolamine derivative having a 1,4−benzodioxane ring or a pharmacologically acceptable salt thereof. (I) The compound is represented by the above formula (wherein R1 to R...
WO/2003/024441A1	NOVEL USE OF TRICYCLIC COMPOUND A medicinal composition which exasperates apo AI expression as a remedy for circulatory diseases based on the HDL function enhancement. It is an apo AI expression accelerator which contains a compound represented by the formula (I), a pr...
WO/2003/022801A1	REVERSE HYDROXAMIC ACID DERIVATIVES Reverse hydroxamic acid derivatives having specific structures represented by the general formula (Ia): (Ia) (wherein A represents hydrogen, etc.&semi Ar1 represents arylene, etc.&semi Ar2 represents optionally substituted aryl, heteroar...
WO/2003/020688A1	SELECTIVE PROTEIN TYROSINE PHOSPHATASE INHIBITORS Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the c...
WO/2003/018523A1	PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOPROPANEDIOL DERIVATIVE A process for easily producing from an inexpensive material an optically active halopropanediol derivative which is useful as an intermediate for medicines. An inexpensively available propargyl alcohol derivative is reacted with a hypoha...
WO/2003/018555A1	PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES A process for the preparation of compounds of formula (I) wherein R¿1? is unsubstituted or substituted C¿1?-C¿8?alkyl, R¿2?, R¿3?, R¿4? and R¿5? are each independently of the others hydrogen, unsubstituted or substituted C¿1?-C¿...
WO/2003/014063A2	PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONE AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to novel protected 3.5-dihydroxy-2.2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and to a method for the production and e use of said novel compounds in the production of epothilones or ep...
WO/2003/013502A1	COMPOUNDS WHICH MIMIC THE CHEMICAL AND BIOLOGICAL PROPERTIES OF DISCODERMOLIDE Compounds which mimic the chemical and/or biological activity of discodermolide are provided.
WO/2003/014068A1	PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilone and epothilone derivatives and a method for producing said novel intermediate products in the synthesis and the use thereof in the product...
WO/2003/014064A1	NAPHTHYLUREA AND NAPHTHYLACETAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS Naphthylurea and naphthylacetamide derivatives of formula (I) which have vanilloid receptor 1 (VR1) antagonistic activity are disclosed, formula (I) wherein Y represents formula (II) and formula (III) and the variables Q, X, R6, R7, R8, ...
WO/2003/009850A1	SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, ...
WO/2003/010157A1	DIOXANE DERIVATIVES AND A PROCESS FOR THEIR PREPARATION The present invention relates to novel antidiabetic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs and pharmaceutically acceptable compositions containing them. More particularl...
WO/2003/007956A1	TREATMENT FOR ATTENTION-DEFICIT HYPERACTIVITY DISORDER A method for treating Attention Deficit/Hyperactivity Disorder (ADHD) in humans and the symptoms associated therewith, inattentiveness, and hyperactivity with impulsivity, using eltoprazine and related compounds is provided.
WO/2003/008399A1	SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
WO/2003/006423A1	N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and ot...
WO/2003/004459A2	PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS A process is provided for the preparation of a compound of Formula (1) wherein: R?1¿ is H, optionally substituted acyl, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl: R² and R³ each ind...
WO/2003/004480A2	SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are us...
WO2002062777A9	AMINO CERAMIDE-LIKE COMPOUNDS AND THERAPEUTIC METHODS OF USE Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present inve...
WO/2003/002524A2	UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY The present invention relates to compounds of the formula I, in which R?1¿, R?2¿, R?4¿, R?5¿, D¿1?, D¿2?, X¿1?, X¿2?, X¿3?, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacol...
WO/2003/002519A1	PHENOL DERIVATIVES AND THEIR USE IN MEDICAMENTS The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.
WO/2003/000181A2	DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such ...
WO/2003/000646A1	SUBSTITUTED AROMATIC ETHERS AS INHIBITORS OF GLYCINE TRANSPORT This invention relates to a series of substituted aromatic ethers of the formula (I), wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptabl...
WO/2002/100822A1	SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medic...
WO/2002/098558A1	CATALYST FOR CARBOXYLIC ESTER PRODUCTION AND PROCESS FOR PRODUCING CARBOXYLIC ESTER A carboxylic ester production catalyst which has higher catalytic activity. The catalyst, which is used for producing a carboxylic ester by reacting oxygen, an aldehyde, and an alcohol or (b) by reacting oxygen with one or more alcohols,...
WO/2002/098832A1	CF¿2?O-BRIDGED, AXIALLY SUBSTITUTED CYCLOHEXANE DERIVATIVES. The invention relates to CF¿2?O-bridged cyclohexane derivatives, in particular compounds of formula (I), R1-(-A1-Z1-)k1-Q-CF2O-A2-(-Z3-A3-)K3-R2, wherein Q represents group (a); W?1¿, W?2¿ represent -CH¿2?- and/or -0- independently f...
WO/2002/098849A2	HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER’S DISEASE AND SIMILAR DISEASES Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...
WO/2002/098851A1	DERIVATIVES 0F N,S-SUBSTITUTIONS N'-1 [(HETERO)ARYL] ALKYL-N'-[HETERO) ARYL] METHYL ISOTHIOUREAS, METHOD FOR PRODUCING SALTS AND BASES THEREOF, PHYSIOLOGICALLY ACTIVE N,S-SUBSTITUTIONS N'-1 [(HETERO)ARYL] ALKYL-N'-[HETERO) ARYL] METHYL ISOTHIOUREAS, A PHARMACEUTICAL COMPOSITION AND CURING METHOD The inventive derivatives of N,S-substitutions N'-1 [(hetero)aryl] alkyl-N'-[hetero) aryl] methyl isothioureas including bases and salts thereof with pharmacologically acceptable acids and individual optical isomers of said compositions ...
WO/2002/099077A2	METHODS AND COMPOSITIONS RELATED TO TAGGING OF MEMBRANE SURFACE PROTEINS The invention relates to methods and reagents for selectively labeling membrane surface proteins using a labeling agent. The label may be used to isolate preparations of membrane surface proteins. Preparations of membrane surface protein...
WO/2002/098854A2	PROCESS FOR PREPARING CHIRAL DIOL SULFONES AND DIHYDROXY ACID HMG COA REDUCTASE INHIBITORS A process is provided for preparing chiral diol sulfones of the structure (I) where R¿3? is preferably (II) or (III) where R¿4a? is preferably aryl such as phenyl, and R¿1a? is preferably alkyl such as t-butyl, which are intermediates...
WO/2002/096864A1	CARBOXAMIDE-SUBSTITUTED PHENYLUREA DERIVATIVES AND METHOD FOR PRODUCTION THEREOF AS MEDICAMENTS The invention relates to carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments, physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), in w...
WO/2002/096424A1	HETEREOCYCLIC BETA-AMINOACIDS AND THEIR USE AS ANTI-EPILEPTOGENIC AGENTS A method for preventing or treating epileptogenesis-associated diseases comprising the administration of a $g(b)-heterocyclic-$g(b)-aminoacid to a subject is disclosed. The disease can be for example head trauma, pain, stroke, anxiety, s...
WO/2002/096858A1	CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS There is provided novel cinnamide derivatives of Formula I wherein R is C¿1-4? alkyl or trifluoromethyl, R?1¿ is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chrom...
WO/2002/089782A2	DIOXANES AND USES THEREOF In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, w...
WO/2002/087723A1	REACTOR FOR GAS/LIQUID OR GAS/LIQUID/SOLID REACTIONS The invention relates to a reactor (1) for gas/liquid or gas/liquid/solid reactions comprising a vertical longitudinal axis, a feed inlet (2) for a liquid or liquid/solid educt stream in the upper area of the reactor and for a gaseous st...
WO/2002/083661A1	GLYCOLIDE PRODUCTION PROCESS, AND GLYCOLIC ACID OLIGOMER FOR GLYCOLIDE PRODUCTION The invention relates to a glycolide production process wherein a depolymerization reaction system comprising a glycolic acid oligomer or a glycolic acid oligomer and a polar organic solvent is heated to depolymerize the glycolic acid ol...
WO/2002/079124A2	METHOD OF PRODUCING HIGH YIELD ALDITOL ACETALS WITH MINERAL ACIDS AND SURFACTANTS This invention relates to a process for preparing alditol acetals, such as dibenzylidene sorbitols, monobenzylidene sorbitols, and the like, through the reaction of unsubstituted or substituted benzaldehydes with alditols (such as sorbit...
WO/2002/080161A2	OPTICAL DATA CARRIER THAT CONTAINS A MEROCYANINE DYE AS THE LIGHT-ABSORBING COMPOUND IN THE INFORMATION LAYER The invention relates to an optical data carrier that contains a preferably transparent substrate that is optionally already coated with one or more reflective layers, onto whose surface an information layer which can be written on with ...
WO/2002/079143A1	N-PHENPROPYLCYCLOPENTYL-SUBSTITUTED GLUTARAMIDE DERIVATIVES AS NEP INHIBITORS FOR FSAD The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R?1¿ is optionally substituted C¿1-6?alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C¿1-...
WO/2002/076964A1	DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME The invention relates to compounds having formula (I). Said compounds have an affinity for bradykinin receptors with a selectivity for B¿1? receptors and they can be used to prepare medicaments that are intended to treat or prevent pers...
WO/2002/076972A1	NOVEL DIOXIN ANALOGUES AND METHODS AND KITS FOR SEARCHING OUT DIOXIN-DECOMPOSING ORGANISMS OR EMZYMES OR DIOXIN-DECOPOSING ENZYME GENES Novel compounds for searching out dioxin-decomposing organisms or the like easily and simply. Specifically, novel dioxin analogues of formulae (1) and (2).

Matches 851 - 900 out of 5,848	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >