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Matches 51 - 100 out of 7,615

Document Document Title
WO/2016/078505A1
Provided is a preparation method of a fluorene ethyl ketone derivative, particularly a preparation method of a compound of formula I, each group being as defined in the specification. The compound can be used as an intermediate in the pr...  
WO/2016/074324A1
Provided is a preparation method of 2-((4R, 6S)-6-bromomethyl-2, 2-dimethyl-1, 3-dioxane-4-yl)acetate (I). Such compound is a key chiral intermediate in preparing a statins lipid-lowering drugs. The method comprises: carrying out a bromi...  
WO/2016/070708A1
Disclosed is a fluorinated liquid crystal containing a difluoromethoxy (CF2O) bridge bond and a composition thereof as well as the preparation method and use thereof. In the method of the present invention, difluoro dibromomethane is use...  
WO/2016/056031A1
The patent discloses novel diol derivatives of general formula I, [Formula should be inserted here] A chiral pool process for the synthesis of the compound of formula I from D glucose. Further, it discloses a process for the synthesis of...  
WO/2016/046843A1
Novel methods for preparation of Carfilzomib and intermediates thereof with high stereo selection are reported. The synthetic procedures result in substantially pure Carfilzomib (I).  
WO/2016/028959A1
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V) and/or a salt thereof, wherein R1 is OH or OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as ...  
WO/2016/008411A1
Disclosed are compounds of Formula (I), pharmaceutical compositions comprising the same, processes for the preparation thereof, and the use thereof.  
WO/2016/001885A3
The present application relates to the solid state forms of Eliglustat hemitartrate and the processes for the preparation thereof. The application further provides solid dispersion of Eliglustat hemitartrate having Eliglustat hemitartrat...  
WO/2015/195656A3
Methods of making compounds of Formula (I) are disclosed.  
WO/2015/184256A2
The present invention provides, in part, a biodegradable compound of formula I, and sub- formulas thereof:Formula (I) or a pharmaceutically acceptable salt thereof, where each X independently is O or S, each Y independently is O or S, an...  
WO/2015/175984A1
Described herein are compounds which can be used in topical liquids, creams, or other dosage forms such as solids, for reducing intraocular pressure, treating glaucoma, growing hair, treating wounds, or other medical and/or cosmetic uses.  
WO/2015/168998A1
The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, ...  
WO/2015/160641A2
The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical composit...  
WO/2015/155230A1
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...  
WO/2015/156580A2
The present invention relates to a novel organic compound and an organic electroluminescent element comprising same. The organic compound according to the present invention is used for the organic layer(s) of an organic electroluminescen...  
WO/2015/156580A3
The present invention relates to a novel organic compound and an organic electroluminescent element comprising same. The organic compound according to the present invention is used for the organic layer(s) of an organic electroluminescen...  
WO/2015/141765A1
 The purpose of the present invention is to provide novel compounds useful in the production of salacinol and a method for producing these compounds, a method for producing salacinol, methods for protecting and deprotecting a diol grou...  
WO/2015/138969A1
Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subjec...  
WO/2015/134923A1
A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.  
WO/2015/116786A1
In one aspect, the invention relates to compounds having the formula (I): where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another asp...  
WO/2015/107548A1
The present invention relates to a novel synthetic route for the preparation of fingolimod and its pharmaceutically acceptable salts. The synthetic strategy comprises reaction of 2-(4- octylphenyl)-acetaldehyde with nitro acetonide, and ...  
WO/2015/109080A1
Potent opioid receptor antagonists and there use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed.  
WO/2015/102448A1
The present invention relates to a hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide. The hybrid anticancer prodrug according to the present invention sequentially releases quinone methide and cinnamal...  
WO/2015/099438A1
The present invention relates to a novel compound and an organic electroluminescent element including the same. The compound, according to the present invention, is used for a compound for an organic matter layer of the organic electrolu...  
WO/2015/091499A1
The present invention relates to six-membered cyclic biscarbonates of formula (I), wherein: - A is selected from the group consisting of -CH=CH- and -CH2CHR'-S-R-S-CHR''CH2-, wherein R is a linear or branched alkylene radical in C2-C6, o...  
WO/2015/095346A1
This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cation...  
WO/2015/089137A1
The present invention is directed to acylguanidines which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPHl), that are useful in the treatment of diseases or disorders associated with peripheral serotonin inclu...  
WO/2015/088272A1
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/086614A1
Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i) Depolymerizing polylactide into its corresponding dimeric cyclic esters by heating the pol...  
WO/2015/088272A9
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/086494A1
The invention relates to a method for quantification of the amount of impurities in lactide. Said method is characterized in that the quantification of the impurities is based on measurements performed on absorptions in the near Infra-Re...  
WO/2015/080402A1
The present invention relates to a method for producing lactide comprising an evaporation concentration step (first step) for a lactic acid solution, a lactic acid oligomerization step (second step) and a lactic acid oligomer depolymeriz...  
WO/2015/080675A1
The present invention relates to a molecular weight enhancing agent of polyester comprising amido alkylidene malonate, a process for enhancing molecular weight and polyester obtained from the molecular weight enhancing agent. The molecul...  
WO/2015/075981A1
In order to provide a method for producing a carbonyl compound with an improved yield, the present invention produces a carbonyl compound represented by general formula (I) by removing the carbonylalkoxy from a compound represented by ge...  
WO/2015/067532A1
Cyclic carbonate azide having a structure according to the following formula (A) wherein R1-R5 are independently selected from the group consisting of hydrogen, C6-20 aryl, C7-36 aralkyl, and C1-30 alkyl groups; said aryl, aralkyl, and a...  
WO/2015/059679A1
The present invention provides an improved process for the preparation of eliglustat to salts thereof. Present invention also provides a crystalline eliglustat free base form R1.  
WO/2015/051525A1
The present invention concerns a process for preparing cyclic acetal or ketal by reacting a carbonyl compound (a) with a polyol (b), wherein said carbonyl compound (a) and polyol (b) are forming a biphasic liquid system when mixed togeth...  
WO/2015/049535A1
The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to t...  
WO/2015/049940A1
The present invention relates to a compound having a 2,6-difluorophenyl ether structure, which is useful as an organic electronic material or a medicinal or agrochemical agent, particularly a material for liquid crystal display elements....  
WO/2015/048692A1
The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising ...  
WO/2015/042397A1
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associat...  
WO/2015/032622A1
An improved process for preparing Carfilzomib of Formula 13 is provided, as well as novel compounds that can be used as intermediates in the process for preparing Carfilzomib.  
WO/2015/034820A1
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowin...  
WO/2015/030189A1
Provided is a compound which exhibits bone formation acceleration activity (and/or bone resorption suppression activity). The compound is either a compound having a general formula (I) (wherein the substituents are as defined in the desc...  
WO/2015/014326A3
The present invention relates to a modified oligoester constituted by an oligoester (1) that, at one of the ends thereof has a group that reacts with organic acids or alcohols, forming covalent bonds, and at one or more of the other ends...  
WO/2015/016815A1
Antiperspirant and/or deodorant compositions containing lactic acid oligomers. The lactic acid oligomers provide a long lasting protection.  
WO/2015/012156A1
The present invention pertains to compounds having a 2,6-difluorophenyl ether structure useful as an organic electronic material, or a medical or agricultural chemical, and particularly as a material for liquid crystal display elements; ...  
WO/2015/009061A1
The present invention relates to a polyketone polymerization catalyst and, more specifically, to: a novel polyketone polymerization catalyst, which is prepared by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2 -methox...  
WO/2014/202168A1
Compounds of the formula I in which R1, R4, R6, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, card...  
WO/2014/203045A1
The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -b...  

Matches 51 - 100 out of 7,615