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Matches 401 - 450 out of 3,567

Document Document Title
WO/2006/001318
Disclosed are a compound represented by the formula (I) below, prodrugs thereof, pharmaceutically acceptable salts of those and solvates of those. (I) (In the formula, R1 represents an ethyl which may be substituted by a halogen or an am...  
WO/2006/002361
The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the ...  
WO/2005/123710
The invention relates to the derivatives of the benzoylcyclohexandiones of formula (I), wherein R1 and R2 represent different groups and Het represents a saturated heterocyclic group containing oxygen and carbon atoms, and to their use a...  
WO/2005/123712
The invention relates to a method for the synthesis of compounds of general formula (1), (2), (3), (4). Said method consists of converting formulae (5) and (6) in the presence of formula (7), wherein R = substituted or unsubstituted alky...  
WO/2005/123089
Disclosed herein are carbonyl compounds of Formula (I) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous sys...  
WO/2005/123668
The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another ...  
WO/2005/121157
The present invention provides a compound represented by the formula (I): wherein ring A is void or a benzene ring optionally having substituent(s), R1 and R2 are each independently a phenyl group optionally having substituent(s), a cycl...  
WO/2005/118566
A method for producing a 1,3-dioxolan-4,6-dione compound from a ketone compound and a malonic acid, the method comprising: precipitating a 1,3-dioxolan-4,6-dione compound as a crystal from a mixed solvent comprising a first organic solve...  
WO/2005/118530
Disclosed are novel triketone compounds, a method for producing those, and an excellent herbicide containing those. Specifically disclosed are triketone compound represented by the formula (I) below or salts thereof. (I) [In the formula,...  
WO/2005/116119
A compound represented by the formula (I) defined herein, and a process producing the compound represented by the formula (I) which comprises reacting the compound represented by the formula (III) defined herein with the compound represe...  
WO/2005/115972
Compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are ...  
WO/2005/113527
The present invention relates to novel tetrahydronaphthylpiperazines derivatives, that are compounds of the formula (I) wherein R1, R2 and R6 are as defined herein, X is CH2 or O, A is a group of the formula (G1, G2, G2a, G3, G4, G5 or G...  
WO/2005/111134
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2005/111134
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2005/108479
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2005/108338
The present invention is directed to novel compounds according to formulae (I) wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease trea...  
WO/2005/105744
This invention is directed to a compound of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or conditi...  
WO/2005/105776
Compounds of the formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defined herein as well as compositions comprising these compounds and uses of the s...  
WO/2005/105775
For chemical recycling of polylactic acid or derivatives thereof or resin compositions containing them, there is provided a method of efficiently recovering or producing a lactide of high optical purity through depolymerization of polyla...  
WO/2005/100308
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl ace...  
WO/2005/100301
The present invention relates to certain 2-aryloxyethyl glycine derivatives that exhibit activity as inhibitors of the glycine type-1 transporter, to pharmaceutical compositions containing them and to their use in the treatment of neurol...  
WO/2005/100345
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and ...  
WO/2005/097773
The present invention is related to carboxylic acids of Formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and...  
WO/2005/094805
A medicine having prostaglandin D2 (PGD2) production inhibitory activity and having as an active ingredient a substance selected from compounds represented by the general formula (I): A-Y-B &lcub wherein A and B each independently repres...  
WO/2005/095343
The invention relates to compounds of formula (I), Z-C(R1R2)-C(R3NH2)-C(R4R5)-X-N(R6R7), wherein Z, R1-7 and X have the meaning as cited in the description and the claims. Said compounds are useful as DPP-lV inhibitors. The invention als...  
WO/2005/095378
The present invention is directed to carboxylic acid and ester moieties that are attached to a carbon chain that is between 2 and 24 carbons in length wherein, the chain contains at least one dioxanone ring system, said dioxanone being f...  
WO/2005/087236
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.  
WO/2005/083102
It is intended to provide a novel process for producing an optically active 1,4-benzodioxin-2-carboxylic acid derivative, which is usable as an intermediate in synthesizing an optically active drug, via biological conversion. Namely, a 6...  
WO/2005/082842
A compound (II), compound (IV), compound (VI), and compound (VII); and processes for producing these. Also provided is a process for producing the compound (X) which comprises the steps of (II)→(IV)→(VI)→(VII)→(X).  
WO/2005/080322
A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly...  
WO/2005/079378
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.  
WO/2005/077943
The present invention discloses novel compounds of formula (I) and their pharmaceutically useful compositions as modulators of PPAR ligands  
WO/2005/077882
A chain or cyclic oligolactate having an aminoethyl, hydroxyethyl, or carboxymethyl group in a side chain. A chain oligolactate having an aminoethyl, hydroxyethyl, or carboxymethyl group in a side chain is synthesized first. This chain o...  
WO/2005/077943
The present invention discloses novel compounds of formula (I) and their pharmaceutically useful compositions as modulators of PPAR ligands  
WO/2005/077868
The invention relates to congeneric, halogenated, fluorinated, aromatic compounds (I), (II), (IIIa) or (IIIb), (IV), (V), (VI) or (VII), in which A and B represent phenyl groups, L represents an oxygen atom, sulphur atom or an alkene gro...  
WO/2005/075451
Disclosed is a highly reliable material for organic electroluminescent devices which has high luminance and high luminous efficiency, hardly deteriorates in emission, and is excellent in use and storage at high temperatures. Also disclos...  
WO/2005/075401
The invention relates to a method for producing 2,5-dimethylphenyl acetic acid by reacting p-xylol with chloroacetyl chloride to form 2-chloro-1-(2,5-dimethylphenyl) ethanone, which reacts with the compound of formula (II) to form the co...  
WO/2005/072681
N-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndrom...  
WO/2005/070885
bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndr...  
WO/2005/060456
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2005/060456
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2005/061459
The present invention relates to biaryl sulfonamides of the formula 1: wherein: R1 is H or Cl-.C6 a]kyl; R2 is H, C I -C6 alkyl, (CH2)nR2' , phenyl, or benzyl; n is 0-6; R2'is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, in...  
WO/2005/056509
The present case relates to a process for the purification of lactide from a crude lactide vapour product stream which process comprises a rectification/condensation step leading to a lactide-enriched condensate.  
WO/2005/051895
Disclosed are &dgr -amino-&gammad -hydroxy-&ohgr -aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and ...  
WO/2005/046683
Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals in...  
WO/2005/047249
The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula (I) wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaceutical compositi...  
WO/2005/042513
There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected...  
WO/2005/040138
This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one o...  
WO/2005/040355
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity ...  
WO/2005/040127
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPAR&gammad ) and alpha (PPAR&agr ), processes of preparing the same, and pharmaceutical compositions contain...  

Matches 401 - 450 out of 3,567