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Matches 101 - 150 out of 1,401

Document Document Title
WO/2007/123736A2
In one aspect, the invention relates to processes for producing substantially free-flowing shapes of macrocyclic oligoester, wherein the freshly-shaped macrocyclic oligoester is maintained at elevated temperature for a sufficient time. I...  
WO/2007/117180A1
The invention relates to novel azaheterocycles of interest as potential physiologically active substances (agonists, antagonists, receptor modulators, ferment inhibitors, oncolytics, antibacterial and antiparasitic agent etc.), to combin...  
WO/2007/110415A2
The invention relates to a cosmetic or therapeutic use of one or more compounds having formula (I) wherein R denotes hydrogen, an alkyl group having 1 to 32 C atoms or an acyl group having 1 to 20 C atoms, for the lightening of skin and/...  
WO/2007/089310A1
The invention provides a compound having a structural formula (I): X-Ī±-Y, wherein X is an moiety that binds to the Rif pocket of a bacterial RNA polymerase, Y is a moiety that binds to the secondary channel of a bacterial RNA polymerase...  
WO/2007/009201A3
The invention refers to a process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of parti...  
WO/2007/050380A3
The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET...  
WO/2006/067466A3
The present invention pertains to certain pyrazines and pyridines, and dervatives thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the f...  
WO/2006/074147A3
Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontroll...  
WO/2007/057658A1
The present invention relates to a process for preparing arylated or vinylated olefins.  
WO/2007/047306A1
The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal depositi...  
WO/2007/039105A1
The invention relates to chiral compounds, methods of their preparation, and to their use in optical, electrooptical, electronic, semiconducting or luminescent components or devices, and in decorative, security, and cosmetic or diagnosti...  
WO/2007/039104A1
The invention relates to ch'iral binaphthol derivatives, methods of their preparation, and to their use in optical, electrooptical, electronic, semiconducting or luminescent components or devices, and in decorative, security, cosmetic or...  
WO/2005/111134A3
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2007/009388A1
Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing them and the use thereof are disclosed. The artemisinin derivatives have the structure as following(formula I): These compounds ...  
WO/2007/009201A2
The invention refers to a process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of parti...  
WO2005108479A3
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2006/128126A1
The present invention relates to methods for the conversion of amorpha-4,11-diene to artemisinin and various artemisinin precursors.  
WO2006061372A3
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention...  
WO/2006/123726A1
A pharmaceutical composition comprising (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmacologically acceptable salt thereof and (b) vitamin D or a vitamin D derivative or a pharmacologically acceptable salt thereof; a therapeutic a...  
WO2006036941A3
Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ...  
WO/2006/098308A1
An anthranilic acid derivative represented by the general formula below or a salt thereof: wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a phenyl, cycloalkyl or bicyclic heterocyclic group which may...  
WO/2006/095020A1
Compounds of the general formula (I) in which the meanings of the substituents R1 and R2 are as stated in claim 1, have renin-inhibiting properties and can be used as medicines.  
WO/2006/092403A1
Disclosed is a continuous method for producing a dioxirane in a liquid phase in a reactor by oxidizing a ketone with a solution containing active oxygen in the presence of a buffer substance and stripping out the contained dioxirane with...  
WO/2006/092623A1
A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group -(CH2)...  
WO2006004774A3
Laulimalide analogues useful as microtubule stabilizing agents, and in the treatment of abnormal cell proliferation, are disclosed. Methods of making the compounds, as well as methods of using such compounds in treating abnormal cell pro...  
WO/2006/081771A1
The invention provides a artemisine derivative of the following formula I, its preparation method and use, as well as a pharmaceutical composition containing such artemisine derivative and its use. The artemisinin derivatives of the pres...  
WO2005060456A8
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2006/067466A2
The present invention pertains to certain pyrazines and pyridines, and dervatives thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the f...  
WO2006039383A3
Chiral synthesis from an achiral starting material by chiral diamineĀ­mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.  
WO/2006/061372A2
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention...  
WO/2006/010082A1
In general, the present invention relates to compounds capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and meth...  
WO/2006/007436A1
The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.  
WO/2006/007435A1
The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical composlons containing them and their use in the treatment of epilepsy and related disorders.  
WO2005062811A3
One aspect of the present invention relates to a method of preparing allylic carboxylate compounds comprising the step of contacting a compound comprising an allylic hydrogen atom with a carboxylic acid in the presence of palladium, a su...  
WO/2006/001494A1
A compound represented by the general formula (II), (II) which is a key intermediate for the production of optically active citalopram, or a salt of the compound. Also provided is optically active citalopram produced via the compound.  
WO/2005/117849A1
The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds - diarylalkanes and/or diarylalkanols within those ...  
WO/2005/115972A1
Compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are ...  
WO/2005/116007A1
The invention relates to novel 7,7-disubstituted derivatives of (5H,9H)-6,8-dioxabenzocycloheptene, the preparation methods thereof and the use of same as intermediates in the synthesis of non-steroidal derivatives of vitamin D.  
WO2005060456A3
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  
WO/2005/111134A2
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2005/108479A2
An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. ...  
WO/2005/100333A1
Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved...  
WO/2005/100308A1
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl ace...  
WO2005049562A3
Compositions that include compounds capable of producing a cooling sensory effect such as certain hydroxy-ketones and hydroxy-aldehyde compounds, their cyclic semi-ketals and semiacetals, and other derivatives thereof. The compounds impa...  
WO/2005/092328A1
A more potent therapeutic agent for hyperlipemia. It contains a compound having FXR activity and represented by the following formula (1) or (2).  
WO/2005/087236A1
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.  
WO2005044130A9
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula (I): wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, n...  
WO2004074810A3
Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula (I) is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is indep...  
WO/2005/062811A2
One aspect of the present invention relates to a method of preparing allylic carboxylate compounds comprising the step of contacting a compound comprising an allylic hydrogen atom with a carboxylic acid in the presence of palladium, a su...  
WO/2005/060456A2
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The a...  

Matches 101 - 150 out of 1,401