Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 1,330

Document Document Title
WO/2018/006031A1
The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditi...  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/191282A1
The present invention regards new adipate-type compounds suitable as an intermediate in organic chemistry, a platform chemical for the production of other chemicals, and as a monomer and co-monomer useful for the preparation of polymers ...  
WO/2017/177004A8
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation ...  
WO/2017/177026A1
In alternative embodiments, provided are methods for: modifying circadian rhythmicity or timing in a mammal, treating psychiatric conditions or symptoms due to alterations in a human circadian regulatory system, treating sleep problems i...  
WO/2017/177004A1
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation o...  
WO/2017/173105A1
Reagents for stabilizing the nucleic acids of a biological cell, compositions, kits and methods of use thereof are described. The stabilization reagents may prepare the nucleic acids within the biological cell for storage and preserve th...  
WO/2017/158404A1
This invention relates to an improved method for preparing alkylenedioxybenzene compounds of Formula I, from the corresponding ortho-dihydroxy aromatic compound of Formula II wherein n is 0, 1, 2 or 3; and R1 and R2 independently represe...  
WO/2017/148874A1
The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for...  
WO/2017/130191A1
The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes, and com...  
WO/2017/116949A1
This disclosure relates to macrocyclic picolinamides of Formula (I) and their use as fungicides.  
WO/2017/096559A1
The present invention relates to the production of xylene derivatives from furfural and its derivatives. The invention describes new routes for converting furfural and its derivatives into xylene derivatives including novel intermediates.  
WO/2017/003188A1
The present invention relates to: a novel compound which has an outstanding luminescent ability; and an organic electroluminescent element having improved properties including high luminous efficiency, low drive voltage and long lifespan...  
WO/2016/201214A1
The present invention relates to compounds which have been discovered to be potent ligands (inhibitors) of human GLUT5 (glucose transporter type 5), a facilitative glucose transporter that transports fructose, and their use as ligands as...  
WO/2016/104630A1
The present invention pertains to: a condensed heterocyclic compound having an inhibitory effect on enteropeptidase, the condensed heterocyclic compound being useful in the treatment or prevention of obesity, diabetes, and the like; and ...  
WO/2016/097569A1
The invention relates to novel fragrant compounds having animalic or ambergris notes, without any woody characteristic. More specifically, the invention relates to novel acetal derivatives of 1-(3,3-dimethylcyclohex-1-enyl) ethanone of g...  
WO/2016/069370A1
This disclosure relates to macrocyclic picolinamides of formula (I) and their use as fungicides.  
WO/2016/013877A3
The present invention relates to a novel methanocyclopenta[e][1,3]dioxepin-7-yl 3,4-dihydroxybenzoate derivative (KS534) represented below as the Chemical Formula 1, the pharmaceutically acceptable salt or solvates thereof, a composition...  
WO/2016/013877A2
The present invention relates to a novel (3R,5S,5aS,6R,7S,8R,8aS)-8-chloro-8a-hydroxy-5-(2-hydroxy acetoxy) hexahydro-1H-3,6-methanocyclopenta[e][1,3]dioxepin-7-yl 3,4-dihydroxybenzoate (KS534), the isomer thereof, the pharmaceutically a...  
WO/2016/008904A1
The present invention relates to a method for purifying raw γ-butyrolactone that comprises at least one of the compounds 3-tetrahydrofuran-2-yl-propan-1-ol or 1,3-dioxepan-2-yl-methanol.  
WO/2016/007525A1
The present disclosure relates to the use of a compound of Formula I as a seed treatment to prevent or control plant diseases.  
WO/2016/007529A1
This disclosure relates to macrocyclic picolinamides of Formula (I) described herein, wherein X, Y, R1 and R2 are as defined herein and to their use as fungicides in a formulation comprising a phytologically acceptable carrier. Also prov...  
WO/2016/007531A1
This disclosure relates to macrocyclic picolinamides of Formula (I), wherein X, Y, R1 and R2 are as defined herein and to their use as fungicides in a formulation comprising a phytologically acceptable carrier. The compounds of Formula (...  
WO/2015/175978A1
The application relates to macrocyclic compounds and related polymers, as well as to processes for synthesizing them, e.g., using olefins as starting material.  
WO/2015/155230A1
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...  
WO/2015/155593A1
The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal ato...  
WO/2015/127011A1
Systems and methods for determining whether a cancer patient may respond to inhibition of RNA polymerase II as a treatment for the patient are provided. Inhibition of RNA polymerase II may be by way of chemotherapy with an agent such as ...  
WO/2015/112016A1
The present invention relates to a cycloaddition process comprising the step of reacting a halogenated aliphatic 1,3-dipole compound with a (hetero)cycloalkyne according to Formula (1): Preferably, the (hetero)cycloalkyne according to Fo...  
WO/2014/180556A1
The present invention relates to arylpiperazines, and to the efficient treatment of an individual afflicted with L-DOPA-induced dyskinesia, which condition typically arises as a consequence of long-term treatment with L-DOPA therapy in P...  
WO/2014/110491A1
Prodrugs of treprostinil are provided which can be used in the treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable...  
WO/2014/097952A1
Provided is a chiral compound having considerable helical twisting power, a low melting point, and good solubility with other liquid-crystal compounds. Also provided is a liquid-crystal compound composed of the chiral compound of the pre...  
WO/2014/085491A3
Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease. Embodiments of the present invention are directed to compositions having utility as therapeutics in neurodegenerat...  
WO/2013/191778A9
Cavitand compositions that comprise void spaces are disclosed. The void spaces may be empty, which means that voids are free of guest molecules or atoms, or the void spaces may comprise guest molecules or atoms that are normally in their...  
WO/2013/191778A3
Cavitand compositions that comprise void spaces are disclosed. The void spaces may be empty, which means that voids are free of guest molecules or atoms, or the void spaces may comprise guest molecules or atoms that are normally in their...  
WO/2013/169662A2
The invention relates to macrocyclic picolinamides of Formula (I) and their use as fungicides.  
WO/2013/140969A1
The present invention is a photoresist composition which contains [A] a polymer that has a structural unit (I) containing an acid-cleavable group and a compound (I) that is represented by formula (1). In formula (1), each of R1, R2, R3 a...  
WO/2013/122582A1
A dioxirane-containing compound has a first substituent that is an alkyl, polyalkoxy, aryl, heleroaryl, or heterocyclyl group, and a second substituent that is an electron withdrawing group, and where the first and second substituents ca...  
WO/2013/093320A1
The invention relates to the use of 1-aryl-2-aryloxyethane compounds with formula I, wherein n and m are equal to 0 or 1, provided that n+m=1, R1 and R2 particularly representing hydrogen atoms, R3 and R4 particularly representing hydrog...  
WO/2013/068042A1
The present invention relates to the preparation of cyclopropane derivatives, in particular 2- amino-9-[[(1S,2R)-1,2- bis(hydroxymethyl) cyclopropyl] methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyc...  
WO/2013/034756A1
The present invention relates to a compound of formula (I), wherein R1 and R2 are independently selected from (a) C1 to C6 alkyl; C2 to C6 alkenyl; C2 to C6 alkynyl; substituted or unsubstituted heterocycloalkyl or cycloalkyl, substituen...  
WO/2013/013240A2
Compounds and compositions, which can be use for example, for treating cancer, are described herein.  
WO/2013/013240A3
Compounds and compositions, which can be use for example, for treating cancer, are described herein.  
WO/2012/151142A2
Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these comp...  
WO/2012/151142A3
Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these comp...  
WO/2012/138254A3
The invention relates to medicine and pharmacology. The novel 4,4'-biphenylamide derivatives are pharmacologically active and can be used as new effective allosteric modulators of АМРА receptors for treating Alzheimer's, Parkinson's ...  
WO/2012/138776A1
The present invention relates to compounds of formula I or II, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diab...  
WO/2012/096934A3
Methods for preventing or treating retroviral infection, such as human immunodeficiency virus, in vivo utilize transcriptional inhibitory compounds. These include cortistatin A and analogs of the cortistatin family.  
WO/2012/078147A1
A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.  
WO/2012/070015A9
The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other act...  
WO/2012/070015A1
The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other act...  

Matches 1 - 50 out of 1,330