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WO/2005/012281A1 |
This invention relates to benzo[1,3]oxathiol-2-ones, derivatives, and precursors thereof, and their use as neuroprotective agents in the treatment and prevention of neuronal disorders of the central and peripheral nervous systems.
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WO/2005/009981A1 |
The invention relates to surface-functionalized support materials, respectively comprising a polymer surface and at least one linker compound which is bonded to said surface in a covalent manner, as well as to the production and use ther...
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WO/2005/004799A2 |
The invention provides novel non-β-lactam inhibitors of β-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with β-lactam antibiotics to bacteria...
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WO/2004/108129A1 |
It is intended to provide an inhibitor of the invasion of bone marrow-origin vascular stem cells or inflammatory cells into vessel wall, a blood vessel restenosis inhibitor and a preventive or a remedy for angitis or carditis, each conta...
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WO/2004/103989A1 |
The invention relates to a process for the preparation of endosulfan enriched in the ß-isomer thereof (ß-endosulfan). The invention also provides a process for enriching the ß-isomer content of a mixture of a- and ß-endosulfan, and t...
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WO/2004/089927A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases o...
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WO/2004/072023A2 |
The invention relates to the novel oxathiin carboxamide of formula (I), wherein G1, G2, G3, n, R1, R2, R3, R4, R5 and Z are defined as in the description. The invention also relates to several methods for producing these substances and t...
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WO/2004/063173A1 |
A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.
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WO/2004/058723A1 |
A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R1 is hydrogen, formyl, CO-C1-4 alkyl, COO-C1-4 alkyl, C1-4 alkoxy(C1-4)alkylene, CO-C1-4 alkylenoxy(C1-4)alkyl, propargyl or a...
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WO/2004/054982A1 |
Disclosed are novel biphenylcarboxamides of formula (I), wherein R, Z, X, Y, m, n, and A have the meanings indicated in the description, several methods for producing said substances, the use thereof for controlling undesired microorgani...
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WO/2004/055000A1 |
Compounds of formula (I): [where: R1 is a direct bond, oxygen, a group >CH2, sulphur, a group >C=O, a group-(CH2)2- or a group-N-Ra, where Ra is hydrogen or alkyl; R3, R4, R5 and R6 are hydrogen or substituents&agr ; R8, R9, R10 and R11 ...
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WO/2004/045557A2 |
The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can a...
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WO/2004/035589A1 |
The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that t...
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WO/2004/018410A1 |
A novel agricultural chemical, especially an insecticide or acaricide; and a substituted benzanilide compound represented by the general formula (1): (1) G-7 G-13 G-71 [wherein G represents a ring represented by G-7, G-13, G-71, etc.; W1...
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WO/2004/007476A1 |
The invention relates to 5-thiapethilones and 15-disubstituted epothilones according to formula I (I) with the following meanings: X= >C = O or >S = O R1 = C1-6 alkyl or C2-6 alkenyl R2 = H or C1-6 alkyl Y - Z = >C=C< or >C-O-C< (epoxide...
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WO/2004/007483A1 |
The invention relates to novel macrocycles of general formula (1) and to the use thereof in the treatment of cancer diseases.
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WO/2004/007492A1 |
The present invention relates to new Macrocycles of Formula (I), and their use for the treatment of cancer.
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WO/2003/104199A2 |
This invention relates to organic catalysts comprising iminium or oxaziridinium moieties, cleaning compositions comprising such catalysts; and processes for making and using such catalysts and cleaning products.
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WO/2003/099804A1 |
The invention relates to novel oxathiincarboxamides of formula (I) wherein R, R1 and m have the designations cited in the description, to a plurality of methods for producing said substances, and to the use of the same for controlling un...
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WO/2003/091239A1 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2003/086388A1 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2003/087073A1 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2003/078409A1 |
Carboxylic acid compounds represented by the following general formula (I) (wherein each symbol is as defined in the description) and drugs containing these compounds: (I) Because of binding to DP receptor and antagonizing the same, the ...
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WO/2003/074491A1 |
A compound of formula (I): F1 Het is a 5− or 6−membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R4, R5 and R6&semi R1 ...
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WO/2003/061651A1 |
The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of...
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WO/2003/051865A1 |
The invention relates to 1,3,2-dioxathian-2-ones with an exocyclic double bond in the 5-position as in formula (I), a method for production of said dioxathianones and use thereof as synthetic component for the production of compounds of ...
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WO/2003/043960A2 |
A purification method is disclosed for a predetermined water-insoluble extractant present in a liquid phase composition that additionally contains one or more additional extractants, synthesis reaction starting materials, and reaction by...
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WO/2003/040096A2 |
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
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WO/2003/040080A2 |
This invention is directed to lipoxin A¿4? analogs of the following formulas (I) and (II), wherein R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in ...
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WO/2003/031431A1 |
The present formula application describes novel cyclic sulfone derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, X, U?a¿, X?a¿, Y?a¿, Z?a¿, R?1¿, R?2¿, R?b¿ and q are defined in ...
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WO/2003/018029A1 |
Compounds of the structure I are useful for treating bacterial growth. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such com...
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WO/2003/002557A1 |
Asymmetric compounds of formula (I): [in which: R?1¿, R?2¿ and R?3¿ each represents a direct bond, an oxygen atom, a group >CH¿2?, a sulphur atom, a group >C=O or a group (CH¿2?)¿2?-; R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10Â...
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WO/2002/102796A1 |
A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, compris...
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WO/2002/085884A1 |
A process for the stereoselective preparation of insecticide 6,7,8,9,10,10-hexahalo-1,5,5a,6,9,9a-hexahydro-6,9-methano-2
,4,3-benzodioxathiepin-3-oxide of general formula (I), wherein X is a halogen such as fluorine, chlorine or bromine...
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WO/2002/081464A1 |
The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R�1? and R�2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hyd...
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WO2001057015A9 |
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into op...
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WO/2002/057211A1 |
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is al...
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WO2002042250B1 |
The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydrxoybutanoic acid and of its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues,...
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WO/2002/039816A1 |
The present inventors have found that the contrasting chemical, physical and environmental characteristics of alpha and beta endosulfan provide an opportunity to formulate an effective endosulfan formulation with lower risk to the enviro...
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WO/2002/032377A2 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2002/032373A2 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2002/018333A1 |
A compound of general formula (I) wherein R?1¿ and R?2¿ are H, C¿1?-C¿6?alkyl or (CH¿2?)¿d?(C¿3?-C¿6?cycloalkyl) wherein d = 0, 1, 2 or 3; or R?1¿ and R?2¿ together with the nitrogen to which they are attached from an azetidine...
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WO/2002/008197A1 |
The invention relates to novel biphenyl carboxamides of formula (I), wherein A, R, Z, X, Y, m and n have the meanings given in the description, to multiple methods for producing these substances, to their use for combating unwanted micro...
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WO/2001/051479A2 |
The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X = O, (CH¿2?)¿m?, S, SO, SO¿2?, NH, NR¿8? or ...
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WO/2001/049275A2 |
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...
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WO/2001/042226A1 |
The present invention relates to a compound of formula (I) wherein R?1¿ is an unsubstituted or substituted hydrocarbon radical having a total of 1 to 10 carbon atoms, preferably 1 to 6 carbon atoms, R?2¿ is an unsubstituted or substitu...
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WO/2001/040214A1 |
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or improved recognition domains are disclosed, including methods of preparing and utilizing the same.
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WO/2001/018008A2 |
The invention relates to decahydronaphthalene derivatives of general formula (1) wherein A is a CH or CH¿2? radical, R¿1? is a receptor group, R¿2? is an effector group and n denotes 1 or 2. The inventive compounds are utilized for mo...
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WO/2001/005742A1 |
The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A¿1? an...
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WO/2001/004124A1 |
This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharm...
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