Heterocyclic Compounds

Matches 301 - 350 out of 1,336	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1996/022987A1	PROCESS FOR THE PREPARATION OF 1-(THIOMETHYL)-CYCLOPROPANEACETIC ACID The present invention provides a novel process for the preparation of 1,1-cyclopropanedimethanonl cyclic sulfite which comprises: (a) contacting 1,1-cyclopropanedimethanol with dialkylsulfite in the presence of a base; and (b) removing f...
WO/1996/019471A1	POLYMERISABLE MONOMERS AND POLYMERS Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R1 and ...
WO/1996/015792A1	CERTAIN SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES Disclosed are compounds of formula (I), or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independ...
WO/1996/016052A2	CERTAIN SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES Disclosed are compounds of formula (I), wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; o...
WO/1996/012716A1	NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF According to the present invention, nucleoside derivatives represented by formula (I), wherein: R1 represents hydrogen, phosphate or phosphonate group, R2 represents substituted or unsubstituted pyrimidine or purine base, and Z represent...
WO/1996/008458A1	METHOD OF MAKING 1,1-BIS-(4-HYDROXYPHENYL)-3,3,5-TRIMETHYLCYCLOHEXANE This invention provides a unique method of producing 1,1-bis-(4-hydroxyphenyl)-3,3,5-trimethylcyclohexane ("BPTMC"). The disclosed method manufactures BPTMC from ketals and hemithioketals of 3,3,5-trimethylcyclohexanone ("TMC"). The reac...
WO/1995/033745A2	NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY Novel compounds are provided which are useful for the regulation of gene expression by retinoids; these compounds are represented by structural formula (I), wherein the substituents R1 through R5 are as defined herein. Additional compoun...
WO/1995/032200A1	OXATHIOLANES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME The present invention pertains to the field of organic chemistry, and particularly therapeutic chemistry. The invention provides cis-form 5-(cytosinyl-1) 1,3-oxathiolanes of general formula (I), wherein R is an acyl or aralkoyl radical, ...
WO/1995/029925A1	THIOETHER COMPOUNDS FOR USE IN PREPARING BIFUNCTIONAL CHELATING AGENTS FOR THERAPEUTIC RADIOPHARMACEUTICALS A compound consisting essentially of a multidentade ligand including at least two thioether groups for being complexed to Rhodium-105 in specific activities that are sufficiently high for use in formulating therapeutic 105Rh-radiopharmac...
WO/1995/029174A1	PROCESS FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES A diastereoselective process for the preparation of compounds of formula (I), wherein W is S, S=O, SO2, or O; X is S, S=O, SO2, or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof, is ...
WO/1995/024379A1	BENZAMIDE ANALOGS, USEFUL AS PARP (ADP-RIBOSYLTRANSFERASE, ADPRT) DNA REPAIR ENZYME INHIBITORS A range of 3-oxybenzamide compounds (I) and related quinazolinone compounds (II) are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can pr...
WO/1995/015958A1	COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the com...
WO/1995/014928A1	METAL CHELATE CONTAINING COMPOSITIONS FOR USE IN CHEMILUMINESCENT ASSAYS Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium in at least a hexacoordinated state and (b) a compound hav...
WO/1995/013262A1	SUBSTITUTED PHENYL COMPOUNDS Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q(CO2R6 or OH), -CN, -C(R7)=NOR8, NO2, -O(lower alkyl)R9, -CC-R10, -CR11=C(R12)(R13), -C(=O)CH2C(=O)CO2H, -CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, c...
WO/1995/006631A1	POLYCYCLIC ARTHROPODICIDES Arthropodicidal compounds, compositions and use of compounds having Formula (I), wherein A is selected from the group H, CN, C1-C6 alkyl, C1-C6 haloalkyl and halogen; E is selected from the group H, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 al...
WO/1994/026943A1	PROCESS FOR REMOVING, SEPARATING, AND CONCENTRATING METALS A method for the removal, separation, and concentration of alkali metal, alkaline earth metal, Pb and/or Tl cations from a source solution which may contain larger concentrations of other ions which comprises bringing the source solution...
WO/1994/019344A1	AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...
WO/1994/015608A1	HIV PROTEASE INHIBITORS HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that cont...
WO/1994/015906A1	HIV PROTEASE INHIBITORS AND THEIR PREPARATION HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that cont...
WO/1994/015920A1	BENZANILIDE DERIVATIVES AS 5-HT1D-ANTAGONISTS Compounds of formula (I) and salts and solvates (eg hydrates) thereof, in which R1 represents a hydrogen atom, a halogen atom, C1-6alkyl or C1-6alkoxy; R2a and R2b each represents H, a halogen atom, C1-6alkoxy, hydroxy or C1-6alkyl; R3 r...
WO/1994/014802A1	PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The inventi...
WO/1994/014792A1	NOVEL RING OPENING MONOMERS Compounds of formula (1), wherein: R1 and R2 are independently selected from the group comprising hydrogen, C1 to C6 alkyl, C1 to C6 haloalkyl, phenyl, and substituted phenyl; X is selected from the group comprising sulfur, sulphone, dis...
WO/1994/012880A2	RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...
WO/1994/010127A1	TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS Tartronic acid acetalic ethers and esters thereof of general formula (I), wherein the substituents have the meanings defined in the disclosure, are useful in the treatment of bones dysmetabolism.
WO/1994/009793A1	ENANTIOMERICALLY PURE beta-D-DIOXOLANE NUCLEOSIDES WITH SELECTIVE ANTI-HEPATITIS B VIRUS ACTIVITY The invention is a method for the treatment of humans infected with HBV that includes administering an HBV treatment amount of an enatiomerically pure beta-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2 or H, and...
WO/1994/006790A1	2,4-DIARYL-1,3-DITHIOLANES; 2,4-DIARYL-1,3-DIOXOLANES; 2,4-DIARYL-1,3-OXATHIOLANES; AND 2,5-DIARYL-1,3-OXATHIOLANES AS PAF RECEPTOR ANTGONISTS AND INHIBITORS OF 5-LIPOXYGENASE 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of po...
WO/1994/004154A1	ENANTIOMERICALLY PURE beta-D-DIOXOLANE-NUCLEOSIDES A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure beta-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, ...
WO/1993/025223A1	RXR HOMODIMER FORMATION The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...
WO/1993/016800A1	CATALYTIC SOLUTION A catalyst solution comprising one or more compounds of a metal catalyst and an organic solvent selected from the group consisting of a glycol derivative, an alkyl pyrrolidone, and an alkoxy ethyl ether, wherein no additional chloride co...
WO/1993/012754A2	TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
WO/1993/011122A1	PIPERAZINE DERIVATIVES AS 5-HT1A ANTAGONISTS Compounds of formula (I) where A is a C1 or C2 alkylene chain optionally substituted by lower alkyl, Z is a bicyclic oxygen-containing radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl), R is hydrogen or lower alkyl, R1 is aryl or aryl(lowe...
WO/1993/001199A1	CHIRAL PHOSPHOLANES VIA CHIRAL 1,4-DIOL CYCLIC SULFATES This invention relates to novel chiral 1,4-diol cyclic sulfates and their use as precursors in the preparation of chiral phospholane ligands, and chiral complexes useful as catalysts for carrying out enantioselective reactions.
WO/1992/020670A1	NEW CHIRAL SULPHATES PREPARATION THEREOF AND UTILIZATION IN THE SYNTHESIS OF PHARMACEUTICAL PRODUCTS The invention relates, to the isomers (R) and (S) of sulphate of chloromethyl-1 ethylene, their preparation and their utilization particularly in the synthesis of adrenergic (S)-beta-blockers or the synthesis of L-carnitine or phospholip...
WO/1992/020669A1	PROCESSES FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
WO/1992/020696A1	PROCESSES FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
WO/1992/014729A1	ANTIVIRAL 1,3-DIOXOLANE NUCLEOSIDES AND SYNTHESIS THEREOF A synthesis of 1,3-dioxolane nucleosides that includes condensing a 2-O-protected-5-O-acylated-1,3-dioxolane with a purine or pyrimidine base in the presence of a titanium containing Lewis acid to provide predominately the desired $g(b)-...
WO/1992/014743A2	ANTIVIRAL ACTIVITY AND RESOLUTION OF 2-HYDROXYMETHYL-5-(5-FLUOROCYTOSIN-1-YL)-1,3-OXATHIOLANE A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable deriva...
WO/1992/012222A1	LUBRICANT ADDUCTS AND THEIR PREPARATION Alkylated diphenyl ethers, alkylated diphenyl methanes, alkylated phenoxathins and alkylated diphenyl sulfides are high-temperature stable lubricant fluids having excellent low temperature viscometrics, and excellent additive solubility....
WO/1992/011254A1	HETEROCYCLIC PESTICIDAL COMPOUNDS The present invention describes a method for controlling pests which comprises contacting the pest with a pesticidally effective amount of a compound of formula (I) which contains between 8 and 30 carbon atoms, and wherein Y is oxygen or...
WO/1992/010496A1	ENANTIOMERICALLY PURE $g(b)-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES An asymmetric process for the preparation of enantiomerically pure $g(b)-L-(-)-1,3-oxathiolane-nucleosides that includes the initial preparation of the key chiral intermediates (2R,5R) and (2R,5S)-5-(O-protected)-2-(protected-oxymethyl)-...
WO/1992/010497A1	ENANTIOMERICALLY PURE beta-D-(-)-DIOXOLANE-NUCLEOSIDES An asymmetric process for the preparation of enantiomerically pure beta-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared rac...
WO/1992/004897A1	1-SUBSTITUTED PHENOXATHIIN DERIVATIVES AS ANTIDEPRESSANTS Compounds of formula (I), wherein R?4¿ is hydrogen and either R?5¿ is hydrogen and R?6¿ is hydroxyl or R?5¿, R?6¿ and the carbon to which they are attached together form a carbonyl group; or R?6¿ is hydrogen and R?4¿ and R?5¿ tog...
WO/1992/003131A1	USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which t...
WO/1992/000975A1	METHOD FOR PREPARING CYCLIC SULPHATES A method for preparing cyclic sulphates having general formula (I), wherein sulphuric anhydride and an alkylene oxide are simultaneously added to the dioxane. In general formula (I), R1, R2, R3 and R4 are the same or different and are a ...
WO/1991/019725A2	HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS Heterocyclic anthracyclinone and anthracycline derivatives are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, CNS cancer and me...
WO/1991/017151A1	NEW PHARMACOLOGICALLY ACTIVE CATECHOL DERIVATIVES Compounds of formula (I), wherein R�1? is an electronegative substituent such as nitro, halogeno or cyano group and R�2? is a group selected from (Ia) and (Ib), wherein R is hydrogen, or an alkyl, cycloalkyl, aralkyl or aryl group, w...
WO/1991/011186A1	METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF BCH-189 AND RELATED COMPOUNDS The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation...
WO/1991/010659A1	OXATHIANE DERIVATIVES Oxathiane derivatives of formula (I) in which R represents alkyl and A represents optionally substituted phenyl or a heteroaromatic group containing 1 or 2 nitrogen atoms optionally substituted by alkyl, alkoxy or halogen, and salts ther...
WO/1991/009851A1	1,3,2-DIOXATHIOLANE OXIDE DERIVATIVE A 1,3,2-dioxathiolane oxide derivative of general formula (I) wherein x represents -S(O)- or -S(O)�2?-; R?1� represents hydrogen, alkali metal atom, benzyl or lower alkyl; R?2� represents lower alkyl which may be substituted by met...
WO/1991/005761A1	TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...

Matches 301 - 350 out of 1,336	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >