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Matches 201 - 250 out of 579

Document Document Title
JPWO2004052849A1
本発明は、式〔I〕〔式中、Qは次の群から 選ばれる基を表し、R1,R4〜R15は水 素原子、アルキル基等を、R2,R3はアル キル基、ヘテロ環またはR2とR3が一...  
JP1999263764A5  
JPWO2004024142A1
抗腫瘍剤などの医薬品として有用な一般式( I)[式中、R1、R2、R3およびR4は 同一または異なって、水素原子、ヒドロキシ 、置換もしくは非置換の低級アルキルな...  
JP2005539088A
The present invention is an effective amount of formulas I. : It is related with the medical treatment method of the morbid obstacle which has susceptibility in steroid hormone nuclear receptor regulation including medicating the patient...  
JP2005289949A
To provide a method for simply preparing a ketone compound in high yield at high purity.In preparing a ketone compound such as 2-(10,11-dihydro-10-oxydibenzo[b,f]thiepin-2-yl)propionic acid by the Friedel-Crafts reaction type intramolecu...  
JP2005247778A
To provide a method for producing dibenzothiepinpropionic acid derivative having antiinflammatory and analgesic actions in an practically industrial scale by using a recyclable condensing agent in no use of polyphosphoric acid as a conde...  
JP2005526827A
The present invention 1-, 3-チアベンゾナフト azulene derivative or its salt that can be offered pharmaceutically, and a solvation thing, It is related with prevention of these production methods, these intermediate fields for man...  
JP3701878B2
To provide amino group substituted bicyclic compounds which are useful as a PGD2 antagonist. The compound is useful as a PGD2 antagonist represented by formula I [wherein the group (II) represents group (III), group (IV) and group (V)] a...  
JP2005521653A
チエピン tip sodium simultaneous dependence bile-acid-transport (ASBT) inhibitor is indicated together with the tablet composite containing the directions for use and the compound of the same thing for treating the production method ...  
JP2005518338A
The present invention relates to separation of エナンチオマー of the racemic compound of formula (I). This separation is carried out by applying the target racemic compound to continuation エナンチオ selection chromatography,...  
JP2005518347A
1 fluoridation and 2 fluoridation ベンゾチエピン 頂端 sodium co-dependence nature bile-acid-transport (ASBT) inhibitor are indicated with the pharmacological composite containing the directions of the compound and the compound f...  
JP2005139120A
To provide a method for industrially advantageously producing zaltoprofen as an anti-inflammatory/analgesic agent.The method comprises the following process: Zinc iodide, sodium cyanide or potassium cyanide, and trimethylsilyl chloride a...  
JPWO2003053917A1
本発明は、下記式[I−1]、[I−2]ま たは[I−3]で表される新規なグアニジン 化合物およびそれらを有効成分として含有す る有害生物防除剤に関する。  
JP2005510565A
The present invention relates to the low molecular compound which is a modulator of a chemokine receptor function. The present invention indicates the method of treating the disease relevant to mobilization and/or activation of a new mol...  
JP2005507854A
The present invention offers the combination and the method of medical treatment whether it deals with the condition related to inflammation, and for preventing with regards to high cholesterol 血症 in the patient who needed such dispo...  
JP2005506328A
The present invention relates to those use as ileum bile-acid-transport (IBAT) inhibitor for dealing with the compound of formula (I) [the inside of a formula and a variable machine are as giving a definition in a specification], salt le...  
JP2005504096A
Are the method of preparing a substitution pen タセン compound, and the step which cyclizes screw (Ben Jill) phthalic acid using the acid composite containing truffe ルオロ methanesulfonic acid is contained, This substitution bis (...  
JP2005502702A
In some modes, the present invention, Tetra-ヒドロベンゾチエピン- 1 and 1-ジオキシド compound. The process in which it has been improved for preparing. From the single diastereomer of; tetra-ヒドロベンゾチエピン-...  
JP2005501861A
The present invention relates to the mixture of the propanol amine derivatives of the formula I which has the meaning to which the basis pointed, those physiologically permissible salt, a physiologically functional derivative, and the su...  
JP2004359694A
To provide a method for producing new benzothiepines, and derivatives and analogs thereof.The invention relates the new benzothiepines, and derivatives and analogs thereof; methods of preparing such compounds; pharmaceutical compositions...  
JP2004256443A
To obtain a new compound having inhibiting action of protein/tyrosine/phosphatase, etc.The compound, its pharmaceutically permissible salt or its pharmaceutically permissible ester is represented by general formula (I) (X is a single bon...  
JP2004203891A
To provide a method for producing a novel benzothiepin compound or its derivative or analogue.A pharmaceutical composition containing the novel bnzothiepin compound or its derivative or analogue is provided. The novel benzothiepin compou...  
JPWO2002078710A1
式(I)[式中、R1は水素原子、置換もし くは非置換の低級アルキル基等を表し、X1 −X2−X3はCR5=CR6−CR7=C R8、CR5=CR6−S等、を表し、...  
JPWO2004052849A
The present invention is formula [I].[Q expresses among a formula the basis chosen from the following group,About a hydrogen atom, a アルキル machine, etc., R1 and R4*R15 are R2, and R3 are a アルキル machine, It is a weed killer...  
JP2004510298A
Are a substrate and at least one semiconducting polymer supported by the above-mentioned substrate an optical device to provide, and the above-mentioned semiconducting polymer, They are コポリマー which is a basis of formula (I) of ...  
JPWO2004024142A
General formula (I) useful as medical supplies, such as an anti-tumor agentInside of [type, R1R2R3And R4the same in は -- or -- differing and expressing a hydrogen atom, hydroxy 、 substitution, or unsubstituted low-grade アルキル ...  
JP2004083567A
To provide a new tricyclic condensed heterocyclic compound and its production method and use.A pharmaceutical composition comprises a compound represented by formula (1), its optical isomer and its conjugate, or their pharmaceutically pe...  
JPWO2002036583A1
代謝的に安定なPGD2受容体拮抗活性を有 する化合物として、式(I):(式中、Yは ビシクロ環;R1は置換されていてもよいヘ テロアリール;R2は水素など;R3は...  
JP2004504394A
The intermediate field of the replaced amino methyl compound with the present annular invention, its production method, and this method, The medicine containing at least one sort of replaced annular amino methyl compounds, In order to ma...  
JP3471778B2  
JP3493288B2
To obtain the subject compound in high yield, characterized by high availability of the stock materials and easiness of handling the materials in volved, by (1) diazotization of aminocarboxymethylphenylpropionic acid, (2) reaction of the...  
JP2003528830A
(57) Summary book invention especially, Tetra-ヒドロベンゾチエピン*1 and 1* ジオキシド compound. The method of improving for manufacturing. Offer the method for providing and manufacturing the diastereomer mixture of; tetr...  
JP2003517449A5  
JP2003517449A
(57) Summary book invention has the meaning which X, A, R, R, and (R) gave by Claim 1, It is related with the manufacture methods of these compounds, concerning the medicine composite which contains them about the ベンゾ pyran and the...  
JP2003507465A
(57) Summary book invention is formula (I) (among a formula a sign). The new RAR selective retinoid agonist, its salt which can be permitted pharmacologically, each isomer, or racemic 若しく of being as having defined it as the specif...  
JP3374129B2  
JP2002533414A
(57) Summary book invention offers the combination of the compound for cardiovascular medical treatment for preventing and treating cardiovascular disease, such as high cholesterol 血症, an atherosclerotic cardiovascular disease, and h...  
JP3328673B2  
JP2002528489A
(57) Inside of the compound type of the summary type VIII: A and B, B is formula (IX) when formula (IX) or formula (X) to A is formula (X), Are chosen so that B may be formula (X), when A is formula (IX), and;R Hydrogen, It is chosen fro...  
JP2002527503A
The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (P...  
JP2002527502A
(57) Summary book invention relates to the compound of general formula (Ia) : 化 1. The compound is useful for the medical treatment and/or prevention in the state where the receptor in a core, especially a peroxisomal proliferation fac...  
JP3304093B2  
JP2002519418A
(-- 57) summary -- new ベンゾチエピン, those derivatives, and an analog --The directions for the above-mentioned compound in the medicinal manufacture used for the prevention and medical treatment of hyperlipemia especially releva...  
JP2002519410A
(57) Summary book invention is various compounds containing the 脂環 type machine which has nitrogen or sulfur as a ring member, 2, the tetra-ヒドロ thiophene replaced five to two times, 2, the pyrrolidine replaced five to two times...  
JP2002517491A5  
JP2002517491A
(57) Summary book invention relates to ベンゾ (b) チエピン *1 replaced, 1* ジオキ side derivative, and its acid addition salt. The present invention relates to the compound of formula (I) which is a thing of this statement of R...  
JP2002517490A
(57) Summary book invention relates to the derivative which has the physiologically permissible compound, salt, and physiological function of formula (I) in which ベンゾチエピン*1 and 1* ジオキ side derivative and its acid addi...  
JP2002515913A
(57) General formula (I) : (X, Y, Z, R, R, and m are defined as this specification among a formula) summary book invention New N* substitution-ized アザヘテロ cyclic compound, To or the composite which contains them in the method fo...  
JP2002515849A
(57) The tree and tetra substitution チエパン compound which have a use as a summary immunity field, a curative medicine, a diagnostic product, and other industrial purposes are indicated. The compound checks the proteolysis activity...  
JP3283267B2  

Matches 201 - 250 out of 579