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JPH0314576A |
NEW MATERIAL:A 1-benzothiepin compound expressed by formula I (R1 and R2 are same or different and each are H, halogen, lower alkyl, lower alkoxy or hydroxyl group; the ring expressed by formula II is cyclic amino, >=X, >=O or formula II...
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JPH0247469B2 |
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JPH0242833B2 |
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JPH0242826B2 |
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JPH029591B2 |
Novel 3-hydroxymethyldibenzo[b,f]thiepin and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.
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JPH0245483A |
PURPOSE: To provide the subject compound by a simple operation in a high purity by subjecting a mixture of optically active dibenzothiepinpropionic acids to a separation process using a high speed liquid chromatography composed of a fixe...
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JPH024740A |
NEW MATERIAL: A compd. represented by formula I [wherein V is O, S, NR (wherein R is H or a 1-4C or 1-4C alkyl or -CH2-, R1 and R2 are each H, OH, a 1-6C alkyl, alkoxy, halogen or 1-4 substituents at a benzo region of CF3CN, R3 and R4 ar...
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JPH02250A |
NEW MATERIAL:A compound expressed by formula I {X1-X2 is -CH2-O-, etc.; L is -CH=CH or S; broken line is single bond or double bond; W is -S-, -O-, etc.; n is 0-3; Z is -NR1CO- (R1 is H, lower alkyl, etc.), etc.; Q is 1-18C alkyl, etc.; ...
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JPH01308275A |
NEW MATERIAL: A thioformaldehyde derivative represented by formula I [wherein R is 1-4C alkyl, Ar is (substituted) phenyl, Y is ethylene, methylene or valence and n is 0 or 1], a precursor thereof and a pharmacologically acceptable slat ...
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JPH0141627B2 |
Azatetracyclic compounds of formula I are obtained by reaction of a reactive diester of a diethanol of formula II with a compound of formula III The meaning of the individual symbols is given in Claim 1. The novel compounds may be used a...
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JPH01153685A |
NEW MATERIAL: A compound expressed by formula I, wherein (n) is 0 to 3; R is H, OH, acyloxy of OCOR1 (R1 is 1 to 9C alkyl). EXAMPLE: 2-{4-[2-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yloxy)
- ethyl]piperadin-1-yl}ethanol. USE: Noncat...
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JPH0129793B2 |
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JPS6468348A |
NEW MATERIAL: A compound of formula I [X is S, -CH=CH-, -S(CH2)2S-; R1 is 1-6C alkyl, phenyl 1-6C alkyl; R2 and R3 are each H or 1-6C alkyl which is substituted with OH, COR1, etc., COOR1 or R2, R3 together form thiophene ring; formula I...
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JPS644519B2 |
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JPS6366285B2 |
A new pharmaceutical use of 2-chloro-11-(2-dimethylaminoethoxy)dibenzo(b,f) thiepin or its pharmaceutically acceptable salt for lowering uric acid, a pharmaceutical composition comprising a pharmaceutical uric acid-lowering composition c...
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JPS6363543B2 |
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JPS6332786B2 |
Novel acetic acid derivatives of the formula: (I) wherein X is oxygen or sulfur; R1 is hydrogen or a lower alkyl; R2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a substituted aryloxy, an aryl-lower alkoxy, a substi...
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JPS638109B2 |
Techniques for the preparation of 3-fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(b,f) thiepins and their addition salts with organic and inorganic acids are disclosed. The described compositions evidence psychotropic activity...
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JPS633860B2 |
1. A compound of the formula see diagramm : EP0002500,P10,F1 wherein X and Y are the same or different and each can be hydrogen, halogen C1 -C6 -alkylsulfonyl, Z is see diagramm : EP0002500,P10,F2 wherein R**1 is hydrogen, straight or br...
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JPS631311B2 |
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JPS63435B2 |
Aminoalcohol derivatives corresponding to the formula (I) in which Q is a group and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group or , with a...
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JPS6250470B2 |
The invention provides 7- and 8-R-dibenzo[b,f]- thiepin derivatives of formula : in which n is O or an integer from 1 to 4; Z is thio, sulfinyl, or sulfonyl; R is hydrogen, halogen, amino, C1-4 alkyl, C1-4 alkanoyl, hydroxyl, C1-4 alkoxy...
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JPS6245869B2 |
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JPS62135459A |
NEW MATERIAL:The compound of formula I (R1 and R2 are H or methyl; X is S or NH when Y is O or X is O when Y is H2; the configuration of 22 and 23-OH is cis). EXAMPLE: (2R, 3S, 22S, 23S, 24S)-24-ethyl-2,3,22,23-tetrahydroxy-B-homo-7-aza-...
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JPS6160074B2 |
The invention provides dibenz [b, f] oxepin and dibenzo [b, f] thiepin derivatives of the formula wherein X is an oxygen or sulfur atom, each of R1 and R2 is a hydrogen atom or a methyl group, and R3 is a hydrogen atom or a 2-(2-hydroxye...
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JPS6159313B2 |
Acetic acid derivatives having the formula, wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon a...
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JPS61251682A |
PURPOSE: To produce the titled compound useful as an anti-inflammatory agent, in short steps, economically on an industrial scale, by using 5-propionyl-2- phenylthiophenylacetic acid ester as a raw material, and reacting the compound wit...
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JPS61251655A |
PURPOSE: To obtain the titled compound useful as an intermediate for anti- inflammatory agent, easily, safely and economically on an industrial scale, by using 5-propionyl-2-phenylthio phenylacetic acid as a starting material and reactin...
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JPS6141359B2 |
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JPS61204181A |
The invention relates to N-substituted 2-chloro-7-fluoro--10-piperazino-10,11-dihydrodibenzo (b,f) thiepins of the general formula I in which R represents an aminocarbonyl, amino--oximinomethyl, 1,3-dioxolan-2-yl or 1,3-dioxan-2-yl group...
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JPS6126544B2 |
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JPS6193153A |
The invention concerns novel compounds of the formula I I wherein: m is an integer selected from 1 to 4; n is zero or an integer selected from 1 to 4; X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, ...
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JPS6144813A |
A cardiovascular composition is disclosed which comprises a dibenzo-thiepin compound having the formulawherein: X is a C1-C4 hydrocarbon group, optionally containing O, N or CO; Z is S, SO, S02, CO, CR4R5 wherein R4 and R5 taken together...
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JPS617199B2 |
A compound of the formula, wherein R represents a hydroxy or amino group is an antiinflammatory and analgesic agent.
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JPS613345B2 |
A compound of the formula (I), wherein R1 represents a halogen atom, or a hydroxy, nitro, amino, trihalogenomethyl or lower alkoxy group having 1 to 5 carbon atoms, and R2 represents a hydroxy or amino group is an antiinflammatory agent.
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JPS613343B2 |
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JPS613346B2 |
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JPS60246363A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPS6039677B2 |
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JPS6029715B2 |
1449300 Tricyclic compounds F HOFFMAN-LA ROCHE & CO AG 7 June 1974 [8 June 1973] 13215/76 Divided out of 1449297 Heading C2C Compounds of the general formula (X = O, S; R 1 = H, C 1-7 alkyl; R 4 , 5 = H, C 1-7 alkyl or hydroxyalkyl, alka...
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JPS60115573A |
Dibenzo[b,f]thiepin-3-substituted derivatives having the formula: and their pharmaceutically acceptable salts are novel. They are made into pharmaceutical compositions and used in the treatment and control of allergic conditions such as ...
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JPS6097976A |
Novel dibenz[b,flthiepin derivatives have the formulawherein n is 1 or 2;the broken lines represent optional double bonds;Z is thio, sulfinyl or sulfonyl;each of R2, R3 and R9, independently of the others, is a hydrogen or halogen atom o...
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JPS6021156B2 |
PURPOSE:Benzothiepin derivs. of formula I(R is OH or amino; Y is CH or N; N is O or two H's), e.g. 2-(10,11-dihydro-11-oxodibenzo [b, f] thiepin-2-yl) propionamide.
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JPS6020392B2 |
1449300 Tricyclic compounds F HOFFMAN-LA ROCHE & CO AG 7 June 1974 [8 June 1973] 13215/76 Divided out of 1449297 Heading C2C Compounds of the general formula (X = O, S; R 1 = H, C 1-7 alkyl; R 4 , 5 = H, C 1-7 alkyl or hydroxyalkyl, alka...
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JPS6017778B2 |
Aminoalcohol derivatives corresponding to the formula (I) in which Q is a group and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group or , with a...
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JPS59196894A |
Compounds of the formula in which R is an optionally esterified or amidated carboxyl group, R1 is hydrogen or an optionally substituted aliphatic or cycloaliphatic- aliphatic hydrocarbon radical, X is epoxy or epithio, and n is 1 or 2, o...
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JPS5998056A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5953422A |
PURPOSE: To provide an agent for lowering the uric acid level, and useful for the remedy and prevention of gout, by using zotepine or its salt as an active component. CONSTITUTION: The objective agent contains zotepine of formula or its ...
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JPS5946280A |
11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thie
pin-2-carb onitri l e of formula I and pharmaceutically acceptable salts thereof show inhibition of neurotransmitter amine uptake and therefore have utility in the treatment of...
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JPS595593B2 |
The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.
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