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Matches 351 - 400 out of 439

Document Document Title
JPS5823391B2  
JPS5855479A
NEW MATERIAL:The compound of formulaI(X is O or S; R is halogen, hydroxy, lower alkyl or lower alkoxy). EXAMPLE: 6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepin. USE: Useful as a hypotensor or an intermediate of pharmaceuticals....  
JPS5811870B2  
JPS58424B2
The present invention is concerned with tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.  
JPS57171991A
PURPOSE: To obtain the titled compound having the pharmacological action in high yield, with the reduced cost of the raw material and the load on the treatment of waste acids, by the selective ring closing reaction of a 5-(1-carboxyethyl...  
JPS5788176A
7-Fluoro-dibenzo[b,f]thiepin derivatives of formula: -in which n is 0, 1, 2, 3 or 4; Z is thio, sulfinyl, or sulfonyl; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-2,5-dioxo- DELTA <3>-pyrrolin-3-yl, or -CO-R2, where R2 ...  
JPS5748948A
Propanolamine derivatives of the formula: wherein R2 is CH3SO or CH3SO2; R3 is hydrogen, methyl or methoxy; or R2 and R3 are together -S(O)m(CH2)4-when S is attached at R2 or -(CH2)nS(O)m- when S is attached at R3(where m=1 or 2 and n=3 ...  
JPS56167623A
1. Anti-inflammatory compositions for local topical administration containing an effective amount of a compound of the general formula see diagramm : EP0039059,P10,F2 wherein X signifies a sulphur or oxygen atom, Y signifies the group -C...  
JPS5645472A
NEW MATERIAL:A dibenzo[b,f]thiepin derivative expressed by formula I (R1 is H or lower alkyl; R2 is H or esterified carboxy, or R1 and R2 together form phthaloyl; A is lower alkylene; X is halogen), and a salt thereof. EXAMPLE: 8-Chloro-...  
JPS5626838A
PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent, industrially and advantageously, by the reaction of a novel propionic acid ester derivative with sulfur and a secondary amine, and the subsequent hydrolysis and...  
JPS568379A
NEW MATERIAL:A dibenzo[b,f]thiepin-5-oxide derivative of formula I (R1 is lower alkylene group; R2 and R3 are lower alkyl groups, etc.; X is halogen), and its salt. EXAMPLE: 8-Chloro-10-(2-dimethylaminoethoxy)dibenzo[b,f]thiepin-5-oxi de...  
JPS568378A
NEW MATERIAL:A dibenzo[b,f]thiepin derivative of formula I (R1 is lower alkylene group; R2 and R3 are lower alkyl groups; R4 is H etc.; X is halogen). EXAMPLE: 2-Hydroxy-8-chloro-10-( 2-dimethylaminoethoxy )-dibenzo[b,f]-thiepin and 2-hy...  
JPS55164681A  
JPS55127386A
NEW MATERIAL:Dibenzthiepin derivatives of formula I (R1 is trihalogenomethyl; R2 is hydroxyl, amino) and their nontoxic salts. EXAMPLE: 2-[10,11-Dihydro-8-trifluoromethyl-11-oxobenzo[b, f]thiepin-2-ylpropionic acid. USE: Anti-inflammator...  
JPS55104277A
NEW MATERIAL:2-( 10,11-Dihydro-8-hydroxy-11-oxodibenzo[b,f]thiepin-2-yl )- propionic acid of formula I and its non-toxic salt. USE: Antiphlogistic agent. PROCESS: The compound I is prepared by heating and refluxing a compound II (R1 is l...  
JPS5572186A
NEW MATERIAL:A dibenzothiepin derivative of formula I (R is OH or amino group). EXAMPLE: 2-(10,11-Dihydro-11-oxodibenzo [b,f] thiepin-4-yl)-propionamide. USE: Antiphlogistics. PROCESS: 2-[2-(α-Cyanoethyl)-phenylthio]phenylacetic acid of...  
JPS5566576A
NEW MATERIAL:Carboxylic derivatives of formula I (A is O, S; R1 is H, methyl; R2 is H, lower alkyl). EXAMPLE: 2-[Dibenz(b,f)apin-2-yl]propioic acid. USE: They have anti-inflammatory activity and are used as anti-inflammotory. They are bo...  
JPS5511596A
Azatetracyclic carbonitriles of the formula I (I) in which R1 is hydrogen, lower alkyl, cycloalkyl-lower alkyl, lower alkenyl or free, etherified or esterified hydroxy-lower alkyl, and X is epoxy, epithio, methylene of a divalent radical...  
JPS54157584A
This invention concerns compounds showing activity as histamine H2-receptor antagonists. The compounds of the invention are of Structurewhere Het is a substituted or unsubstituted, fully-unsaturated 5- or 6- membered heterocycle containi...  
JPS54141793A
Novel 6, 11-dihydrodibenzo-[b.e.]-thiepin-11-one S-oxides, and intermediates useful in the preparation thereof, having the formulae wherein R is hydrogen, an alkyl group containing from 1 to twelve carbon atoms or a pharmaceutically acce...  
JPS54125662A  
JPS54117489A
Novel 4-(8X-6, 11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl)-4-oxobutyric acids of the formula: wherein X is hydrogen, methoxy or chloro; and the pharmaceutically acceptable salts and C1-12 alkyl esters thereof. Also described are me...  
JPS5418267B2  
JPS5481287A
Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. These compounds are useful for preparing corresponding amino derivatives that possess antihypertensive and CNS activity.  
JPS5481285A
NEW MATERIAL:A propionamide derivative of formula I: (A is O or S; X is N or CH). EXAMPLE: 2-[10,11-Dihydrodibenzo [b,f] thiepin-2-yl]-propionamide. USE: Anti-inflammatory drugs. PROCESS: A compound of formula III or its reactive derivat...  
JPS5411320B1
1334945 Dibenzothiepinopyrrole derivatives CIBA-GEIGY AG 25 May 1971 [26 May 1970] 16904/71 Heading C2C Novel compounds of the Formula I wherein R is hydrogen, C 1-6 straight chain alkyl, isopropyl or allyl and pharmaceutically acceptabl...  
JPS5411318B1  
JPS5444692A
The invention provides 7- und 8-R-dibenzo[b,f]thiepin derivatives of formula: in which n is 0 or an integer from 1 to 4; Z is thio, sulfinyl, or sulfonyl; R is hydrogen, halogen, amino, C1-4 alkyl, C1-4 alkanoyl, hydroxyl, C1-4 alkoxy, m...  
JPS543841B1
1,228,094. Sulphonium salts. J. R. GEIGY A.G. 14 Oct., 1969 [15 Oct., 1968], No. 50552/69. Heading C2C. Novel sulphonium salts are prepared by adding an organic sulphide in a strongly acid medium to an aliphatic or cycloaliphatic unsatur...  
JPS5414992A
PURPOSE: Cyclopropylmethylamine derviatives of formula I (R1 is H, lower alkyl; R2 is lower alkyl) and their acid adducts.  
JPS5331929B2  
JPS5320515B1
Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazino]-10,11-dihydrodibenzo[b,f]thi epins and oxepins having the formula IN WHICH X is a sulfur or oxygen atom, R1 is a hydrogen, chloro, or trifluoromethyl radical, a lower alk...  
JPS5346990A
PURPOSE: Dibenzo[b,f] thiepin derivatives of formula I [R1 is H, halogen, -OCH2CH2OCH2CH2OH; R2 is H, CF3; Y is OH, -NR3R4 (R3 and R4 are C1-4 lower alkyl, these together with adjacent N atom form a heterocycle)], e.g. 2-fluoro-8-bromo-1...  
JPS5346989A
PURPOSE: Dibenzo[b,f] thiepin derivatives of formula I (R1 is H, F, V1-5 lower alkoxy, -OCH2CH2OCH2CH2OH; R2 is H, C(F3), e.g. 2-dluoeo-9-chloro10,11-dihydro-11-hydroxy-dibenzo[b,f] thiepin.  
JPS535661B2  
JPS535148A
1530062 Tricyclic carboxylic acid amides BOEHRINGER MANNHEIM GmbH 4 April 1977 [2 July 1976] 14161/77 Heading C2C Novel compounds I: wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa...  
JPS535182A
A procedure for the preparation of new 6,11-dihydrodibenzo- [b, e] -tiepin-11-one derivatives of formula: *** where R represents hydrogen or methyl and each of R1 and R2 which may be the same or different, represents a lower alkyl group ...  
JPS52156881A
6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid is prepared from 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile, a novel intermediate, by strong acid or base hydrolysis.  
JPS52105184A
PURPOSE: Morpholine derivatives I (R1 is H or lower alkyl; R2 is H, lower alkyl, lower alkenyl or aryl-lower-alkyl, etc.; A is lower alkylene; B is -CH2CH2-, -CH=CH-, etc.; C1 and C2 are 1,2-phenylene or substituted 1,2phenylene; D-E-is ...  
JPS5231354B1  
JPS5283674A  
JPS5283682A  
JPS5283591A
PURPOSE: Thionothiepin or oxepin derivatives of formula II(R1 and R2 are H, lower alkyl; Y is O,S; A is thiophene ring); for example, 4,10-dihydro10-oxobenzo[b] thieno[2,3-e] oxepin-7-acetic acid.  
JPS5259147A
PURPOSE: Olefinic aminoalcohol derivatives I (where R1 is H or lower alkyl; R2 is H, lower alkyl, aryl-lower alkyl or lower hydroxyalkyl; A is 25C alkylene; B is -CH2CH2-, -CH=CH-, O, -CH2-O-, -CH2-S-; C1 and C2 are 1,2-phenylene), e.g. ...  
JPS5253876A
PURPOSE: 9-Carboxy-10, 11-dihydrodibenzo [b.f] thiepin derivatives of the formula I (where R is CF3, F or lower alkoxy). For example, 9-carboxy10, 11-dihydro-2-ethoxydibenzo [b,f] thiepin may be cited.  
JPS52289A
1-Polyfluoroalkoxyphenyl-4-substituted-5-halopyridazones-6 in which the 4-substituent is amino, monoalkylamino, dialkylamino (1 to 3 carbon atoms per alkyl) or lower alkoxy, chloroacetamido, CH3COOCH2-CO-NH- or trimethylenimino and herbi...  
JPS51146486A
PURPOSE: Benzo [b, f] thiepine derivatives of formula I are new: (where R is H, fluoro, trifluoromethyl, 1 W 5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy or -OCH2CH2OCH2CH2OH; Y is hydroxy or a group represented by the formula-NR...  
JPS51146487A
(+)-(S)-enantiomer of 3-{2-[4-(8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin- 10-yl)-1-p iperazinyl]-ethyl} -2-oxazolidinone, active as a neuroleptic agent, is described.  
JPS51143688A
1505085 6,11-Dihydro-dibenzo[b,e]thiepin- 11-ones SYNTEX (USA) Inc 16 Jan 1976 [18 Feb 1975 30 June 1975 21 Nov 1975 (2)] 01783/76 Heading C2C Novel compounds I in which R is H, C 1-12 alkyl or a salt-forming group and R11 is H or Me are...  
JPS51108081A  

Matches 351 - 400 out of 439