Document |
Document Title |
JPS5823391B2 |
|
JPS5855479A |
NEW MATERIAL:The compound of formulaI(X is O or S; R is halogen, hydroxy, lower alkyl or lower alkoxy). EXAMPLE: 6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepin. USE: Useful as a hypotensor or an intermediate of pharmaceuticals....
|
JPS5811870B2 |
|
JPS58424B2 |
The present invention is concerned with tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.
|
JPS57171991A |
PURPOSE: To obtain the titled compound having the pharmacological action in high yield, with the reduced cost of the raw material and the load on the treatment of waste acids, by the selective ring closing reaction of a 5-(1-carboxyethyl...
|
JPS5788176A |
7-Fluoro-dibenzo[b,f]thiepin derivatives of formula: -in which n is 0, 1, 2, 3 or 4; Z is thio, sulfinyl, or sulfonyl; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-2,5-dioxo- DELTA <3>-pyrrolin-3-yl, or -CO-R2, where R2 ...
|
JPS5748948A |
Propanolamine derivatives of the formula: wherein R2 is CH3SO or CH3SO2; R3 is hydrogen, methyl or methoxy; or R2 and R3 are together -S(O)m(CH2)4-when S is attached at R2 or -(CH2)nS(O)m- when S is attached at R3(where m=1 or 2 and n=3 ...
|
JPS56167623A |
1. Anti-inflammatory compositions for local topical administration containing an effective amount of a compound of the general formula see diagramm : EP0039059,P10,F2 wherein X signifies a sulphur or oxygen atom, Y signifies the group -C...
|
JPS5645472A |
NEW MATERIAL:A dibenzo[b,f]thiepin derivative expressed by formula I (R1 is H or lower alkyl; R2 is H or esterified carboxy, or R1 and R2 together form phthaloyl; A is lower alkylene; X is halogen), and a salt thereof. EXAMPLE: 8-Chloro-...
|
JPS5626838A |
PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent, industrially and advantageously, by the reaction of a novel propionic acid ester derivative with sulfur and a secondary amine, and the subsequent hydrolysis and...
|
JPS568379A |
NEW MATERIAL:A dibenzo[b,f]thiepin-5-oxide derivative of formula I (R1 is lower alkylene group; R2 and R3 are lower alkyl groups, etc.; X is halogen), and its salt. EXAMPLE: 8-Chloro-10-(2-dimethylaminoethoxy)dibenzo[b,f]thiepin-5-oxi
de...
|
JPS568378A |
NEW MATERIAL:A dibenzo[b,f]thiepin derivative of formula I (R1 is lower alkylene group; R2 and R3 are lower alkyl groups; R4 is H etc.; X is halogen). EXAMPLE: 2-Hydroxy-8-chloro-10-( 2-dimethylaminoethoxy )-dibenzo[b,f]-thiepin and 2-hy...
|
JPS55164681A |
|
JPS55127386A |
NEW MATERIAL:Dibenzthiepin derivatives of formula I (R1 is trihalogenomethyl; R2 is hydroxyl, amino) and their nontoxic salts. EXAMPLE: 2-[10,11-Dihydro-8-trifluoromethyl-11-oxobenzo[b, f]thiepin-2-ylpropionic acid. USE: Anti-inflammator...
|
JPS55104277A |
NEW MATERIAL:2-( 10,11-Dihydro-8-hydroxy-11-oxodibenzo[b,f]thiepin-2-yl )- propionic acid of formula I and its non-toxic salt. USE: Antiphlogistic agent. PROCESS: The compound I is prepared by heating and refluxing a compound II (R1 is l...
|
JPS5572186A |
NEW MATERIAL:A dibenzothiepin derivative of formula I (R is OH or amino group). EXAMPLE: 2-(10,11-Dihydro-11-oxodibenzo [b,f] thiepin-4-yl)-propionamide. USE: Antiphlogistics. PROCESS: 2-[2-(α-Cyanoethyl)-phenylthio]phenylacetic acid of...
|
JPS5566576A |
NEW MATERIAL:Carboxylic derivatives of formula I (A is O, S; R1 is H, methyl; R2 is H, lower alkyl). EXAMPLE: 2-[Dibenz(b,f)apin-2-yl]propioic acid. USE: They have anti-inflammatory activity and are used as anti-inflammotory. They are bo...
|
JPS5511596A |
Azatetracyclic carbonitriles of the formula I (I) in which R1 is hydrogen, lower alkyl, cycloalkyl-lower alkyl, lower alkenyl or free, etherified or esterified hydroxy-lower alkyl, and X is epoxy, epithio, methylene of a divalent radical...
|
JPS54157584A |
This invention concerns compounds showing activity as histamine H2-receptor antagonists. The compounds of the invention are of Structurewhere Het is a substituted or unsubstituted, fully-unsaturated 5- or 6- membered heterocycle containi...
|
JPS54141793A |
Novel 6, 11-dihydrodibenzo-[b.e.]-thiepin-11-one S-oxides, and intermediates useful in the preparation thereof, having the formulae wherein R is hydrogen, an alkyl group containing from 1 to twelve carbon atoms or a pharmaceutically acce...
|
JPS54125662A |
|
JPS54117489A |
Novel 4-(8X-6, 11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl)-4-oxobutyric acids of the formula: wherein X is hydrogen, methoxy or chloro; and the pharmaceutically acceptable salts and C1-12 alkyl esters thereof. ?>Also described are me...
|
JPS5418267B2 |
|
JPS5481287A |
Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. These compounds are useful for preparing corresponding amino derivatives that possess antihypertensive and CNS activity.
|
JPS5481285A |
NEW MATERIAL:A propionamide derivative of formula I: (A is O or S; X is N or CH). EXAMPLE: 2-[10,11-Dihydrodibenzo [b,f] thiepin-2-yl]-propionamide. USE: Anti-inflammatory drugs. PROCESS: A compound of formula III or its reactive derivat...
|
JPS5411320B1 |
1334945 Dibenzothiepinopyrrole derivatives CIBA-GEIGY AG 25 May 1971 [26 May 1970] 16904/71 Heading C2C Novel compounds of the Formula I wherein R is hydrogen, C 1-6 straight chain alkyl, isopropyl or allyl and pharmaceutically acceptabl...
|
JPS5411318B1 |
|
JPS5444692A |
The invention provides 7- und 8-R-dibenzo[b,f]thiepin derivatives of formula: in which n is 0 or an integer from 1 to 4; Z is thio, sulfinyl, or sulfonyl; R is hydrogen, halogen, amino, C1-4 alkyl, C1-4 alkanoyl, hydroxyl, C1-4 alkoxy, m...
|
JPS543841B1 |
1,228,094. Sulphonium salts. J. R. GEIGY A.G. 14 Oct., 1969 [15 Oct., 1968], No. 50552/69. Heading C2C. Novel sulphonium salts are prepared by adding an organic sulphide in a strongly acid medium to an aliphatic or cycloaliphatic unsatur...
|
JPS5414992A |
PURPOSE: Cyclopropylmethylamine derviatives of formula I (R1 is H, lower alkyl; R2 is lower alkyl) and their acid adducts.
|
JPS5331929B2 |
|
JPS5320515B1 |
Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazino]-10,11-dihydrodibenzo[b,f]thi
epins and oxepins having the formula IN WHICH X is a sulfur or oxygen atom, R1 is a hydrogen, chloro, or trifluoromethyl radical, a lower alk...
|
JPS5346990A |
PURPOSE: Dibenzo[b,f] thiepin derivatives of formula I [R1 is H, halogen, -OCH2CH2OCH2CH2OH; R2 is H, CF3; Y is OH, -NR3R4 (R3 and R4 are C1-4 lower alkyl, these together with adjacent N atom form a heterocycle)], e.g. 2-fluoro-8-bromo-1...
|
JPS5346989A |
PURPOSE: Dibenzo[b,f] thiepin derivatives of formula I (R1 is H, F, V1-5 lower alkoxy, -OCH2CH2OCH2CH2OH; R2 is H, C(F3), e.g. 2-dluoeo-9-chloro10,11-dihydro-11-hydroxy-dibenzo[b,f] thiepin.
|
JPS535661B2 |
|
JPS535148A |
1530062 Tricyclic carboxylic acid amides BOEHRINGER MANNHEIM GmbH 4 April 1977 [2 July 1976] 14161/77 Heading C2C Novel compounds I: wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa...
|
JPS535182A |
A procedure for the preparation of new 6,11-dihydrodibenzo- [b, e] -tiepin-11-one derivatives of formula: *** where R represents hydrogen or methyl and each of R1 and R2 which may be the same or different, represents a lower alkyl group ...
|
JPS52156881A |
6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid is prepared from 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile, a novel intermediate, by strong acid or base hydrolysis.
|
JPS52105184A |
PURPOSE: Morpholine derivatives I (R1 is H or lower alkyl; R2 is H, lower alkyl, lower alkenyl or aryl-lower-alkyl, etc.; A is lower alkylene; B is -CH2CH2-, -CH=CH-, etc.; C1 and C2 are 1,2-phenylene or substituted 1,2phenylene; D-E-is ...
|
JPS5231354B1 |
|
JPS5283674A |
|
JPS5283682A |
|
JPS5283591A |
PURPOSE: Thionothiepin or oxepin derivatives of formula II(R1 and R2 are H, lower alkyl; Y is O,S; A is thiophene ring); for example, 4,10-dihydro10-oxobenzo[b] thieno[2,3-e] oxepin-7-acetic acid.
|
JPS5259147A |
PURPOSE: Olefinic aminoalcohol derivatives I (where R1 is H or lower alkyl; R2 is H, lower alkyl, aryl-lower alkyl or lower hydroxyalkyl; A is 25C alkylene; B is -CH2CH2-, -CH=CH-, O, -CH2-O-, -CH2-S-; C1 and C2 are 1,2-phenylene), e.g. ...
|
JPS5253876A |
PURPOSE: 9-Carboxy-10, 11-dihydrodibenzo [b.f] thiepin derivatives of the formula I (where R is CF3, F or lower alkoxy). For example, 9-carboxy10, 11-dihydro-2-ethoxydibenzo [b,f] thiepin may be cited.
|
JPS52289A |
1-Polyfluoroalkoxyphenyl-4-substituted-5-halopyridazones-6 in which the 4-substituent is amino, monoalkylamino, dialkylamino (1 to 3 carbon atoms per alkyl) or lower alkoxy, chloroacetamido, CH3COOCH2-CO-NH- or trimethylenimino and herbi...
|
JPS51146486A |
PURPOSE: Benzo [b, f] thiepine derivatives of formula I are new: (where R is H, fluoro, trifluoromethyl, 1 W 5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy or -OCH2CH2OCH2CH2OH; Y is hydroxy or a group represented by the formula-NR...
|
JPS51146487A |
(+)-(S)-enantiomer of 3-{2-[4-(8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin-
10-yl)-1-p iperazinyl]-ethyl} -2-oxazolidinone, active as a neuroleptic agent, is described.
|
JPS51143688A |
1505085 6,11-Dihydro-dibenzo[b,e]thiepin- 11-ones SYNTEX (USA) Inc 16 Jan 1976 [18 Feb 1975 30 June 1975 21 Nov 1975 (2)] 01783/76 Heading C2C Novel compounds I in which R is H, C 1-12 alkyl or a salt-forming group and R11 is H or Me are...
|
JPS51108081A |
|