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Matches 1 - 50 out of 578

Document Document Title
WO/2013/161842A1
The invention pertains to a method for producing zaltoprofen or a zaltoprofen derivative by an intramolecular cyclization reaction of the Friedel-Crafts reaction type, wherein zaltoprofen or a zaltoprofen derivative is produced at an ind...  
WO/2013/141264A1
The purpose of the present invention is to provide a novel compound with Eg5 inhibiting activity that is useful as an antitumoral agent. The present invention pertains to a compound expressed by the general formula (I) (in formula (I), A...  
WO/2013/131521A8
The present application discloses an open-cage fullerene having a sulphur-containing 17 membered opening of the general formula : Xn@3, wherein X is selected from the group consisting of H2O, N2, H2, O2 and O3, and n is from 0 to 1; and ...  
WO/2013/131521A1
The present application discloses an open-cage fullerene having a sulphur-containing 17 membered opening of the general formula : Xn@3, wherein X is selected from the group consisting of H2O, N2, H2, O2 and O3, and n is from 0 to 1; and ...  
WO/2011/012987A1
The present invention relates to pharmaceutical compositions comprising rifampicin, piperine as a bioenhancer for rifampicin and isoniazid is in delayed release form, wherein the said pharmaceutical compositions have maintained bioavaila...  
WO/2010/137620A1
Disclosed is a phenoxyethylamine derivative having an excellent selective α1D adrenergic receptor antagonistic activity. Specifically disclosed is a compound represented by formula (I) [wherein each symbol is as defined in the descripti...  
WO/2010/070910A1
Disclosed is a 1-heterodiene derivative represented by the formula (2); or, a salt thereof. In formula (2), W represents a hydrogen atom or the like; A, an oxygen atom or the like; R1, a C1-6 alkyl group or the like that is unsubstituted...  
WO/2009/152347A3
The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these ...  
WO/2009/152347A2
The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these ...  
WO/2009/132832A3
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.  
WO/2009/132832A2
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.  
WO/2008/133288A1
Compounds represented by the general formula (1) or pharmacologically acceptable salts thereof; and squalene synthase inhibitors containing the same as the active ingredient: (1) (wherein R1 is phenyl which may be substituted with haloge...  
WO/2008/109840A1
This invention is directed to, for example, compounds of formula (I): wherein n, m, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically accep...  
WO/2008/096755A1
Disclosed is a novel vanilloid receptor (VR1) inhibitor which can be used as an effective therapeutic agent for an acute pain and/or a chronic pain which has less adverse side effects and can be used safely. The vanilloid receptor (VR1) ...  
WO/2008/065796A1
It is intended to provide an α-glucosidase inhibitor which is new and has a high activity. Accordingly, after a root or/and aerial part of Salacia reticulata is extracted with water, insoluble components are removed by adding ethanol. T...  
WO/2008/058629A1
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. These compounds are suitable, for example, as hypolipidemics.  
WO/2008/061029A1
Compounds of formula (I) and pharmaceutically acceptable salt thereof, which are modulators of secreted frizzled related protein-1, are disclosed. The compounds, and compositions containing the compounds, can be used to treat various dis...  
WO/2007/047737A1
Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or con...  
WO/2006/122776A1
The invention relates to substituted benzo-condensed cycloheptanone derivatives, to methods for producing them, to drugs containing said compounds and to the use of said compounds for producing drugs.  
WO2006036941A3
Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ...  
WO2006004774A3
Laulimalide analogues useful as microtubule stabilizing agents, and in the treatment of abnormal cell proliferation, are disclosed. Methods of making the compounds, as well as methods of using such compounds in treating abnormal cell pro...  
WO/2005/082874A1
It is intended to provide a drug useful as a remedy and a preventive for hyperlipemia; a drug also useful as a remedy and a preventive for liver disorders accompanying bile stasis, in particular, primary biliary cirrhosis, primary sclero...  
WO/2005/079785A1
Preventive or therapeutic agents for hyperuricemia and/or gout which little produce adverse effect, containing as the active ingredient substances having both dibenzo[b,f]thiepin or dibenzo[b,f]oxepin skeletons and antioxidant substituen...  
WO/2005/053676A1
The use of a pentadienoic acid derivative of formula (I) for the preparation of a medicament for the prevention or treatment of hyperuricemia and/or one or several associated disorders or diseases, and/or for reducing the serum uric acid...  
WO/2005/011674A1
Preventive and/or therapeutic agents for bronchial asthma and tachykinin inhibitors, containing as the active ingredient tricyclic compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherei...  
WO2004064771A3
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or ...  
WO/2004/087131A1
Antitussives containing as the active ingredient tricyclic compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 is hydrogen, substituted or unsubstituted lower alkyl, or the like;...  
WO/2004/076430A1
Compounds of formula: (I) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia are described. Processes...  
WO2004052847A3
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO/2004/064771A2
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or ...  
WO/2004/052847A2
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO2002078626A3
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation-related condition in a subject in need of such treatment or prevention. One therapeutic comb...  
WO2003027050A3
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...  
WO2003061604A3
Thiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as well as pharmaceutical compositions contain...  
WO2003022804A9
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO2003022804A3
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO/2003/084961A1
The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effect...  
WO/2003/061604A2
Thiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as well as pharmaceutical compositions contain...  
WO/2003/039255A1
A composition comprising a) compounds of formula (I):, wherein A−B denotes C−C or C=C&semi x is S, O, SO, SO2, NRa, or CRbRc&semi R1, R2 are H, halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alky­lamino, dialkylamino, alkylthio, alke...  
WO/2003/040127A1
Mono-fluorinated and di-fluorinated benzothiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as we...  
WO/2003/027050A2
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...  
WO/2003/022830A1
The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport ...  
WO/2003/022804A2
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO2002078625A3
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation -related condition in a subject in need of such treatment or prevention. One therapeutic com...  
WO/2003/018024A1
The invention relates to mixtures of substances, containing propanolamine derivatives of formula I, in which the radicals have the indicated meanings, their physiologically acceptable salts and physiologically functional derivatives as w...  
WO/2003/016245A1
The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is perf...  
WO2001068637A3
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO/2002/078625A2
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation -related condition in a subject in need of such treatment or prevention. One therapeutic com...  
WO/2002/078626A2
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation-related condition in a subject in need of such treatment or prevention. One therapeutic comb...  
WO/2002/078710A1
Remedies for vesical hyperactivity which contain as the active ingredient tricyclic compounds represented by the following general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R¿1? represents hydrogen, optional...  

Matches 1 - 50 out of 578