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Matches 451 - 500 out of 2,521

Document Document Title
WO/1996/038437A1
A process for the preparation of lipoic acid (thioctic acid), or a derivative thereof, is one in which a 2-substituted cyclohexanone is transformed in an oxidation reaction to a lactone having formula (I), wherein X is a heteroatom subst...  
WO/1996/034846A1
Compounds of 1,3-propane diol linked structure (I), when for use in therapy, where R1 is an acyl or fatty alcohol group derived from a C12-30 preferably C16-30 fatty acid desirably with two or more cis or trans double bonds, and R2 is hy...  
WO/1996/034855A1
Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or colu...  
WO/1996/034858A1
Niacin as a compound, per se or for use in therapy, of structure (I), where B is -C(=O)- (nicotinic acid) or -CH2-O- (niacin alcohol), the "link" C which is optional is a diol or hydroxy carboxylic acid or dicarboxylic acid residue, and ...  
WO/1996/033711A2  
WO/1996/028418A1
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors...  
WO/1996/028463A1
Selected amino acid hydroxyethylamino sulfonamide compounds of formula (I) are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibi...  
WO/1996/027584A1
An energy-sensitive (e.g., thermal, radiation or photosensitive) initiator, curative, and/or catalytic salt that has an anion comprising a tris-(highly fluorinated alkylsulfonyl)methide, tris-(fluorinated arylsulfonyl)methide, bis-(highl...  
WO/1996/026200A1
The invention concerns benzoyl derivatives of formula (I) in which the substituents have the following meanings: L and M represent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy (these groups being optionally substitut...  
WO/1996/026193A1
Phenyldiketone derivatives have the formula (I), in which the substituents have the following meanings: L, M are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy optionally substituted by 1 to 5 halogen atoms or C1-C4 al...  
WO/1996/020930A1
Acetylenes substituted with a phenyl or heteroaryl group and with a 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group have retinoid-like biological activity. The 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group is substitute...  
WO/1996/019471A1
Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R1 and ...  
WO/1996/014277A1
This invention provides a novel compound for 35S-labelling oligonucleotides. The compound is 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). In Structure (I), the asterisk indicates the position of the 35S. Also provided is a method of sy...  
WO/1996/010561A1
2-aroylcyclohexandiones have general formula (I), in which X, Y stand for O or S; Ar stands for phenyl or heteroaryl with 1 to 4 substituents; or two adjacent carbon atoms of the phenyl or heteroaryl ring may also be bridged by a chain; ...  
WO/1996/009629A1
A composition comprising a matrix of a thermoplastic, thermosetting or a structurally crosslinked polymer, in which is incorporated an electroconductive network of crystal needles of a charge transfer complex (abbreviated to CT complex) ...  
WO/1995/035292A1
An antiviral agent containing a 1,4-dihydro-2,3-benzodithiin derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, wherein R1, R2, R3 and R4 represent each hydrogen, (un)su...  
WO/1995/032194A1
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent...  
WO/1995/029925A1
A compound consisting essentially of a multidentade ligand including at least two thioether groups for being complexed to Rhodium-105 in specific activities that are sufficiently high for use in formulating therapeutic 105Rh-radiopharmac...  
WO/1995/029174A1
A diastereoselective process for the preparation of compounds of formula (I), wherein W is S, S=O, SO2, or O; X is S, S=O, SO2, or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof, is ...  
WO/1995/024404A1
Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by C...  
WO/1995/023139A1
The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as...  
WO/1995/014466A1
Novel palladium-lipoic acid complexes as shown in the figure, and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium)m(lipoic acid)n, wherein m and n are each independently 1 or 2. A process ...  
WO/1995/012567A1
The present invention provides three basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediate...  
WO/1995/005817A1
This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those...  
WO/1995/005398A1
Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies, ligands such as biotin and anti-ligands such as streptavidin with radionuclide metals such as 99mTc, 18...  
WO/1995/004053A1
The invention provides a compound of formula (I), wherein Y is an aryl or heteroaryl group substituted by a group chosen from amino, C1-C6 monoalkylamino, 3-pyrrolin-1-yl, pyrrolidin-1-yl, morpholin-4-yl and piperidin-1-yl, the aryl or h...  
WO/1994/027997A1
This application is directed to optoelectronic materials which are bistable organic tautomeric compositions of dithio or diseleno carbamate esters of cyclic 1,3-dithio or diselena-2-iminium salts. Specifically, it is concerned with compo...  
WO/1994/027592A1
The invention concerns the use of dihydroliponic acid or physiologically tolerated salts thereof in the preparation of pharmaceutical compositions for the treatment of disorders caused by radicals in living body tissue, e.g. eye ailments...  
WO1994012880A3  
WO/1994/019344A1
Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...  
WO/1994/014428A1
A method of reducing the rate of mammalian hair growth includes topically applying a composition containing a sulfhydryl reactive compound to the skin.  
WO/1994/013319A1
Disclosed are methods for regulating formation of beta-amyloid protein with inhibitors of proteases specific for the Precursor to the Alzheimer's Disease beta-amyloid protein, such as inhibitors of aspartic protease, cathepsin D, and a c...  
WO/1994/012450A1
The invention relates to a method of preparing sulfur-containing compounds, comprising reacting a sulfur compound with a compound containing unsaturated carbon-carbon bonds, wherein in a solvent one or more compounds containing non-activ...  
WO/1994/012880A2
The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...  
WO/1994/008573A1
A method of reducing the damaging effect of an injury to mammalian cells by treatment of the cell or mammalian tissue in vivo with a cell membrane permeant calcium buffer. The method comprises treating mammalian tissue with a damage redu...  
WO/1994/006790A1
2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of po...  
WO/1993/025223A1
The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...  
WO/1993/022280A1
Substituted cyclohexene-1,2-bicarboxylic acid derivatives (I), (R?1¿, R?2¿ = H, possibly substituted C¿1?-C¿6? alkyl, C¿3?-C¿6? alkenyl or C¿3?-C¿6? alkinyl, C¿3?-C¿8? cycloalkyl, possibly substituted phenyl or heterocyclyl) an...  
WO/1993/020036A1
The present invention provides two basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates ...  
WO/1993/016800A1
A catalyst solution comprising one or more compounds of a metal catalyst and an organic solvent selected from the group consisting of a glycol derivative, an alkyl pyrrolidone, and an alkoxy ethyl ether, wherein no additional chloride co...  
WO/1993/007234A1
Compounds of general formula (I), wherein R signifies hydrogen, halogen, cyano, isothiocyanato, or alkyl, alkenyl or alkynyl with 1 to 15 carbon atoms, which is unsubstituted or substituted with at least one of halogen, cyano and/or trif...  
WO1993002710A3  
WO1992019613A3  
WO/1993/002710A2
The present invention provides the use of a persistent aryloxy or arylthio free radicals, other than perhalo radicals, for the manufacture of a contrast medium for use in magnetic resonance imaging. Also provided are magnetic resonance i...  
WO/1993/002711A1
The present invention provides the use of a persistent $g(p)-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising $g(p)-system of said radical comprises at ...  
WO/1993/002076A1
A 1,2-dithiolane compound with antibacterial and cell growth inhibitory activities represented by general formula (I), wherein n represents an integer of 0 to 2; R1 represents OR3 (wherein R3 represents hydrogen or lower alkyl), NR4R5 (w...  
WO/1993/002383A1
Nonlinear optical (NLO) compositions are disclosed which contain polar disulfone-functionalized molecules (PDFMs), wherein the polar disulfone-functionalized molecules are of formula (I), where n is 0, 1 or 2; R1 and R2 each independentl...  
WO1992017549A3  
WO/1992/020669A1
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.  
WO/1992/020696A1
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.  

Matches 451 - 500 out of 2,521