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Patent Searching and Data


Matches 351 - 400 out of 2,553

Document Document Title
WO/2002/030919A1
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic 6,8-halo-octanoic acid with S(-)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt o...  
WO/2002/030918A2
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)$g(...  
WO/2002/030917A2
Process for the synthesis of racemic thiotic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound f...  
WO/2002/026909A1
Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.  
WO/2002/024613A2
The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.  
WO/2002/022694A1
Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising two nitrogen donor atoms independently su...  
WO/2002/010151A2
The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents...  
WO/2002/010113A1
The invention relates to a method for producing compounds of general formula (I) wherein R?1¿ represents a C¿1?-C¿20? alkyl group, a C¿3?-C¿12? cycloalkylgroup, a C¿7?-C¿12? aralkyl group, or a mono or bicyclic aryl group. A keton...  
WO/2002/002533A1
Medicinal compositions, in particular, GnRH receptor antagonists comprising propane-1,3-dione derivatives represented by the following general formula (1) as the active ingredient; and novel propane-1,3-dione derivatives having a GnRH an...  
WO2001049250A3
Active acne and acneiform scars are treated by topical application of a composition containing lipoic acid and/or a lipoic acid derivative such as dihydrolipoic acid, a lipoic or dihydrolipoic acid ester, a lipoic or dihydrolipoic acid a...  
WO2001015693A3
The invention relates to the use of racemic alpha -lipoic acid, or its enantiomers or pharmaceutically acceptable salts, amides, esters or thioesters thereof in reduced or oxidised form, as an active ingredient for the prevention or trea...  
WO2001049275A3
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...  
WO/2001/093824A1
The present invention relates to the use of lipoic acid, lipoic acid derivatives or salts thereof having an (R)-enantiomer-excess in cosmetic compositions for skin or hair and for the preparation of dermatological compositions for the tr...  
WO/2001/093865A2
The invention relates to the use of $g(a)-lipoic acid in reduced or oxidised form, or derivatives thereof which have an intact dithiolane structure in the form of enantiomers, or pharmaceutically acceptable salts, amides, esters, thioest...  
WO/2001/092252A1
A sulfurized (meth)acrylic ester compound represented by the formula (1) (wherein R¿1? and R¿2? each represents hydrogen or alkyl and may be bonded to each other to form a ring; R¿3? represents hydrogen or methyl; X¿1? represents oxy...  
WO2001009118A3
The invention provides methods to treat neurological disorders such as Alzheimer's disease, or to slow the progression of such diseases, or to treat and/or prevent other disorders as disclosed in the specification, by administering to pa...  
WO/2001/085165A2
The invention relates to the use of lipoic acid and C¿1? donors, especially S-adenosylmethionine and/or 5-methyltetrahydrofolate, for treating disorders of the central nervous system. The invention also relates to agents containing a co...  
WO/2001/085677A1
The invention concerns novel amino acid derivatives and their use as medicines. Said derivatives have an inhibiting activity towards NO-synthase enzymes producing nitrogen monoxide NO and/or (optionally): either an activity trapping reac...  
WO/2001/083571A2
Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or...  
WO/2001/080856A2
The invention concerns the use of anethole-dithiolethione for producing a medicine for preventing drug-induced tendon toxicity.  
WO2000035903A3
The invention relates to thiochromanoyl cyclohexenone derivatives of formula (I), wherein the variables have the following meanings: A is an optionally substituted, saturated or unsaturated alkyl chain; R<1> is cyano, rhodano, nitro, OR<...  
WO/2001/068575A1
A cation or acid generator which, upon irradiation with energy rays, can generate cations or an acid with high sensitivity and which is suitable for use in chemical amplification type resist materials. It comprises an energy-ray-sensitiv...  
WO/2001/068643A2
The invention concerns novel heterocyclic or benzene derivatives comprising a lateral chain derived from lipoic acid, having an activity inhibiting NO-synthase enzymes producing NO nitrogen monoxide and/or are agents enabling regeneratio...  
WO/2001/064667A1
The invention relates to a method for producing compounds that have at least one -CF¿2?-O bond in the molecule by reacting a bis(alkylthio) carbenium salt in the presence of a base with a compound that contains at least one hydroxy grou...  
WO/2001/049250A2
Active acne and acneiform scars are treated by topical application of a composition containing lipoic acid and/or a lipoic acid derivative such as dihydrolipoic acid, a lipoic or dihydrolipoic acid ester, a lipoic or dihydrolipoic acid a...  
WO/2001/049275A2
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...  
WO/2001/047911A1
The invention concerns cationic amphiphiles derived from lipoic acid, their uses as DNA transfection vectors and their synthesis method.  
WO/2001/040175A1
A process for producing a sulfur compound bearing at least one thio group in the molecule by reacting a thiol compound with an organic compound bearing at least one functional group capable of reacting with a mercapto group to thereby fo...  
WO/2001/040874A1
The use of a compound of formula (A), which comprises a group of sub-formula (I) where R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, X?1¿ and Y?1¿ are various specified organic groups wherein at least one of said groups has sufficient elec...  
WO/2001/025226A1
The present invention describes methods for synthesizing novel dithiolane derivatives, ligands with high affinity for the nuclear hormone receptors, peroxisome proliferator-activated receptor-$g(g)(PPAR$g(g)) and/or PPAR$g(a). Methods fo...  
WO2000071533A3
The invention is directed to 1,4-dithiin- and 1,4-dithiepin- 1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds ...  
WO2000040576A3
A compound of formula (I) in which R<1> is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R<2> is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or optio...  
WO/2001/019341A1
The invention relates to a process of modification of the nitrogen oxides metabolism by means of modification of the micellar catalysis parameters of NO oxidation. According to the invention, the number of phases and/or the volume ratio ...  
WO2000059899A8
The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping rea...  
WO/2001/015693A2
The invention relates to the use of racemic $g(a)-lipoic acid, or its enantiomers or pharmaceutically acceptable salts, amides, esters or thioesters thereof in reduced or oxidised form, as an active ingredient for the prevention or treat...  
WO1999057111A9
The invention relates to cyclohexenondioxothiochromanoyl derivatives of formula (I) wherein the variables have the following meanings: X is oxygen, sulphur, S=O, S(=O)2, CR<4>R<5>, C=O or C=NR<6>; R<1> is hydrogen, nitro, halogen, cyano,...  
WO/2001/012620A1
The invention relates to a method used for the production of a solvent-free a-liponic acid, wherein: a) the $g(a)-linoleic acid which is to be purified is dissolved in an aqueous alkaline solution or the salt thereof in water, and the pH...  
WO/2001/009118A2
The invention provides methods to treat neurological disorders such as Alzheimer's disease, or to slow the progression of such diseases, or to treat and/or prevent other disorders as disclosed in the specification, by administering to pa...  
WO2000054756A3
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...  
WO/2000/071533A2
The invention is directed to 1,4-dithiin- and 1,4-dithiepin- 1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds ...  
WO/2000/069810A1
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or preventio...  
WO/2000/059899A1
The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping rea...  
WO/2000/058258A1
Compounds which are useful in the efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. The compounds are 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives represented by formula (1) [wherein R?1¿ represe...  
WO/2000/054756A2
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...  
WO/2000/052530A1
Radically photopolymerizable compositions comprising (a) at least one ethylenically unsaturated photopolymerizable compound; (b) as photoinitiator, at least one compound of formulae (I, II, III, IV, V and/or VI), wherein m is 0 or 1; n i...  
WO/2000/044731A1
The current invention discloses novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors. Compounds of particular interest are defined by Formula (I) wherein X, Y, A, J, R?1¿, R?2¿ R?3¿, R?4¿, R?7¿ and...  
WO2000003975A3
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...  
WO/2000/040576A2
A compound of formula (I) in which R?1¿ is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R?2¿ is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or opt...  
WO/2000/035903A2
The invention relates to thiochromanoyl cyclohexenone derivatives of formula (I), wherein the variables have the following meanings: A is an optionally substituted, saturated or unsaturated alkyl chain; R?1¿ is cyano, rhodano, nitro, OR...  
WO/2000/034348A1
Cationic polymerization initiators of formula (I) are disclosed. The acyl sulfonium salts of the present invention differ from known acyl sulfonium initiators in that the substituents R?2¿ and R?3¿ on the sulfur are larger and more com...  

Matches 351 - 400 out of 2,553