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Patent Searching and Data


Matches 401 - 450 out of 2,553

Document Document Title
WO/2000/031060A1
The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The c...  
WO/2000/031072A1
This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.  
WO2000004892A3
This invention is the coadministration of ACAT and MMP inhibitors for the reduction of both the macrophage and smooth muscle cell component of atherosclerotic lesions, thus impairing the expansion of existing lesions and the development ...  
WO/2000/024734A1
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poi...  
WO/2000/012464A1
Fluorobicyclo[3.1.0]hexane derivatives represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same wherein R?1¿ and R?2¿ represent each hydrogen, alkyl, cycloalkyl, etc.; and Y?1¿ and Y?2¿ re...  
WO/2000/008012A1
The invention relates to enantiomer-free crystalline (R) or (S) lipoic acid, where the reflection line at 2 $g(U) = 23° is the most intensive one in the 13° to 30° range in the 2 $g(U) diffractogram.  
WO1999065922A3
A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by five formulas (I), (II), (III), (IV), (V). Each of the R groups is defined in the disclosure.  
WO/2000/004892A2
This invention is the coadministration of ACAT and MMP inhibitors for the reduction of both the macrophage and smooth muscle cell component of atherosclerotic lesions, thus impairing the expansion of existing lesions and the development ...  
WO/2000/003975A2
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...  
WO/1999/065922A2
A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by five formulas (I), (II), (III), (IV), (V). Each of the R groups is defined in the disclosure.  
WO/1999/062968A1
Methods for preparing olefin polymers, and catalysts for preparing olefin polymers are disclosed. The polymers can be prepared by contacting the corresponding monomers with a Group 8-10 transition metal catalyst and a solid support. The ...  
WO/1999/059989A1
Process for preparing a benzo fused heterocyclo sulfonyl halide intermediate, comprising reacting a benzo fused heterocyclic compound with a -SO3- complex in the presence of a solvent and then adding oxalyl halide.  
WO/1999/057111A1
The invention relates to cyclohexenondioxothiochromanoyl derivatives of formula (I) wherein the variables have the following meanings: X is oxygen, sulphur, S=O, S(=O)¿2?, CR?4¿R?5¿, C=O or C=NR?6¿; R?1¿ is hydrogen, nitro, halogen,...  
WO/1999/045922A1
A compound is provided having formula (I) wherein R?1¿ and R?2¿ independently denote a methylene, ethylene or unbranched or branched C¿3-16? alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or mo...  
WO1999024024A3
Retinoids with retinoid receptor antagonistic activity called retinoid antagonists, pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, have been found to be efficacious in the treatment of T-he...  
WO/1999/040025A1
The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least...  
WO/1999/036384A1
Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.  
WO/1999/033781A1
Compounds represented by formulae (I, II or III), wherein U is CH, O, or S; Z is -C(R¿2?)(R¿3?), -CH-N(R¿2?)(R¿3?), C(R¿3?)[(CH¿2?)nR¿2?], CH-C(R¿3?)(R¿8?)(CH¿2?)nR¿2?, C[(CH¿2?)nR¿2?]-[CH(R¿3?)(R¿8?)], C[(R¿3?)][CH[(CH¿...  
WO/1999/028292A1
The invention concerns ionic compositions with high ionic conductivity, comprising a salt with delocalized anionic charge. An ionic composition comprises a salt dissolved in a solvent and has a conductivity higher than 10?-5¿ S.cm?-1¿ ...  
WO/1999/028984A1
The invention concerns novel electrode materials derived from polyquinoid ionic compounds and their uses such as in electrochemical generators. It concerns in particular compounds such as a rhodizonic acid salt; a rufigallic acid salt; a...  
WO/1999/024024A2
Retinoids with retinoid receptor antagonistic activity called retinoid antagonists, pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, have been found to be efficacious in the treatment of T-he...  
WO/1999/020668A1
The invention relates to sulfone functionalized prepolymers useful in making high index of refraction optical lenses which have superior hardness and thermal stability. The invention further relates to the resins produced from the prepol...  
WO1998058246A3  
WO/1999/006036A1
Certain retinoid derivatives, most or all of which are selective RXR retinoid agonists, have been found to be useful in the prevention or minimization of surgical adhesion formation.  
WO1998040420A3  
WO/1998/058246A2
The invention provides compounds and intermediaries in their production useful as cation sensors and/or extractors, the compounds comprising a redox active group and a cation sensing group and/or a thiol terminating group. The compounds ...  
WO1998040374A3  
WO/1998/052935A1
The invention concerns compounds of formula (I) in which: R�1?, R�2? and R�3? are as define in the description; X is as defined in the description; Y represents an oxygen atom, a sulphur atom, a CH�q?, SO or SO�2? group; n is b...  
WO/1998/048806A1
The present invention provides a class of substituted indene compounds and their pharmaceutically acceptable salts which possess selective estrogen receptor modulator (SERM) activity and are thus useful in the treatment of osteoporosis a...  
WO/1998/047933A1
Provided are certain transition metal complexes which are useful as catalysts in the polymerization of olefinic monomers. In particular, the invention provides complexes of certain bidentate ligands bonded to Ni, Pd, Co, or Fe, and optio...  
WO/1998/046076A1
A method of inhibiting endothelin-1 in a subject comprising administering to the subject an inhibiting amount of a suitable retinoid or retinoid related molecule and a method of treating pain and diseases associated with the presence of ...  
WO/1998/042661A1
An organic compound is provided which contains at least one nitric oxide donor group and at least one group being, or being adapted to be converted in vivo to a free sulfhydryl group. A preferred compound contains at least one sulfhydryl...  
WO/1998/040420A2
The present invention includes novel ligands which may be utilized as part of a catalyst system. A catalyst system of the present invention is a transition metal-ligand complex. In particular, the catalyst system includes a transition me...  
WO/1998/040374A2
Methods for preparing olefin polymers, or oligomers catalysts for preparing olefin polymers and bidentate ligand used for preparing these catalysts are disclosed. The polymers can be prepared containing the corresponding monomers with a ...  
WO/1998/038185A1
The unsymmetrical linchpin coupling of 2-t-bityldimethylsilyl-1,3-dithiane with two electrophiles has been achieved as a single operation via solvent-controlled Brook rearrangement. The new protocol has also been extended to five-compone...  
WO/1998/035955A1
The invention concerns novel monomers of formula A: (A) in which: Z represents H or CH�3? and X represents O or S, and Y is a heterocyclic compound consisting of hydrogen, carbon and sulphur atoms, having 5 to 8 chains and at least two...  
WO1997048672A3
Compounds of formulas (1-6) where the symbols have the meaning described in the specification, have retinoid and/or retinoid antagonist-like biological acitivity. 00000  
WO/1998/023606A1
Cyclic dithio compounds of general formula I, wherein A is (a) or (b) [(wherein the substituents are each as defined in the claims)]; and remedies for diabetic kidney diseases, lenitives for digestive disorders, hypoglycemic agents or hy...  
WO/1998/022423A1
The invention concerns novel bi-aromatic compounds of general formula (I): (I) and their use in pharmaceutical compositions for use as human or veterinary medicine (in particular for treating dermatological, rheumatic, respiratory, cardi...  
WO/1998/022434A1
The invention relates to novel glyoxylic acid amides, a method for the production and the use thereof as pesticides.  
WO1998001440A3  
WO/1998/018751A1
Compounds of 1,2-propane diol linked structure (I), when for use in therapy, wherein R?1� or R?2� comprises an acyl or fatty alcohol group derived from a C�12-30? preferably C�16-30? fatty acid desirably with two or more cis or t...  
WO/1998/017630A1
The invention relates to novel amides of the general formula (I), a method for their production and their use as pesticides.  
WO/1998/014436A1
The present invention relates to benzoxazinones of formula I, or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical comp...  
WO/1998/014418A1
Liqud crystal compounds and liquid crystal compositions which are best suited as a liquid crystal material required to have negative permittivity including an IPS mode. The compounds are represented by general formulae (1) and (1-1), whe...  
WO/1998/003474A1
The invention concerns novel glyoxylic acid derivatives, a process for their preparation and their use as pesticides.  
WO/1998/001440A2
The present invention is directed to pharmaceutical compositions including a saturated 1,2-dithiaheterocyclic compound having anti-viral activity. The present invention also provides a kit containing the pharmaceutical composition and me...  
WO/1998/001441A1
Disclosed is (2-thione-1,3-dithiole 4,5-diyl)bis(thiocyanate), its preparation and its use as an antimicrobial and marine antifouling agent.  
WO/1998/001442A1
Disclosed are (2-one (or thione)-1,3-dithiole-4,5-diyl)bis(thiomethylthiocyanate) compounds corresponding to formula (I) wherein Z is oxygen or sulfur, compositions containing said compounds and their use as antimicrobial and marine anti...  
WO/1998/000411A1
A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by either of two formulas (I, II). Each of the R groups is defined in the disclosure.  

Matches 401 - 450 out of 2,553