Heterocyclic Compounds

Matches 51 - 100 out of 53,970	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2024/067675A1	FUSED RING KIF18A INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present invention provides a compound represented by formula (I), a pharmaceutical composition, and a preparation method therefor and use thereof. The compound has a good inhibitory effect on KIF18A, and can be used alone or in a bin...
WO/2024/071439A1	FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME The present invention provides a novel compound that has an STAT6 inhibitory effect and is efficacious in treating inflammatory diseases and allergic diseases such as atopic dermatitis. A compound represented by general formula (I) and h...
WO/2024/067818A1	CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF The present disclosure relates to a chimeric compound used for targeted degradation of a BCL-2 protein, a preparation method therefor, and pharmaceutical application thereof. Specifically, the present disclosure relates to a heterocyclic...
WO/2024/072178A1	COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF The present invention relates to a compound for targeted protein degradation and a use thereof, and more specifically, the compound according to the present invention degrades epidermal growth factor receptor (EGFR) mutant proteins, and ...
WO/2024/072075A1	PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME The present invention relates to a pharmaceutical composition for preventing and treating cancers, including lung cancer, caused by abnormal cell growth, the composition containing, as active ingredients, a novel trisubstituted pyrimidin...
WO/2024/068947A1	MICROBIOCIDAL PYRAZOLE DERIVATIVES A compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, which can be used as fungicides.
WO/2024/072793A1	PYRIDINE CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS The invention provides pyridine carboxamide compounds, pharmaceutical compositions, and their use in treating medical conditions.
WO/2024/073587A1	N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF Compounds and methods for inhibiting Nrf2 by activating KEAP1.
WO/2024/069423A1	THERAPEUTIC FORMULATION Ingestion of therapeutic agents are characterized by low bioavailability, a lengthy onset of action, and inconsistent absorption. The present disclosure provides a therapeutic formulation for pulmonary or sublingual administration of an ...
WO/2024/072768A1	SUBSTITUTED FLUOROPYRIDINE AS HERBICIDES Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides (Formula 1) wherein J is selected from the group consisting of (Formula...
WO/2024/072794A1	PYRIDINE CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS The invention provides pyridine carboxamide compounds, pharmaceutical compositions, and their use in treating medical conditions.
WO/2024/067694A1	NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF The present invention relates to a nitrogen-containing heterocyclic compound and pharmaceutical use thereof. Specifically, the present invention relates to a nitrogen-containing heterocyclic compound represented by general formula (I), a...
WO/2024/067302A1	AMIDE COMPOUND AND USE THEREOF IN PREPARATION OF INHIBITOR OF SIGMA2 AND 5HT2A The present invention provides an amide compound, which has inhibitory activity against the Sigma2 receptor and 5HT2A receptor and can be used as a dual-target inhibitor of Sigma2 and 5HT2A for the treatment of a related disease mediated...
WO/2024/073426A1	1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF Provided dihydroquinazolinone and azadihydroquinazolinone compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.
WO/2024/073502A1	HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related ...
WO/2024/050374A9	ANTI-INFLAMMATORY COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING HEMOCHROMATOSIS, AND OTHER DISORDERS Pharmaceutical compounds have anti-inflammatory activity. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating hemochromatosis, hyp...
WO/2024/067781A1	PHARMACEUTICALLY ACCEPTABLE SALT AND CRYSTAL FORM OF TETRAHYDRONAPHTHALENE DERIVATIVE, AND PREPARATION METHOD The present invention relates to a pharmaceutically acceptable salt and a crystal form of a tetrahydronaphthalene derivative, and a preparation method. Specifically, the present disclosure provides a pharmaceutically acceptable salt and ...
WO/2024/067744A1	HETEROCYCLIC SUBSTITUTED QUINAZOLINE, PREPARATION METHOD THEREFOR, AND USE THEREOF The present invention relates to heterocyclic substituted quinazoline, a preparation method therefor, and use thereof. Specifically, the compound of the present invention has a structure represented by formula (IA), formula (IB) or formu...
WO/2024/071219A1	SULFONAMIDE COMPOUND, AND HARMFUL-ARTHROPOD EXTERMINATION COMPOSITION CONTAINING SAME According to the present invention, a compound represented by formula (I) (wherein, Q (# denotes a bonding site with a sulfur atom, and ● denotes a bonding site with Het) represented in the formula denotes a group or the like represent...
WO/2024/073576A1	4-((2-(3,5-DICHLOROPHENYL)-6-((PYRIMIDIN-5-YL)OXY)PYRIDIN-4-YL)METHYL)PIPERAZINE DERIVATIVES AS FURIN INHIBITORS AND USES THEREOF Provided herein are compounds of Formula (I) which are inhibitors of furin, pharmaceutical compositions containing them, processes for their preparation, and their use in therapy (e.g., for the treatment of respiratory syncytial virus).
WO/2024/071395A1	PHENYLPYRAZOLE COMPOUND, AND PLANT DISEASE CONTROL METHOD The present invention provides an excellent control method against plant diseases. A compound represented by formula (I) or an N oxide thereof or salts thereof can be used for controlling plant diseases (in the formula, Z represents a C6...
WO/2024/066454A1	DRUG FOR TREATING HUMAN TUMOR BY ERF3A TARGETED PROTEIN DEGRADATION MECHANISM Provided are a targeted protein degradation compound TPB-L-E3B, and a synthetic method therefor and use thereof. Such compounds can be used for treating human tumor diseases by means of an eRF3a targeted degradation mechanism, and have s...
WO/2024/073662A1	AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION The subject matter described herein is directed to myelin-promoting compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of admin...
WO/2024/067845A1	IMIDAZOPYRIDINE COMPOUND AS IRAK4 DEGRADATION AGENT AND USE THEREOF An imidazopyridine compound represented by formula (I) as an IRAK4 degradation agent, a tautomer thereof, a stereoisomer thereof, a hydrate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The...
WO/2024/068467A1	TETRAHYDROQUINOLINE COMPOUNDS AS ANTITUMOR AGENTS The invention relates to a tetrahydroquinoline compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein A is (C3-C7)cycloalkyl; (C3-C7)heterocycloalkyl comprising from 1 to 3 heteroatoms selected from O, N, and S; (C...
WO/2024/073371A1	AKT1 MODULATORS Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.
WO/2024/069448A1	SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME The present disclosure includes substituted 1-arylaminocarbonyl-1'-heteroaryl compounds, substituted 1-heteroarylaminocarbonyl-1'-heteroaryl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds...
WO/2024/064274A1	PYRAZOLE AMIDE INSECTICIDES Disclosed are compounds of Formula 1, and A, R1. R2, R3, R4, R5, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling and combating an invertebrate pe...
WO/2024/064024A1	((4-OXO-3,4-DIHYDROQUINAZOLIN-8-YL)METHYL)AMINE DERIVATIVES AS P13K INHIBITORS FOR THE TREATMENT OF CANCER The present invention relates to ((4-oxo-3,4-dihydroquinazolin-8-yl)methyl)amine derivatives of formula (I) as well as to said compounds for use as P13K inhibitors in methods of treatment of cancer.
WO/2024/062363A1	BICYCLIC HETEROCYCLIC COMPOUNDS AS CBL-B INHIBITORS The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as CBL-b inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and...
WO/2024/064778A2	SMALL MOLECULE INHIBITORS OF NEUTROPHIL EXOCYTOSIS AND INFLAMMATION The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt thereof, wherein R1, X, and n are defined herein, their pharmaceutical compositions, and methods of use for treating diseases that are vulnerab...
WO/2024/064358A1	COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY This disclosure features chemical entities (e.g., a compound of Formula (I), (I-a), (I-b), or (I-c), or a pharmaceutically acceptable salt thereof) that induce degradation of Stimulator of Interferon Genes (STING). Said chemical entities...
WO/2024/061345A1	HPK1 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF The present application belongs to the field of medicines, and provides an HPK1 inhibitor, a preparation method therefor, and use thereof. Particularly, disclosed are a compound of formula (I'), a preparation method therefor, a pharmaceu...
WO/2024/063576A1	NOVEL QUINAZOLINE COMPOUND AS KRAS INHIBITOR The present invention relates to a novel quinazoline compound as a KRAS inhibitor and, more specifically, to a novel quinazoline compound useful as a KRAS protein inhibitor, an isomer, and a pharmaceutical composition for cancer treatmen...
WO/2024/062090A1	PCSK9 INHIBITORS AND METHODS OF USE THEREOF A compound with the Formula (I): A-B-C wherein A is of the formula (Ia) where X1 is N B is of formula (B-1) or (B-2) and C is selected from the group consisting of optionally substituted C6-10 carboaryl, C5-6 heteroaryl and C5-10 heteroc...
WO/2024/063670A1	CYCLIN-DEPENDENT KINASE 7 INHIBITORS The present invention relates to novel compounds of formula I, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, which exhibit the properties of a CDK7 inhibitor, as well as to a pharmaceutical composition containin...
WO/2024/062250A1	IMIDAZOLYL-AMINO-PYRAZINE-CARBONITRILS AS CHK-1 INHIBITORS The present invention relates to compounds of Formula (I) that may act as inhibitors of checkpoint kinase 1 (Chk1). The invention also relates to pharmaceutical compositions comprising those compounds, and to their use in the treatment o...
WO/2024/062089A1	PCSK9 INHIBITORS AND METHODS OF USE THEREOF A compound with the Formula (I): A-B-C wherein A is of the following formula (II): where X1 is C-RA1; B is of formula (B-1) or (B-2) and C is selected from the group consisting of optionally substituted C6-10 carboaryl, C5-6 heteroaryl a...
WO/2024/064745A1	SYNTHESIS OF RELDESEMTIV Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.
WO/2024/063648A1	Platform and scaffold for FAP targeting agents The present invention is directed to a scaffold and a compound for targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs). The scaffold comprises a (4-quinoinolyl)glycinyl-2-cyanopyrrolidine scaffold that i...
WO/2024/061365A1	PYRIMIDINE FUSED RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Provided are a compound represented by formula (I), or a tautomer, a cis-trans isomer, a mesomer, a racemate, an enantiomer, a diastereomer, or an atropisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt, a s...
WO/2024/059951A1	INHIBITORS OF THE ANDROGEN RECEPTOR DNA-BINDING DOMAIN This invention provides compound having a structure of Formulas I-VI. Uses of such compounds for treatment of various indications that would benefit from modulation of the androgen receptor, including prostate cancer. Also provided are m...
WO/2024/064646A1	SALTS AND SOLID FORMS OF (S)- OR RACEMIC 3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND METHODS OF USING THE SAME Provided herein are salts of and solid forms comprising free base or salts of (S)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione. Pharmaceutical compositions comprising such salts and solid ...
WO/2024/056732A1	PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
WO/2024/059317A1	YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS Provided are YAP/TAZ-TEAD oncoproteins inhibitors of Formula (I), or a stereoisomer, and/or a pharmaceutically acceptable salt, and/or solvate thereof, pharmaceutical compositions thereof, and methods of treatment.
WO/2024/058617A1	ANTIVIRAL USE OF HETEROARYL DERIVATIVE COMPOUND The present invention relates to an antiviral use of a fused heteroaryl derivative. A fused heteroaryl derivative according to the present invention exhibits excellent inhibitory activity against ANO6, and thus can be effectively used as...
WO/2024/057021A1	COMPOUNDS FOR TARGETED PROTEIN DEGRADATION The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.
WO/2024/056019A1	BICYCLIC COMPOUNDS AS CDK INHIBITORS Disclosed herein are bicyclic compound derivatives used as inhibitors of cyclin-dependent kinases. Disclosed herein is the use of these inhibitors for inhibiting cyclin-dependent kinases, and the use of such compounds for treating cancer.
WO/2024/055801A1	PYRIDINAMIDE DERIVATIVE AND USE THEREOF The present invention relates to a pyridinamide derivative and a use thereof, and specifically relates to a compound of formula (I) or an isotope labeled compound thereof as a pyridinamide derivative, or an optical isomer, a geometric is...
WO/2024/059659A1	CYCLOALKYL CARBOXYLIC ACID DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, Y1, Y2, X1, X2, X3, Q1, and Ra are as defined elsewhere herein. Also provid...

Matches 51 - 100 out of 53,970	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >