Heterocyclic Compounds

Matches 401 - 450 out of 53,970	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >

Document	Document Title
WO/2023/241507A1	CRYSTAL FORM OF ALKYNYLPYRIDINE COMPOUND AND PREPARATION METHOD THEREFOR Disclosed in the present invention are a crystal form of an alkynylpyridine compound and a preparation method therefor, specifically disclosed are a crystal form of a compound represented by formula (I) and a preparation method therefor.
WO/2023/243677A1	PLANT DISEASE CONTROL METHOD The present invention provides a plant disease control method having an excellent efficacy for controlling plant diseases, the method comprising treating plants or soil used for plant cultivation with a compound represented by formula (I...
WO/2023/244574A1	ALDH-2 INHIBITOR COMPOUNDS AND METHODS OF USE Disclosed herein are aldehyde dehydrogenase (ALDH-2) inhibitor compounds, such as a compounds of Formula (I) or Formula (II), pharmaceutical compositions comprising these inhibitor compounds, and uses of these compounds and compositions,...
WO/2023/244818A1	MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME Described herein, in part, are compounds that mediate the degradation of casein kinase 1α (CK1α), and are therefore useful in the treatment of various disorders, such as cancer.
WO/2023/241608A1	CSF-1R INHIBITORS AND USES THEREOF The present application relates to compounds of formula (I) and formula (1'), which are useful as inhibitors of CSF-1R in the treatment of various diseases.
WO/2023/241652A1	PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING SAME, AND USE THEREOF The present invention provides a pharmaceutical composition, a method for preparing same, and use thereof. The pharmaceutical composition comprises a compound represented by formula I. The pharmaceutical composition of the present invent...
WO/2023/241598A1	AROMATIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF IN PREPARATION OF ESTROGEN RECEPTOR DEGRADER The present invention provides an aromatic compound, a method for preparing same, and use thereof in the preparation of an estrogen receptor degrader, and belongs to the technical field of chemical medicines. The aromatic compound is a c...
WO/2023/241644A1	FIVE-MEMBERED RING-FUSED SIX-MEMBERED COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF Disclosed in the present invention are a five-membered ring-fused six-membered compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented ...
WO/2023/243678A1	PYRAZOLE COMPOUND, PRODUCTION INTERMEDIATE THEREOF, AND PEST CONTROL AGENT The present invention provides a pyrazole compound represented by formula (1) or a salt thereof, and a novel bactericide containing same as an active ingredient, particularly, a bactericide for agricultural and horticultural use. In the ...
WO/2023/245091A1	PYRIDAZINONE-DERIVED COMPOUNDS FOR THE MODULATION OF MYC AND FOR MEDICAL USES Compositions, systems, and methods are described herein for the modulation, and in particular the reduction or inhibition, of expression or activity of MYC in a cell, animal or human subject. Such compositions, systems, and methods are u...
WO/2023/242228A1	4-SUBSTITUTED (1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLES AS BUB1 INHIBITORS USEFUL FOR TREATING CANCERS The present invention relates to 4-substituted (1H-benzo[d]imidazol-2-yl)-1H- pyrazole compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of cancers assoc...
WO/2023/244815A1	MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME Described herein, in part, are compounds that mediate the degradation of casein kinase 1α (CK1α), and are therefore useful in the treatment of various disorders, such as cancer.
WO/2023/244563A1	ALDH-2 INHIBITOR COMPOUNDS AND METHODS OF USE Disclosed herein are aldehyde dehydrogenase (ALDH-2) inhibitor compounds, such as a compounds of Formula (I) or Formula (II), pharmaceutical compositions comprising these inhibitor compounds, and uses of these compounds and compositions,...
WO/2023/241618A1	AMINOPYRIMIDINE COMPOUNDS AND USE THEREOF Disclosed are a series of aminopyrimidine compounds and use thereof, and specifically disclosed are a compound represented by formula (XI), a stereoisomer thereof and a pharmaceutically acceptable salt thereof, and use thereof.
WO/2023/244584A1	ALDH-2 INHIBITOR COMPOUNDS AND METHODS OF USE Disclosed herein are aldehyde dehydrogenase (ALDH-2) inhibitor compounds, such as a compounds of Formula (I) or Formula (II), pharmaceutical compositions comprising these inhibitor compounds, and uses of these compounds and compositions,...
WO/2023/241627A1	CDK8/19 DUAL INHIBITORS AND METHODS OF USE THEREOF The disclosure provides for compounds and methods for modulating or inhibiting CDK8/19.
WO/2023/243601A1	AZACYCLOALKYL CARBONYL CYCLIC AMINE COMPOUND Provided is an azacycloalkyl carbonyl cyclic amine compound that is useful as an active ingredient in a pharmaceutical composition for treating neutrophilic inflammatory diseases. An azacycloalkyl carbonyl cyclic amine compound according...
WO/2023/242597A1	BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.
WO/2023/236927A1	4-CARBONYLAMINOISOINDOLINE-1,3-DIONE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF A 4-carbonylaminoisoindoline-1,3-dione compound as represented by formula (I), or an optical isomer, pharmaceutically-acceptable salt, solvate (such as hydrate), inclusion compound, racemate, isotopic marker, or nitrogen oxide thereof; a...
WO/2023/237012A1	BICYCLIC SUBSTITUTED AROMATIC CARBOXYLIC ACID-TYPE DEUTERATED COMPOUND Provided are a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof.
WO/2023/239227A1	NOVEL COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT The present invention relates to a novel compound that regulates the function and differentiation of the cytoskeleton, which is involved in pulmonary fibrosis, and thus is useful in the preparation of drugs that can treat associated dise...
WO/2023/237732A1	RSV INHIBITING TRIAZOLO BEARING DERIVATIVES The invention concerns compounds having antiviral activity, in particular having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising th...
WO/2023/236955A1	POLYSUBSTITUTED CARBAZOLE DERIVATIVE AND USE THEREOF The present invention relates to the technical field of organic electroluminescent materials, and particularly relates to a polysubstituted carbazole derivative and use thereof. The structural formula of the polysubstituted carbazole der...
WO/2023/236920A1	SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF This disclosure provides compounds of Formula (1), compositions comprising the same, and methods of using the same, including uses in modulating SARM1 and treating various diseases and conditions, e.g., those caused by axonal degeneration.
WO/2023/236945A1	PYRIDAZIN-3-CARBOXAMIDE COMPOUND AS TYK2 INHIBITOR The present invention provides a pyridazin-3-carboxamide compound of general formula (I), or a pharmaceutically acceptable salt, enantiomer, diastereomer, raceme, solvate, hydrate, polymorphic form, prodrug, or isotopic variant thereof. ...
WO/2023/240038A1	TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS This disclosure provides compounds of Formula (I) (e.g., Formula (I-aa) (e.g., Formula (I-aa-1), (I-aa-2), (I-aa-3), (I-aa-4), (I-aa-5), or (I-aa-6)), Formula (I-a) (e.g., Formula (I-a-1), (I-a-2), (I-a-3), (I-a-4), (I-a-5), or (I-a-6)),...
WO/2023/240251A1	POLYMORPHS OF SUBSTITUTED ISOQUINOLINE-BASED RHO KINASE INHIBITORS The present disclosure relates to crystalline polymorphs of (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-am ine, salts thereof, pharmaceutical compositions thereof, pharmaceutical compositions comprising crystalline polymorp...
WO/2023/237015A1	N-TETRAZOLYL ARYL UREA DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF The present invention relates to the field of biological medicines. Disclosed are N-tetrazolyl aryl urea derivatives, a preparation method therefor, and the use thereof. The present invention has recently discovered the N-tetrazolyl aryl...
WO/2023/239697A1	MDM2 DEGRADERS AND USES THEREOF The present invention relates to MDM2 degraders, their liquid formulations, and methods of use thereof for treating cancer.
WO/2023/236926A1	4-CARBONYLAMINO ISOINDOLIN-1-ONE DERIVATIVE, COMPOSITION COMPRISING SAME, AND USE METHOD THEREOF A 4-carbonylamino isoindolin-1-one compound represented by formula (I), or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate (such as a hydrate) thereof, or an inclusion compound thereof, or a racemat...
WO/2023/239629A1	COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT DEGRADE CDK2 This disclosure provides compounds and pharmaceutically acceptable salts thereof that are useful as modulators of targeted ubiquitination. The compounds disclosed herein bind to and degrade one or more cyclin dependent kinases 2 (CDK2).
WO/2023/236199A1	CRYSTAL OF N-(BENZOYL)-PHENYLALANINE COMPOUND, AND PHARMACEUTICAL COMPOSITION THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present invention relates to a crystal of an N-(benzoyl)-phenylalanine compound and a pharmaceutical composition thereof, and a preparation method therefor and the use thereof. Specifically, the compound is as represented by formula ...
WO/2023/239710A1	BENZOPYRIMIDIN-4(3H)-ONES AS PI3K INHIBITORS Novel PI3K inhibitors of the general Formula (1) are described along with methods of their preparation and their use in the treatment of diseases associated with the elevation or activation of the PI3K pathway, wherein R1 to R8 are as de...
WO/2023/235925A1	COMPOUNDS WITH MERTK ACTIVITY The present invention provides compounds of Formula (I), which have activity as inhibitors of MERTK. The present invention also provides radio-labelled compounds which may be used in diagnostic and imaging compositions. The present inven...
WO/2023/239941A1	IMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS RIPK2 INHIBITORS The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof, and compositions comprising same. Also described are methods of treating the diseases and disorders disclosed ...
WO/2023/239945A1	BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Disclosed herein relates to the biological activities and preparation of 5-(2-(4-(4-fluoro-2- methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5- azaspiro[2.4]-heptan-7-ol (Compound A) stable crystalline form (Compound A-Xln); i...
WO/2023/237055A1	USE OF CDK4/6 INHIBITOR IN TREATMENT OF DEDIFFERENTIATED LIPOSARCOMA The present disclosure belongs to the technical field of medicines, and relates to the use of a CDK4/6 inhibitor in treatment of dedifferentiated liposarcoma, in particular to the use of a compound of formula (I) in treatment of dediffer...
WO/2023/238112A1	SOLID STATE FORMS OF PALTUSOTINE AND PROCESS FOR PREPARATION THEREOF The present disclosure encompasses solid state forms of Paltusotine, in embodiments crystalline polymorphs of Paltusotine or salts of Paltusotine, particularly Paltusotine monomesylate and Paltusotine hemimesylate, processes for preparat...
WO/2023/236820A1	AROMATIC SIX-MEMBERED RING-FUSED IMIDAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF An aromatic six-membered ring-fused imidazole derivative, and a preparation method therefor and the use thereof, which belongs to the field of drug synthesis. Specifically, the present invention relates to an aromatic six-membered ring-f...
WO/2023/239750A1	BICYCLIC-SUBSTITUTED GLUTARIMIDE CEREBLON BINDERS This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail....
WO/2023/239729A1	PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS The present disclosure is directed to compounds of Formula (I): wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable s...
WO/2023/239634A2	INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM The present invention is directed to novel organic compounds demonstrating the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems. The novel compounds include zwitterion moieties...
WO/2023/236947A1	SUBSTITUTED PYRIDAZINE-3-CARBOXAMIDE COMPOUND SERVING AS TYK2 INHIBITOR The present invention provides a pyridazine-3-carboxamide compound of general formula (I), or a pharmaceutically acceptable salt, enantiomer, diastereomer, racemate, solvate, hydrate, polymorph, prodrug or isotopic variant thereof. The p...
WO/2023/237049A1	DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE Disclosed herein are novel bifunctional compounds formed by conjugating IRAK4 inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparati...
WO/2023/240205A1	DEUTERATED COMPOUNDS The present disclosure provides deuterated compounds and their use as T-type calcium channel blockers in the treatment or prevention of various diseases or disorders associated with calcium T channels.
WO/2023/237116A1	PROTEIN DEGRADERS AND USES THEREOF The present invention discloses a protein degrader such as a GSPT1 degrader and use thereof, particularly use in the prevention and/or treatment of diseases.
WO/2023/239846A1	HETEROCYCLIC COMPOUNDS AS PI3KΑ INHIBITORS The present application provides heterocyclic compounds of formula (I) that modulate the activity of the PI3Ka, which are useful in the treatment of various diseases, including cancer.
WO/2023/231795A1	HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME The present invention relates to the technical field of organic electroluminescent materials, and particularly relates to a heterocyclic compound and the use thereof. The structural formula of the compound is as shown in formula (I). The...
WO/2023/235305A2	SULFONYL CYCLIC DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF The invention provides novel sulfonyl cyclic derivatives, and compositions and methods of preparation and use thereof, that are useful in treating various diseases and disorders related to TRPML activities such as lysosome storage diseas...
WO/2023/232917A1	NOVEL COMPOUNDS The invention relates to novel compounds having the general formula (Ib) or (Ib'), (Ib) or (Ib') wherein R1, R2, R6, A3, A4, A5, X, Y and W are as described herein, composition including the compounds and methods of using the compounds.

Matches 401 - 450 out of 53,970	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >