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Matches 1 - 50 out of 63,766

Document Document Title
WO/2019/200114A1
The invention relates to novel, scalable methods of making substituted bicyclic compounds that are useful to treat and/or prevent HBV and/or HDV infection and related conditions in a subject.  
WO/2019/197407A1
The invention relates to pyridine-substituted 2,2'-di-9H-carbazol-9-yl-[1,1'-biphenyl]dicarbonitrile derivatives and related compounds of formula (I), especially for use in optoelectronic components. T, V, W, X are selected from a group ...  
WO/2019/196802A1
The present invention relates to a crystal form of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and the use thereof. Specifically, disclosed are a crystal form A of a monohydrochloride anhydrous substance of 3...  
WO/2019/197502A1
The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate.The invention further provides uses of the compounds of formula (I...  
WO/2019/198692A1
The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is in...  
WO/2019/199864A1
The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or in...  
WO/2019/197682A1
The invention relates to pharmaceutical combination products comprising an HDAC inhibitor, e.g. (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-be nzenesulfonyl]-1H-pyrrol-3-yl}- acrylamide as well as salts and or solvents ther...  
WO/2019/200120A1
The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.  
WO/2019/200267A1
Provided herein are compounds, preferably ASK1 inhibitor compounds, compositions thereof, and methods of their preparation, and methods of inhibiting ASK1 and methods for treating disorders mediated by ASK1.  
WO/2019/165158A8
The instant invention describes compounds having IL-6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by IL-6.  
WO/2019/196619A1
Disclosed are a quinazoline derivative salt-form crystal form, and a preparation method therefor and an application thereof. The quinazoline derivative salt-form crystal form is specifically hydrochloride crystal forms A, B, C, D, F, H, ...  
WO/2019/196945A1
Disclosed is a novel method for synthesizing deuterated amides and deuterated sulfonamides, the steps being as follows: (1) adding a compound M, DMAP, R3-X to a solvent to obtain a compound N after a reaction is complete; (2) adding the ...  
WO/2019/196937A1
Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation...  
WO/2019/199733A1
Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.  
WO/2019/200161A1
The present disclosure relates to compounds and methods which may be useful for modulating the expression of cnbp and treating diseases and conditions in which cnbp plays an active role.  
WO/2019/199816A1
The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and ot...  
WO/2019/196938A1
Related to a quinazoline compound serving as an EFGR triple mutation inhibitor and applications thereof. Specifically, disclosed are a compound as represented by the following formula (I), a pharmaceutical composition comprising the comp...  
WO/2019/199979A1
The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.  
WO/2019/198024A1
Compounds of Formula (I), including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: Formula (I):  
WO/2019/197468A1
The present invention relates to N-(cyclopropylmethyl)-5-(methylsulfonyl)-N-{1-[1-(pyrimidin- 2-yl)-1H-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as well as related compounds of ...  
WO/2019/200032A1
The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technolog...  
WO/2019/196812A1
The present disclosure relates to a compound of formula (I), an anti-tumor use thereof, intermediate compounds thereof of formula (III) and formula (IV), and a use thereof. The compound of formula (I) has a degrading effect on a specific...  
WO/2019/196622A1
Disclosed is a 5-substituted difluoropiperidine compound capable of passing through a blood-brain barrier. The structural formula of the compound is formula (I). The 5-substituted difluoropiperidine compound, a derivative, and a pharmace...  
WO/2019/196948A1
Disclosed are a compound using an aryl ketone as a core as represented by general formula (1), a preparation method therefor and an application thereof on an OLED. A parent nucleus of the organic compound is an aryl ketone, the parent nu...  
WO/2019/200310A1
E3 ubiquitin ligase agonists, pharmaceutical compositions including the E3 ubiquitin ligase agonists, and related methods of use are described.  
WO/2019/192992A1
The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-l,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiet...  
WO/2019/195777A1
Compounds of formula (I): wherein,R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as...  
WO/2019/194220A1
Provided are compounds represented by formula (1) or salts thereof, and a pest control agent, an insecticide or miticide, a nematicide, and an endoparasite control or eliminating agent, which contain, as an active ingredient, at least on...  
WO/2019/195682A1
Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are ...  
WO/2019/193071A1
The present invention relates to novel bis-hydrazone derivatives of formula (I) wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III) Y1 and Z1...  
WO/2019/193509A1
The present invention provides substituted pyrazole derivatives of formula (I), which are therapeutically useful as selective CDK12/13 inhibitors. These compounds are useful in the treatment and/or prevention of diseases and/or disorders...  
WO/2019/194381A1
Provided in the present specification are a compound represented by chemical formula 1, a photosensitive resin composition comprising same, a photosensitive material, a color filter, and a display device.  
WO/2019/193342A1
The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates...  
WO/2019/194207A1
Disclosed are: a heteroaryl-substituted pyrazole compound or a pharmaceutically acceptable salt thereof having SGLT1 inhibitory activity and medicinal usefulness; a medicinal composition comprising same; and medicinal uses of the compoun...  
WO/2019/193516A2
Substituted pyrimidine and pyridines as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated ...  
WO/2019/185468A1
An aqueous composition comprising (a) metal ions comprising tin ions and silver ions and (b) at least one complexing agent of formula (C1) R1-X1-S-X21[D1-X22-]nS-X3-R2, (C2) R1-X1-S-X31-D2-[X32-S-]nX3-R2, (C3) R3-X1-S-X41-[D3-X42-]nS-X3-...  
WO/2019/191665A1
The present disclosure relates to compounds capable of emitting delayed fluorescence, and uses of the compounds in organic light-emitting diodes.  
WO/2019/184918A1
The present invention relates to a 3-aminopyrazole compound represented by formula (I) or a pharmaceutically acceptable salt, stereoisomer, prodrug, or deuterated form thereof and an application of the same. The compound and a pharmaceut...  
WO/2019/184744A1
The present invention relates to a tetrahydroisoquinoline derivative, a preparation method therefor and uses thereof, and more particularly relates to a tetrahydroisoquinoline derivative or a pharmaceutically acceptable salt, an ester, a...  
WO/2019/185525A1
The present invention covers 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-trimethyl-1,4- dihydropyridine-3,5-dicarbonitrile compounds of general formula (I) : in which R1, R2 and R3 are as defined herein, methods of preparing said compound...  
WO/2019/191092A1
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the presen...  
WO/2019/189555A1
Provided is a compound that can have a CDK12-inhibiting effect and that is expected to be useful as a preventive or therapeutic drug for cancer and the like. The compound or salt thereof is represented by formula (I) (where each symbol i...  
WO/2019/190259A1
The present invention relates to the compound represented by the following chemical formula 1, or a pharmaceutical composition for prevention or treatment of cancer having EGFR mutation, the composition comprising the compound and a phar...  
WO/2019/191166A1
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life c...  
WO/2019/189553A1
The present invention provides a heterocyclic compound having an activity to enhance the maturation of a cardiomyocyte. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof has an...  
WO/2019/185806A1
The present invention relates to a chemical compound according to general formula (1).  
WO/2019/191229A1
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the presen...  
WO/2019/189717A1
Provided is a novel method for producing a compound represented by formula (I). The invention according to the present application provides: a method for producing a compound represented by formula (I); and methods respectively for produ...  
WO/2019/191620A1
Crystalline Forms of Compound (I); crystalline Forms of Compound (II) and crystalline forms of pharmaceutically acceptable salts of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating ...  
WO/2018/214867A9
An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (1), a preparation method therefor, and a use thereof, each substituent being defined in the description and claims. The compound can be widely applied to t...  

Matches 1 - 50 out of 63,766