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Matches 1 - 50 out of 62,145

Document Document Title
WO/2019/008520A1
The present invention relates to a process for preparing the Alectinib or a pharmaceutically acceptable salt thereof using lesser reaction steps and also eliminating expensive and time- consuming column chromatography. The invention also...  
WO/2019/008029A1
The present invention relates to compounds of formula (I): wherein Q is O or S, R1 is a 6-membered heteroaryl group containing at least one nitrogen atom in the 6-membered ring structure, wherein R1 may optionally be substituted, and R2 ...  
WO/2019/008594A1
of the invention The invention relates to a commercially viable, cost effective and energy efficient process for the preparation of 2-(1H-Imidazol-4-yl) ethanamine or pharmaceutically acceptable salts thereof in high purity and yield via...  
WO/2019/007710A1
The invention relates to myobacterium tuberculosis-thioredoxin reductase inhibitors, processes for the preparation thereof, drugs containing said compounds, and the use of said compounds for manufacturing drugs.  
WO/2019/008034A1
The present invention relates to crystalline forms of N-[1-(5-cyano-pyridin-2-ylmethyl)-1H- pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-a cetamide, pharmaceutical compositions comprising said crystalline forms and their us...  
WO/2019/007989A1
The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging.  
WO/2019/007696A1
The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) recep...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/010419A1
A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp and cannabis leaves can use a continuous simulated moving bed process and a combination of one or more of a...  
WO/2019/007382A1
Disclosed are an indole-formamide derivative, a preparation method therefor and the use thereof in medicine. In particular, disclosed are an indole-formamide derivative as shown in general formula (I), a preparation method therefor, a ph...  
WO/2019/008072A1
Compounds of formula (I), wherein R2, G1, G2, X, X1, A, R4 and R5 are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and ...  
WO/2019/006548A1
A class of fluorinated 2,4-diaminopyrimidine compounds of Formula (I) have been prepared for use in the treatment of cancers and other MERTK related disorders. (Formula (I))  
WO/2019/007293A1
Disclosed are a compound as shown in formula I, and a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, wherein each symbol is as defined in the claims. The compound as shown in formula I has a good inhibitory a...  
WO/2019/008025A1
The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylure...  
WO/2019/008554A1
A method for the oral treatment and prevention of cardiovascular disease utilizes a quantity of non-peptidyl growth hormone secretagogues for: the prophylaxis of atherosclerosis and hypercholesterolemia, preventing the development athero...  
WO/2019/000682A1
The invention relates to a Rho-associated protein kinase (ROCK) inhibitor of formula (I), a pharmaceutical composition containing said Rho-associated protein kinase inhibitor, a preparation method thereof and an application of the ROCK f...  
WO/2019/004421A1
The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, and medical uses thereof. In the formula, R1 is optionally substituted C1-6 alkyl, etc.; L is -C(=O)-...  
WO/2019/003141A1
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. F...  
WO/2019/004082A1
A compound represented by formula (I) or a salt thereof. In formula (I): A1 represents CR1 or a nitrogen atom; A2 represents CR2 or a nitrogen atom; A3 represents CR3 or a nitrogen atom, provided that two or more of A1 to A3 do not repre...  
WO/2019/006157A1
Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions co...  
WO/2019/002571A1
This invention relates to compounds of formula (I) and their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prev...  
WO/2019/000237A1
Provided are pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. Provided is also use of the compounds described herein in the potential treatment or prevention of neurological and...  
WO/2019/002174A1
The invention relates to an organic molecule, in particular for use in organic optoelectronic devices. According to the invention, the organic molecule consists of - a first chemical moiety with a structure of formula (I), and - two seco...  
WO/2019/000024A1
The present invention relates to certain pyridinium enolates which due to their high stokes shift find applications as fluorescent materials in solar concentrators. The invention also relates to solar concentrators containing molecules o...  
WO/2019/006126A1
Disclosed embodiments concern kinase inhibitors, such as interleukin receptor associated kinases (IRAK) inhibitors, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and composition...  
WO/2019/003142A1
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. F...  
WO/2019/006322A1
The present disclosure relates to chemical compounds that inhibit HP1-mediated heterochromatin formation, pharmaceutical compositions containing such compounds, methods of identifying such compounds, and their use in the treatment of dis...  
WO/2019/005980A1
The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I)...  
WO/2019/006445A1
The present invention is related to compositions and methods for treating platelet-related diseases.  
WO/2019/003433A1
The present invention provides: a novel benzazepine compound which is represented by formula (1) and has vasopressin V1a and V2 antagonism, or a salt thereof; and a pharmaceutical use thereof. [In formula, R1 represents optionally substi...  
WO/2019/004464A1
The purpose of the present invention is to provide a composition for inhibiting the proliferation and/or infiltration of tumor cells, an enhancer of an anti-tumor effect of a drug for the purpose of removing immunosuppression associated ...  
WO/2019/002355A1
The invention relates to an organic compound, in particular for the application in organic optoelectronic devices. According to the invention, the organic compound consists of -a first chemical moiety with a structure of formula I, and-t...  
WO/2019/001572A1
The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated...  
WO/2019/001420A1
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.  
WO/2019/002175A1
The invention relates to an organic molecule, in particular for use in optoelectronic components. According to the invention, the organic molecule contains - a first chemical unit having a structure of formula (I) and - two second chemic...  
WO/2019/005883A1
The disclosure is directed to compounds of the formula (IA), (I)-(V) and others disclosed herein and uses of such compounds.  
WO/2018/235966A1
The present invention provides a compound which has an excellent inhibitory activity on histone acetyltransferase of EP300 and/or CREBBP, or a pharmacologically acceptable salt of the compound. A compound represented by formula (1) or a ...  
WO/2018/237370A1
The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necro...  
WO/2018/234978A1
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders, Formula (I), wherein ...  
WO/2018/234354A1
The invention relates to novel 3-indole and 3-indazole compounds characterized in that the compound has general formula (I) in which the chemical groupings, substituents. variables and indices are as defined in the description, and to th...  
WO/2018/236971A1
The invention relates to compounds useful for inhibiting PARP and at least one other protein and to methods of treating diseases including cancer by administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts the...  
WO/2018/235785A1
The present invention relates to a compound set forth as an example compound or a pharmaceutically acceptable salt of the compound.  
WO/2018/234808A1
The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.  
WO/2018/233678A1
The present invention provides crystal forms B and C of a dexrabeprazole sodium compound. The crystal form B of the present invention has good stability and flowability. The crystal form C of the present invention is an anhydrous crystal...  
WO/2018/234807A1
The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections. (I)  
WO/2018/237393A1
The present disclosure relates to compounds capable of emitting delayed fluorescence, and uses of these compounds in organic light-emitting diodes.  
WO/2018/236066A1
The present invention provides a novel heterocyclic compound and an organic light-emitting device using same.  
WO/2018/233620A1
Provided is a use of SERD with a CDK4/6 inhibitor and a PI3K/mTOR pathway inhibitor. In particular, provided is a use of a selective estrogen receptor downregulator (SERD) in combination with one or more selected from a cyclin dependent ...  
WO/2018/233797A1
The invention relates to a molecule intended for swiftly treating swimming-pool water in a few hours, with the aim of eliminating, through a complexing process, the isocyanuric acid that it contains, in order to delay (or indeed avoid) t...  
WO/2018/234488A1
The present invention relates to cyclopropyl compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their...  

Matches 1 - 50 out of 62,145