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Matches 1 - 50 out of 6,543

Document Document Title
WO/2018/004202A1
The present invention relates to an improved method for producing a diphenylmethane derivative useful as a sodium-dependent glucose cotransporter (SGLT) inhibitor. Performed in a convergent synthesis manner in which main groups are indiv...  
WO/2018/002948A1
In accordance with the present subject matter there is provided sugar-based compounds of formula I, methods of making such compounds, gels comprising such compounds, methods of making gels, methods of using such compounds for the contain...  
WO/2017/220446A1
The present invention pertains generally to the field of therapeutic compounds, and more specifically to crystalline forms of 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benz oic acid (referred to herein as "BHBA-001"), which...  
WO/2017/221002A1
The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infe...  
WO/2017/223491A1
Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin ...  
WO/2017/223177A1
The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at leas...  
WO/2017/217792A1
The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthes...  
WO/2017/214024A1
The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug m...  
WO/2017/214423A2
In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed here...  
WO/2017/202798A1
The present invention provides novel compounds having the general formula (I) wherein R1 to R6, X, Y, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2017/203457A1
The present invention provides solid state forms of empagliflozin, complexes of empagliflozin with amino acids, processes for their preparation and their use in purification of empagliflozin and also provided pharmaceutical compositions ...  
WO/2017/198339A1
The present invention relates to tetrahydropyran derivatives of formula (I) having dual pharmacological activity towards both the sigma (ο) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmace...  
WO/2017/195113A1
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infect...  
WO/2017/192929A1
The invention provides substituted pyrrolo[1,2-α]triazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gauche...  
WO/2017/187321A1
The present invention provides for compounds of formula (I), wherein R1, m, Z, G1, R2, and R3 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment ...  
WO/2017/189953A1
Compositions comprising polymers comprising one or more ketal, monothioketal, and/or thioketal bonds are provided, as well as related methods and kits. In some embodiments, a polymer may comprise one or more repeat units comprising one o...  
WO/2017/181383A1
A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.  
WO/2017/184545A1
The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and water in the presence of water, solvent and an acid catalyst. In some embodime...  
WO/2017/178510A1
The present invention relates to arylamide derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit,of the voltage-gated calcium channel and the µ-opioid receptor, to processes o...  
WO/2017/178582A1
The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1, R1, Ra, Rb, Rc and Rd are as defined herein. The invention further relates to herbicidal compositions which comp...  
WO/2017/174620A1
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.  
WO/2017/165822A1
A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, according to formula (III) or according to Table A, a pharmaceutical composition comprising said compound and at least one pharmaceutically acceptable add...  
WO/2017/165822A8
A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, according to formula (III) or according to Table A, a pharmaceutical composition comprising said compound and at least one pharmaceutically acceptable add...  
WO/2017/161095A1
Provided herein are rigid macrocycles comprising a first redox-active subunit and a second redox-active subunit, wherein the first redox-active unit and the second redox-active unit are different subunits. Also provided herein are method...  
WO/2017/156454A1
There are provided inter alia stable anti-cancer compounds and splice modulators and methods of synthesis and use thereof.  
WO/2017/149551A1
The present invention relates to new generation of aurone alkaloid agents, their method of preparation and their use as drugs for treatment of tuberculosis.  
WO/2017/149551A4
The present invention relates to new generation of aurone alkaloid agents, their method of preparation and their use as drugs for treatment of tuberculosis.  
WO/2017/144639A1
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2017/140728A1
The present invention relates to lactam derivatives of formula (I) for use as medicaments as well as pharmaceutical compositions comprising these compounds, particularly for use as inhibitors of the bromodomain-containing protein TAF1 (i...  
WO/2017/141202A1
The present invention relates to a crystalline Form A of complex of Empagliflozin with L-Proline and process for preparation thereof. The present invention further relates to a method of preparing pure crystalline Empagliflozin via forma...  
WO/2017/137319A1
The present invention relates to compounds of the general formula (I), in which Q, V, T, W, X, Y, and A have the meanings given in the description, and to the use thereof for controlling animal pests.  
WO/2017/137895A1
The subject-matter of the present invention relates to the synthesis of new dendrimeric molecules based on polyhydroxylated pyrrolidines obtained by means of Click Chemistry reactions. The proposed molecules inhibit the enzymes N-acetylg...  
WO/2017/137339A1
The present invention relates to compounds of the general formula (I), where to Q, V, T, W, X, Y, and A have the meanings given in the description, and to the use thereof for controlling animal pests.  
WO/2017/137338A1
The present invention relates to compounds of the general formula (I), wherein Q, V, T, W, X, Y and A have the meanings given in the description, and to the use thereof for controlling animal pests.  
WO/2017/125900A1
The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl) chromans of formula I. The intermediates thus obtained can ...  
WO/2017/122209A3
Disclosed herein are compounds capable of inhibiting dimerization of NF- KB, for example, p65-p65 homodimerization and/or p50-p65 heterodimerization, the compounds being represented by formula I: X-L2-L1-L'2-Y Formula I wherein X, Y, Li,...  
WO/2017/122209A2
Disclosed herein are compounds capable of inhibiting dimerization of NF-κB, for example, p65-p65 homodimerization and/or p50-p65 heterodimerization, the compounds being represented by formula I: X-L2-L1-L'2-Y Formula I wherein X, Y, L1,...  
WO/2017/121444A1
Compounds of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.  
WO/2017/114937A1
The invention relates to a compound of general formula (I), where Y, Y', Z, Z' and X, as well as the structural units D1 to D3 having coefficients o, p and q and the groups A1 and A2 are respectively defined as disclosed in claim 1. The ...  
WO/2017/113964A1
Provided is a novel stilbene derivative, being a compound having the general formula (I) or general formula (II), or an acceptable salt formed from the compound having the general formula (I) or general formula (II) with an inorganic aci...  
WO/2017/112777A1
Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are compositions and methods for treating cancer and inflammatory disease.  
WO/2017/106520A1
Disclosed are compounds of formulas I and II, in which R, R0, R1-R4, R7-R10, n, X, Y, Y', and E are as described herein, pharmaceutical compositions containing such compounds. The compounds and pharmaceutical compositions are for use in ...  
WO/2017/102064A1
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.  
WO/2017/102784A1
The present specification provides a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an RORγ and/or RORγt mediat...  
WO/2017/100558A1
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.  
WO/2017/095704A1
Polymerizable compositions comprising a redox initiator system is disclosed. The redox initiators comprises a photolabile reducing agent, that photolyzes and initiates the redox cycle. Dental compositions comprising dental resins and the...  
WO/2017/095075A1
The present invention provides a novel compound capable of improving the luminous efficiency, stability and lifespan of a device, an organic electric device using the same, and an electronic device .  
WO/2017/089389A1
The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used in the treatment of Human African TRypanosomiasis.  
WO/2017/083914A1
The present invention provides compounds for use in treating and/or preventing influenza. The compound comprises a first and second domain in which the first domain comprises at least one anchoring group which binds to the surface of inf...  
WO/2017/082556A1
The present invention relates to a compound represented by [chemical formula A] or [chemical formula B] and an organic light-emitting device comprising same.  

Matches 1 - 50 out of 6,543