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Matches 1 - 50 out of 6,744

Document Document Title
WO/2019/035408A1
The present invention provides a method for producing a compound (i) having a group represented by a partial structure (A), a partial structure (AI), a partial structure (D), or a partial structure (DI), and a group represented by a part...  
WO/2019/034686A1
The present invention relates to compounds of formula (I): Formula (I) wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; ...  
WO/2019/036534A1
Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising t...  
WO/2019/027040A1
A compound represented by formula (1) (in the formula, R1-R8, R11-R18, R21-R28, R31-R38, X, Y, L1, L2, L3, and Ar are as defined in the specification) provides an organic electroluminescent element having a low drive voltage and exceptio...  
WO/2019/023450A1
Described herein are compounds of the formulae (l)-(lII) and (la)-(llla) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods usin...  
WO/2019/016269A1
The present invention relates to derivatives of formula (I) which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR.  
WO/2019/011200A1
The invention relates to a preparation method of a pyridinecarboxamide derivative and an intermediate thereof wherein the reaction step is shortened, the reaction yield is improved, the method is simple and easy to control, and is advant...  
WO/2019/002183A1
The invention relates to a method for producing substituted nitrogen-containing heterocycles which can be used, in particular, in electronic devices.  
WO/2019/002571A1
This invention relates to compounds of formula (I) and their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prev...  
WO/2019/003237A1
The present invention discloses novel indolylkojyl compounds of formula 1 The invention also provides a one pot, green chemistry method for preparation of indolylkojyl compounds. The compounds of the present invention are selectively tox...  
WO/2018/232805A1
Provided are a puerarin derivative represented by formula (I) or formula (II) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a use thereof for the prevention and treatment of cardiovascular and cerebrov...  
WO/2018/234343A1
Compounds of Formula (0), and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.  
WO/2018/234284A1
The invention relates to compound of formula (I) wherein R1 to R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2018/229193A1
The present invention relatesto a pharmaceutical composition comprising acompound of the formula Ias described belowor a tautomeror a pharmaceutically acceptable salt thereof; to the compound of the formula Ias described below or a tauto...  
WO/2018/231618A1
The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kap...  
WO/2018/229237A1
The present invention relates to the production of tri-functional aromatic molecules from diformylfuran, in particular to the production of tri-methyl benzene derivatives such as for example trimellitic acid or 1,2,4-tri(aminomethyl)benz...  
WO/2018/220634A1
The invention generally provides a method for the synthesis of a π-conjugated system from oligofurans, under conditions involving cycloaddition.  
WO/2018/216013A1
The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as wel...  
WO/2018/215798A1
The present invention relates to compounds of formula I that function as inhibitors of BCL6(B- cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates ...  
WO/2018/210297A1
Disclosed are an intermediate of Eribulin and a preparation method therefor. In particular, disclosed are compounds as represented by formula II, formula III and formula V and a preparation method therefor. Ar is C1-10 alkyl substituted,...  
WO/2018/200471A1
The present invention is directed to reactor systems and processes for producing organic acids through thermolysis of polylactones. In preferred embodiments, the reactor systems and processes are capable of introducing at least one epoxi...  
WO/2018/192083A1
Methods and compounds for preventing and /or treating Zika virus(ZIKA) infection. And methods to screen for compound to prevent or treat Zika virus infection.  
WO/2018/195155A1
The present embodiments related to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-m...  
WO/2018/188643A1
Relating to an opioid receptor agonist (1S,4S)-4-ethoxy-N-(2-((R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]d eca-9-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-1-amine fumarate salt, a fumarate salt I crystal form thereof, and a preparation method and ...  
WO/2018/188795A1
The present invention relates to sulfonamide-, sulfinamide- or sulfonimidamide containing compounds which bind to the liver X receptor (LXRa and/or LXRß) and act preferably as inverse agonists of LXR.  
WO/2018/179998A1
The purpose of the present invention is to provide: a novel procyanidin having an excellent polysaccharide digestion inhibition effect; and a method for producing the same. Provided is a procyanidin characterized by having a basic skelet...  
WO/2018/169055A1
It is known that foods containing a carbohydrate, e.g., starch, in a large amount generate acrylamide upon heating at high temperatures. Some documents state that acrylamide is formed by the Maillard reaction of an amino acid, e.g., aspa...  
WO/2018/167270A1
Anticancer compounds of general formula (I), wherein R1 to R4 take various meanings, for use in the treatment of cancer. A novel Labrenziasp. strain named PHM005 with Accession Deposit Number CECT-9225, a method of producing compounds of...  
WO/2018/163194A1
The present invention relates to a process for the preparation of D-glucitol, 1,5- anhydro-1-C-[4-chloro-3-[[ 4-[[(3S)-tetrahydro-3-furanyl)oxy )phenyl] methyl]phenyl]-, (IS) formula-1.  
WO/2018/159964A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, it is possible to pro...  
WO/2018/155340A1
The purpose of the present invention is to provide a liquid crystalline compound; a liquid crystal composition containing the compound; and a liquid crystal display element including the composition, the liquid crystalline compound satis...  
WO/2018/154493A1
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compo...  
WO/2018/153507A1
Compounds of formula (I), wherein R', R'', R, X, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2018/149857A1
The present invention relates to novel 2-oxo-2H-chromen compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositio...  
WO/2018/150421A1
The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).  
WO/2018/149991A1
The present invention relates to particular sulfonamide derivatives, the pharmaceutically acceptable addition salts thereof, the hydrates thereof and/or the solvates thereof, and also the use thereof as inverse agonists of retinoid-relat...  
WO/2018/146471A1
There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings5 provided in the description, which compounds are useful in the treatment of cancers.  
WO/2018/141706A1
The invention relates to propellane compounds according to defined formula, to the use of said compounds in electronic devices, and to electronic devices containing one or more of the known propellane compounds. The invention also relate...  
WO/2018/138029A1
The present invention relates to compounds of general formula (I), wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate...  
WO/2018/139767A1
The present invention provides a novel amine-based compound and an organic light emitting device using the same.  
WO/2018/133795A1
An inhibitor of a wild type and Y641F mutant of human histone methyltransferase EZH2. Particularly, the inhibitor is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The inhibitor can be used to treat ...  
WO/2018/130625A1
The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable ...  
WO/2018/122232A1
Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.  
WO/2018/116185A1
The invention discloses compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, A, R19, R20, and R21 are as defined herein. The present invention relates to deuterated compounds and their ...  
WO/2018/113201A1
A compound as represented by formula (I), or a stereoisomer, a tautomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or a prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising ...  
WO/2018/112331A1
The present invention provides lifitegrast formulations useful for the treatment of immune-related diseases of the ocular surface. The formulations and methods provided herein are particularly useful for treatment of ocular anterior segm...  
WO/2018/104295A1
Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases...  
WO/2018/099431A1
Disclosed is a pyrene organic compound having the following structural formula. The pyrene organic compound has better charge transfer performance and luminous efficiency, and also has better thermal stability. Therefore, by providing an...  
WO/2018/100834A1
Provided is a composition that has excellent near-infrared ray absorption stability and is useful for an optical film. The composition includes at least two of the compounds represented by general formula 2 or general formula 5.  
WO/2018/098831A1
Provided are a biomass-based epoxy resin and method for preparation thereof; under conditions of N,N-dimethylformamide as a catalyst, 2,5-furandicarboxylic acid and thionyl chloride are acylated to obtain 2,5-furan diformyl chloride; the...  

Matches 1 - 50 out of 6,744