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Matches 1 - 50 out of 30,276

Document Document Title
WO/2018/109643A1
The present invention relates to bisaryl heterocycle compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula...  
WO/2018/109271A1
The present invention provides novel spiro[cycloalkyl-1,3'-indolin]-2'-one derivatives of formula (I), in which Cy1,Cy2,R1,R2, R3,R4, L,m, n and q have the meaning given in the specification, and pharmaceutically acceptable salts thereof...  
WO/2018/108156A1
A ROCK inhibitor represented by formula (I) and a preparation method and application thereof. An experiment has demonstrated that the compound has good ROCK-inhibiting activity, and can be effectively used in treating a disease related t...  
WO/2018/112420A1
Disclosed herein, inter alia, are compositions and methods for modulating Ras and treating cancer.  
WO/2018/105888A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, an organic electrolum...  
WO/2018/104295A1
Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases...  
WO/2018/101691A1
The present invention provides an organic light-emitting element having improved driving voltage, effectiveness and lifespan.  
WO/2018/100834A1
Provided is a composition that has excellent near-infrared ray absorption stability and is useful for an optical film. The composition includes at least two of the compounds represented by general formula 2 or general formula 5.  
WO/2018/100029A1
The invention relates to heterocyclic compounds, particularly for use in electronic devices. The invention further relates to a method for producing the compounds according to the invention, and to electronic devices comprising same.  
WO/2018/102006A1
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of indoleamine-2,3-dioxygenase (IDO) activity, and methods of treating IDO-related disorders.  
WO/2018/097945A1
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other condit...  
WO/2018/095379A1
A metal organic complex has the following general formula (I): Ar1, selected from at least one of aromatic hydrocarbyl,R1-substituted aromatic hydrocarbyl, heterocyclic aromatic hydrocarbyl and R1-substituted heterocyclic aromatic hydroc...  
WO/2018/097318A1
The present invention provides a tetrazolinone represented by formula (I) and a pest control agent comprising the same, and their use thereof. Formula (I) [wherein, W1 represents an oxygen atom or a sulfur atom; W2 represents a hydrogen ...  
WO/2018/098296A1
Provided herein are compounds of formula (II), pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDACl and/ or HDAC2 activity.  
WO/2018/095877A1
The present invention relates to compounds of general formula (I), wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate...  
WO/2018/093080A1
The present invention provides a novel compound and an organic light-emitting device using same.  
WO/2018/091153A1
The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (l-A): wherein R1 and R2 represent independently a hydrogen atom or a deuterium atom; A represents an oxygen or nitrogen atom; and SER...  
WO/2018/093231A1
The present invention relates to a novel compound having excellent functions, such as electron injection and transport and light emission functions, and an organic electroluminescence device. By using the novel compound in an organic lay...  
WO/2018/087775A1
The Present Invention relates to process for the preparation of 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin -2(1H)-one represented by the following structural formula-1.  
WO/2018/088665A2
The present invention relates to a compound for an organic optoelectric device represented by chemical formula 1, an organic optoelectric device employing the same, and a display device. Details of said chemical formula 1 are as defined ...  
WO/2018/086546A1
Provided are a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof or a pharmaceutically acceptable salt or solvate thereof. The compound and the optical isomer thereof or the pharmaceutically acceptable s...  
WO/2018/081863A1
The present invention broadly relates to 6-substituted derivatives of hexamethylene amiloride, the preparation thereof, and their use in the treatment of diseases such as cancer.  
WO/2018/083105A1
Compounds of formula (I): (I) or pharmaceutical salts thereof, wherein m, n,, p, q A, B, Ri, R2, R3, R4, R5, R6and R7are as defined herein. Also disclosed are methods of making the compounds and using the compounds as RORs modulators for...  
WO/2018/082962A1
Process for preparation of tetrahydrothiophene derivatives The present invention relates to a process for preparation of tetrahydrothiophene derivatives of formula I, (I) wherein the variables have the meanings as defined in the specific...  
WO/2018/084321A1
The purpose of the present invention is to develop a safe covalent drug having little fear of side effects by searching for a reactive group having lower reactivity as a substitute for a Michael acceptor and by designing a drug molecule ...  
WO/2018/084423A2
The present invention provides a novel heterocyclic compound and an organic light emitting element using the same.  
WO/2018/081381A1
The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.  
WO/2018/080066A1
The present invention relates to a new compound and an organic electroluminescent device comprising the same. As the compound according to the present invention is used for an organic layer of an organic electroluminescent device, and pr...  
WO/2018/081530A1
Methods for designing bivalent compounds which selectively degrade/disrupt EZH2 and compositions and methods of using such degraders/disruptors to treat EZH2-mediated cancer are provided.  
WO/2018/081168A3
This invention is benzothiophene-based selective mixed estrogen receptor downregulators and their compositions and uses to treat estrogen-related disorders.  
WO/2018/077699A1
The present invention relates to compounds of general formula (I) wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...  
WO/2018/081378A1
The present disclosure is directed to pyridazinone derivatives of generic formula that modulate, e.g., address underlying defects in cellular processing of CFTR activity.  
WO/2018/078360A1
There are described compounds of formula (I): and there use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the of the hedgehog pathway, such as cancer, fibrosis and chronic graft-versus...  
WO/2018/073110A1
The present invention relates to compounds I, wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and intermediates for compounds I.  
WO/2018/074881A1
The present application relates to a compound of chemical formula 1 and an organic light emitting element comprising the same.  
WO/2018/068357A1
Disclosed are a compound as shown in formula I, or a pharmaceutically acceptable salt, a crystal form, a solvate thereof, wherein Z is selected from (II), (III), (IV) or (V); R1 is selected from H or (VI); R2 is selected from (VII) or (V...  
WO/2018/069935A1
The present invention disclosed a novel (4,8-bis(5-(trimethylstannyl)thiophen-2- yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstan nane) compound, its preparation and use for the synthesis of polymers, which is used to build d...  
WO/2018/070641A2
The present invention relates to a compound represented by chemical formula 1 for an organic optoelectronic element, an organic optoelectronic element employing the same, and a display device. The details for chemical formula 1 above are...  
WO/2018/068690A1
The invention provides a new crystal form of brexpiprazole and a preparation method thereof. The crystal form of brexpiprazole was named crystal form II. An X-ray powder diffraction pattern using Cu-Kα radiation detected characteristic ...  
WO/2018/067423A1
Compounds of general formula (la), compounds of general formula (la'), compounds of general formula (lb), compounds of general formula (lb'), compounds of general formula (I), compounds of general formula (Ι'), and their pharmaceuticall...  
WO/2018/065607A1
The invention relates to compounds which are suitable for the treatment of a disease associated with kallikrein related peptidase 6 overexpression and to pharmaceutical compositions containing such compounds. The invention further relate...  
WO/2018/067615A1
The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are i...  
WO/2018/067834A1
Relapse and resistance to therapy is the most significant challenge in the treatment of lymphoblastic leukemia. Mutations in NT5C2 (a cytosolic nucleotidase activated by gain of function mutations in about 20% of relapse ALL cases) chara...  
WO/2018/060074A1
The present invention relates to novel 5-substituted imidazolylmethyl derivatives, to processes for preparing these compounds, to compositions and mixtures comprising these compounds, and to the use thereof as biologically active compoun...  
WO/2018/060072A1
The invention relates to new substituted benzimidazoles, to methods for the production thereof, to the use thereof alone or in combinations to treat and/or prevent diseases, and to the use thereof to produce drugs for treating and/or pre...  
WO/2018/059279A1
Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw ...  
WO/2018/064119A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2018/064476A1
Crystalline 2-hydroxy-N,N-dimethylethanaminium 1 -(2-(5-(tert-butyl) -thiophene-2-carboxamido)-3-(4-(5-(4'-ethyl-[1,1'-bi(cyclohe xan)]-3- en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxyl ate salt, and methods related to synt...  
WO/2018/062778A1
The present disclosure relates to an organic electroluminescent device comprising a first electrode, a second electrode facing the first electrode, a light-emitting layer between the first electrode and the second electrode, and an elect...  
WO/2018/062721A1
The present invention relates to a novel compound and to an organic electroluminescent device comprising same, and the compound according to the present invention is used in an organic material layer, or preferebly a light-emitting layer...  

Matches 1 - 50 out of 30,276