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Document Title |
JP4891435B2 |
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are also provided.
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JP4873650B2 |
The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions ...
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JP2012501983A |
Use of 4-alkyl-substituted diaminopyrimidines of the formula (I) as fungicide in which R1 to R13 and X1 and X2 have the meanings given in the description, and agrochemically active salts thereof, and also methods and compositions for con...
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JP2012501981A |
Heterocyclically substituted anilinopyrimidines of the formula (I) in which R1 to R12 and E1, E2, E3, L1, Y, Z and L2 have the meanings given in the description, and agrochemically active salts thereof, their use and also methods and com...
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JP4861163B2 |
The invention also relates to novel compounds of formula (1) where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted...
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JPWO2010016230A1 |
The benzoyl derivative of the present invention has the formula (I) [in the formula: E represents an alkoxy group, an alkoxycarbonyl group, etc .; R.1Represents a halogen atom or an organic group, etc .; p represents an integer from 0 to...
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JPWO2010013849A1 |
The following general formula (II), which is a GPR119 agonist, (During the ceremony, Ar0Is C1-8Represents a phenyl group or pyridyl group that may be substituted with a substituent such as an alkylsulfonyl group.0Is (CH2)p, O, etc., B0Is...
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JP4847314B2 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases o...
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JP4831966B2 |
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JP4796732B2 |
Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameli...
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JP4785881B2 |
To provide an antipsychotic agent having a wider therapeutic spectrum and excellent in tolerability and safety with little adverse effects in comparison with conventional typical antipsychotics and atypical antipsychotics. A medicinal ag...
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JP4785677B2 |
A heterocyclic compound or a salt thereof represented by the formula (I): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or a lower alkenylene group; and R 1 represents a cylo C3-C8 alkyl...
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JP4774043B2 |
A compound of general formula (I): A process for preparing this compound. An intermediate of general formula (II) for the preparation of a compound of general formula (I). A fungicidal composition comprising a compound of general formula...
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JP4745315B2 |
To provide a new 3-aminothiophene derivative useful as an agricultural or a horticultural bactericide or its intermediate. This 3-aminothiophene derivative is expressed by general formula (6a) [wherein, R9is H, carboxyl or a 1-6C alkoxyc...
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JPWO2009123194A1 |
Provision of compounds useful as prophylactic / therapeutic agents for obesity, etc., which have melanin-aggregating hormone receptor antagonism and low toxicity. Equation (I):(In the formula, each symbol is as described in the specifica...
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JP2011521978A |
The class compounds of the present invention may be represented by Formula (I), wherein X may be O, S, or N. R1 and R2 are independently either H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. R3 and R4 are independen...
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JP2011519822A |
Use of diaminopyrimidines of the formula (I) in which R1 to R11a,b,c and X1, X2 have the meanings given in the description, and also agrochemically active salts thereof as crop protection agents. Diaminopyrimidines of the formulae (Ia), ...
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JP4705630B2 |
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters...
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JP4700696B2 |
The present invention discloses nitromethylene derivatives and the uses thereof. These derivatives are obtained by adding ring structure onto the known nitromethylene compounds, by which both their stability for light and their liposolub...
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JP4695588B2 |
Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors...
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JP4686126B2 |
Novel compounds comprising a C-C double bound substituted at one carbon with two sulphur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with...
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JP2011079840A |
To provide a method for treating human hepatitis B virus infection by combining or alternately administering synergistically effective amount of agents having already known to have anti-hepatitis B virus activity.The method for treating ...
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JP4673061B2 |
A fungicidally active compound of formula (I): where X is (X1), (X2) or (X3); Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that t...
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JP4648894B2 |
Quinoline derivatives (I) and their tautomers, optical and geometrical isomers, racemates, salts, hydrates or mixtures are new. Quinoline derivatives of formula (I) and their tautomers, optical and geometrical isomers, racemates, salts, ...
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JP4643441B2 |
The present invention relates to compounds of formula (IIIa) wherein Q, X, R 13 , R 14 , R 15 , and R 16 are as defined in the claims.
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JP4630271B2 |
Compound of general formula (I): ?>Process for preparing this compound. ?>Novel intermediate of general formula (E): for the preparation of compound of general formula (I) ?>Fungicidal composition comprising a compound of general f...
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JP4583598B2 |
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents th...
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JP4575918B2 |
The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described herein which comprises the steps of a) reacting a compound of formula with a compound of formula to form a c...
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JP4558510B2 |
The problem of the present invention is to provide a carbazole derivative which has an excellent heat resistance and can be formed into a film without crystallization. Also, a problem is to produce an organic semiconductor element, a lig...
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JP2010215656A |
To provide related structures having the same or higher level antitumor activities than conspicuous antitumor activities of the ecteinascidin (Et) 743 compound.Compounds having structural formula of the figure have the same or higher lev...
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JP4554219B2 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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JP4542776B2 |
A process for producing predominantly cis nucleosides or nucleoside analogues and derivates of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, comprisin...
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JP4522850B2 |
The invention relates to 3-pyridylcarboxamide derivatives of formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processes for their prepar...
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JP4511191B2 |
A compound of formula (I): Het is pyridinyl, pyrimidinyl, thiophenyl, furyl, isothiazolyl or isoxazolyl, each being substituted by groups R 4 , R 5 and R 6 ; R 1 is hydrogen or halo; R 2 is hydrogen or halo; R 3 is optionally substituted...
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JP4508531B2 |
3-(arylthiopropylamino)-1,5-aryloxathiepine derivatives (I) are new. 3-(arylthiopropylamino)-1,5-aryloxathiepine derivatives of formula (I) and their (hydrated) addition salts with (in)organic acids, tautomers, enantiomers and stereoisom...
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JP4503206B2 |
A method and composition for the treatment of humans infected with HIV that includes administration of an HIV treatment amount of an enantiomerically pure beta -D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, or ...
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JP4496377B2 |
The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparati...
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JP4485744B2 |
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specificat...
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JP4490421B2 |
The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In p...
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JP4471928B2 |
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JP4463900B2 |
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JP2010100640A |
To provide a new five-membered heterocyclic compound useful for treating and/or preventing diabetes and diabetes-related diseases.The invention discloses the followings: a compound expressed by formula (1) and salts thereof; a method for...
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JP4440642B2 |
The subject invention provides compounds having the structure: wherein R1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5 heteroatoms; R2 is hydrogen, or a substituted o...
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JP4432123B2 |
There can be provided a liquid crystalline compound expressed by the general formula (1): wherein R represents a hydrogen atom, a cyano group, a halogen atom, a C1 to C20 alkyl group or a halogenated alkyl group, B1, B2, B3 and B4 are in...
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JP2010507640A |
The invention relates to a novel group of compounds of Formula (I) or a salt thereof: wherein R1, A and HET-1 are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition med...
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JPWO2008035737A1 |
The present invention is a 4-nitrobenzoyl derivative represented by the following formula [I] or a salt thereof, and a herbicide for paddy rice containing these as an active ingredient.[In the formula, R1 represents a halogen atom, an or...
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JP2010013466A |
To provide a new therapeutic agent for hepatitis B virus infection.This therapeutic agent is an L-enantiometric isomer of cis-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-5-fluorocytosi
ne represented by formula (I) and its pharmaceutically...
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JP4399478B2 |
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are also provided.
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JP4341989B2 |
1-Arylpyrazoles of the formula: wherein R31, R32, R33, R4, R5, R12, R13, R14, R15 and Z are as defined in the specification, are useful as pesticides or as intermediates to other pesticides. Compositions comprising the compounds of formu...
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JP4332032B2 |
The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are ...
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