Heterocyclic Compounds

Matches 251 - 300 out of 970	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2004/074280A1	PYRIDINE DERIVATIVES AS FUNGICIDAL COMPOUNDS Compound of general formula (I): Process for preparing this compound. Novel intermediate of general formula (E): for the preparation of compound of general formula (I) Fungicidal composition comprising a compound of general formula (I). ...
WO/2004/067524A1	EP4 RECEPTOR ANTAGONISTS Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either -(CH2)n-X-, where n is 1 or 2 and X is O, S, S(=O), S(=O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl,...
WO/2004/065380A1	1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PRPPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of...
WO/2004/063191A1	PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM Therapeutically active compounds of formula (I) or (II) wherein X is -O-, -CH2- or -C(O)-; Z is -CHR12- or a valence bond; Y is -CH2-, -C(O)-, CH(OR13)-, -O-, -S-; provided that in case Z is a valence bond, Y is not C(O); the dashed line...
WO/2004/048343A1	CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
WO/2004/039799A1	CYCLOPROPYL-THIENYL-CARBOXAMIDE AS FUNGICIDES A fungicidally active compound of formula (I): where X is (X1), (X2) or (X3); Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that t...
WO2002085897A9	HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS The invention discloses a new clause of a five membered heterocyclic ring compounds of general formula (1) and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specifi...
WO/2004/018438A2	MICROBIOCIDAL (E.G. FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES A compound of formula (1):where A is an ortho-substituted ring selected from a number of specified rings; R1 is halogen, cyano, nitro, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy or C 1-4 haloalkoxy or optionally substituted C 2-4 alkenyl...
WO/2004/009586A1	NOVEL PIPERAZINYL-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF 5-HT2A RECEPTOR-RELATED DISORDERS Compounds of the general formula (I): (I)wherein m, n, R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the us...
WO/2004/000808A2	N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS Disclosed herein are compounds of Formula I, or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof. Also disclosed are methods of inhibiting an activity of a monoamine receptor comprising contacting the monoamine recept...
WO/2003/105850A1	2-AMINOQUINOLINES AS MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor a...
WO/2003/097605A1	PESTICIDAL PYRIDINECARBOXAMIDE DERIVATIVES The invention relates to a 3-pyridylcarboxamide derivative of formula (I), wherein the various symbols are as defined in the description, compositions thereof, their use for the control of pests, and to processes for their preparation.
WO/2003/091239A1	ESTROGEN RECEPTOR MODULATORS The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
WO/2003/091247A2	PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS This invention is directed generally to proteinase (also known as 'protease') inhibitors, and more particularly, to piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids that inter alia, inhibit matrix metalloproteinase (also known...
WO/2003/086388A1	ESTROGEN RECEPTOR MODULATORS The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
WO/2003/087073A1	ESTROGEN RECEPTOR MODULATORS The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
WO/2003/074491A1	O-CYCLOPROPYL-CARBOXANILIDES AND THEIR USE AS FUNGICIDES A compound of formula (I): F1 Het is a 5− or 6−membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R4, R5 and R6&semi R1 ...
WO/2003/070726A1	PYRANONES USEFUL AS ATM INHIBITORS The application concerns a compound of formula I: (I) wherein one of P and Q is O, and the other of P and Q is H, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group;Y is either O or S...
WO/2003/070277A1	ANTIPRURITICS It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having a cannabinoid receptor agonism shows an antipruritic effect.
WO/2003/053366A2	PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE The subject invention provides compounds having the structure:, wherein R1 is substituted or unsubstituted phenyl or a 5−6 membered heterocyclic or heteroaromatic ring containing from 1 to 5 heteroatoms&semi R2 is hydrogen, or a substi...
WO/2003/053934A1	IMPROVED COMPOUNDS FOR GENERATING CHEMILUMINESCENCE WITH A PEROXIDASE Novel compounds comprising a C-C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a...
WO/2003/040096A2	N, N'−SUBSTITUTED−1,3−DIAMINO−2−HYDROXYPROPANE DERIVATIVES Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
WO/2003/040109A2	QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS The invention concerns quinazoline derivatives of Formula (I); wherein each of Q?1¿, Q?2¿, Z, R?1¿, R?2¿, R?3¿, L and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical composition...
WO/2003/040108A1	QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS The invention concerns quinazoline derivatives of Formula (I); wherein each of Q?1¿, Z, R?1¿ and Q?2¿ have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them an...
WO/2003/040139A1	DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF THE ANTIVIRAL AGENT4-AMINO-1-(2R-HYDROXYMETHYL-[1,3]OXATHIOLAN-5S-YL)-1H-PYRIMIDIN-2-ONE Process for the synthesis of 4-amino-1-(2R-hydroxymethyl - [1,3]oxathiolan-5S-yl)-1H-pyrimidin-2-one (LAMIVUDINE) comprising the reduction of 2-(R)-(4'-(R)acetonyl)-5-oxo-1,3-oxathiolan to give 2-(R)-(4'-(R)-acetonyl)-5-hydroxy-1,3-oxath...
WO/2003/032993A1	USE OF PHOSPHORODIESTERASE IV INHIBITORS The invention relates to the use of Phosphodiesterase IV inhibitors and/or the physiologically acceptable salts thereof in the production of a medicament for the treatment of osteoporosis, tumors, tumor metastases, atherosclerosis, rheum...
WO/2003/027106A1	PROCESS FOR THE PREPARATION OF CRYSTALLINE POLYMORPH II OF LAMIVUDINE A process for the direct preparation of Lamivudine polymorph of Form II is disclosed. The process of the invention involves the direct preparation of Lamivudine polymorph of form II from its salicylate salt thereby avoiding the formation...
WO/2003/024949A1	DNA-PK INHIBITORS The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R?1¿ and R?2�...
WO/2003/022813A1	INDOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Indole derivatives represented by the following general formula (I): (I) wherein each symbol is as defined in the description&semi a process for producing the same&semi and DP receptor antagonists containing the same as the active ingred...
WO/2003/020302A1	HEPATITIS B VIRUS PROLIFERATION INHIBITOR A drug inhibiting the proliferation of lamivudine−tolerant hepatitis B virus under prolonged administration of lamivudine. By administering IFN−β to YMDD mutant virus developing during prolonged administration of lamivudine, the re�...
WO/2003/006452A1	NEW COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA?+¿/CA?2+¿ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS Therapeutically active compounds of formula (I): wherein X is -O-, -CH¿2?- or -C(O)-; Z is -CHR¿9?- or valence bond; Y is -CH¿2?-, -C(O)-, CH(OR¿10?)-, -CH(NR¿11?R¿12? )-, -O-, -S-, -S(O)- or -S(O¿2?)-, provided that in case Z is ...
WO/2003/006440A2	AMIDE-CONTAINING COMPOUND HAVING IMPROVED SOLUBILITY AND METHOD OF IMPROVING THE SOLUBILITY OF AN AMIDE-CONTAINING COMPOUND The present invention is directed to novel amide-containing compounds which have an improved solubility and a method of improving the solubility of amide-containing compounds. The amide-containing compounds include oxazolidinone compound...
WO/2002/102796A1	STEREOSELECTIVE METHOD FOR THE PREPARATION OF NUCLEOSIDE ANALOGUES A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, compris...
WO/2002/100846A1	COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS the present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection.
WO/2002/092591A1	ACRYLIC ESTERS AND USE THEREOF Acrylic esters represented by the general formula (I); polymerizable compositions containing the esters; and cured articles and optical elements, produced by polymerizing the compositions; wherein a is an integer of 0 to 4; R¿1? is a si...
WO/2002/083643A1	PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS The invention relates to compounds of the formula (I) which exhibit activity as selective serotonin re-uptake inhibitors.
WO/2002/081464A1	BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R�1? and R�2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hyd...
WO/2002/070518A1	POLYMORPHIC AND OTHER CRYSTALLINE FORMS OF CIS-FTC Solid phases of (-)-cis-FTC, which are designated herein as amorphous (-)-FTC and Forms II and III (-)-cis-FTC) are provided that can be distinguished from Form I (-)-cis-FTC by X-ray powder diffraction patterns, thermal properties, and ...
WO/2002/067704A1	A REDUCED IGNITION PROPENSITY SMOKING ARTICLE A smoking article (10) having reduced ignition propensity is disclosed. The smoking article includes a tobacco column (12), a wrapper (14) surrounding the tobacco column (12), and a filter element (16). The wrapper (14) has a base permea...
WO/2002/066465A1	WATER-SOLUBLE TRIAZOLE FUNGICIDE A triazole compound represented by the general formula (I) (I) [wherein X represents such a group that the compound represented by the formula X-OH has antifungal activity; L represents -(C¿6-10? aryl)CH¿2?- in which the aryl has subst...
WO/2002/057211A1	SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is al...
WO/2002/040473A1	PYRIMIDINE COMPOUNDS OR SALTS THEREOF, HERBICIDES CONTAINING THE COMPOUNDS OR THE SALTS, METHODS FOR CONTROL OF WEEDS BY APPLYING THE SAME Pyrimidine compounds represented by the general formula (I) or salts thereof; and herbicides containing the compounds or the salts: (I) wherein Ar is optionally substituted thienyl, optionally substituted furyl, or the like; R?1¿ is hyd...
WO/2002/039954A2	NOVEL COMPOUNDS The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activit...
WO/2002/032377A2	ESTROGEN RECEPTOR MODULATORS The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
WO/2002/032373A2	ESTROGEN RECEPTOR MODULATORS The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
WO/2002/006247A1	SUBSTITUTED AMIDOALKYL-URACILS AS PARP INHIBITORS The invention relates to novel PARP inhibitors in the form of amidoalkyl-uracil derivatives of formula (I), to a method for producing them and to their use as active agents of medicaments, for preventing and/or treating ischaemia and rep...
WO/2001/098306A1	COMPOUNDS FOR TREATING IMPAIRED FUNDIC RELAXATION The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharma-ceutically acceptable acid addition salt thereof, wherein -a?1¿=a?2¿-a?3¿=a?4¿- is a bivalent radic...
WO/2001/090082A1	SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (1) wherein one of X, Y, or Z is independently -S-, -O-, or > N-R?4¿, the others are-CH¿2-;? (p) is an i...
WO/2001/090101A1	ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS Provided herein are compounds of formula (I) wherein R?1-4¿, n and Ar are as defined in claim 1, and their pharmaceutical compositions. These compounds are tryptase inhibitors and may be used in the treatment of e.g. asthma and inflamma...
WO/2001/090081A1	SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (I) wherein one of X, Y or Z is independently -S-,-0- CH¿2?- or $m(g)N-R?6¿, the others are -CH¿2?-; m ...

Matches 251 - 300 out of 970	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >