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Matches 1 - 50 out of 36,790

Document Document Title
WO/2019/197502A1
The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate.The invention further provides uses of the compounds of formula (I...  
WO/2019/198692A1
The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is in...  
WO/2019/197682A1
The invention relates to pharmaceutical combination products comprising an HDAC inhibitor, e.g. (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-be nzenesulfonyl]-1H-pyrrol-3-yl}- acrylamide as well as salts and or solvents ther...  
WO/2019/197468A1
The present invention relates to N-(cyclopropylmethyl)-5-(methylsulfonyl)-N-{1-[1-(pyrimidin- 2-yl)-1H-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as well as related compounds of ...  
WO/2019/197371A1
The present disclosure relates to oxadiazoline derivatives that may be used as fungicides.  
WO/2019/196720A1
Disclosed are an arginine methyltransferase inhibitor, a pharmaceutical composition thereof and a use thereof. Specifically, disclosed are a compound represented by formula (I), a pharmaceutically acceptable salt, isomer, racemate, prodr...  
WO/2019/196948A1
Disclosed are a compound using an aryl ketone as a core as represented by general formula (1), a preparation method therefor and an application thereof on an OLED. A parent nucleus of the organic compound is an aryl ketone, the parent nu...  
WO/2019/192992A1
The application relates to a series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives and 3-imino-5-methyl-l,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted by an arylaminophenyl or heteroarylaminophenyl moiet...  
WO/2019/195641A2
Disclosed herein are inhibitors of Rho/MRTF/SRF-mediated gene transcription, and methods for their use in treating or preventing diseases such as cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and pharm...  
WO/2019/194220A1
Provided are compounds represented by formula (1) or salts thereof, and a pest control agent, an insecticide or miticide, a nematicide, and an endoparasite control or eliminating agent, which contain, as an active ingredient, at least on...  
WO/2019/192506A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2019/195201A1
The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand...  
WO/2019/193342A1
The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates...  
WO/2019/194556A1
The present invention relates to a novel 6-heteroarylamino-2,4,5-trimethylpyridin-3-ol compound, or a pharmaceutically acceptable salt thereof. In particular, the present invention relates to a novel 6-heteroarylamino-2,4,5-trimethylpyri...  
WO/2019/184744A1
The present invention relates to a tetrahydroisoquinoline derivative, a preparation method therefor and uses thereof, and more particularly relates to a tetrahydroisoquinoline derivative or a pharmaceutically acceptable salt, an ester, a...  
WO/2019/189555A1
Provided is a compound that can have a CDK12-inhibiting effect and that is expected to be useful as a preventive or therapeutic drug for cancer and the like. The compound or salt thereof is represented by formula (I) (where each symbol i...  
WO/2019/191707A1
Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorder...  
WO/2019/185033A1
The present invention provides an amide pyrazole compound used as a FGFR irreversible inhibitor, a preparation method therefor and uses thereof. The present invention specifically provides a compound of formula (I), a stereoisomer, a rac...  
WO/2019/190999A1
Disclosed herein are methods of treating fibrotic disorders by administering compounds selective for CAPN1, CAPN2, and/or CAPN9 such that side effects, off pathway interactions, and/or toxicities are minimized. Such methods may, for exam...  
WO/2019/189553A1
The present invention provides a heterocyclic compound having an activity to enhance the maturation of a cardiomyocyte. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof has an...  
WO/2018/214867A9
An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (1), a preparation method therefor, and a use thereof, each substituent being defined in the description and claims. The compound can be widely applied to t...  
WO/2019/190885A1
Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by...  
WO/2019/185875A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as herbicides.  
WO/2019/186590A1
The present disclosure relates to compounds of Formula (I), its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active ...  
WO/2019/189731A1
The present invention provides a compound that has a superior control effect on arthropod pests, and is represented by formula (I) [in the formula, Q represents a group or the like represented by Q1, n represents 0, 1, or 2, R2 represent...  
WO/2019/190223A1
The present application relates to a compound of chemical formula 1 and an organic light-emitting device comprising same.  
WO/2019/189778A1
A compound with anticancer activity or a pharmaceutically permissible salt thereof is provided. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof is used. (In the formula, L1 andL2 are the same or differ...  
WO/2019/138296A3
Provided are a radionuclide-labeled compound having both tau protein affinity and amyloid protein affinity; an imaging agent that contains the radionuclide-labeled compound and that is used for imaging tau proteins and/or amyloid protein...  
WO/2019/183145A1
Disclosed are compounds of Formula (I) and (Ia) or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described ...  
WO/2019/183636A1
The present invention provides, in part, compounds of Formula I: or an N- oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X1, X2, R1, R2, m and n are as described herein; processes for the pr...  
WO/2019/183589A1
The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.  
WO/2019/178801A1
The invention provides a novel PDGFR kinase inhibitor comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The invention further provides uses of the compound of...  
WO/2019/150219A3
The present invention relates to novel oxadiazoles of Formula (I),wherein, R1, L1, A, L2 and R10 are as defined in the detailed description. The oxadiazoles of Formula (I) are useful in controlling phytopathogenic fungi.  
WO/2019/183186A1
Compounds having the following formula (I) or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFN╬▒, by acting on Tyk-2 t...  
WO/2019/180445A1
Polycyclic aromatic hydrocarbon derivatives represented by the following general formula: (I) wherein R independently represents an aromatic group and/or an aliphatic group; Q is one of a cyclic aliphatic hydrocarbon, a cyclic aromatic h...  
WO/2019/183148A1
Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 ...  
WO/2019/177975A1
Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, suc...  
WO/2019/176791A1
The present invention relates to: a compound represented by formula (I) which has excellent insecticidal activity, miticidal activity and/or nematicidal activity, while having excellent safety, and which is able to be industrially advant...  
WO/2019/175464A1
The present invention related to compounds of formula (I) wherein R1, R2, ring A and ring Bare as defined in the claims. The compounds are potent inhibitors of the sodium-calcium exchanger (NCX) and are useful in the treatment or prevent...  
WO/2019/177374A1
The present invention relates to a 2, 4, 5-substituted pyrimidine derivative, a preparation method therefor, and a pharmaceutical composition comprising same as an effective ingredient for prevention or treatment of cancer or inflammator...  
WO/2019/177375A1
The present invention relates to 2, 4, 5-substituted pyrimidine derivatives, a method for preparing same, and a pharmaceutical composition for preventing or treating cancer comprising same as an active ingredient. Since the compound exhi...  
WO/2019/170745A1
The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4 and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controllin...  
WO/2019/173761A1
Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as "c-Abl"). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site an...  
WO/2019/170055A1
The present invention relates to compounds having CDK4/6 kinase inhibitory activity, a pharmaceutical composition thereof and a use thereof. The present invention relates in particular to compounds represented by formula I, and further r...  
WO/2019/145726A9
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases an...  
WO/2019/173790A1
The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyc...  
WO/2019/173182A1
The disclosure relates to compounds of Formula (II), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for ...  
WO/2019/099977A3
The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.  
WO/2019/171234A1
The present invention relates to novel heterocyclic compound of Formula (I), (I) wherein, Het, L1, A, L2 and R12 are as defined in the detailed description, for use as fungicides.  
WO/2019/170731A1
The present disclosure relates to novel nucleotide precursors and nucleotide analogs that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs. Oligonucleotides containing these analogs hav...  

Matches 1 - 50 out of 36,790