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Matches 1 - 50 out of 35,125

Document Document Title
WO/2018/071535A1
The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B1, B2, B3, R1, P1, P2, Y and Q are described herein are as defined in the description. The inventi...  
WO/2018/069732A1
This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compo...  
WO/2018/071679A1
The present disclosure provides certain N-Acylethanolamide derivatives, and uses relating thereto.  
WO/2018/071622A1
The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.  
WO/2018/069222A1
The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compoun...  
WO/2018/068283A1
Provided herein are compounds of formula (I) wherein R 1, Y, L 1, G 1, X 1, X 2, L 2, R 2, R 3, and R 4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the...  
WO/2018/067704A1
The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.  
WO/2018/065536A1
A furazan-3-carboxylic acid derivative or pharmaceutically acceptable salt thereof for treatment of acute myeloid leukemia.  
WO/2018/067615A1
The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are i...  
WO/2018/065768A1
The present invention relates to cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having u...  
WO/2018/065414A1
Compounds of Formula (I): wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2018/065311A1
The present invention provides a composition comprising (A) a compound of formula (I): (I) wherein R is methyl or methoxy, R is hydrogen, methyl or ethoxy and A is a substituted heteroaryl group, or an N-oxide or salt form thereof, and (...  
WO/2018/060714A1
The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following gene...  
WO/2018/059314A1
Provided are azabicycle derivatives and a preparation method and use thereof. In particular, provided are an FXR agonist compound and a stereomer, a tautomerid, a polymorphic substance, a solvate (such as a hydrate), a pharmaceutically a...  
WO/2018/060072A1
The invention relates to new substituted benzimidazoles, to methods for the production thereof, to the use thereof alone or in combinations to treat and/or prevent diseases, and to the use thereof to produce drugs for treating and/or pre...  
WO/2018/064119A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2018/062778A1
The present disclosure relates to an organic electroluminescent device comprising a first electrode, a second electrode facing the first electrode, a light-emitting layer between the first electrode and the second electrode, and an elect...  
WO/2018/062978A1
The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds repr...  
WO/2018/060689A1
The present invention relates to substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having ut...  
WO/2018/060691A1
The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30...  
WO/2018/060075A1
The present invention relates to 1-[2-(1-chlorocyclopropyl)-2-hydroxy-3-(3-phenyl-1,2-oxazol- 5-yl)propyl]-1H-imidazole-5-carbonitrile derivatives and related compounds, to processes for preparing these compounds, to compositions and mix...  
WO/2018/055402A1
The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, and n are each as defined her...  
WO/2018/057808A1
The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5, R6 and R7are as described herein. The compounds of f...  
WO/2018/053588A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/057933A1
The invention provides compounds, compositions, and methods for reducing oxidative stress in cardiomyocytes. In certain embodiments, the compound or composition comprises a selective class IIa histone deacetylase (HDAC) inhibitor, or a s...  
WO/2018/055235A1
The present invention concerns compounds of Formula 1a and its uses as a drug, particularly in treatment of cardiac diseases, and in methods and products relating to cell differentiation.  
WO/2018/055499A1
A novel one pot and high yield process for the preparation of substituted phthalimidooxazolidinone compounds by using recyclable heterogeneous catalyst and preparation of oxazolidinoneantibacterials and oxazolidinoneantithrombotics thereof.  
WO/2018/055135A1
A method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a fungicidally effective amount of a compound of Formula (I) wherein the substituents are as defined in claim 1, is applied to ...  
WO/2018/054989A1
The invention relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kin...  
WO/2018/055524A1
The present invention relates to pyrrolidine sulfonamide analogs (I), pharmaceutical compositions containing them and their use as TRPV4 antagonists.  
WO/2018/054359A1
A salt of a quinazoline derivative (N-[4-(3-chlorine-fluoanilino)]-7-(3-morpholinepropanol)-6-( 2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the sal...  
WO/2018/057805A1
The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R1, R2, R3, R4, and R6 are as described herein. The compounds of formula I selectively ...  
WO/2018/052065A1
Provided is a heterocyclic compound that can have a PRS inhibitory effect and is expected to be of use as a prophylaxis or a therapeutic agent for PRS-related diseases, including cancer. A compound or a salt thereof, said compound being ...  
WO/2018/052058A1
The present invention provides: a heterocyclic compound which has an IRAK-4-inhibiting activity and is expected to be useful for the prevention/treatment of inflammatory diseases, autoimmune diseases, osteoarticular degenerative diseases...  
WO/2018/052035A1
Provided is a compound represented by formula (I), or a salt thereof. [Formula 1] In formula (I), R1 represents an unsubstituted or substituted C1–6 alkylthio group or the like. A1 represents a nitrogen atom or CH. A2 represents a nitr...  
WO/2018/050677A1
The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein Q, X1, X2, X3, X4 and R2 are as defined herein. The invention further relates to herbicidal compositions which compr...  
WO/2018/052244A1
The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure comprises a specific combination of an electron buffer material and an electron transport material wh...  
WO/2018/049861A1
The present invention discloses a compound having the following general formula (I), K being selected from a cycloalkyl group aa or bb, a halogenated alkyl group cc, or N-R6. The invention also discloses a tyrosine kinase inhibitor conta...  
WO/2018/051930A1
The purpose of the present invention is to provide: a composition for forming a resist lower-layer film that allows the formation of a resist lower-layer film with outstanding flatness and outstanding solvent resistance and etching resis...  
WO/2018/048977A1
Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are pharmaceutical compositions comprising the deuterium-substituted oxazepin compou...  
WO/2018/049263A1
The present disclosure provides methods and kits for treating or slowing the progression of a hematological malignancy, by administering to a subject in need thereof a therapeutically effective amount of: (i) at least one inhibitor of PI...  
WO/2018/048346A1
The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of thes...  
WO/2018/047948A1
The present invention is capable of providing an organic light-emitting element with a high luminescent efficiency using a compound having a structure which comprises a carbazol-9-yl group substituted with perfluoroalkyl groups at the 2-...  
WO/2018/041729A2
Compounds of formula I, wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoismers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in...  
WO/2018/041123A1
The present invention discloses a compound with a nucleus of a fluorene and a six-membered nitrogen-containing heterocycle. The compound has a general structural formula (I), wherein R1, R2, and R3 are respectively one of a phenyl, biphe...  
WO/2018/041964A1
Compounds of formula (I) and salts thereof: wherein R1, R2, R3, a, X1, X2, X3, X4, and X5 are as defined hereinbefore. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain con...  
WO/2018/041260A1
Disclosed are a compound of general formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a prodrug, a solvate, a hydrate and a crystal form thereof. The compound of general formula (I) of the present invention can inhibit...  
WO/2018/042343A2
Compounds, specifically protease inhibitors, more specifically 3C and 3CL protease inhibitors, for the treatment of viral infections, and methods of preparing and using such compounds.  
WO/2018/040885A1
Provided are an irreversible inhibitor of a fibroblast growth factor receptor (FGFR) as indicated by formula I, a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical preparation, a pharmaceutical composition and an applica...  
WO/2018/043913A1
The present invention relates to a novel compound and an organic electroluminescent device comprising the same. The compound according to the present invention is used for organic material layers of the organic electroluminescent device,...  

Matches 1 - 50 out of 35,125