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Patent Searching and Data


Matches 1 - 50 out of 36,506

Document Document Title
WO/2019/138017A1
A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of va...  
WO/2019/140095A1
The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparatio...  
WO/2019/137985A1
The present invention relates to a novel class of tetrahydroisoquinoline compounds of formula I and to compositions comprising the same. The compounds and compositions of the present invention can be used as medicaments in the treatment ...  
WO/2019/140194A1
Described herein are compounds of the formula (I), as well as pharmaceutical compositions comprising such compounds, and methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzhe...  
WO/2018/111315A8
Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein ...  
WO/2019/134707A1
Provided are a compound as presented in formula (I), a tautomer and enantiomer thereof, or a pharmaceutically acceptable salt, a cristal form, a hydrate or a solvate thereof. The compound of formula (I) can be effectively combined with S...  
WO/2018/065536A8
A furazan-3-carboxylic acid derivative or pharmaceutically acceptable salt thereof for treatment of acute myeloid leukemia.  
WO/2019/130230A1
Disclosed are compounds having the formula (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.  
WO/2019/119206A1
Provided herein is compounds of formulas (Ia) and (Ib) which are PI3K-delta inhibitors, and uses for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.  
WO/2019/126087A1
The present invention provides compounds of Formula (Ia) or (Ib):Formula (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds ...  
WO/2019/122323A1
The present invention relates to heterocyclylaminophenyloxadiazole and derivatives thereof that may be used and as fungicides.  
WO/2019/123219A1
Disclosed is a novel salt form of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1, 4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, in particular crystalline forms thereof and pharmaceutical compositions containing the same....  
WO/2019/126103A1
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...  
WO/2019/126731A1
The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described ...  
WO/2019/121352A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2019/121606A1
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glu...  
WO/2019/126094A1
The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA ...  
WO/2019/126568A1
Nifuroxazide analogs, and their pharmaceutically acceptable salts and derivatives are described. Methods and uses are also provided that include the administration of an effective amount of the nifuroxazide analogs, or their pharmaceutic...  
WO/2019/122393A1
The present disclosure relates to the use of hydroxyisoxazolines and derivatives thereof as fungicide. It also relates to new hydroxyisoxazolines derivatives, their use as fungicide and compositions comprising thereof.  
WO/2019/121691A1
The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for...  
WO/2019/123194A1
The present invention provides novel anthranilamides of Formula I, wherein, the definition of W1, W2, D, Z1, E, R1, R2, R3, R4, m is as described in the description. The present invention also relates to the composition, combination, use...  
WO/2019/126253A1
Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmace...  
WO/2019/125849A1
The present invention provides for the treatment of disorders related to TLR7/8 overexpression or abherrant activation, wherein the disorder is selected from multiple sclerosis, Alzheimer's Disease, myositis, stroke, ischemia, CNS neurop...  
WO/2019/126084A1
The present invention provides compounds of Formula (Ia) or (Ib) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein wherein X1, X2, X3, and X4 are each independently CR6 or N; provided that no mo...  
WO/2019/123066A1
The present invention i s relates to a process for the preparation of opicapone and a process to prepare intermediates to be used therein.  
WO/2019/122265A1
The present application relates to compounds of formula (I') or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerativ...  
WO/2019/119207A1
Provided are compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.  
WO/2019/123375A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/126505A1
This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of ΡΙ3Κ-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular dis...  
WO/2019/121543A1
The invention relates to substituted thiophenyl uracils of general formula (I) or salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use thereof as herbicides, in particular for con...  
WO/2019/120213A1
The present invention relates to a series of quinazoline compounds, especially compounds as represented by formula (I), isomers thereof or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use thereof as...  
WO/2019/126443A1
The present invention relates to quinazolinones and related compounds which are inhibitors of PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.  
WO/2019/122932A1
Compounds of general formula (I): (Formula (I)) wherein R1, R2, X1 and X2 are as defined herein are useful for the treatment of cancer, particularly solid tumours.  
WO/2019/119331A1
Disclosed are a fluorescent dye, a preparation method therefor and the use thereof. The fluorescent dye has a general structural formula as shown in formula I, wherein X and Y are the same or different and are O, S, C(CH3)2 or NR6, R2 an...  
WO/2019/120237A1
Provided is a compound represented by formula (I). Also provided are a pharmaceutical composition containing the compound of formula (I) and use of the compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor drugs. The compound...  
WO/2019/123007A1
Disclosed is an aryl hydrocarbon receptor modulator of formula (I), and a pharmaceutically acceptable salt thereof, wherein R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, formula (IV), formula (II), or formula (II); the two Ra are in...  
WO/2019/123190A1
Provided is a light-emitting element having excellent reliability and a low drive voltage. This light-emitting element has an electron injection layer between a negative electrode and a light-emitting layer. The electron injection layer ...  
WO/2019/124538A1
Provided is an agricultural and horticultural fungicide exhibiting a high control effect against a wide range of plant pathogens. A compound represented by formula (1) or a salt thereof (in the formula, each symbol is as defined in the d...  
WO/2019/120079A1
The present invention provides a thioxoimidazole dione compound as shown in formula (I). The compound can act as an androgen receptor antagonist and can be used to prepare a drug for treating an androgen receptor-related disease or disor...  
WO/2019/121541A1
The invention relates to substituted N-heterocyclyl- and N-heteroaryl-tetrahydropyrimidinones of general formula (I) or the salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use of...  
WO/2019/123378A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/120088A1
The present invention generally relates to an isoxazole derivative, a preparation therefor, and a use thereof. In particular, the present invention provides a farnesoid X receptor (FXR) agonist compound, and a stereoisomer, a tautomer, a...  
WO/2019/120298A1
The present application relates to an N-(2-cyclohexylethyl)formamide derivative, a preparation method therefor, and pharmaceutical use thereof. Specifically, a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer...  
WO/2019/121374A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2019/122345A1
The present invention relates to benzamide compounds of formula I wherein the variables are defined as in the claims and the description, the N-oxides and salts thereof,and to compositions comprising the same. The invention also relates ...  
WO/2019/121547A1
The invention relates to substituted thiophenyl uracils of general formula (I) or the salts thereof, wherein the groups in general formula (I) are as defined in the description, and to the use thereof as herbicides, in particular for con...  
WO/2019/115660A1
The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of ...  
WO/2019/114364A1
Provided are a photoelectric material containing 4-sulphur sulphone aryl dibenzofuran, and an application, a specifically-arranged bipolar material based on 4-sulphur sulphone aryl dibenzofuran, and a compound having a structure represen...  
WO/2019/114478A1
Disclosed are an organic compound based on triazine and benzoxazole and the use thereof in OLED devices. The compound has a higher glass transition temperature and molecular thermal stability; and has a low absorption and a high refracti...  
WO/2019/115640A1
The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relate...  

Matches 1 - 50 out of 36,506