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Matches 1 - 50 out of 543

Document Document Title
WO/2018/019574A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2018/014829A1
The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossif...  
WO/2018/007323A1
The present disclosure relates to fungicidal active compounds of formula (I), more specifically to benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, part...  
WO/2017/153234A1
The invention relates to new substituted N-Cyclo-2-aryl-quinoline-4-carboxamide derivatives, to methods for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases and to their us...  
WO/2017/147526A1
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathoge...  
WO/2017/099516A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present disclosure is capable of producing an...  
WO/2017/096472A1
Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or...  
WO/2017/092473A1
Provided are a compound with connected indole heterocycles, and a mixture, a composition, an organic electronic device containing the compound, and a use. In certain preferred embodiments, the hydrogen atom in a C-H bond on a indolocarba...  
WO/2017/044571A1
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus : The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP...  
WO/2016/199172A3
The present invention disclosed a novel compound of formula (I), (II) and (III) and process for preparation thereof. Further, the present invention provides a pharmaceutical composition comprising compound of formula (I) or (II) or (III)...  
WO/2016/180537A1
The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.  
WO/2015/196258A1
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosur...  
WO/2015/134210A1
The present disclosure is directed to certain inhibitors of RLK and ITK of formula (I), pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by inhibition of RLK and ITK.  
WO/2015/134039A1
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.  
WO/2015/117912A1
Compounds of formula (I), wherein (II) is a five-membered, aromatic ring system which may contain 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur,and where each ring system may not contain more than ...  
WO/2015/104677A1
The present invention provides a compound of formula I, or an isotopic form, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparati...  
WO/2015/075174A1
The present invention relates to N-acylimino compound of formula (I): wherein X is O or S, in particular O; Y is a single bond, O, S or NR5; Het is a 5 or 6 membered carbon-bound or nitrogen-bound heterocyclic ring, W1-W2-W3-W4 represent...  
WO/2015/042414A8
The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use...  
WO/2015/042414A1
The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use...  
WO/2014/172190A1
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A is a radical selected from the group consisting of A-1 through A-11, L is C(R12a)R12b-C(R13a)R13b; or 1,2-phenylene G is a radical ...  
WO/2014/152588A1
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.  
WO/2014/128022A1
Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.  
WO/2014/086712A1
The present invention relates to compounds of general formula I, wherein the groups (Het)Ar and R1 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activ...  
WO/2014/063929A1
The present invention relates to substituted pyrazoles of formula (I) wherein the variables have the meaning as defined in the description, combinations of these compounds and other pesticides, methods and use of these compounds and comb...  
WO/2014/057435A1
The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]- methanone derivatives of formula (I) wherein R, and the rings A1 A2 and A3 are as described in the description, to pharmaceutically ac...  
WO/2014/047707A1
The present invention relates to a compound of formula (I) or to a pharmaceutically acceptable salt thereof with analgesic activity. In particular, the compounds according to the present invention are useful for treating or preventing ac...  
WO/2013/135674A1
The present invention provides compound of formula I (I) wherein A1 is C-R5b; A2, A3 and A4 are independently of one another C-H or C-R5a, or nitrogen; G1 is oxygen; Y1--Y2-Y3 is -C=N-0-; X1 is halogen; X2 is hydrogen, or halogen; R3 is ...  
WO/2013/098229A3
The invention relates to heteroarylpiperidine and piperazine derivatives of formula (I) in which the symbols RA1, RA2, X, Y, L1, L2, RB1, RB2, G, Q, p, R1, R2 and R10 have the meanings indicated in the description, as well as to salts, m...  
WO/2013/098229A2
The invention relates to heteroarylpiperidine and piperazine derivatives of formula (I) in which the symbols RA1, RA2, X, Y, L1, L2, RB1, RB2, G, Q, p, R1, R2 and R10 have the meanings indicated in the description, as well as to salts, m...  
WO/2013/006485A1
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the c...  
WO/2012/173682A2
The invention relates to compounds of Formula I pharmaceutically acceptable salt, ester or prodrug thereof:  
WO/2012/173682A3
The invention relates to compounds of Formula I pharmaceutically acceptable salt, ester or prodrug thereof:  
WO/2012/153775A1
Provided is an anticancer agent which has an Ras function inhibitory effect. The present invention provides an Ras function inhibitor which contains a compound represented by formula (I') (wherein the symbols are as defined in the descri...  
WO/2012/130306A1
The present invention provides novel 2,3-dihydrobenzazine compounds of formula (I) and to their salts. The compounds inhibit cell proliferation and cell division and they also inhibit the activation of Hypoxia Inducible Factor (HIF)-medi...  
WO/2012/120055A1
The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.  
WO/2012/120050A1
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.  
WO/2012/120058A1
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.  
WO/2012/120057A1
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.  
WO/2012/120056A1
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.  
WO/2012/120135A1
The invention relates to new isoxazoline compounds of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compo...  
WO/2012/102255A1
The present invention provides a compound represented by general formula (I) (in the formula: A is a benzene ring, pyridine ring, or the like; Y1 is an alkylene group having 1-6 carbon atoms, or the like; Y2 is a single bond or the like;...  
WO/2012/098049A1
The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are...  
WO/2012/098050A1
The present invention relates to a process for the preparation of a 1-methyl-1H-tetrazole-5-thio derivative comprising reaction of a halomethyl substrate with 1-methyl-H-tetrazole-5-thiol to obtain a thio-ether compound, and oxidizing th...  
WO/2012/098048A1
The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to...  
WO/2012/025213A3
The present invention describes a series of novel therapeutically active compounds of formula (I), X-Y-Z that are useful for treating a disorder in a mammal.  
WO/2011/162514A3
The present invention provides a novel method for preparing [1,2,3]-oxathiazolidine-2,2-dioxide or [1,2,5]-thiadiazolidine-1,1-dioxide derivatives. According to the manufacturing method of the present invention, it is possible to conveni...  
WO/2011/162514A2
The present invention provides a novel method for preparing [1,2,3]-oxathiazolidine-2,2-dioxide or [1,2,5]-thiadiazolidine-1,1-dioxide derivatives. According to the manufacturing method of the present invention, it is possible to conveni...  
WO/2011/141848A1
Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.  
WO/2011/117806A3
Pyridazine Compounds for Controlling Invertebrate Pests. The present invention relates to pyridazine compounds of formulae I or II and the salts and N-oxides thereof, (I) (II) wherein the substituents are as defined in the description, a...  
WO/2011/073098A1
The invention relates to formula (I) or the salts thereof, in which the divalent groups X1, X2, X3, and X4 mean a group of the formulas CH, N, NH, O, or S, wherein the ring bonded to the 1-N atom of the pyrazol ring is a heteroaromatic f...  

Matches 1 - 50 out of 543