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WO/2004/087700A1 |
The invention relates to novel benzenesulphonamide compounds, as defined in formula (I) and the description, the method for preparation and therapeutic use thereof.
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WO/2004/087159A1 |
Certain novel bicyclic N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatm...
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WO/2004/076448A1 |
The present invention relates to compounds of Formula (I), wherein: Ar, Arl, R3-R5, E, F, T, Q and m are as defined in the specification. The compounds are useful as CCR-3 Receptor antagonists, and therefore, may be used for the treatmen...
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WO/2004/076444A2 |
The present invention relates to new compounds of the general formula (I) or (II), their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compou...
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WO/2004/072075A1 |
This invention relates to novel 8-aza-bicyclop[3.2.1 ]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharm...
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WO/2004/072071A1 |
This invention relates to novel 8-aza-bicyclop[3.2. 1 ]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to phar...
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WO/2004/069285A1 |
The present invention relates to stabilised technetium and rhenium metal complex compositions comprising a radioprotectant and a radiometal complex of a tropane-tetradentate chelating agent conjugate, wherein the radiometal complex is ne...
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WO/2004/064789A2 |
The present invention relates to a method for treating bladder disease, including urinary incontinence, which involves intravesical administration of quaternary antimuscarinic compounds having longer duration of effect and fewer side eff...
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WO/2004/062610A2 |
The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco addiction, nicotine addiction, parkinsonim including Parkinson's disease, female ...
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WO/2004/060865A2 |
It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r,...
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WO/2004/060371A1 |
It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, ...
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WO/2004/058712A2 |
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I are suitable for use as herbicides.
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WO/2004/055011A1 |
The present invention relates to compounds of the following formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV rep...
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WO/2004/054507A2 |
This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions...
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WO/2004/055012A1 |
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the ...
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WO/2004/054581A2 |
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the ...
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WO/2004/054974A2 |
The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replicatio...
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WO/2004/050681A2 |
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, t...
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WO/2004/050610A2 |
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by f...
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WO/2004/048373A1 |
The invention relates to novel carbamic acid esters of general formula (1), in which X- and the groups A, R1, R2, R3 and R4 can be defined as cited in the claims and the description. The invention also relates to a method for producing s...
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WO/2004/045536A2 |
A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject are disclosed. The modified compounds a...
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WO/2004/045533A2 |
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious par...
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WO/2004/037810A1 |
The invention relates to CGRP antagonists of general formula (I), in which A, U, V, W, X and R1 to R 3 are as defined in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures, salts, hydrates of the salts, in particular ...
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WO/2004/035569A2 |
The invention relates to novel antibacterial compounds of formula (I).
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WO/2004/031185A1 |
The present invention relates compounds of the formula (I) : wherein X represents hydrogen, C1-4alkyl optionally substituted by a hydroxy, methoxy or benzyloxy group, or CO2(C1-2alkyl); Z is -CR9R10CH2- or -CH2CR9R10-; and R1, R2, R3, R4...
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WO/2004/024702A1 |
The invention relates to carboxamide compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1, R2, R3, and k have the meanings indicated in claim 1. The invention also relates to methods for producing said ...
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WO2004010512A9 |
Novel heterodiamondoids are disclosed. These heterodiamondoids are diamondoids that include heteroatoms in the diamond lattice structure. The heteroatoms may be either electron donating, such that an n-type heterodiamondoid is created, o...
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WO/2004/022060A2 |
(1H-Benzoimidazol-2-YL)-(Piperazinyl)-Methanone derivatives of formula (I) and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders (I) wherein B and B1 are C or up to one of B a...
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WO/2004/018464A1 |
This invention provides a method for preparing a hydroxyalkyl tropane ester, comprising: (a) contacting a tropane and 1,1'-carbonyldiimidazole to produce an activated tropane ester; (b) contacting the activated tropane ester with an exce...
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WO/2004/014851A2 |
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a co...
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WO/2004/013120A1 |
The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment an...
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WO/2004/013282A2 |
The present invention provides molecular building blocks of rigid bis (amino acids). The molecular building blocks can be linked together through the formation of rigid diketopiperazine rings, to provide the desired three dimensional str...
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WO/2004/009588A1 |
A compound of the formula (I) wherein a, b, cR1, R2, R3, R4, R5, R6, Q, W, Y, and Z are defined as above, useful as potent and selective inhibitors of MIP-1&agr (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulato...
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WO/2004/009544A1 |
It is intended to provide a compound having an excellent effect of inhibiting dipeptidylpeptidase IV, and an excellent remedy for insulin-dependent diabetes (type 1 diabetes), in particular, insulin-independent diabetes (type 2 diabetes)...
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WO/2004/006846A2 |
The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions...
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WO/2004/004725A2 |
The present invention relates to novel pharmaceutical compositions based on anticholinergics of Formula A and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases (I).
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WO/2004/002964A1 |
A compound which is usable in the prevention of and/or treatments for respiratory diseases in which STAT 6 participates, especially asthma, chronic obstructive pulmonary diseases, etc. The compound is either a pyrimidine derivative havin...
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WO/2003/106456A2 |
The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane (B) building blocks.
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WO/2003/106452A2 |
This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R9)-, R1, R2, R3, R4,...
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WO/2003/101927A1 |
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A...
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WO/2003/101986A1 |
The invention relates to a novel, technically applicable production method for preparing tropenol, optionally in the form of acid addition salts thereof.
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WO/2003/101453A1 |
The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain.
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WO/2003/099783A2 |
The present invention provides novel tropane compounds and methods for their use.
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WO/2003/094830A2 |
This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological pr...
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WO/2003/093249A1 |
The invention relates to thiazolidones of general formula (I), in which R1, R2, R3, X and Y have the meanings as cited in the description and wherein represents an E or Z double bond. The invention also relates to the production of these...
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WO/2003/089439A1 |
The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, A, B, C, D, E and X are defined as in Claim 1, to tautomers, stereoisomers, mixtures and salts thereof, particularly their physiologically compat...
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WO/2003/086399A1 |
The invention relates to novel medicament compositions based on long-acting steroids and salts of a novel anticholinesterase drug, to methods for the production of these compositions and their use in treating respiratory tract diseases.
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WO/2003/087096A1 |
The invention relates to novel compounds of general formula 1, in which X- and the radicals A, B, R, R1, R2, R3, R3', R4, R4', Rx, and Rx' can have the meanings mentioned in the claims and in the description, methods for the production t...
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WO/2003/087097A1 |
The invention relates to novel medicament compositions based on long-acting beta2 agonists and salts of a novel anticholinesterase drug (I), to methods for the production of these compositions and their use in treating respiratory tract ...
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WO/2003/087049A2 |
The invention relates to novel pharmaceutical compositions based on a novel anticholinergic agent (1) and heterocyclic compounds (2), to methods for the production thereof, and to the use of the same in the treatment of respiratory tract...
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