| Document |
Document Title |
|
WO/2003/084954A1 |
The present invention provides compounds of formula (I) wherein, X, Y, R1, R2 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. ...
|
|
WO/2003/084502A1 |
The invention relates to a method for the administration of powdered preparations containing tiotropium via inhalation.
|
|
WO/2003/082272A1 |
New substituted benz-azole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with ...
|
|
WO/2003/082808A1 |
Because of having an Rho kinase inhibitory effect, compounds represented by the following general formula (1), prodrugs thereof or pharmaceutically acceptable salts of the same are useful in treating diseases such as hypertension the pat...
|
|
WO/2003/080574A1 |
The invention provides a compound of formula (I) wherein A, R1, R2, R3, R3a, R4, R4a, R5, and R6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof; compositions containing these compounds,processes for pr...
|
|
WO/2003/078428A1 |
The invention relates to novel difurylglycolic acid esters of general formula (I), wherein X- and groups A, R, R1, R2, R3 and R3' can have the meanings as cited in the claims and in the description, to methods for the production thereof,...
|
|
WO/2003/078429A1 |
The invention relates to a micronized crystalline (1alpha, 2beta, 4beta, 5alpha, 7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa
-9-azoniatricyclo[3.3.1.02,4]nonane bromide, methods for the production thereof, and the use th...
|
|
WO/2003/076398A2 |
The present invention provides kinase inhibitors of Formula (I)
|
|
WO2002058695A9 |
Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
|
|
WO/2003/074500A2 |
The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
|
|
WO/2003/068234A1 |
The invention relates to a combination of a nicotinamide derivative of formula (1) and tiotropium or a derivative thereof, compositions containing it and the uses of, such a combination. The combination according to the present invention...
|
|
WO/2003/068235A1 |
The invention relates to nicotinamide derivatives of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives a...
|
|
WO/2003/068220A1 |
The present invention relates to 1- arylsulfonyl-3 substituted indoline derivatives having the general formula (I) (I) wherein the dotted line represents an optional bond, n is 0 or 1, m is 0-5 and Ar, R6-R11 are as defined in the descri...
|
|
WO/2003/068232A1 |
The invention relates to nicotinamide derivatives of formula (1) and to processes for the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are phos...
|
|
WO/2003/068233A1 |
The invention relates to a combination of a nicotinamide derivative of formula (1) and tiotropium or a derivative thereof, compositions containing it and the uses of, such a combination. The combination according to the present invention...
|
|
WO/2003/066004A2 |
This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or rec...
|
|
WO/2003/064418A1 |
The invention relates to novel anticholinergic agents of general formula (1), in which X - and the groups A, B, R, R1, R2, R3, R3', R4, R4', Rx and Rx' can be defined as per the claims and the description. The invention also relates to a...
|
|
WO/2003/064417A1 |
The invention relates to novel xanthene-carboxylic acid esters of general formula (1), in which X and the groups A, R, R1, R2, R3, R3', R4 and R4' are defined as per the claims and the description. The invention also relates to a method ...
|
|
WO/2003/064419A1 |
The invention relates to novel fluorene carboxylic acid esters of general formula (I) wherein X- and the groups A, R, R1, R2, R3, R3', R4 and R4' have the designations cited in the claims and in the description. The invention also relate...
|
|
WO/2003/064432A1 |
Intermediates for the total synthesis of ecteinascidins which are represented by the general formula (2) and bear the skeletal pentacyclic structure of ecteinascidins, characterized in that the 4-position OH group and trichloroethoxycarb...
|
|
WO/2003/061657A1 |
The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for the treatment of irritable bowel syndrome...
|
|
WO/2003/062235A1 |
The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged...
|
|
WO/2003/057672A2 |
The present invention relates to tetrahydroquinoline compounds as formulas I, as well as salts and isomers thereof wherein m is 0, 1 or 2; C3-C4 is CH2-CH or CH=Cor C4 is CH and C3 is absent; L1 and L2 are biradicals independently select...
|
|
WO/2003/057694A1 |
The invention relates to a novel method for producing the scopine esters of general formula (1), wherein X- and the groups R1 and Ar may be defined as in the claims and in the description.
|
|
WO/2003/055879A2 |
The present invention relates to a tropane derivative, to a chelation product composed of this tropane derivative and of a metal or of a metal complex, and to a radiopharmaceutical comprising the said product. The tropane derivative of t...
|
|
WO/2003/045388A1 |
The present invention relates to the use of tropane derivatives having dopamine reuptake inhibitor activity for the treatment of diseases associated with reduced blood flow to the brain or with instances of a temporary break in blood sup...
|
|
WO/2003/042209A1 |
This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaini...
|
|
WO/2003/042176A1 |
An azabicyclo compound (I) or a salt thereof which each has excellent inhibitory activity against matrix metalloproteases (MMPs) and is useful in medicinal compositions, cosmetic compositions, and skin preparations. In the formula (I), R...
|
|
WO/2003/039469A2 |
Novel compounds of the formula (I), wherein R is optionally substituted heteroaryl or (a); R1 is H or C1-C6 alkyl; and R2 and R3 are -CH3, -OCH3 or halo; or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositio...
|
|
WO/2003/032997A1 |
The invention concerns tri-substituted pyrimidines of formula (I), wherein Ra to Re are such as defined in the description, said compounds being used for treating diseases characterized by excessive or abnormal cell proliferation. The in...
|
|
WO/2003/031452A2 |
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compoun...
|
|
WO/2003/031397A1 |
A compound of formula (I), wherein R¿1? is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C¿6-18?)aryl, and R¿1? or R¿2? independently of each other are substituted (C¿4-8?)cycl...
|
|
WO/2003/028459A1 |
The invention relates to amides of formula (I) and to the salts thereof, whereby the symbols and indices have the following meanings: X represents CH or N; Y represents O or S; n is 0 or 1; R?1¿ represents (C¿1?-C¿4?) alkyl halide; R?...
|
|
WO/2003/028650A2 |
Benzimidazolidinone derivative compounds, which increase acetylcholine signalling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprisi...
|
|
WO2002012245B1 |
Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the cen...
|
|
WO/2003/022836A1 |
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
|
|
WO/2003/017764A1 |
The invention relates to the use of substituted arylpropargylamines and heteroarylpropargylamines of general formula (I), optionally also in the form of an N-oxide or a salt, wherein a) R?1¿ represents an aryl or a heteroaryl which is o...
|
|
WO/2003/015517A1 |
The present invention provides compositions and methods for controlling an helminth or arthropod pest. In a preferred embodiment of the invention provided herein, the compositions comprise compounds which alter the 5-HT¿3? receptor of t...
|
|
WO/2003/014114A2 |
This invention relates to novel substituted amine derivatives of general formula (I) and a pharmaceutical composition comprising these compounds. In a further aspect the invention provides a method of treatment, prevention or alleviation...
|
|
WO/2003/009847A1 |
Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, ...
|
|
WO/2003/009850A1 |
Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, ...
|
|
WO/2003/010159A1 |
The present invention relates to new carboxylic acid amide derivatives of formula (I), wherein U, V, W, X, Y, Z, n and m are as defined as in Claim 1. A further object of the invention are the processes for producing of carboxylic acid a...
|
|
WO/2003/004493A1 |
The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compo...
|
|
WO/2003/002531A2 |
The present invention relates to novel compounds of formula (I): , their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeut...
|
|
WO/2003/002530A2 |
The present invention relates to novel compounds of formula (I):, their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeuti...
|
|
WO/2003/002553A2 |
The present invention relates to novel compounds of following formulae (I)-(VI) their use for inhibiting post prolin/analine-cleaving proteases, such as serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DP...
|
|
WO/2003/002562A1 |
The invention relates to a novel, technically viable method for producing tropenol, optionally in the form of its acid addition salts.
|
|
WO/2003/000265A1 |
The invention relates to crystalline, water-free (1$g(a),2$g(b),4$g(b),5$g(a),7$g(b))-7-[(hydroxydi-2-thienyl
acetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0?2,4Â
¿]nonane-bromide, to a method for its production, and to the use t...
|
|
WO/2002/102801A1 |
This invention relates to tropane derivatives. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the optically active isomer of the invention.
|
|
WO/2002/096906A1 |
The present invention includes compounds of formula (I), wherein A, X, n, Ar¿1?, and Ar¿2? are defined as set forth herein. These compounds may be used to treat depression. The invention also includes formulations containing these comp...
|
