| Document |
Document Title |
|
WO/2004/113391A2 |
The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-l-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-...
|
|
WO/2004/113275A2 |
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
|
|
WO/2004/110609A2 |
One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona-alkaloid catalyst. Another aspect of the present invention relates...
|
|
WO/2004/108086A2 |
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables L, Z0, R1, R4, R5, and R11 are defined are as defined herein, which are useful as inhibito...
|
|
WO/2004/108636A2 |
A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number ...
|
|
WO/2004/108668A2 |
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease...
|
|
WO/2004/098590A1 |
Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 rec...
|
|
WO/2004/098589A1 |
Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor...
|
|
WO/2004/099206A1 |
The present invention relates to novel isoquinoline-3-carboxylic acid amides having &agr 7 nicotinic acetylcholine receptor agonistic activity, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
|
|
WO/2004/099202A1 |
The invention provides the malate salt of compounds of Formula I, wherein X is malate salt, including D- or L-; wherein A is (a), wherein B is (b) or pharmaceutical composition, racemic mixture, or pure enantiomer thereof. The compounds ...
|
|
WO/2004/096800A2 |
Compounds of formula (I), in salt or zwitterionic form wherein, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceu...
|
|
WO2004026844A9 |
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or bl...
|
|
WO/2004/089931A1 |
The invention relates to the compounds of formula (I) and the salts and solvates thereof, wherein X, R1, R2, R3, R4 and R5 are defined as in claim 1. The inventive compounds are suitable as ligands of 5 HT receptors.
|
|
WO/2004/087700A1 |
The invention relates to novel benzenesulphonamide compounds, as defined in formula (I) and the description, the method for preparation and therapeutic use thereof.
|
|
WO/2004/087696A1 |
The invention relates to novel compounds of formula (I), where R, R1, R2 and R3 have the meanings given in claim 1, which are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseas...
|
|
WO/2004/084898A1 |
The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemo...
|
|
WO2004074276B1 |
This invention provides biphenyl derivatives containing (i) a (biphenyl-2-yl)oxycarbonylamino- or (biphenyl-2-yl)aminocarbonylamino-substituted (2-7C)azacycloalkyl or (5-10C)azabicycloalkyl group; (ii) a substituted 2-(4-hydroxyphenyl)-2...
|
|
WO/2004/078686A1 |
A novel process for producing optically active alcohols through asymmetric hydrogenation of prochiral carbonyl compounds allows high-yield, industrially favorable production of an optically active alcohol at a high enantiomeric excess. T...
|
|
WO2004043389B1 |
Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidaz
ol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including pro...
|
|
WO/2004/076448A1 |
The present invention relates to compounds of Formula (I), wherein: Ar, Arl, R3-R5, E, F, T, Q and m are as defined in the specification. The compounds are useful as CCR-3 Receptor antagonists, and therefore, may be used for the treatmen...
|
|
WO/2004/076449A2 |
The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes,...
|
|
WO/2004/074246A2 |
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl deri...
|
|
WO/2004/074812A2 |
This invention provides a library of biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a salt or stereoisomer thereof. The library is useful for identifying compo...
|
|
WO2004018419B1 |
Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutic...
|
|
WO/2004/062601A2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...
|
|
WO/2004/052889A1 |
Radiolabeled ligands useful as probes for determining the relative abundance, receptor occupancy, and/or function of nicotinic acetylcholine receptors. The compounds of Formula I as described herein are labeled with a radioactive isotopi...
|
|
WO/2004/050610A2 |
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by f...
|
|
WO/2004/043349A2 |
The present application describes novel isoxazoline of formula I or II: [TWO CHEMICAL STRUCTURES]or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, R1, R2, R3, R4, Z, U, X, Y, Za, and n are defined in the present sp...
|
|
WO/2004/039801A1 |
The invention features quaternary ammonium compounds of formula (I), described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.
|
|
WO/2004/039780A1 |
The invention relates to alkyne compounds of general formula (I), in which groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings as cited in Claim 1. The invention also relates to medicaments containing at least one inventive...
|
|
WO/2004/039815A2 |
The invention discloses compounds that are selective &agr 7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases. The compounds have the following Formula (I): Azabicyclo-N(H)-C(=O)-W0 wherein Aza...
|
|
WO/2004/037810A1 |
The invention relates to CGRP antagonists of general formula (I), in which A, U, V, W, X and R1 to R 3 are as defined in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures, salts, hydrates of the salts, in particular ...
|
|
WO/2004/035574A2 |
This invention is directed towards substituted aminoquinuclidine compounds of Formula (I); (I) wherein: Ar is selected from the group consisting of aryl and heteroaryl; n is an integer from 0 to 2; useful as delta-opioid receptor modulat...
|
|
WO/2004/034985A2 |
3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment...
|
|
WO/2004/035575A1 |
A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine. The process includes the steps of contacting a compound containing a mixture of R- and S-isomers and having Formula (I), with an effective amount of a chiral organ...
|
|
WO/2004/029050A1 |
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylchol...
|
|
WO/2004/022556A1 |
The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I), wherein X is CH2 or a single bond; Y is a group of formula (II, III, IV) and wherein R has the meanings as defined in the specification, which compounds are ...
|
|
WO/2004/018455A1 |
New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the...
|
|
WO/2004/018420A1 |
The invention relates to a group of novel indole compounds of Formula (I): wherein: R1, R2, R4, R6, R6a, R7, R8, R9, R10, and A are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The inv...
|
|
WO/2004/018458A1 |
The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an ...
|
|
WO/2004/016608A1 |
This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those r...
|
|
WO/2004/016590A1 |
The present invention discloses a series of derivatives by the reaction between 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy) quinuclidines and organic acid or inorganic acid, their preparation an applications in pharmaceutical industry. An...
|
|
WO/2004/013136A1 |
The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, l...
|
|
WO/2004/012671A2 |
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...
|
|
WO/2004/013137A1 |
The invention provides compounds of Formula (I), wherein Azabicyclo is Formula (I, II, III, IV, V, VI, VII); W is Formula (m); where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutica...
|
|
WO/2004/006930A1 |
Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
|
|
WO/2004/005285A1 |
New quinuclidine amide derivatives having the chemical structure of general formula (I) and pharmaceutically acceptable salts thereof including quaternary salts of formula (II) are disclosed; as well as processes for their preparation, p...
|
|
WO/2004/005293A2 |
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryldiazaspirocyclic compounds, bridged analogs of N-heteroaryl diazaspirocyclic compounds, or ...
|
|
WO/2004/002964A1 |
A compound which is usable in the prevention of and/or treatments for respiratory diseases in which STAT 6 participates, especially asthma, chronic obstructive pulmonary diseases, etc. The compound is either a pyrimidine derivative havin...
|
|
WO/2004/000833A1 |
The present invention provides a facile process for the preparation of tri-and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for tr...
|
