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Matches 1 - 50 out of 1,280

Document Document Title
WO/2018/006737A1
Disclosed are a mangiferin-6-O-calcium salt and a preparation method thereof, and the use of the mangiferin-6-O-calcium salt as an intermediate in the preparation of a mangiferin-6-O-berberine salt.  
WO/2018/001335A1
Crystal forms of NBI-98854 (of a structure as represented by formula I), a preparation method therefor and use thereof. The crystal forms of NBI-98854 are named as crystal form CS1 and crystal form CS2 respectively, and can be used in th...  
WO/2017/214683A1
The present invention provides a method for the treatment or prophylaxis of an ectoparasitic infestation, the method comprising the step of: contacting an external surface of an animal in need thereof with an effective amount of a berber...  
WO/2017/182916A1
The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) an...  
WO/2017/106071A1
The present invention relates to spirocyclic quinolizine derivatives and pharmaceutically acceptable salts or prodrug thereof, compositions comprising at least one spirocyclic quinolizine derivative, and methods of using the spirocyclic ...  
WO/2017/103825A1
Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof (I), wherein R1-R5, and n are as defined in the specification, pharmaceutical compositions including a compound,...  
WO/2017/071576A1
The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of gene...  
WO/2017/067366A1
The invention relates to a method for extracting and refining alkaloid from ipecac. The method comprises the following steps: (1) extraction and concentration: grinding an ipecac medicinal material, adding an acidic methanol solution or ...  
WO/2017/066227A1
The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical composit...  
WO/2017/062804A1
The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the inve...  
WO/2017/027971A1
The present application is directed to transdermal formulations for the delivery of berberine compounds to a subject for the treatment of berberine-responsive diseases. In particular, the transdermal formulation comprises: (a) an aqueous...  
WO/2017/016921A1
The present invention relates to a new crystalline form of compound (I), (6S)-10-methoxy-6-isopropyl-9-(3-methoxypropoxy)-2-oxo-6,7-d ihydrobenzo[a]quinolizine-3- carboxylic acid and pharmaceutical compositions comprising the crystalline...  
WO/2017/016960A1
The present invention relates to a process for synthesizing a compound of formula (I), wherein R1 is C1-6alkoxy or haloC1-6alkoxy, R2 is C1-6alkyl unsubstituted or substituted by a substituent selected from C1-6alkoxy and haloC1-6alkoxy,...  
WO/2017/017042A1
The invention provides novel compounds having the general formula wherein R1 to R6, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2016/199789A1
The present invention addresses the problem of efficiently synthesizing a trifluoromethyl substituted semisquarate in a short process, in order to manufacture trifluoromethyl compounds with various functionalities. A method was developed...  
WO/2016/161921A1
Conjugate compounds having at least one of a moiety derived from ursodeoxycholic acid, or eicosapentaenoic acid, or docosahexaenoic acid, or rhein, or R- (+) -α-lipoic acid, or ursolic acid, or corosolic acid, or hydroxycitric acid, or ...  
WO/2016/154527A1
The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present inve...  
WO/2016/143699A1
Provided are: a compound which is useful as an amyloid oxygenation catalyst that is applicable in vivo and is amyloid-selective, while being applicable not only to Aβ peptides but also to other amyloids; and a prophylactic and therapeut...  
WO/2016/127133A1
Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: wherein R1 is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMA...  
WO/2016/110250A1
Provided in the present invention are a mangiferin-6-O-berberine salt and a preparation method thereof. In addition, also provided is a use of the mangiferin-6-O-berberine salt as an AMPK activator for treating diabetes, etc.  
WO/2016/041515A1
Provided are compounds of formula (VI), a preparation method therefor and a pharmaceutical application of said compounds. The compounds can increase LDLR expression and reduce PCSK9 expression, and can be used for preventing and treating...  
WO/2016/041514A1
Disclosed are compounds of formula (V), a preparation method and a pharmaceutical application of said compounds. Specifically, disclosed are derivatives of compounds having the general formula (V), a preparation method and a use of said ...  
WO/2016/015634A1
Compositions of berberine in combination with pharmacologically active organic acids, and methods of their use in treating various diseases or disorders. Compounds prepared from berberine and pharmacologically active organic acids and pr...  
WO/2016/010092A1
Provided are: a compound that is useful as an amyloid oxidation catalyst which can be applied inside a living body and can be applied not only to Aβ peptides but also to other amyloids; and an amyloid-related preventive or therapeutic d...  
WO/2015/191837A1
The present disclosure provides oxidized berbine derivatives, processes for their preparation, and methods of using the oxidized berbine derivatives.  
WO/2015/173164A1
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X and Y are as described in the description and in the claims, as well as or pharmaceutically acceptable salts, or enantiomers, or diaster...  
WO/2015/125125A1
Compounds of Formula (I) used as semiconductors, in particular as semiconductors in organic electronics and organic photovoltaics are disclosed, wherein X1, X 2 are O or C(CN)2, A is selected Formula (II1), Formula (II2), Formula (II3) f...  
WO/2015/120110A3
The present invention relates to new extended release pharmaceutical compositions and methods of use thereof for the treatment of disorders. In certain embodiments, disclosed herein is an extended-release pharmaceutical formulation compr...  
WO/2015/103900A1
Disclosed is a polynuclear molecular compound. The polynuclear molecular compound is prepared by synthesizing berberrubine and magnolol. The present invention provides an all-new polynuclear molecular compound for the first time. The pol...  
WO/2015/097642A1
The present invention relates to oral capsules effective for treating cancer. The pharmaceutical composition comprises berberine and one or more additives and excipients. The additives and excipients comprise one or more binding agent, l...  
WO/2015/077520A1
Methods for treating abnormal muscular activity are disclosed. The methods may be performed remotely and permit monitoring of a subject outside a healthcare provider's office.  
WO/2015/077521A1
The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof. (I)  
WO/2015/051106A1
The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds preferably through a Bischler-Napieralski cyclization followed by reduction, as well as intermediates used in the synthesis...  
WO/2015/048370A1
The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof represented by structural Formula I.  
WO/2015/048363A1
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also...  
WO/2014/144097A1
The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of phar...  
WO/2014/119895A1
The present invention provides: a novel compound for improving the hole injection and transport properties in a light emitting device; a light emitting device comprising the compound; and an electronic device comprising a light emitting ...  
WO/2014/089112A1
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure ...  
WO/2014/075309A1
Provided in the present invention are the use of compounds having the structure of general formula (I) and medicinal salts, hydrates or solvates thereof in the preparation of drugs for treating nervous system diseases associated with dop...  
WO/2014/000586A1
Provided are phenanthroindolizidine alkaloid derivates and salt thereof as well as preparation, a plant-virus resisting activity, and an anti-cancer activity of phenanthroindolizidine alkaloid derivates and salt thereof. The derivates an...  
WO/2013/166862A1
Provided are a diaryl[a, g]quinolizidine compound, enantiomers, diastereomeric isomers, racemates and mixtures thereof, pharmaceutically acceptable salts thereof, crystalline hydrates or solvates thereof, the preparation method therefor,...  
WO/2013/147586A1
A method for preparing an immunogen to trigger production of anti(9-methoxy corynantheidine) antibody for a use in detecting presence of mitragynine in humans.  
WO/2013/133218A1
The objective of the present invention is to provide a photoelectric conversion element provided with a photoelectric conversion film that can even be produced by means of a continuous vapor deposition process under high temperature cond...  
WO/2013/060274A1
Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberi...  
WO/2013/046061A1
Pure S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-met hyl-1-oxo-1H,- 5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate and a process for its preparation is disclosed.  
WO/2013/020229A1
Tetrahydroprotoberbine (THPB) compounds and their use in the treatment of neurological, psychiatric and neurodegenerative diseases is provided. The compounds include d-govadine, l-govadine and racemic govadine, as well as d-THPBs of gene...  
WO/2012/168368A1
The present invention relates to benzoquinolizidine derivatives that are alpha-2 adrenergic receptor antagonists, and to the use thereof in human therapy. Said compounds correspond to general formula 1, where, in particular: X is an oxyg...  
WO/2012/163179A1
The present invention relates to a novel hexahydrodibenzo[a,g]quinazine compound represented by General Formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable sal...  
WO/2012/162175A1
Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the em...  
WO/2012/143526A1
The present invention relates to a compound of general formula (I), where: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN' group...  

Matches 1 - 50 out of 1,280