| Document |
Document Title |
|
JPS59130252A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
|
|
JPS59112919A |
A combination of an ergot alkaloid, e.g., lisuride, and L-dopa has synergistic cytostatic activity.
|
|
JPS5919116B2 |
This invention provides new compounds of formula I, I wherein R is branched chain alkyl of 3 to 6 carbon atoms, useful as venoconstrictors and venotonics.
|
|
JPS5976085A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
|
|
JPS59500717A |
The composition is based on alkaloids of the ergot as lisurid with an affinity to monoamine receivers.
|
|
JPS5948480A |
2-methyl-lysergyl ethers and thioethers are useful neuroleptics, anti-migraine agents, cerebral insufficiency agents, agents for senile dementia and anti-depressants. Preferably compounds of formula where X is O or S, R1 is H, C1-4 alkyl...
|
|
JPS5944384A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
|
|
JPS5910358B2 |
|
|
JPS5933212A |
1. Stable solutions of ergot alkaloids and hydrated forms thereof and salts thereof characterized in that they have been dissolved in solvents or solvent mixtures which are free of ethyl alcohol and stabilizing additives, the solvent mix...
|
|
JPS58210081A |
A process for the preparation of dihydrolysergic acid esters of the formula wherein R is alkyl of up to 3 carbon atoms and the substituent in the 8-position can be in the alpha - or beta -position, comprising reacting the corresponding a...
|
|
JPS58188883A |
There are provided ergoline derivatives of the formula: I wherein R1 represents a hydrogen atom or a methyl group, R2 represents a hydrogen or halogen atom or a methyl group, R3 represents a hydrogen atom or a methoxy group, R4 represent...
|
|
JPS58180484A |
1-Substituted N-(8 alpha -ergolinyl)- N',N'-diethylureas of general formula (I> (wherein R<1> represents an alkyl group having from 1 to 4 carbon atoms and R<2> represents an alkyl group having from 1 to 4 carbon atoms, a benzyl group, a...
|
|
JPS58152884A |
1-aryl ergot alkaloids and their acid addition salts thereof are indicated for use as an anti-parkinson agent, anti-depressant, neuroleptic, vigilance increasing agent or for the treatment of senile dementia. Aryl includes heteroaryl and...
|
|
JPS58150592A |
A process for the preparation of anilides in the ergoline series of the general formula in which R1 denotes a hydrogen, chlorine or bromine atom, R2 denotes an alkyl group having 1 to 4 carbon atoms, X denotes the group R2, a free or sub...
|
|
JPS5888379A |
1451724 D - 2 - substituted - 8 - substituted ergoline derivatives ELI LILLY CO 5 Feb 1974 [28 Nov 1973] 05346/74 Addition to 1423065 Heading C2C Novel ergoline derivatives of the Formula II wherein X is Cl, Br, I, CH 3 or CN, R is CH 2 ...
|
|
JPS5813541B2 |
1423065 D-6-Methyl-2,8-disubstituted ergoline ELI LILLY & CO 10 July 1973 [21 July 1972] 32890/73 Heading C2C Novel D-6-methyl-2,8-disubstituted ergoline compounds of the Formula (I) wherein X is halo, methyl or CN and R is CH 2 CN or CH...
|
|
JPS5813542B2 |
8,8-Disubstituted-6-methylergolines and 9-ergolenes, are prepared by alkylation of lysergic, or isolysergic acid or their 9,10-dihydro analogues.
|
|
JPS589111B2 |
1497681 6 - Methyl - 8 - mercaptomethylergolenes and ergolines SANDOZ Ltd 10 March 1975 [14 March 1974 23 July 1974] 9807/75 Heading C2 [Also in Division A5] Novel compounds of the Formula I wherein # is the group -CH = CH or and R is hy...
|
|
JPS5824584A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
|
|
JPS582946B2 |
1505296 8-Thiomethylergoline derivatives ELI LILLY & CO 3 June 1975 [6 June 1974] 23869/75 Heading C2C Novel compounds of the Formula II wherein R is H, CN, COalk, phenyl or alk; R1 is H, Cl or Br; alk is C 1-3 alkyl and the dotted line ...
|
|
JPS57159783A |
A process for the production of an ergot alkaloid comprising intramolecularly cyclizing a 3-iminoethyl-4-trans-buta-1',3'-dienylindole to produce an 8-ergolene and as necessary converting the resultant ergolene into the desired ergot alk...
|
|
JPS57156485A |
The invention relates to compounds of the formula I in which R1, R2 and R3 independently of one another denote an alkyl group having 1 to 4 carbon atoms, and to a process for the preparation of the compounds of the formula I by oxidation...
|
|
JPS5785385A |
PCT No. PCT/CH81/00105 Sec. 371 Date Apr. 26, 1982 Sec. 102(e) Date Apr. 26, 1982 PCT Filed Sep. 23, 1981.The invention concerns a process for the isomerization of ergoline derivatives substituted in the 8 beta position by an electron wi...
|
|
JPS5782317A |
|
|
JPS576431B2 |
1423065 D-6-Methyl-2,8-disubstituted ergoline ELI LILLY & CO 10 July 1973 [21 July 1972] 32890/73 Heading C2C Novel D-6-methyl-2,8-disubstituted ergoline compounds of the Formula (I) wherein X is halo, methyl or CN and R is CH 2 CN or CH...
|
|
JPS575237B2 |
The invention relates to new 8 beta -hydrazinomethyl-ergoline derivatives of the general formula (I), (I) wherein x y stands for a or group, R stands for hydrogen or methyl group, and R1 stands for hydrogen, a lower acyl group, a di-(low...
|
|
JPS56164188A |
The compounds have the general formula in which R1 is hydrogen or the methyl group, x@y is the group -CH2 or -CH, R2 is the group in which n is 1 or 2, R3 is Cl, Br, I, OH, OR4, NH2 or NO2 and R4 is a straight-chain or branched C1-C4-alk...
|
|
JPS5648512B2 |
A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: (I) wherein R1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms, R2 ...
|
|
JPS5648509B2 |
A method is disclosed for recovering ergolic alkaloids from the seeds of the Kaladana plant, the latter being a plant of the Ipomoea section of Convolvulaceae, Calonyction genus (Choisy) Hallier f, species nova. The method is a selective...
|
|
JPS5634598B1 |
|
|
JPS5634597B2 |
Title derivs. of formula (I) (where R is H or CH3 R1 and R2 are H, 1-3C alkyl or phenyl, and R3 is H, halogen, CH3, C2H5, OCH3, OC2H5 phenyl, NO2, (acyl)amino CN or carboxamido) which are long-acting adrenolytics with low toxicity, are p...
|
|
JPS5692286A |
|
|
JPS5690087A |
A compound of formula I wherein R is (i) alkyl(C2-8), (ii) alkenyl(C3-6) or alkinyl (C3-6) wherein the double bond is other than in the alpha , beta position, (iii) cycloalkylalkyl(C4-10) or (iv) phenylalkylalkyl(C7-10) or a pharmaceutic...
|
|
JPS5661376A |
|
|
JPS5657787A |
Novel D-6-n-propylergolines of the formula: wherein Y is O or S and R<1> is n-propyl, and pharmaceutically-acceptable acid addition salts thereof can be used to lower the prolactin level in mammals or for treating symptoms of Parkinson's...
|
|
JPS5626874A |
of formula (I) and their salts are new, (where R1 = 1-4C alkyl, benzyl or phenethyl, R2 = H, acyloxy, alkoxy, amino, cyano, or carbamoyl, or an optionally substd. heterocyclic gp. of 5-6 atoms at least one of which is N attached to the m...
|
|
JPS5550038B2 |
A process for the preparation of a 2-bromo-alpha-ergocryptine is characterised in that alpha-ergocryptine in an inert atmosphere is brominated with pyrrolidinone hydrotribromide or N-bromosaccharin in solution in cyclic ether in the pres...
|
|
JPS55141412A |
|
|
JPS55124784A |
Compounds which in form of therapeutic compositions exhibit antihypertensive activity and are of low toxicity. These compounds are of general formula I wherein R1 represents a hydrogen atom, or a carboxy, alkoxycarbonyl, the alkoxy group...
|
|
JPS5512909B2 |
|
|
JPS559791A |
A process for isolating ergot alkaloids from culture suspensions, in which after mechanical filtration, the residue is dried in a fluidized drying bed and the alkaloids are extracted with an aprotic organic solvent, reextracted with a we...
|
|
JPS54157840A |
A material and composition for reducing blood pressure are provided. The blood pressure in animals is reduced by administering lergotrile, viz. 2-chloro-6-methylergoline-8 beta -acetonitrile or pharmaceutically acceptable salts thereof e...
|
|
JPS54112899A |
Novel ergoline derivatives are disclosed having the general formula (I) wherein R1 is hydrogen, and alkyl radical (C1 to C4) either straight of branched chain, Z is hydrogen, bromine, S-RIV (in which RIV is an alkyl of from C1 to C4, RII...
|
|
JPS54100396A |
Compositions containing D-2- bromo-6-methyl-8beta-(morpholinocarbonyloxymethyl) ergoline as such or in the form of its salts in pharmaceutically acceptable formulations are used in the treatment of asthma.
|
|
JPS54100395A |
Disorders of psychogenic origin are treated with a composition containing D-2-bromo-1,6-dimethyl- 8beta-(perhydroazepinyl-carbonyloxymethyl) ergoline as such or salified in a pharmaceutically acceptable form.
|
|
JPS5448880A |
Compounds of formula I I wherein R1 is hydrogen or lower alkyl, R2, R3 and R4 are, independently, hydrogen, halogen lower alkyl, lower alkoxy or CONR5R6 wherein R5 and R6 are, independently, hydrogen or lower alkyl, and x y is -CH2-CH= o...
|
|
JPS5448800A |
Compounds of formula I I wherein R1 is hydrogen or lower alkyl, R2, R3 and R4 are, independently, hydrogen, halogen lower alkyl, lower alkoxy or CONR5R6 wherein R5 and R6 are, independently, hydrogen or lower alkyl, and x y is -CH2-CH= o...
|
|
JPS5344478B1 |
1315439 Ergoline derivatives SOC FARMACEUTICI ITALIA 8 Nov 1971 [12 Nov 1970] 51772/71 Heading C2C Novel compounds I in which R is alkoxy, NH 2 , substituted alkylamino, cycloalkylamino or a radical II in which X and Y are H or CH 3 ; an...
|
|
JPS53119898A |
A description is given of the preparation of ergolene derivatives with an action lowering blood pressure and the formula I in which R1 and R2 are each hydrogen or an alkyl group with 1 to 4 carbon atoms, or else together form an alkylide...
|
|
JPS53105499A |
|
